原著・報告・記録（４４行）／Ｐ１４５～１５９＿報告　肝移植症例登録

Size: px

Start display at page:

Download "原著・報告・記録（４４行）／Ｐ１４５～１５９＿報告　肝移植症例登録"

せせらいしなみ
5 years ago
Views:

1 145 Liver Transplantation in Japan Registry by the Japanese Liver Transplantation Society The Japanese Liver Transplantation Society Summary As of December 31, 2015, a total of 8,387 liver transplants have been performed in 67 institutions in Japan. There were 8,066 living-donor transplants and 321 cadaveric-donor transplants318 from heart-beating donor and 3 from non-heart-beating donor. The annual total of liver transplants in 2015 was 448. The number of liver transplants from living-donor decreased to 391, from 419, in 2014, whereas the number of liver transplants from deceaseddonor exceeded 50 for the first time. The most frequent indication was cholestatic disease, followed by neoplastic disease. As for the graft liver in living-donor cases, right-lobe graft was the most popular35%. Patient survival following transplantation from heart-beating donor1, 86.7%; 3, 83.4%; 5, 81.1%; 10, 75.8%; 15, 75.8%was similar to those from living-donor1, 84.4%; 3, 80.3%; 5, 77.8%; 10, 72.5%; 15, 68.4%; 20, 66.1%; 25 ; 65.0%. Graft survival was very much the same as patient survival. Survival data were provided according to age and sex of recipient, indication, age and sex of donor, ABOcompatibility, and other factors. Japanese Liver Transplantation Society, registry, cadaveric liver transplantation, living-donor liver transplantation, prognosis web web 2011 web web 2015 web Kaplan-Meier logrank test ,

2 146 Vol. 51, No Living-donor Transplantation 8,066 Deceased-donor Transplantation 321 Heart Beating Donor 318 Non-heart Beating Donor 3 Primary Transplantation 8,117 Retransplantation 256 Third Transplantation 14 8, ,066 8, , C 9 74 Adults: 18 s Year Living-donor Deceaseddonor Total Total , , , ,445

3 147 primary biliary cirrhosispbc 7 6 / 11 7 / 4 B NASH cryptogenic cirrhosis solid pseudopapillary tumor 1 epithelioid hemangioendothelioma primary sclerosing cholangitispsc5caroli 2 1B 1cryptogenic cirrhosis NASH DNA Dubin- Johnson Protein C GVHD 5 4 severe combined immunodeficiency disease SCID monosegment graft graft graft graft graft graft graft graft graft split 31 2 dual graft 2 split dual graft 2 8, , split ,064 95% 44%24%18% 10% dual graft 8, ,068 4 split 8,064 split FAP ABO

4 148 Vol. 51, No. 23 Age Total Male Female Total Age Total Male 1, , ,841 Female 1, ,225 Total 2, ,066 1, ,066 Age of Recipient 18 y.o. 18 y.o. Total Cholestatic Diseases Biliary Atresia Primary Sclerosing Cholangitis Primary Biliary Cirrhosis Alagille Syndrome Caroli Disease Others Hepatocellular Diseases HCV HBV Alcoholic NASH AIH Cryptogenic Cirrhosis Vascular Diseases Budd-Chiari Others Neoplastic Diseases Hepatocellular Carcinoma Hemangioma Acute Liver Failure HBV Drug-induced Autoimmune Hepatitis ViralHBV Neonatal Hemochromatosis Unknown Metabolic Diseases Wilson Disease Citrullinemia OTC Deficiency Familial Amyloid Polyneuropathy Glycogen Storage Disease Others Others Polycystic Liver Others Total

5 149 Age of Recipient 18 y.o. 18 y.o. Total Cholestatic Diseases 2,052 1,127 3,179 Biliary Atresia 1, ,085 Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Alagille Syndrome Byler s Disease Caroli Disease Congenital Bile Duct Dilatation Others Hepatocellular Diseases 45 1,531 1,576 HCV HBV Alcoholic Autoimmune Hepatitis NASH Cryptogenic Cirrhosis Others Vascular Diseases Budd-Chiari Syndrome Congenital Absence of Portal Vein Others Neoplastic Diseases 113 1,584 1,697 Hepatocellular Carcinoma 8 1,543 1,551 HCV HBV Alcoholic Primary Biliary Cirrhosis NASH Others Hepatoblastoma Liver Metastatis Hemangioma Cholangiocellular Carcinoma Others Acute Liver Failure HBV Autoimmune Hepatitis Drug-induced ViralHBV Neonatal Hemochromatosis Unknown Others Metabolic Diseases Wilson Disease Familial Amyloid Polyneuropathy OTC Deficiency Citrullinemia Glycogen Storage Disease Methylmalonic Acidemia Primary Hyperoxaluria CPS deficiency Tyrosinemia Propionic acidemia Others Others Total 2,795 5,067 7,862

