フタル酸ジペンチル
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- しほこ とべ
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1 147
2 148
3 Wistar- Hannover BrlHan: (GALAS) µg/kg/day 1 ml/kg/day 1 1 g/kg/day ml/kg/day AGD SD
4 g/kg/day mg/kg/day , ER M 16% M ER 10-4 M 11% M E-screen 10-7 M E2 9% M AR ( ) M AR ( ) M AR IC50= M M TR <10-5 M TR <10-5 M 150
5 µ /kg/day g/kg/day /12 0/10 0/11 0/12 0/11 10/10 0/12 0/10 0/11 0/12 0/11 1/10 0/12 0/10 0/11 0/12 0/11 0/ ±17 214±14 213±13 210±15 220±21 218± ±17 244±18 243±14 240±17 246±22 242± ±20 273±21 274±16 273±20 277±24 268± ±34 343±30 345±27 351±27 349±31 258± ±19 258±23 264±18 261±22 264±25 (g) 7 283±19 279±20 284±19 284±24 280± ±20 299±27 301±20 302±23 298± ±17 292±23 292±19 287±25 290± ±6 25±6 26±8 26±4 24±6 22± ±4 25±6 26±5 25±5 24±5 22± ±22 79±12 81±16 90±12 81±15-4± ±22 104±16 107±18 115±13 105±19 18±7 41± ±25 129±20 132±19 141±16 129± ±12-7±13-8±8-15±19-8± ±13 31±15 21±11 34±12 19±12 28±15 23±9 26±12 16±17 26±10 (g) ±8 20±9 17±7 18±10 18± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±11.8 (g/day) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.0 2/12 0/10 0/11 0/12 1/11 0/10 (p0.01) 151
6 µ /kg/day (g) 1.89± ± ± ± ±0.07 (mg) 12.9± ± ± ± ±2.3 (mg) 19.0± ± ± ± ±8.0 (mg) 188±72 234± ±58 173±69 186±68 (mg) 730± ± ± ± ±308 (g) 11.8± ± ± ± ±1.7 (mg) 96.2± ± ± ± ±7.7 (g) 2.14± ± ± ± ±0.17 (mg) 91.8± ± ± ± ±10.0 (mg) 607± ±85 579±64 631± ±92 (g) 0.70± ± ± ± ±0.08 (mg) 4.79± ± ± ± ±0.97 (mg) 7.04± ± ± ± ±3.17 (mg) 69.9± ± ± ± ±30.1 (mg) 274± ±82 231±90 243± ±129 (g) 4.34± ± ± ± ±0.62 (mg) 35.6± ± ± ± ±4.1 (g) 0.79± ± ± ± ±0.08 (mg) 34.0± ± ± ± ±6.6 (mg) 224±41 235±24 215±26 238±50 214±34 % g/100g B.W. mg/100g B.W. (p<0.05) 152
7 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.08 (/bw 1/3 ) ± ± ± ± ±0.17 ( 3) 98.7± ± ± ± ±3.2 ( 12) 96.9± ± ± ± ±4.9 ( 16) 98.8± ± ± ± ±4.9 µ /kg/day / /139 1/126 0/116 0/151 0/130 0/139 0/126 1/116 0/151 0/130 0/139 0/126 0/116 0/151 1/ ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±1.67 (mm) ± ± ± ± ± ± ± ± ± ± % 100.0± ± ± ± ±0.0 ( 11)* 3.9± ± ± ± ±0.3 % 100.0± ± ± ± ±0.0 % 100.0± ± ± ± ±0.0 % 100.0± ± ± ± ±0.0 1 % 98.3± ± ± ± ±3.3 ( 11)* 3.8± ± ± ± ±0.0 % 100.0± ± ± ± ±0.0 % 100.0± ± ± ± ±0.0 % 100.0± ± ± ± ±0.0 *.0 Mean of littermeans 153
