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1 POLYAMINE -P Ver.1.0 MM
2 ver. 1.0MM POLYAMINE 1. 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, (1983). 2) Ha.C. et al., The natural polyamine spermine functions directly as a free radical scavenge. Proc. Natl. Acad. Sci. USA., 95, (1998). 3) Fujisawa S. et al., Kinetic evaluation of polyamines as radical scavengers. Anticancer Res. 25, (2005). 4) Soda K. et al., Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte. J. Immunol. 175, (2005). 1
3 ver. 1.0MM 5) Zhang M. et al., Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells:a counterregulatory mechanism that restrains the immune response. J. Exp. Med. 185, (1997). 6) Gugliucci A. et al., The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?life Sci. 72, (2003). 7) Gugliucci A., Alternative antiglycation mechanisms: are spermine and f ructosamine-3-ki nase part of a carbonyl damage control pathway?. Med. Hypotheses (2005). 8) Soda K., Polyamine intake, dietary pattern, and cardiovascular disease. Med. Hypotheses (2010). 9) de la Pena N.C. et al., Inhibition of platelet aggregation by putrescine, spermidine, and spermine in hypercholesterolemic rabbits. Arch. Med. Res., (2000). 10)RamotY.et al., Polyamines and hair: a couple in search of perfection.exp. Dermatol. 19, (2010). 11) Ramot Y., Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. Plos One, 6,1-11(2011) H N NH H 2 N 2 H 2 N N H H N NH2 H 2 N NH
4 ver. 1.0MM ODC 2 12,13) 3 ODC S ) Yoshinaga K. et al., Age-related changes in polyamine biosynthesis after fasting and 3
5 ver. 1.0MM refeeding. Exp. Gerontol.28, (1993). 13) Scalabrino G. et al., Polyamines in mammalian ageing: an oncological problem, too? A review., Mech. Ageing Dev., 26, (1984)
6 ver. 1.0MM Okamoto A. et al., Polyamine content of ordinary foodstuffs and various fermented foods. Bios ci.biotech.biochem.61, (1997) ,13) 5
7 ver. 1.0MM (Diamine Oxidase) 6
8 ver. 1.0MM 4. (1) 1 ) 3 6 1mRNA p < NA βactin n=4 = 7 :2 :1100 g/ ml 3 RNA 1 2 ) mg / ml, 0.1 mg/ml, 1 1), 2),, 7
9 ver. 1.0MM 1 GAPDH mg/ ml 3 1 Western blotting (2) 8 15 % 8
10 ver. 1.0MM 1 ) 1 9 1mRNA (A) Western blotting, 1 B 10 () () (A) p <0.01 βactin n=3-5. ontrol mRNA 9
11 ver. 1.0MM Control 10. HE ICR5 = 7 :2 :1 10 mg/ kg Western blotting
12 ver. 1.0MM 2 ) 0.2 HE ( 11-A) Western blotting, 1 11-B 1 (A) 11
13 ver. 1.0MM (B) (3) ) 12. n=4~8 12
14 ver. 1.0MM (4) ** P<0.01, * P<0.05 T-test **; P<0.01, *; P<0.05 ** ** 150 * ** % 0.02 % 0.05 % 0.1 %Control (Water) 13. n=4~8 ) Igarashi K., Physiological functions of polyamines and regulation of polyamine content in cells. YAKUGAKU ZASSHI, 126, (2006). 13
15 ver. 1.0MM (5) () 15. () 14
16 ver. 1.0MM ) Ramot Y. et al., Polyamines and hair: a couple in search of perfection. Exp. D ermatol. 19, (2010). 16) Ramot Y. et al., Spermidine promotes human hair growth and is a novel modulator of uman epithelial stem cell functions. Plos One, 6, e22564 (2011). (6) GAP junction 17,18) ) 17) Ishimura H., Improvement of intercellular communication through epidermal GAP junction by seaweed plasmodesmata extract and its application to cosmetics. FRAGRANCE J., 31(12), (2003). 18) Provost N. et al., Ultraviolet A radiation transiently disrupts gap junctional communication in human keratinocytes. Am. J. Physiol. Cell Physio., 284 C51-9 (2003). 19) Shore L. et al., Polyamines regulate gap junction communication in connexin 43-expressing cells. Biochem. J. 357, (2001). 15
17 ver. 1.0MM (7) 20) Lefevre P. L. et al., Polyamines on the reproductive randscape. Endocr. Rev. 26, (2011). (8) %0.0223% 50 21) Minois N. et al., Polyamines in aging and disease., Aging, 3, 1-17 (2011). 22) Soda K. et al., Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp. Gerontol. 44, (2009). (9) TNFIL-1 6MIP-1α 1β LFA-1 23) Zhang M. et al., Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. J. Exp. Med. 185, (1997). 16
