スライド 1

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1 msv CT mSv 10 40mSv mSv 5 (CT) mSv mSv BRCA mSv3% BRCA60-280% 3 5m Sv 1m Sv 12%

2 .

3 SMR

4 SMR

5 SMR

6 SMR

7 1.10 SMR

8 10mSv BRCA Pijpe A, Andrieu N et al. Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE- RAD- RISK). BMJ Sep 6;345:e5660

9 Anouk Pijpe BMJ 2012 BRCA BRCA

10 BRCA X0.5mSv 25

11 X X 5 Andrieu N et al. Effect of chest X- rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO- HEBON, and IBCCS Collaborators' Group. J Clin Oncol Jul 20;24(21): Epub 2006 Jun 26.

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13 CT 195% PearceLancet 2012

14 CT 195% PearceLancet 2012

15 X 1. CT mSv mSv3% 40mSv12% CMAJ Mar 8;183(4): Epub 2011 Feb 7. Cancer risk related to low- dose ionizing radiation from cardiac imaging in patients after acute myocardial infarction. Eisenberg et al.

16 X (+3%) %/10mSv (+6%) (+9%) (+12%) mSv 10mSv 20mSv 30mSv 40mSv msv 0mSv=1.000;2SD Eisenberg CMAJ. 2011

17 5m Sv 1m Sv 12 This work was supported by the Department of Health for England and Wales, Scottish Government and CHILDREN with CANCER (UK), Kendall GM. et al. A record- based case- control study of natural background radiation and the incidence of childhood leukemia and other cancers in Great Britain during Leukemia Jun 5. doi: /leu

18 Kendall GMLeukemia, % 95% mgy

19 10mSv3 10mSv mSv101

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21 % 100 () 30% 3%

22 1. 2.

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28 1995 Thyroid

29 Ito M, Yamashita S, Ashizawa K, Namba H, Hoshi M, Shibata Y, Sekine I, Nagataki S Thyroid FNA 55,04526,406 28,648 1,396197FNA

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36 ,054 38, * 16mm 1015mm Ito M, Yamashita S, Nagataki S Thyroid

37 * IJC6%3E3.0.CO;2-3/pdf Int J Cancer Jan 3;65(1): Histopathological characteristics of childhood thyroid cancer in Gomel, Belarus. Ito M, Yamashita S, Ashizawa K, Hara T, Namba H, Hoshi M, Shibata Y, Sekine I, Kotova L, Panasyuk G, Demidchick EP, Nagataki S. 38

38 39

39 ,054 38,114 40

40 ,949 38,114 41

41 3 1 42

42 u.ac.jp/nsrg/seminar/no91/malko_comments.pdf Malko 43

43 44

44 367 55,054 Our results provide the first epidemiological evidences of cytologically diagnosed childhood thyroid diseases among 55,054 children and suggest a high incidence of thyroid cancer and possibly also of autoimmune thyroid disease around Chernobyl. In radiosensitive children, the thyroid may be affected directly or indirectly, by either immediate exposure to radiation or continuous exposure to low- dose radiation in the contaminated area. To shed light on these possibilities, long- term follow- up studies should be organized through international scientific cooperation. This study will serve as an important data base for further analyses, and suggests that childhood thyroid diseases, including both neoplasms and immunological disorders, are consequences of radioactive fallout. 45

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対象集団 報告年 がんの種類 累積被ばく量 1 医療被曝 2006 乳がん数 msv 2 日本原発労働者 低線量被ばくによる有意ながんリスク増加が証明されたチェルノブイリ以外の研究一覧 2011 全がん 肺がん 肝がん 3 医療被曝 (CT) 2011 全がん 10mSv 3~10% 10~ 40m

対象集団 報告年 がんの種類 累積被ばく量 1 医療被曝 2006 乳がん数 msv 2 日本原発労働者 低線量被ばくによる有意ながんリスク増加が証明されたチェルノブイリ以外の研究一覧 2011 全がん 肺がん 肝がん 3 医療被曝 (CT) 2011 全がん 10mSv 3~10% 10~ 40m ファイルご希望の方 メールを matsuzak@maple.ocn.ne.jp 対象集団 報告年 がんの種類 累積被ばく量 1 医療被曝 2006 乳がん数 msv 2 日本原発労働者 低線量被ばくによる有意ながんリスク増加が証明されたチェルノブイリ以外の研究一覧 2011 全がん 肺がん 肝がん 3 医療被曝 (CT) 2011 全がん 10mSv 3~10% 10~ 40mSv 4 医療被曝 2012

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