8 2. -4 µ /kg/day (g) 1.40± ± ± ± ±0.06 (mg) 1.47± ± ± ± ±0.68 (mg) 6.55± ± ± ± ±1.70 (mg) 131±29 122±20 153±38 135±32 125±31 (g) 1.31± ± ± ± ±0.22 (mg) 12.4± ± ± ± ±2.9 (mg) 400±58 383±71 449±75 414±64 408±52 (mg) 138±43 120±46 164±65 139±41 141±46 (mg) 175±27 165±30 200±35 187±32 183±28 (mg) 34.0± ± ± ± ±7.3 (mg) 16.3± ± ± ± ±2.3 (mg) 29.3± ± ± ± ±5.5 (g) 1.38± ± ± ± ±0.08 (mg) 1.68± ± ± ± ±0.58 (mg) 7.03± ± ± ± ±1.44 (mg) 133±27 126±26 154±32 144±26 139±38 (g) 1.35± ± ± ± ±0.33 (mg) 14.2± ± ± ± ±4.2 (mg) 435±86 406±49 461±96 445±72 436±93 (mg) 142±43 121±34 157±55 152±40 134±45 (mg) 12.1± ± ± ± ±4.9 (mg) 40.2± ± ± ± ±5.0 * # Mean of littermeans 154
9 2. -5 µ /kg/day (g) 3.90± ± ± ± ±0.39 (mg) 3.99± ± ± ± ±1.89 (mg) 17.7± ± ± ± ±4.9 (mg) 358±47 351±39 374±57 363±61 338±44 (g) 3.57± ± ± ± ±0.26 (mg) 34.5± ± ± ± ±3.3 (mg) 1097± ± ± ± ±62 (mg) 370±71 335±81 391±82 369±70 376±62 (mg) 480±31 475±45 493±26 506±42 501±41 (mg) 93.5± ± ± ± ±21.1 (mg) 44.9± ± ± ± ±7.4 (mg) 80.2± ± ± ± ±13.5 (g) 3.83± ± ± ± ±0.59 (mg) 4.54± ± ± ± ±1.61 (mg) 19.3± ± ± ± ±4.2 (mg) 362±54 355±41 386±37 378±32 373±30 (g) 3.71± ± ± ± ±0.25 (mg) 39.1± ± ± ± ±3.5 (mg) 1190± ± ± ± ±36 (mg) 384±79 339±52 385±86 397±62 356±57 (mg) 33.1± ± ± ± ±9.2 (mg) 110±22 119±25 99±27 94±23 99±25 1/21 6/19 5/19 2/23 1/20 0/21 1/19 0/19 0/23 0/20 0/21 0/19 2/19 1/23 0/20 3/21 1/19 3/18 3/24 0/20 % g/100g B.W. mg/100g B.W. # Mean of littermeans 155
10 2. -6 µ /kg/day ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±22.9 g ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±
11 2. -7 µ /kg/day ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±39.5 (s) 2.9± ± ± ± ±2.3 (b) 0.7± ± ± ± ± ± ± ± ± ±37.6 (s) 2.8± ± ± ± ±2.1 (b) 0.6± ± ± ± ± ± ± ± ± ±35.9 (s) 2.8± ± ± ± ±1.5 (b) 1.1± ± ± ± ± ± ± ± ± ±30.6 (s) 3.1± ± ± ± ±1.9 (b) 0.5± ± ± ± ± ± ± ± ± ±18.2 (s) 2.2± ± ± ± ±1.3 (b) 0.6± ± ± ± ± ± ± ± ± ±19.9 (s) 2.0± ± ± ± ±1.2 (b) 0.9± ± ± ± ± ± ± ± ± ±18.8 (s) 1.8± ± ± ± ±0.9 (b) 0.5± ± ± ± ± ± ± ± ± ±11.1 (s) 0.5± ± ± ± ±0.8 (b) 0.1± ± ± ± ± ± ± ± ± ±16.8 (s) 0.5± ± ± ± ±1.0 (b) 0.0± ± ± ± ±0.0 ( p<0.05 p<0.01) Error (s) : Select error, Error (b) : Backing error 157
