橡'98寺尾班報告書.PDF

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1 (OHSS) interleukin-8 (IL -8) 33 histamine prostaglandin angiotensin 8 IL-8 OHSS 1 IL-8 23 Wistar rat pregnant mare serum gonadotropin 10 unit 48 human chorionic gonadotropin(hcg) 10 unit IL-8 0.2, 2.0, 20µg hcg IL-8 20 g OHSS 2 IL-8 7 Wistar rat IL-8 0.1, 1.0, 10 g IL-8 10 g OHSS 1)2) IL-8 OHSS OHSS albumin A OHSS [hmg/fsh ] [hcg/lh ]

2 Pride, J., Ho, Y. I. (1990) The ovarian histamine prostaglandins renin-angiotensin system interleukins endothelin-1 vascular endothelial factor estrogen OHSS Prostaglandin hcg Schenker, J. G., Polishuk, W. Z. (1976) histamine The role of prostaglandins in ovarian first messenger hyperstimulation syndrome. Euro. J. Obstet. Gynecol. Reprod. Biol., 6, OHSS [rabbit] B MEDLINE gonadotropin-releasing hormone, danasol C Histamine Knox, G. E., Dowd, A. J., Spiesel, S. A., Hong, R. (1975) Antihistamine blockade of the ovarian hyperstimulation syndrome, : possible role of antigen -antibody complexes in the pathogenesis of the syndrome. Fertil. Steril., 26, [rabbit] : antihistamine OHSS 29, [ human] Erlik, Y., Naot, Y., Friedman, M. et al. (1979) Histamine levels in ovarian hyperstimulation syndrome. Obstet. Gynecol., 53, [rabbit] : OHSS histamine level hyperstimulation syndrome. Semin. Reprod. Endocrinol., 8, [rabbit] : H1 receptor blocker : indomethacin prostaglandin OHSS Pride, S. M., Yuen, B. H., Moon, Y. S., Leung, P. C. S. (1986) Relationship of and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit. Am. J. Obstet. Gynecol., 154, [rabbit] : indomethacin OHSS Katz, Z., Lancet, M., Borenstein, R., Chemke, J. (1984) Absence of teratogenisity of indomethacin in ovarian hyperstimulation syndrome. Int. J. Fertil., : indomethacin OHSS Borenstein, R., Elchalal, U., Lunenfeld, B. et al. (1989) Severe ovarian hyperstimulation syndrome : a reevaluated therapeutic approach. Fertil. Steril., 51, [ human]

3 : indomethacin OHSS Renin- angiotensin system Morris, R. S., Wong, I. L., Kirkman, E. et al. (1995) Inhibition of ovarian-derived prorenin to angiotensin cascade in the treatment of ovarian hyperstimulation syndrome. Hum. Reprod., 10, [rabbit] : angiotensin converting enzyme OHSS OHSS 40% Interleukins Endothelin- 1 OHSS Vascular endothelial growth factor histamine D endothelial factor OHSS OHSS [hmg/fsh ] [hcg/lh ] E OHSS antihistamine H1 receptor blocker indomethacin angiotensin converting enzyme hcg (IVF ET) IVF ET IVF ET OHSS hcg estradiol 3,000 pg/ml Coasting albumin albumin IVF ET OHSS prostaglandins renin-angiotensin system interleukins endothelin-1 vascular

4 interleukin-8 (IL -8) OHSS A 3 human chorionic gonadotropin(hcg) [ ] interleukin-8 (IL-8) [ ] 1 23 Wistar rat PMSG 10 unit collagen 48 hcg 10 unit, 3 IL-8 0.2, 2.0, 20µg OHSS Wistar rat 1 IL-8 0.1, 1.0, 10 g 6 IL Wistar hcg rat PMSG 10 unit IL-8 mrna + hcg 10 IL-8 unit +IL -8 20µg 4 2 OHSS 2 IL Wistar rat OHSS IL-8 IL-8 10µg IL-8 rat OHSS PMSG 48 hcg B pregnant mare serum gonadotropin(pmsg) [Sigma ] 24 4 IL-8 6 rat hcg IL-8 24

5 (Fig. 1 6 ) IL g 2.0 g 2) Wistar rat 6 24 IL-8 10N NaOH 10 g OHSS IL g 5-15 kv SEM 1.0 g 1 23 Wistar rat unit +IL-8 20 g 2 hcg IL hcg IL g IL g IL-8 20 g HE [ 24 ] germinal vesicle break down(gvbd) hcg IL g IL g LUZEX IL-8 20 g hcg Statview 4.0 mean ± SD Student s t-test p< C IL (PMSG 10 unit)+ hcg 10 1 ( 10-2 mm 2 ) mean SD [ 6 ] IL-8 20 g (Fig. 2) 12 ( 10-2 mm 2 ) mean SD [ 6 ] IL g IL IL g IL-8 10 g ) IL [ 24 ] Wistar rat IL-8 10 g hcg IL-8 20 g IL OHSS IL-8 10 g

6 2.0% ] 10 [ 14/ % ] (Fig. 3) 1) +IL -8 PMSG 10 unit 48 + Abramov 3) OHSS hcg 10 unit hcg 6 IL-8 Arici 2 +IL-8 20 g hcg IL-8 6 hcg IL-8 mrna OHSS IL-8 hcg (LH) second messenger (Fig. 4 ; 40 Fig. 5 ; 70) 2) +IL-8 +hcg 24 IL-8 IL-8 (Fig. 6) Wistar rat hcg 10 unit IL-8 20 g E IL-8 [GVBD / GVBD hcg (%) ] hcg 10 unit [ 1/51 hcg 2.0% ] 10 [ 52/ % ] D + hcg OHSS IL-8 IL-8 IL-8 20 g [ 1/51 OHSS

7 F Fukumoto, T., Matsukawa, A., Yoshimura, T. et al. (1998) IL-8 is an essential mediator of the increased delayed-phase vascular permeability in LPS-induced rabbit pleurisy. J. Leuko. Bio., 63, ) Arici, A., Oral, E., Bukulmez, O. et al. (1996) Interleukin-8 expression and modulation in human preovulatory follicles and ovarian cells. Endocrinology, 9, ) Abromov, Y., Schenker, J. G., Lewin, A. et al. (1996) Plasma inflammatory cytokines correlate to the ovarian hyperstimulation syndrome. Hum. Reprod., 11,

plasma progestins levels. The results from the present longitudinal studies on hyperprolactinemia revealed characteristic changes accompanied by the r

plasma progestins levels. The results from the present longitudinal studies on hyperprolactinemia revealed characteristic changes accompanied by the r The Response of Ovarian Function to HMG-HCG and Bromocriptine Therapies in Hyperprolactinemic Patients Masateru MATSUOKA and Hiroo IMURA Second Division, Department of Internal Medicine, Kyoto University

橡'98寺尾班報告書.PDF

橡'98寺尾班報告書.PDF