18 ver. 1.0MM 24) Soda K. et al., Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte. J. Immunol. 175, (2005). 25) Soda K. et al.,. Food style 21, 10(10), (2006). (10) 26) Soda K. et al., Polyamine intake, dietary pattern, and cardiovascular disease. Med. Hypotheses (2010). 27) De la Pena N.C., Inhibition of platelet aggregation by putrescine, spermidine,and spermine in hypercholesterolemic rabbits. Arch. Med. Res.75, (2000). (11) DNA 28,29) 28) Thierry D. et al., Protection against radiation-induced degradation of DNA bases by polyamines.,radiation Res. 153,29-35(2000). 29) Waters R.L. et al., Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity ofchromatin is influenced by tightly bound spermine. Radiation Res. 151, (1999). 17
19 ver. 1.0MM ( 17) ph 1 1 ( 18)
20 ver. 1.0MM % ( 19) () -P 70 mg / 19
21 ver. 1.0MM 9. -P 100 g 1.3 g 9.0 g (6.25) 0.1 g 17.5 g 72.1g 100g (+++) 336 kcal 5.2g 3654mg 9.31g * 4; 9; 4; 2 -P : (1) (2) (LD 50 ) 30 g 5 ddy, 2,000 mg/kg 23±2 50±10% 14 LD 50 2,000 mg/kg 20
22 ver. 1.0MM (3) Salmonella typhimurium TA100TA98 Ames 19.55,000 µg/plate P () 5 kg P Na 21
23 ver. 1.0MM (Triticum aestivum) 0.15 % 0.15 % (HPLC ) 10.0 % (1 g1052 ) (1) 20 ppm () Pb (2) 1 ppm ( 3 B ) As 2 O g () g ( ) (BGLB ) 44 % 40 % 8 % 8 % 100 % 22
24 OEM ver. 1.0MM TEL(0586) () FAX(0586) URL/ F TEL(03) FAX(03) * *
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ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504
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ORYZA OIL & FAT CHEMICAL CO., LTD. ポリアミン POLYAMINE 爪, 毛髪ケア, アンチエイジング食品素材 ポリアミン -P ( 水溶性粉末, 食品用途 ) Ver.1.0 MM 爪, 毛髪ケア, アンチエイジング素材ポリアミン POLYAMINE 1. はじめに ポリアミンは, 体内でアミノ酸から合成される 2 つ以上のアミノ基をもつ物質です ポリアミンはすべての動物やヒトの細胞内で,
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ORYZA CERAMIDE -PTPCDP8TP20CD -WSPWSP8 -LL0.8 -PCPC8PC20 -WSPCWSPC8 -LCLC0.8 Ver.13.0HS ORYZA CERAMIDE Ver.13.0HS 1. 2. 20 NMR 4 ( 1) 1 Ver.13.0HS HO CH 2 OH O O OH OH OH C CH CH H 2 NH C O R C H C H (CH
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ver. 3.3JT EVENING PRIMROSE EXTRACT 1 - PMS 1 2 1 4 Oenothera laciniata Oenothera striata Oenothera biennis Oenothera erythrosepala - 2 80 60 40 20 0 1. 2 3 PGGPAC 2. 3 4 ESR3.5 10 5 /g 4 3 1 Helicobacter
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RYZA IL & FAT CHEMICAL C., LTD. SAKURA EXTRACT Ver.1.4MK Ver. 1.4MK 1) 1300 1929 1 Ver. 1.4MK Sakura 1-caffeoyl---D-glucopyranoside quercetin 3---D-glucopyranoside 1) :, 4, 11-22 (1995). 2 Ver. 1.4MK 3
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ORYZA OIL & FAT CHEMICAL CO., LTD. 米胚芽由来ポリアミン RICE GERM POLYAMINE ORYZA POLYAMINE 1. はじめに Ver.4.1 MM ポリアミンは, 体内でアミノ酸から合成される 2 つ以上のアミノ基をもつ物質です ポリアミンはすべての動物やヒトの細胞内で, 成長期に盛んに合成されます 核酸合成やタンパク質の合成促進作用 1) だけでなく,
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ORYZA OIL & FAT CHEMICAL CO., LTD. WHITE JELLY FUNGUS EXTRACT -P () Ver. 1.3SJ Ver. 1.3SJ 1. 3000 ph 1 Ver. 1.3SJ 1. 1 2. 3 2-1. 2-2. 2-3. 2-4. SOD 3. 7 3-1. in vitro 3-2. in vivo 3-3. in vivo 3-4. in
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ORYZA OIL & FAT CHEMICAL CO., LTD. ALPHA LIPOIC ACID --P () --P80 () --WSP8 () --L1 () --PC () --PC80 () --WSPC8 () --LC1 () ver. 5.1HS ver5.1 HS 1. ALPHA LIPOIC ACID 16 3 31 0331009 - () 19 5 24 0524001
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Vol.3 No.2 Nov. 2016 Polyamine Vol. 3 No. 2 Nov. 2016 Bacteroides thetaiotaomicron 37 H 2 N H 2 N H N Spermine Spermidine H 2 N N H SMO H N NH 2 NH 2 Putrescine NH 2 SSAT SSAT AcPAO AcPAO N 1 -Acetylspermine
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