THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr NTT NTT
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1 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS IDSA
2 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr NTT NTT
3 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS MRSA 1 VISA VRSA Vancomycin-intermediate Staphylococcus aureus VISA Vancomycin-resistant S. aureus VRSA 2 VISA MIC 4 8 mg/l vana VISA 1996 VRSA MIC 16 mg/l vanavrsa rpob VISA rpob rpob RNA rpob MRSA 96% VISA 8 VISA MRSA rpob VISA Mu3 grar* grar* Mu3graR* VISA 4 mg/l mg/l 2 2 rpob Fig. 1.VISA Mu3graR* rpob
4 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr Table 1. rpob VISA Mu3graR* 52 Fig. 1 rpob Mu3graR* rpob Mu3graR* RpoB MIC MIC MIC grar* MIC rpob MIC grar* rpob MIC rpob Table 1 rpob 3tness cost rpob tness costrpob grar* rpob tness cost 4 rpob MRSA MRSA 1 Staphylococcal cassette chromosome mec SCCmec -
5 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS Penicillin-binding protein PBP MRSA MSSA 2 PBP2PBP2 - MRSA - PBP2' meca MRSA MSSA SCCmec meca SCCmec mec ccr Cassette Chromosome Recombinase2 Fig. 2. SCCmec Fig. 3.SCCmec mec Fig. 2 mec meca SCCmec 10 mec 4 A D meca Fig. 3 ccr SCCmec ccr mec 2 meca mec 1 mvas truncated mvas mvas mvas Staphylococcus eurettii mvas mec SCCmec A mec nucleotide identity 99Fig. 4 meca S. eurettii 44 S. sciuri S. eurettii Macrococcus Macrococcus mec meca - blaz blazm blar1 blar1m mecam meca Tn6045 Tn6045 Macrococcus meca
6 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr Fig. 4. SCCmec mec Staphylococcus eurettii Fig. 5. mec Tn6045 Macrococcus caseolyticus mec - meca Tn6045 Macrococcus caseolyticus ccr
7 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS mec ccr SCCmec MRSA Fig. 5 3 Macrococcus meca meca S. eurettii meca meca SCCmec SCCmec MRSA MRSA -
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9 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS IDSA Infectious Diseases Society of America IDSA MASCC 2CT -D C 500/ mm 3 MASCC /mm 3 8 Fig. 1 MASCC 21 Table 1 MASCC MDS AML CRP 2 Fig. 1.
10 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr Table 1. MASCC A-II 1 empirical therapy preemptive therapy targeted therapy 4 7 CT -D-PCR 2 A-III CORDONNIER 3 RCT 97.3% 95.1% 9.1% vs 2.7%2 35 Fig. 2 IDSA A-I B-III CT
11 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS Fig. 2. Empirical vs. Preemptive vs. Candida Aspergillus B-II Fig. 3, Fig. 4 4 Fig. 3 3 CT
12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr Fig. 3. Fig. 4.
13 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS / CT, MRI 30 B B B 4 B-III Fig. 5 IDSA IDSA HSCT A-I Fig. 5.
14 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 2 Apr posaconazole AML/MDS 13 posaconazole B-I posaconazole IDSA 2008 A-I IDSA A-I B 2 B B 2 B IDSA A-I 3 IDSA IDSA 2010 posaconazole 1 FREIFELD, A. G.; E. J. BOW, K. A. SEPKOWITZ, et al.: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin. Infect. Dis : e56 e93, NAKAGAWA, Y.; K. SUZUKI & T. MASAOKA: Evaluation of the risk factors for febrile neutropenia associated with hematological malignancy. J. Infect. Chemother : , CORDONNIER, C.; C. PAUTAS, S. MAURY, et al.: Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial. Clin. Infect. Dis : , PAPPAS, P. G.; C. A. KAUFFMAN, D. ANDES, et al.: Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin. Infect. Dis. 48: , 2009
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CHEMOTHERAPY CHEMOTHERAPY Table 1 Antibacterial activity of Sulbactam/CPZ against standard strains MIC mg/ml Inoculum size 106 CFU/ml * Sulbactam/CPZ= 1: 1 ** Concentration of Sulbactam+ CPZ CHEMOTHERAPY
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日本化学療法学会雑誌第50巻第6号
13 11 30 14 4 22 Streptococcus pneumoniae Haemophilus influenzae amoxicillin AMPC cefditoren pivoxil CDTR AMPC 50 mg kg day CDTR 9mg kg day CDTR 18 mg kg day S. pneumoniae H. influenzae 8 17 25 1 25 S.