12 2. -9 (b) 0.5± ± ± ± ± ± ± ± ± ±31.2 (s) 4.2± ± ± ± ±1.0 (b) 1.2± ± ± ± ± ± ± ± ± ±44.3 (s) 3.3± ± ± ± ±1.8 (b) 0.8± ± ± ± ± ± ± ± ± ±31.4 (s) 3.2± ± ± ± ±1.9 (b) 0.5± ± ± ± ± ± ± ± ± ±18.1 (s) 2.5± ± ± ± ±1.2 (b) 0.7± ± ± ± ± ± ± ± ± ±20.9 (s) 2.7± ± ± ± ±1.3 (b) 0.9± ± ± ± ± ± ± ± ± ±25.4 (s) 1.0± ± ± ± ±1.6 (b) 0.3± ± ± ± ± ± ± ± ± ±22.5 (s) 1.3± ± ± ± ±0.8 (b) 0.3± ± ± ± ± ± ± ± ± ±12.2 (s) 1.6± ± ± ± ±1.3 (b) 0.4± ± ± ± ±0.0 µ /kg/day ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±33.7 (s) 3.2± ± ± ± ± ± ± ± ± ± p<0.05) Error (s) : Select error, Error (b) : Backing error 158
13 µ /kg/day ± ± ± ± ±18.8 (g) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±
14 µ /kg/day /22 1/20 0/22 1/24 0/21 0/22 1/20 0/22 1/24 1/21 1/22 0/20 0/22 1/24 0/21 5/22 5/20 5/22 8/24 4/21 0/23 0/20 0/21 0/23 1/22 2/23 2/20 1/21 1/23 4/22 3/23 1/20 0/21 1/23 1/ ± ± ± ± ± ± ± ± ± ±8.26 (mg) ± ± ± ± ± ± ± ± ± ±11.23 ( 10 4 /mg) 17.83± ± ± ± ± ± ± ± ± ±0.70 (g) 2.01± ± ± ± ±0.06 (mg) 10.6± ± ± ± ±0.9 (mg) 27.2± ± ± ± ±4.9 (mg) 397±85 409±69 387±79 390±75 416±90 (g) 14.2± ± ± ± ±1.6 (mg) 64.0± ± ± ± ±13.5 (g) 2.61± ± ± ± ±0.19 (mg) 756±81 732±65 739±77 743± ±129 (g) 3.31± ± ± ± ±0.25 (g) 1.25± ± ± ± ±0.09 (g) 1.37± ± ± ± ±0.22 (g) 0.46± ± ± ± ±0.12 (g) 1.86± ± ± ± ±0.06 (mg) 13.1± ± ± ± ±1.6 (mg) 22.7± ± ± ± ±3.6 (mg) 387±60 349±63 347±54 338±49 340±62 (g) 7.43± ± ± ± ±1.00 (mg) 86.1± ± ± ± ±8.0 (g) 1.60± ± ± ± ±0.19 (mg) 488±59 508±78 519±74 508±56 565±76 (mg) 93.9± ± ± ± ±21.2 (mg) 755± ± ± ± ±210 (p<0.05) 160
15 µ /kg/day (g) 0.49± ± ± ± ±0.04 (mg) 2.54± ± ± ± ±0.16 (mg) 6.45± ± ± ± ±1.11 (mg) 96.2± ± ± ± ±21.7 (g) 3.42± ± ± ± ±0.25 (mg) 15.5± ± ± ± ±2.8 (g) 0.63± ± ± ± ±0.02 (mg) 183±24 175±12 181±15 179±21 192±29 (g) 0.80± ± ± ± ±0.05 (g) 0.30± ± ± ± ±0.04 (g) 0.33± ± ± ± ±0.06 (g) 0.11± ± ± ± ±0.03 (g) 0.76± ± ± ± ±0.08 (mg) 5.33± ± ± ± ±0.72 (mg) 9.19± ± ± ± ±1.29 (mg) 158±25 149±32 145±25 143±20 139±25 (g) 3.03± ± ± ± ±0.34 (mg) 35.1± ± ± ± ±3.3 (g) 0.65± ± ± ± ±0.06 (mg) 199±24 215±25 216±27 215±24 232±38 (mg) 38.3± ± ± ± ±8.4 (mg) 309± ±99 240± ± ±95 6/10 5/10 7/11 4/12 5/10 5/10 3/10 8/11 9/12 6/10 1/10 0/10 1/11 0/12 0/10 4/10 4/10 6/11 6/12 1/10 0/10 2/10 0/11 1/12 0/10 4/10 4/10 9/11 7/12 6/10 0/10 0/10 0/11 1/12 0/10 0/10 0/10 0/11 0/12 2/10 0/10 0/10 0/11 0/12 1/10 3/11 7/10 5/10 8/12 6/11 6/11 4/10 7/10 8/12 8/11 8/11 6/10 6/10 7/12 6/11 2/11 5/10 3/10 6/12 5/11 0/11 1/10 0/10 0/12 1/11 0/11 0/10 1/10 0/12 0/11 0/11 0/10 1/10 0/12 0/11 ( p<0.05 p<0.01) % g/100g B.W. mg/100g B.W. 161
16 162
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