THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr non-albicans 4 non-albicans C. glabrata, C. parapsilosis, C. tropicalis, C. krusei 4 C. guil
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1 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS B ACTIONs Bundle ACTIONs Bundle ACTIONs Bundle ACTIONs project Appropriate Candidal Treatment, Implementation Of Nonneutropenic strategies ABC A Antifungals B Blood stream infection C Colonization & -Dglucan 2011 ABC Bundle Bundle Bundle Candida albicans non-albicans C. glabrata C. parapsilosis non-albicans
2 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr non-albicans 4 non-albicans C. glabrata, C. parapsilosis, C. tropicalis, C. krusei 4 C. guilliermondii C. famata C. guilliermondii C. glabrata non-albicans FLCZ non-albicans 4 Candida spp. C. albicans non-albicans C. albicans FLCZ C. albicans 1 non-albicans C. glabrata, C. krusei, C. guilliermondii VRCZ non-albicans 4 C. parapsilosis C. guilliermondii C. famata 2 L- AMB B AMPH-B C. albicans non-albicans Aspergillus AMPH-B C. lusitaniae C. lusitaniae in vitro MIC C. parapsilosis MIC FLCZ MIC 1 g/ml 2 g/ml MIC C. parapsilosis C. glabrata MIC C. glabrata C. glabrata VRCZ 2009 IDSA C. glabrata VRCZ IDSA VRCZ FLCZ
3 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS MIC MIC AMPH-B MIC 50% AMPH-B MIC MIC Bundle Bundle 1 3 ACTIONs project ABC B blood stream infection 1.Bundle Bundle BAL C. albicans non-albicans 4 C. guilliermondii Bundle 2 3
4 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr Bundle 3.Bundle TPN PFALLER, M. A., et al.: Clin. Microbiol. Rev : , % empiric -D- Bundle 2 2 frequently missed detect
5 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS CNS Bacillus 2 2 -D- empiric Bundle empiric empiric empiric presumptive -D- -D- -D- ICU 20 40% 3 4 L-AMB MIC 4. KUHN, D. M., et al.: Antimicrob. Agents Chemother : , 2002
6 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr L-AMB L-AMB Bundle Earlier appropriate therapy 1 1st F-FLCZ MCFG sepsis L-AMB 1st F-FLCZ MCFG F-FLCZ MCFG L-AMB 1st F-FLCZ MCFG C. glabrata MCFG sepsis septic shock L-AMB sepsis 1,400 sepsis 28 50% sepsis Bundle 1st L-AMB 2 1. Earlier appropriate therapy
7 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS Bundle L-AMB AMPH-B MCFG L-AMB 4 non-albicans Acute physiology and chronic health evaluation APACHE 20 sepsis septic shock L-AMB septic shock 3 g/ MRSA L-AMB L-AMB L-AMB septic shock AMPH-B L-AMB L-AMB C. glabrata C. krusei empiric MCFG L-AMB 2nd L-AMB 2nd F-FLCZ 5 MCFG 3 Bundle
8 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr MCFG nd 2nd sepsis C. glabrata C. krusei L-AMB L-AMB F-FLCZ MCFG F-FLCZ VRCZ VRCZ TDM VRCZ VRCZ L-AMB VRCZ 2 Bundle 5 F-FLCZ AMPH-B L-AMB 5-FC nonalbicans Bundle F-FLCZ 5. Bundle Bundle 2 2 Bundle Bundle Yes/No
9 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS L-AMB 3. Antifungal heterogeneity L-AMB 6 L-AMB AMPH-B 3 L-AMB MCFG C. parapsilosis Trichosporon Antifungal heterogeneity Antifungal heterogeneity 3 L-AMB AMPH-B Infection control team ICT Bundle 1 Jpn. J. Antibiotics 62 5 : , ARENDRUP, M. C.: Curr. Opin. Critics Care 16 5 : , TUMBARELLO, M. et al.: J. Clin. Microbiol : , 2007
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3 A B C A A 2 5 1 62 A 1 1 2 63 3 1 A proven invasive fungal diseases 1 2 3 BAL 24 : Fusarium spp. 4 2 : Candida Trichosporon B probable invasive fungal diseases Cpossible invasive fungal diseases 5 1
感染症学雑誌第80巻第6号
Candida Candida albicans Candida parapsilosis Candida glabrata Candida tropicalis C. albicans C. grabrata C. tropicalis µ Candida guilliermondii µc. parapsilosis µ Candida µcandida C. albicans µ µ µ µ
1 見出し1，12ポ，日本語ゴシック，英語Arial，段落後は6ポの設定です
8. Page1 8. B 1 5) 6) 2099 2370 50 400 mg 19 (1) 1) (a) 78.9% 30/38 4 3 35.7% 5/14 71.4% 10/1485.7% 12/142 1 83.3% 5/63 2 1 1 1 8. Page2 (b) 2099 1897 82.4% 1562/1897 2 84.0% 1298/1545 3 2 80.4% 472/58779.0%
15,000 例の分析では 蘇生 bundle ならびに全身管理 bundle の順守は, 各々最初の 3 か月と比較し 2 年後には有意に高率となり それに伴い死亡率は 1 年後より有意の減少を認め 2 年通算で 5.4% 減少したことが報告されています このように bundle の merit
