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1 2004
2 Sustainable Focus DAAM P19 P32 P42 P19 P41 P18 P16-17 P22 P KYOWA BIO-INNOVATOR
3 Kyowa Hakko Group s Sustainability Universe OUT CO2 SOx NOx IN OUT 2
4 MR IN OUT
5 CONTENTS
6 , TEL: Biokyowa Inc. Agroferm Hungarian-Japanese Fermentation Industry Ltd. (AGROFERM) Select Supplements, Inc. (SSI) Kyowa Pharmaceutical, Inc. Kyowa Hakko U.K. Ltd. BioWa Inc ,299 6,749 6,294 3,749 3,756 3,787 3,593 3,488 7,866 7, Kyowa Hakko U.S.A., Inc. Kyowa Hakko Europe GmbH Kyowa Hakko U.K. Ltd. Kyowa Italiana Farmaceutici S.R.L. Kyowa Hakko (H.K.) Co., Ltd. Kyowa Hakko Industry (Singapore) Pte. Ltd. Kyowa Hakko (Thailand) Ltd. Kyowa Hakko (Malaysia) Sdn. Bhd. Kyowa Pharmaceutical (H.K.) Co., Ltd Degussa AG Agroferm Hungarian-Japanese Fermentation Industry Ltd.
7 KYOWA BIO-INNOVATOR P14, P22-26, P35 P16, P26, P35 P18, P26, P35 P19, P26, P35 5
8 CSR ,
9 KYOWA BIO-INNOVATOR 21 IT
10 P ISO ISO14001 OSHMS ISO % KEP 1% P34 CO2 2010CO % % SOx NOx 2, COD 1, , GOP P34 1% 5% 3 LCA 4 5 GP P CO2 CO SOxNOx HP COD HP HP % 4 50%
11 COD 3.7%CO % P10 P % % % 2010CO21990 P % P42, % 88% % P46 1,07213% % % % P % % % CO % % P32 P32, 40 P48 2.2% 1% 3.5% 56% LCIA 7 4% LCA P34 P19, 35 P34 P25, 43 P12, 19 P32, 46 P1419 EBM EBMEvidence Based Medicine P22, 23 P25, 27 1 ISO OSHMS Occupational Safety and Health Management System ILO 3 4 LCA Life Cycle Assessment LCIA 9
12 1 RC CSR 2 PDCA 9ISO ISO14001OSHMS 4 RC CSR
13 PDCA P34 Plan Plan Act Do Act Do Check Check ISO OSHMS Occupational Safety and Health Management System ILO 5 VSC 11
14 1 LCA MSDS 2 3 MSDS MSDS MSDS ISO14001OSHMS ISO GMP 5 HACCP 6 P8, P34 P8, P32, P48 P8, P22, P25, P MSDS 3 4 ISO GMP 6 HACCP
15 KYOWA BIO-INNOVATOR 13
16 POTELLIGENT TM POTELLIGENT ADCC POTEL- LIGENT TM ADCC Fc NK ADCC ADCC 14 POTELLIGENT TM BioWa, Inc ADCC Antibody-dependent cellular cytotoxicityadcc
17 BioWa, Inc BioWa Kyowa Pharmaceutical, Inc. BioWa BIO2004 BioWa BioWa BioWaPOTELLIGENT TM BioWa POTELLIGENT TM BioWa BioWa 15
18 BCAA BCAABCAA CDP- BCAA
19
20 CONO 37 7 MP
21 HCFC 2010HCFC 5, ,000 DAAM DAAM DAAM DAAM ADH LIME LIME HFC 10,000 5,
22 1970 CO COD ISO
23 21
24 MR 1 MR MR MR SMART SMARTMR MR , , , , , , ,000 10,000 15,000 20, QA 22 1 MRMedical Representatives
25 MR FAX FAX Q&A URL: EBM Evidence-based Medicine ,000 COPE Trial ,0003, COPE Trial COPE Trial EBM 1 COPE Trial Combination Therapy of Hypertension to Prevent Cardiovascular Events Trial
26 1 23 GLP GCP 2 23 GPMSP GLP 2 GCP Good Laboratory Practice Good Clinical Practice 3 GPMSPGood Post Marketing Surveillance Practice
27 P43 OECD 1 lccahpv 2 LRI 3 HPV2 1UNEP JETOC DEHP DEHP DEHP SOT 4 42 SPEED98 DEHP OECD Organization for Economic Cooperation and Development 2 HPV 3 LRI ICCA 4 SOT Society of Toxicology 25
28 CS GMPISO9001HACCP 22SMART CS GMPISOHACCP
29 27 P ISO9001GMP GMP
