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1 Spatio-temporal regulation of ERK1/2 MAP kinase

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6 20) Murphy, L. 0., MacKeigan, J. P., Blenis, J.: Mol. Cell. Biol., 24, (2004) 21) Harada, T., Morooka, T., Ogawa, S., Nishida, E.: Nature Cell Biol., 3, (2001) 22) Yamamoto, T. et al.: Curr. Biol, 16, (2006) 23) Mackeigan, J. P., Murphy, L. 0., Dimitri, C. A., Blenis, J.: Mol. Cell. Biol., 25, (2005) 24) Therrien, M., Michaud, N. R., Rubin, G. M., Morrison, D. K.: Genes Dev., 10, (1996) 25) Morrison, D. K., Davis, R. J.: Annu. Rev. Cell Dev. Biol., 19, (2003) 26) Nguyen, A. et al.: Mol. Cell. Biol., 22, (2002) 27) Schaeffer, H. J. et al: Science, 281, (1998) 28) Teis, D., Wunderlich, W., Huber, L. A.: Dev. Cell, 3, (2002) 29) Sewing, A., Wiseman, B., Lloyd, A. C., Land, H.: Mol. Cell Biol., 17, (1997) 30) Woods, D. et al.: Mol Cell. Biol., 17, (1997) 31) Roovers, K., Assoian, R. K.: Bioessays, 22, (2000) 32) Fukuda, M. et al.: Nature, 390, (1997) 33) Karlsson, M. et al.: J. Biol. Chem., 279, (2004) 34) Khokhlatchev, A. V. et al.: Cell 93, (1998) 35) Adachi, M., Fukuda, M., Nishida, E.: EMBO J., 18, ) Sturgill, T. W., Wu, J.: Biochim. Biophys. Acta, 1092, (1991) 2) Nishida, E., Gotoh, Y.: Trends Biochem. Sci., 18, (1993) 3) Marshall, C. J.: Cell 80, (1995) 4) Treisman, R.: Curr. Opin. Cell Biol., 8, (1996) 5) Robinson, M. J., Cobb, M. H.: Curr. Opin. Cell Biol., 9, (1997) 6) Lewis, T. S., Shapiro, P. S., Ahn, N. G.: Adv. Cancer Res., 74, (1998) 7) Pouyssegur, J., Lenormand, P.: Eur. J. Biochem., 270, (2003) 8) Ebisuya, M., Kondoh, K., Nishida, E.: J. Cell Sci., 118, (2005) 9) Gotoh, Y. et al.: Eur. J. Biochem., 193, (1990) 10) Traverse, S. et al.: Curr. Biol., 4, (1994) (1999) 36) Matsubayashi, Y., Fukuda, M., Nishida, E.: J. Biol. Chem., 276, (2001) 37) Whitehurst, A. W. et al.: Proc. Natl. Acad. Sci. USA, 99, (2002) 38) Robinson, M. J. et al.: Curr. Biol., 8, (1998) 39) Brunet, A. et al.: EMBO J., 18, (1999) 40) Torii, S. et al.: Dev. Cell 7, (2004) 41) Formstecher, E. et al.: Dev. Cell 1, (2001) 42) Gaumont-Leclerc, M. F., Mukhopadhyay, U. K., Goumard, S., Ferbeyre, G.: J. Biol. Chem., 279, (2004) 43) Menice, C. B. et al.: J. Biol. Chem., 272, (1997) 44) DeFea, K. A. et al: J. Cell Biol., 148, (2000) 45) Ishibe, S., Joly, D., Zhu, X., Cantley, L. G.: Mol. Cell 12, (2003) 11) Meloche, S., Seuwen, K., Pages, G., Pouyssegur, J.: Mol. 46) Harrison, R. E., Sikorski, B. A., Jongstra, J.: J. Cell Sci., 117, Endocrinol, 6, (1992) 2157(2004) 12) Cook, S. J., McCormick, F.: Biochem. J., 320, (1996) 13) Roovers, K. et al.: Mol. Biol. Cell 10, (1999) 47) Bivona, T. G., Philips, M. R.: Curr. Opin. Cell Biol., 15, (2003) 14) Di Fiore, P. P., Gill, G. N.: Curr. Opin. Cell Biol., 11, (1999) 15) Hanafusa, H., Torii, S., Yasunaga, T., Nishida, E.: Nature Cell Biol., 4, (2002) 16) York, R. D. et al.: Nature, 392, (1998) 17) Bhalla, U. S., Iyengar, R.: Science, 283, (1999) 18) Bhalla, U. S., Ram, P. T., Iyengar, R.: Science, 297, (2002) 19) Murphy, L. 0. et al.: Nature Cell Biol., 4, (2002)

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