2011 年 11 月 30 日放送 真菌感染症 兵庫医科大学感染制御学教授竹末芳生はじめに深在性真菌症の診断 治療ガイドラインの改訂版が 2007 年に発表され それを普及させる目的で 真菌症フォーラムでは ACTIONs プロジェクトを行ってきました これは侵襲性カンジダ症の病態 診断 治療を Antifungals, Blood stream infection, Colonization &
Key words: yeast, Etest(R), microdilution method, MIC Table 1 MICs of quality control strains The data shown are the range of MIC performed in triplicate Table 2 Renge of MICs, MIC50s and MIC90s for 81
2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 1 Feb. 2014 4 5 CRBSI Catheter related bloodstream infection 1. n 167 I. 4 4, 6 5 71% 7 10 Candida albicans
Feb. 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 1 1 1 1, 3 2, 3 1 2 3 2013 11 13 CRBSI compromised host CRBSI 4 CVC CVC 1 3 - -D- / 1 ICU 2, 3 4 2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 1 Feb. 2014
1.8.2 Page MIC () MIC 50 / MIC 90 µg/ml Candida albicans (54) / Candida glabrata (25) 0.25 / 0.5 Candida guilliermondii a) (2)
1.8.2 Page1 1.8.2 96% 2002 40 B 1 123 (1) in vitro 1) in vitro C. glabrata C. krusei 1 2 19951997 3 1999 2002 MIC MIC 2 1.8.2 Page2 1 19951997 MIC () MIC 50 / MIC 90 µg/ml Candida albicans (54) 0.016 /
Candida albicans In Vitro Diagnostics (13)--D-Glucan Determination Reagents
D 012 Candida albicans In Vitro Diagnostics (13)--D-Glucan Determination Reagents DATA : 1 DATA : 2 3 DATA : UNGITEC 1 1 DATA : 20pg/mL 1020pg/mL 10pg/mL (cut off 20pg/mL) 90.2%(37/41) 100%(85/85) 96.8%(122/126)
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THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr NTT NTT
Apr. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 121 23 7 7 IDSA 122 24 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr. 2012 7 2005 3 10 7 2011 6 2 NTT NTT 2011 6 Apr. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS
VOL.42 NO.3 R= H: Itraconazole R=OH: Hydroxy-itraconazole (R 63373) Fig. 1. Structures of itraconazole and hydroxyitraconazole. Candida albicans, Candida glabrata, Candida guilliermondii, Candida tropicalis,
38 38 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 1 Feb CT A B A CT B 20xx 2 8 LAM 20xx 1 12 CT S6, S10 Aspergillus spp. Micafungin MCFG 150 mg/ I
Feb. 2013 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 1 37 37 Liposomal amphotericin B 1 2 2 2 1 1 1 2 1 1 2 2012 12 25 33 Lymphangioleiomyomatosis: LAM 2 20xx 1 CT Aspergillus spp. Micafungin MCFG Itraconazole
CHEMOTHERAPY FEB. 1994
CHEMOTHERAPY FEB. 1994 CHEMOTHERAPY FEB. 1994 Table 1. In vitro effect of flucytosine combined with fluconazole on Candida app. Fig. 1. Chemotherapeutic effect of combinations of flucytosine and uconazole
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Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 389( 15 ) 1. MDS collagenase 2. 1 3. 4. / 390( 16 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 4 4 2004 10 2 1 NTT Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS
日本化学療法学会雑誌第56巻第3号
β Key words Candida albicans albicans Candida C. albicans Candida glabrata Candida krusei albicans Candida C. glabrata C. albicans albicans Candida β in vitro in vivo C. glabrata C. krusei I β γ µ Candida
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-95- -96- 日中医学協会助成事業 中国吉林省にて分離された Candida guilliermondii の薬剤感受性試験と播種性マウ スモデルにおける micafungin の有用性 研究者氏名 Dongmei Jia 中国所属機関北華大学附属病院 吉林市 吉林省 中国日本研究期間長崎大学大学院医歯薬学総合研究科感染免疫学講座指導責任者教授河野茂共同研究者泉川公一 宮崎泰可 要旨中国吉林省の医療施設で分離されたカンジダ属
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant Fig. 1 Annual changes in percentages of fungi isolated from blood and vascular catheters Fig. 2 Frequencies of fungi
日本化学療法学会雑誌第54巻第S-1号
β β Key words β Candida krusei Candida glabrata β I β Drugadministration Baselinecharacteristics Clinicalsymptom Mycologicaltests Plasmadrugconcn Adverseevents Laboratorytests ) -leadecg Clinicalphotograph
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VOL.51 NO.6 JUNE 2003 JUNE 2003 9) Niederman MS et al: Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy and prevention.