30 RC NGO 50 RC RC JICA ASEAN RC RC
31 Tel: Tel: ,5343,2861, NASANIH 1 RCP11 29
32
33 Kyowa Hakko Europe
34 ,126 OSHMS , m , , ,126 P ,
35
36 GP ISO ISO KEP 2010CO % %3 3 1 CO2 PDCA GOP % 5% GOP GOP 56 34
37 3 10% 10% 10% , , CO CODNP 4 SOxNOx 0.02% 0.7% 0.2% 3.7% 24% 75% 12% 5% 7% 76% 95.5% 0.6% LIME LIME LIME 6 100% 0.7% 1.6% 100% 7.2% 4.4% 100% 4.0% 18.0% 100% 4.7% 2.1% 100% 3.0% 5.6% LIME 35
38 CO2 2 CO COD 53,000 16, T-N 470 T-P 20 CO CO2 670 SOx 1,070 CO ,000 9, NOx ,000 16,000 CO2 82 1,170 1,100 30,000 12, CO LCA LCA-Environmental load of 4000 social stocks CO % 13% 3% 19% 3% 6% 19% 3% 81% 5% 73% 61% 31% 78% 2% 36 COD+N+P SOx+NOx+ CO2
39 , ,400 CO ,800 COD 15 T-N 18 T-P CO2 39 SOx 23 NOx , CO , ,000 4, ,000 COD 470 T-N 430 T-P CO2 210 SOx 990 NOx , ,000 COD 130 T-N 17 T-P 3 44 CO2 410 SOx 2 NOx ,000 1, CO , CO ,700 16,000 CO , ,000 5, ,900 COD 31 T-N 4 T-P CO2 16 SOx 62 NOx ,000
40 COD ,182 5, , COD 263 1, , , , , , ,218 7, , ,488 8,652 31,608 29, ,270 1,
41 COD CO28.2CO2CO COD SOx NOx , /- 166 / /- 4 / COD3, , % % ISO /5,0003,0003 WWF JAPAN 1,365 1, , oxo process 39
42 CO CO CO2 CO2 1, CO CO % ISO CO
43 SOx 1 13NOx SOx COD COD COD SOX NOX 1,500 1,299 1,293 1,229 1,200 1,177 1, SOx 600 1, NOx COD 1,500 COD 1,200 1,172 1,244 1,235 1, SOx 2 NOx 3 CODChemical Oxygen Demand 41
44 ,803 4, , , , , ,961 1, ,570 2,355 2, , , , , ,000 3,000 2,000 1, , %
45 QA % 88% / ,000 16, , ,000 13,114 2, % 10.1% 1
46 , CO2 101 SOx 13 NOx ,000 BOD CO2 15 3SSI BOD 2004Degussa AG 99.8% CO215 55, ,023 1,171 1,394 1, ,500 1, ,500 1, RONG HUIZHU
47 Wuxi Kyowa Food Co., Ltd. Shanghai Kyowa Amino Acid Co., Ltd. 45
48 PRTR MSDS 12 PRTR 500 MSDS MSDSMSDS PRTRPollutant Release and Transfer Register PRTR 1354
49 PRTR1 PRTR PRTR PRTR , , , , , N,N ,5,5--- 1, , , , , mg-teq PRTR1 5,300t 120t 0t 160t 301,000t 30t 8t 0 VOC VOC
50 PCB PCB PCB
51 ISO CO2
52 ,000m 2 ISO % SOx 1, % NOx % % % COD % % % 136, ,254 76% % ,000m 2 ISO SOx NOx COD % % % % % % % % 6,360 7, % % ,000m 2 ISO m 2 SOx NOx COD % % % % % % % % % ,000m 2 ISO SOx NOx COD % % % % % % % % 50
53 ,000m 2 ISO SOx NOx COD % % % % % % % % % % ,000m 2 ISO SOx NOx COD % % % % % % % % 1, % % ,000m 2 ISO SOx NOx COD % % % % % % % % 46,257 42,519 92% % ,000m 2 ISO SOx NOx COD % % % % % % % % 51
54 ,749 3,756 3,786 3,592 3, IR , ROA ROE 1 348,838 26,836 10,017 9,041 11,358 29, ,096 13, ,042 6, ,285 16,089 8,485 11,791 14,768 31, ,772 51, ,047 6, ,668 20,357 5,535 11,454 17,819 29, ,113 74, ,652 7, ,610 17,712 9,395 17,092 18,502 28, ,410 87, ,692 7, ,910 21,656 11,274 21,053 19,153 25, , , ,039 7, $3,300, ,912 94,777 85, , ,336 3,416, ,388 2,129, =
55
56 NGO CERES 2. PDCA CSR 3. PDCAP ISO12100 ILOOSHMSISO12100 OSHMSISO
57 C B J I H D G K L Q M P S T A E F O N U K.Mita: SMRI Sustainable Management Tree
58 Saccharomyces cerevisiae TEL FAX
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