6 150 Vol. 51, No. 23 Year Total HCV HBV Alcohol AIH NASH Cryptogenic Others Total ,577 Age of Recipient Total 18 y.o. 18 y.o. Monosegment Lateral Segment Left Lobe Left Lobe + Caudate Lobe Right Lobe Right Trisegment Whole Liver Age of Recipient Total 18 y.o. 18 y.o. Monosegment Lateral Segment 1, ,001 Posterior Segment Left Lobe 548 1,054 1,602 Left Lobe + Caudate Lobe 110 1,206 1,316 Right Lobe 87 2,757 2,844 Right Trisegment Whole LiverDomino Dual GraftLeft + Right Lobes ,897 5,169 8,066 Age Unknown Total Male Female Unknown Total Age Total Male ,241 1, ,356 Female , ,712 Total ,005 2,810 1,651 1, ,068 dual graft 1 ABO ABO 2 8, ,065 dual graft 1 ABO 2 ABO 10.7% 14.0% ABO

7 y.o. Age of Recipient 18 y.o. Mother 1, ,792 Father 1, ,485 Son 0 1,564 1,564 Daughter Brother Sister Nephew Grandmother Aunt Cousin 3 Male 2, Female 1 30 Male 25, Female 5 33 Uncle Grandfather Niece Father s cousin 2 Male 1, Female Mother s cousin 0 1 Female 1 Grandson Cousin s son Cousin s daughter Wife Husband Brother-in-law Son-in-law Sister-in-law Father-in-law Daughter-in-law Nephew-in-law Mother-in-law Grandfather-in-law Uncle-in-law Common-law husband Common-law wife Friend 0 1 Female 1 Domino 6 Male 3, Female 3 46 Male 22, Female ,897 5,171 8,068 Total Year Total 18 s s Total

8 152 Vol. 51, No. 23 Age of Recipient 18 y.o. 18 y.o. Total Identical 1,903 3,454 5,357 Compatible 589 1,162 1,751 Incompatible ,897 5,168 8,065 Year Total 18 s s Total n Patient Survival% Graft Survival% n Deceased-Donor Heart-beating Non-heart-beating Living Donor 8, , n 1 Cumulative Survival% Primary or Primary Retransplant Re- and Re-re-transplantation Recipient Age Indication Primary Cholestatic Disease Biliary Atresia Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Hepatocellular Disease HCV HBV Neoplastic Disease HCC Acute Liver Failure HBV Unknown Metabolic Disease

9 / p p / p p p p data not shown

10 154 Vol. 51, No. 23 n 1 3 Cumulative Survival% Primary or Primary 7, Retransplant Re- and Re-re-transplantation Recipient Gender Male 3, Female 4, Recipient Age 18 2, , , , , Cholestatic Disease 3, Biliary Atresia 2, Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Alagille Syndrome Byler s Disease Caroli Disease Congenital Bile Duct Dilatation Hepatocellular Disease 1, HCV HBV Alcoholic Autoimmune Hepatitis NASH Cryptogenic Cirrhosis Vascular Disease Budd-Chiari Indication Congenital Absence of Portal Vein Neoplastic Disease 1, HCC 1, Hepatoblastoma Liver Metastasis Hemangioma CCC Acute Liver Failure HBV Drug-induced Autoimmune Hepatitis ViralHBV Neonatal Hemochromatosis Unknown Metabolic Disease Wilson Disease Familial Amyloid Polyneuropathy OTC Deficiency Citrullinemia Glycogen Storage Diseases Methylmalonic Acidemia Primary Hyperoxaluria CPS Deficiency Tyrosinemia Propionic Acidemia

11 155 n Cumulative Survival% Donor Age , , , , Domino Domino Non-Domino 8, ABO Identical 5, Compatibility Compatible 1, Incompatible p p PSC PSC

12 156 Vol. 51, No %3 74.7%5 69.3% % % PBC %3 79.4%5 77.8% % % % p HCV HBV p p epithelioid hemangioendothelioman %3 57.1%5 42.9%

13 157 p % %3 83.4%5 75.8% % n % %GVHDn %3 60.0%5 30.0% 5 ABO data not shown 6 data not shown 710 p HCV p HCV n= %3 49.1%5 40.6% % 66 8 p ABO data not shown 10 ABO p

14 158 Vol. 51, No %3 85.7%5 85.2% % % %3 72.9%5 70.8% % % %367.1% % % % p ABO rituximab % % %3 56.5%5 52.9% % %1 77.3%3 70.9%5 68.4% %p % p

15 159 p p ; 39: ; 35: ; 37: ; 38: ; 39: ; 40: ; 41: ; 43: ; 43: ; 44: ; 45: ; 46: ; 47: ; 48: ; 49: ; 50:

原著・報告・記録（４４行）／Ｐ１３４～１４７＿報告　肝移植症例登録

原著・報告・記録（４４行）／Ｐ１３４～１４７＿報告　肝移植症例登録 134 Vol. 52, No. 23 Liver transplantation in Japan. Registry by the Japanese Liver Transplantation Society The Japanese Liver Transplantation Society Summary As of December 31, 2016, a total of 8,825 liver

原著・報告・記録（４４行）／Ｐ１４５～１５９＿報告 肝移植症例登録

原著・報告・記録（４４行）／Ｐ１４５～１５９＿報告　肝移植症例登録