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日本化学療法学会雑誌第64巻第4号
β β Moraxella catarrhalisescherichia colicitrobacter Klebsiella pneumoniaeenterobacter cloacaeserratia marcescens Proteus Providencia Pseudomonas aeruginosaacinetobacter Bacteroides fragilis β β E. colik.
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Staphylococcus epidermidis Streptococcus pneumoniae Staphylococcus epidermidis Streptococcus pneumontae S. epidermidis Table 1. Summary of the organis
Staphylococcus aureus S. aureus (MRSA) vancomycin (VCM), arbekacin (ABK) Streptococcus pneumoniae cefuzonam (CZON), cefpirome (CPR) S. pneumoniae Enterococcus faecalis ampicillin (ABPC), imipenem (IPM)
History I COE
2008 108-8641 5-9-1 TEL 03-5791-6334FAX 03-5791-6335 e-mailgakufu@lisci.kitasato-u.ac.jp 228-8555 1-15-1 TEL 042-778-9760FAX 042-778-9761 e-mailnyushi@kitasato-u.ac.jp URL http://www.kitasato-u.ac.jp/lisci/index.html
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant
Key words: Candida, fungemia, antifungal activity, micafungin, fluconazole-resistant Fig. 1 Annual changes in percentages of fungi isolated from blood and vascular catheters Fig. 2 Frequencies of fungi
VOL.48 NO.7 lase negative staphylococci, Escherichia coli, Klebsiella spp., Citrobacter freundii, Enterobacter spp., indole-positive Proteus, Serratia
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Table Laboratory data
Key words: TSS, SLE, MRSA Table Laboratory data 出産 後 にTSSを Fig. 1 Fig. 2 finger Rash with at 7 days desquamation on Clinical left course index- 1281 合併 したSLEの1例 A.T. 32-years-old Female わ せ た が,び SLEに
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates
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ワンヘルスに関するシンポジウム 2017 年 11 月 27 日 医療における耐性菌の現状 長崎大学大学院病態解析 診断学 ( 臨床検査医学 ) 同病院検査部栁原克紀 医療における耐性菌の現状 薬剤耐性菌とは? 重要な薬剤耐性菌 医療における耐性菌の現状 薬剤耐性菌とは? 重要な薬剤耐性菌 薬剤耐性とは? 薬剤耐性 ( やくざいたいせい ) とは 微生物が 自分に対して何らかの作用を持った薬剤に対して抵抗性を持ち
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CQ ACC/AHA PECO PatientExposure Comparison OutcomePECO low-density lipoprotein cholesterol LDL C cholesterol cholesterol intensive OR agressive CQ target LDL C PubMed Systematic Reviews Clinical Study
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VOL.42 S-1
CHEMOTHERAPY APR. 1994 VOL.42 S-1 CHEMOTHERAPY APR. 1994 Table 1. Criteria for evaluation of clinical efficacy by the Japanese Society of Oral and Maxillo-Facial Surgeons Grades of symptoms and numerical
Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates
Feb. THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 11( 11 ) 2003 12 17 (MRSA) penicillin-resistant Streptococcus pneumoniae (PRSP) 3 I. 12( 12 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 Feb. 3 1997 1) (1985)
日本化学療法学会雑誌第58巻第4号
Escherichia coli Enterococcus faecalisstreptococcus agalactiae Klebsiella pneumoniae Staphylococcus epidermidis E. colie. faecalispseudomonas aeruginosa K. pneumoniae S. agalactiae E. coli E. coli μ p
Key words: MRSA, Blood culture, TSST-1, Phage type, theory of quantification Table 1 Antibiotic resistant patterns of S. aureus isolated from blood cultures during 1984.1-1986.4 MRSA: methicillin-resistant
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VOL.27 CHEMOT S-1 HERAPY 185 に感 性 を示 して い たが,臨 床 的 に は無 効 で あ った 本 症 る 細 菌学 的 に も検 討 した が,起 炎菌 と考 え られ る細 菌 を 例 で は 基礎 疾 患 と して縦 隔 洞腫 瘍 が あ り,既 に 副 腎
CHEMOTHERAPY Table 1 Clinical evaluation of Mezlocillin treatment against respiratory and other infectious diseases *: fever, eruption, granulocytopenia, thrombocytopenia, GOT, GPT elevation (See table
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C/NC : committed/noncommitted
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364 2015 C 1 2 3 4 5 6 7 8 urinary tract infection UTI 2 1 UTI 1 3 5 2,3 4 1 UTI Escherichia coli E. coli 80 5 Enterococcus 1 UTI 83 78 53 98 5 WBCs HPF 73 81 81 83 or 93 72 ororor 99.8 70 4 Key words