原 著 日集中医誌.2010;17:33 ~38. 深在性真菌症の診断 治療における β-d- グルカン値の評価 *1 *1, 2, 5 *3 藤木早紀子志馬伸朗廣瀬有里 *4 *3, 5 小阪直史藤田直久 要約 : 目的 深在性真菌症の診断における β-d- グルカン (BDG) の測定意義と適正
原 著 日集中医誌.2010;17:33 ~38. 深在性真菌症の診断 治療における β-d- グルカン値の評価 *1 *1, 2, 5 *3 藤木早紀子志馬伸朗廣瀬有里 *4 *3, 5 小阪直史藤田直久 要約 : 目的 深在性真菌症の診断における β-d- グルカン (BDG) の測定意義と適正な適用 評価法を考察した 方法 単一大学病院の感染症検査室および薬剤部データベース解析により, 1998
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平成 25 年 11 月 29 日 ( 金 ) 第 7 回大阪真菌症研究会ホテル日航大阪 深在性真菌症の治療を考える 公益財団法人鹿島病院感染症診療支援センター 菅野治重 講演内容 1 深在性真菌症について 2 抗真菌薬について 3 抗真菌薬の感受性試験について 4 耐性菌の動向 5 今後の課題 内臓真菌症の推移 FLCZ ITCZ MCFG 50.00% VRCZ 40.00% 30.00% 20.00%
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400 46 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 LVFX 100 mg 3 / 7 150 mg 2 / 7 2 2006 2008 9 LVFX PK PD 2009 7 100 mg 1 3 500 mg 1 1 AUC/MIC
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日本化学療法学会雑誌第50巻新薬特集号
micafungin in vitro 3 3 micafungin Candida Aspergillus Candida albicans fluconazole Candida tropicalis, Candida glabrata, Candida krusei Aspergillus 90 MIC90 0. g ml amphotericin B fluconazole itraconazole
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Table 1 Laboratory findings on admission
Key words: acute myelocytic leukemia, pulmonary aspergillosis, immunodiagnosis Table 1 Laboratory findings on admission Fig. 1 Clinical course of Case A. Y. 26y.o. male 山下 え り子 他 88 Fig. 2 A. On admission.
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Apr. 2013 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 111 53 8 8 1. Ph-ALL Liposomal amphotericin B 1 2. CBT MCFG L-AMBAML 2 112 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr. 2013 8 2005 3 10 8 2012 6
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Journal Club ICU 患者におけるエンピリックな抗真菌薬投与 2016/12/13 東京ベイ 浦安市川医療センター 集中治療室薬剤師鈴木俊一郎 本日の論文 背景 抗真菌薬の進歩にも関わらず カンジダ感染症の死亡率は依然として高いままである Intensive Care Med. 2014;40(9):1303-1312. Intensive Care Med. 2014;40(6):839-845.
