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1
2 v
3 CONTENTS COLUMN 15 RAGEAGEs 21 COLUMN COLUMN NADPH COLUMN GLP COLUMN AGEs COLUMN GWAS COLUMN 69 COLUMN vi
4 COLUMN GFR decliner remission RAS COLUMN 124 COLUMN COLUMN RhoRho COLUMN COLUMN diabetic cardiomyopathy 147 COLUMN vii
5 3 162 COLUMN Hb ESA Hb COLUMN COLUMN nephrogenic systemic fibrosisnsf COLUMN FROMJ JDOIT COLUMN vacuolar H ATPase 200 Nrf2 203 COLUMN SIRT1 219 HIF1 225 COLUMN HIF1 229 mtor 231 COLUMN mtor viii
6 ix
7 x
8 Quick Index p.2 p.7 p.78 p.84p.89 p.94 p.66 p.100 p.107p p.128 p.134 p.182 p.139 p.146 p.154 p.162 p.168 p.172 p.176 p.188 p p.182 xi
9 Quick Index 1 ACCOMPLISHAvoiding cardiovascular events through combination therapy in patients living with systolic hypertension 11,506 trial ACE Ca ACCORD LipidAction to control cardio vascular risk in diabetes lipid trial 2 5, ACCORDAction to control cardiovascu lar risk in diabetes 2 10, ADVANCEAction in diabetes and vascu lar diseasepreterax and diamicron modi fiedrelease controlled evaluation , ALLHATAntihypertensive and lipidlow ering treatment to prevent heart attack trial 33,357 Ca ACE ALTITUDEAliskiren trial in type 2 diabe tes using cardiorenal endpoints ACE ARB 2 8,600 ACE ARB ASUCA Assessment of clinical useful ness in CKD patients with atorvastatin CKD egfr 131 AURORAA study to evaluate the use of rosuvastatin in subjects on regular hemo dialysisan assessment of survival and cardiovascular events , BENEDICTBergamo nephrologic diabe tes complications trial 2 1,209 Ca ACE 117 CARECholesterol and recurrent events trial 4, CASEJCandesartan antihypertensive survival evaluation in Japantrial 1 4,728 ARB Ca 120 CHOIRCorrection of hemoglobin and outcomes in renal insufficiencytrial CKD 1, gdL 11.3gdL Chronic kidney disease Japan cohort study CKD 3,000 CKD 162 CORE Collaborative organization of rheothrx evaluation 2, xii
10 CREATEThe cardiovascular risk reduc tion by early anemia treatment with epoe tin beta DAISDiabetes atherosclerosis interven tion study DCCTDiabetes control and complica tions trial DNETTJapanDiabetic nephropathy re mission and regression team trial in Ja pan EDICEpidemiology of diabetes interven tion and complications EMERALDEnhanced myocardial effica cy and recovery by aspiration of liberated debris EUCLIDEURODIAB controlled trial of lisinopril in insulindependent diabetes mellitus FIELD Fenofibrate intervention and event lowering in diabetes CKD , DCCT 1, CKD 165 DCCT PCI ACE 2 9, D German diabetes and dialysis studydie deutsche diabetes dialyse 2 1, FROMJThe frontier of renal outcome modifications in Japan CKD GUARDGauging albuminuria reduction with lotrel in diabetic patients with hyper tension ACE Ca 125 HOPE Heart outcomes prevention evaluation study HOTHypertension optimal treatment study 55 ACE 3, mmHg 18,790 ACE IDEALInitiating dialysis early and late 18 CKD 828 CKD 169 xiii
11 Quick Index p.14 NO NADHDAG AGEs p.21 AGEs RAGEAGEs NFB DAGPKC DAGPKC PKC enoset1 VEGF TGF NFB NADPH p.26 DNA Ang II TGFPAI1 enos p.32 ICAM1 p.54 SLC12A3ELMO1 NCALDACACB p.59 PKCNFB RAGE Ang IITGF1 ROS p.196 Nrf2p.203 p.209 p.215sirt1p.219hif1 p.225mtorp.231 p.46 TGF VEGF p.39 GFR hyperfilterration xvi
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15 1 GFR2 MEMO HDL HDL 10
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19 ACE g cm 47 kg mmhghba1cngsp g 2.6 gdl Ccr68 ml ACE Ca g ACE Ccr 43 ml 1 HbA1c NGSP Ccr ml 4050 ml 142
20 DTP TEL ISBN Published by Nakayama Shoten Co., Ltd. Printed in Japan
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i 1 1 1 2 3 5 5 6 7 9 10 11 13 13 14 15 15 16 17 18 20 20 20 21 22 ii CONTENTS 23 24 26 27 2 31 31 32 32 33 34 37 37 38 39 39 40 42 42 43 44 45 48 50 51 51 iii 54 57 58 60 60 62 64 64 67 69 70 iv 70 71
7 i 7 1 2 3 4 5 6 ii 7 8 9 10 11 1 12 13 14 iii.......................................... iv................................................ 21... 1 v 3 6 7 3 vi vii viii ix x xi xii xiii xiv xv 26 27
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i 1 1 2 3 5 5 6 7 7 8 9 9 10 11 11 11 12 2 13 13 14 15 15 16 17 17 ii CONTENTS 18 18 21 22 22 24 25 26 27 27 28 29 30 31 32 36 37 40 40 42 43 44 44 46 47 48 iii 48 50 51 52 54 55 59 61 62 64 65 66 67 68
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i 1 1 2 2 3 3 4 4 4 5 7 8 8 9 9 10 11 13 14 15 16 17 19 ii CONTENTS 2 21 21 22 25 26 32 37 38 39 39 41 41 43 43 43 44 45 46 47 47 49 52 54 56 56 iii 57 59 62 64 64 66 67 68 71 72 72 73 74 74 77 79 81 84
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HANS CHRISTIAN ANDERSEN The Life of a Storyteller by Jackie Wullschlager HANS CHRISTIAN ANDERSEN The Life of a Storyteller by Jackie Wullschlager Copyright 2000 by Jackie Wullschlager First published 2000
C ontents VI VII
I ntroduction C ontents IV V C ontents VI VII C ontents VIII IX C ontents X XI C ontents XII XIII C ontents XIV XV XVI 01 192 193 02 C olumn 194 195 C olumn C olumn 196 197 03 C olumn C olumn C olumn
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