VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

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1 CHEMOTHERAPY OCT Fig. I Chemical structure of CTRX

2 VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

3 CHEMOTHERAPY Fig. 3 Cumulative curves of MIC E. coll. 46 strains Fig. 4 Cumulative curves of MIC K. pneumoniae 32 strains

4 CHEMOTHERAPY Fig. 5 Cumulative curves of MIC Serratia (31 strains) Fig. 6 Cumulative curves of MIC E. cloacae(lostrains)

5 CHEMOTHERAPY Fig. 7 Cumulative curves of MIC P. aeruginosa (39 strains) Fig. 8 Cumulative curves of MIC P. mirabilis (30 strains)

6 CHEMOTHERAPY Fig. 9 Sensitivity correlogram S. aureus (26 strains)

7 CHEMOTHERAPY Fig. 10 Sensitivity correlogram E. coli L(46 strains)

8 CHEMOTHERAPY

9 CHEMOTHERAPY Fig. 11 Sensitivity correlogram K. pneumoniae (32 strains)

10 CHEMOTHERAPY

11 CHEMOTHERAPY Fig. 12 Sensitivity correlogram Serratia ( 31 strains)

12 CHEMOTHERAPY Fig. 13 Sensitivity correlogram E. cloacae (10 strains)

13 CHEMOTHERAPY Fig. 13 (Continued)

14 CHEMOTHERAPY Fig. 14 Sensitivity correlogram P. aeruginosa (39 strains)

15 CHEMOTHERAPY Fig. 14 (Continued) Fig. 15 Sensitivity correlogram P. mirabilis (30 strains)

16 CHEMOTHERAPY Fig. 15 (Continued)

17 CHEMOTHERAPY Table 2 MIC of P. morganii (9 strains) Table 3 MIC of P. vulgaris (9 strains)

18 CHEMOTHERAPY Fig. 16 Blood level of CTRX Fig. 17 Blood level of CTRX lg. lhr. drip infusion Bac: B. subtiris ATCC 6633 Method: Band culture m. 2g lhl drip infusion Method: HPLC

19 CHEMOTHERAPY Table 4 Clinical cases treated with CTRX

20 CHEMOTHERAPY Table 5 Laboratory findings of before and after treatment with CTRX

21 CHEMOTHERAPY 1) SHANNoN, K. et al.: In Vitro Antibacterial Activity and Susceptibility of the Cephalosporin Ro to Beta-Lactamases. Antimicrob. Agents Chemother. 8 (2) E , Cost:, P.Y. et al.: In Vitro Susceptibility of Salmonela 1 to Various Antimicrobial Agents, Including a new Cephalosporin No Antimicrob. Agents Chemother. 19(1): 8-11, 1981 BASIC AND CLINICAL STUDIES ON CEFTRIAXONE (Ro ) YURUKO OKAMOTO, KEIGO MAEHARA, SEIBUN YONEZU, KANSHI MASE, MUNETO YOSHIOKA and KOJIRO YASUNAGA 1st. Department of Internal Medicine, Kansai Medical University YOSHIHIRO UEDA and HIROSHI OKUBO Rakusai New Town Hospital, Kansai Medical University Basic and clinical studies were made on ceftriaxone (CTRX, Ro ). The results obtained were as follows: 1) Antibacterial activity in vitro CTRX was found to be very active against gram negative bacilli, especially against Proteus, Klebsiella and E. coli. 2) Blood levels and urinary excretion We investigated the serum concentration and urinary excretion after one hour intravenous drip infusion of CTRX: the peak levels being 90ƒÊg/ml for 1.0g dosage and 350ƒÊg/ml for 2.0g dosage at the end of the infusion. The blood levels were very durable: showing 12.5 pg/ml 8 hours after the beginning of 1.0 g infusion and 31.2 pg/m1 24 hours after 2.0 g infusion. 3) Clinical studies All of the five patients of RTI, two of UTI, two of BTI and one typhoid carrier well responded to the therapy with CTRX. Elevation of GOT, GPT, Al-P, BUN or Granulocytopenia were seen in four of the cases following the administration.

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