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Study on Clinical Factors Affecting the Fungal Culture Test - Relevance of Dry Mouth - Yoshiko YAMAMURA, Yukihiro MOMOTA, Hideyuki TAKANO, Koichi KANI, Katsumi MOTEGI, Fumihiro MATSUMOTO, Masayuki AZUMA
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Variegation of pathogenic Candida species and its impact on medical mycology Hideyo YAMAGUCHI 1, 2 1980 i ii iii iv v 3 6 Candida 3, 7 4 23 53 6, 7 Candida albicans non-albicans Candida spp. 4 C. glabrata,
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Key words β Candida Table1. MCFGCPAstudygroup Investigator (representative) YoshitsuguMiyazaki NaoyukiMiyashita RyoichiAmitani KenjiOgawa AtsuyukiKurashima ToshiroKiguchi MichiakiMishima YuichiInoue HiroshiSaito
Table 1 Epidemiologic characteristics in the elderly patients with sepsis Table 2 Main underlying disease
Key words: elderly patient, sepsis, multiple organ failure (MOF) Table 1 Epidemiologic characteristics in the elderly patients with sepsis 1985-1994 Table 2 Main underlying disease Fig. 1 The yearly frequency
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VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )
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CHEMOTHERAPY SEPT Amphotericin B (AMPH-B), flucytosine (5- SDA PDA Procedure for disk method 1. Prepare agar plates containing two-fold dilution
CHEMOTHERAPY SEPT. 1993 Amphotericin B (AMPH-B), flucytosine (5- SDA PDA Procedure for disk method 1. Prepare agar plates containing two-fold dilutions of drugs and dry agar surface at room temperature
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Table 1 Profiles of and number of clinical specimens obtain in febrile episodes *
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Table 1 Eight clinical cases with candidemia gra.; granulocytopenia (<400/ml) before candidemia AMoL; acute monocytic leukemia VH; intravenous yperali
Key words: candidemia, HA-test, Cand-Tec, D-arabinitol, Ĉ-d-glucan Table 1 Eight clinical cases with candidemia gra.; granulocytopenia (
Oct THE JAPANESE JOURNAL OF ANTIBIOTICS Pseudomonas aeruginosa 186 P. aeruginosa piperacillin PIPC, taz
Oct. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 5 327 27 2013 2014 2016 7 5 2013 2014 Pseudomonas aeruginosa 186 P. aeruginosa piperacillin PIPC, tazobactam/piperacillin TAZ/PIPC, ceftazidime CAZ, cefepime
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Key words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination
Key words : candidemia, endotoxin, D-arabinitol, Candida antigen, serological examination Fig. 1 The value of fungal index and D- arabinitol/creatinine. Fungal index was mesured by Endotoxin D and Endospecy
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History I COE
2008 108-8641 5-9-1 TEL 03-5791-6334FAX 03-5791-6335 e-mailgakufu@lisci.kitasato-u.ac.jp 228-8555 1-15-1 TEL 042-778-9760FAX 042-778-9761 e-mailnyushi@kitasato-u.ac.jp URL http://www.kitasato-u.ac.jp/lisci/index.html
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菌種 報告年 株数 MIC(μg/mL) Range MIC50 MIC > ( 幾何平均 ) C.tropicalis >
生物学的同等性試験におけるイトリゾール カプセル 50 のロット間での統計学 的有意差が本剤の有効性及び安全性に与える影響について イトリゾール カプセル 50 は,1993 年に内臓真菌症 ( 深在性真菌症 ), 深在性皮膚真菌症及び表在性皮膚真菌症を適応症として承認され, その後,1999 年に爪白癬等の適応を追加,2004 年及び 2006 年にはそれぞれ爪白癬のパルス療法および注射剤からの切り替えとしての新用法
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1950 1970 1990 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 6,788 7,123 5,384 4,915 4,908 4,927 4,895 4,919 4,936 4,927 4,897 5,010 5,008 1,456 1
1950 1970 1990 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 6,788 7,123 5,384 4,915 4,908 4,927 4,895 4,919 4,936 4,927 4,897 5,010 5,008 1,456 1,616 927 824 826 821 813 808 802 803 801 808 806 18,483
Table 1. Relationship between date of detection in culture and number of colony of N. asteroides isolated from the patients in various media.
Key words: Nocardia asteroides, Nocardiosis, Minocycline Table 1. Relationship between date of detection in culture and number of colony of N. asteroides isolated from the patients in various media. Table
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59 2014 712 59 2014 712 59 171 3F 2F 1F B2F B3F B2F 900 1 2 3 900930 900 1630 30940 1000 1100 9401140 9401050 1 D11 D17 10501200 3 9 D31 D37 9401050 2 10501200 D21 D27 4 D41 D47 1200 1300 12101310 1 12101310
600mg 600mg CTD 2 2.5 2.5 Page 3 2.5...7 2.5.1...7 2.5.2...27 2.5.3...28 2.5.4...42 2.5.5...55 2.5.6...79 2.5.7...97 2.5 Page 5 73 67 31 48 48A 102 104 105 106 ALP ALT(GPT) AST(GOT) AUC AUEC BID BUN
Table 1.Quality control of MICs for reference strains Table 2.Antimicrobial activity of gatifloxacin against aerobic bacteria Table 4.Antimicrobial activity of gatifloxacin and other quinolones against