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1 Mo(V)- ( ALCA(JST)) ( FIRST) ( FIRST) (H 2S) ( ) ( ) A ( ) ( ( ) ) ( ) DNA ( ) ( CREST) ( 21 ) ( ) ph ( ) BODIPY ( ) DNA ( ) atna SNA ( ) ( ) Martinez Caaveiro Jose Manuel

2 Watson-Crick ( JST CREST) ( ) ( ) DNA () ( ) ( ) ( ) ( ) ( ) Caaveiro Jose ( ) Ni ( ) PEG ( ) ( ) ( ) ( ) b 562 ( ) ( ) ( ) DNA ( ) ( ) ( icems UCLA) Stieg Adam Sanghamitra Nusrat Gimzewski James

3 LDT FKBP12 ( ) ( ) ( ) in vivo ( NIH ) Peter Choyke His ( ) Pybox ( ) ( ) Rhodococcus erythropolis N771 ( ) ( Oregon Health and Science University ) () ( FIRST FIBER ) R12 CXCR4 ( ) Thiobacillus thioparus THI115 ( ) SS ( ) ( GCOE) trna ( ) RNA RNA Hfq ( ) ( ) ( )

4 ( ) ( JST ) - ( ) b ( JST ) ( JST CREST) ( JST CREST) ( ) ( ) () ( ) Bacillus pallidus RAPc8 ( ) (College of Chemistry, Liaoning University )Qian Zhang Yun Qiao Fei Hao Xi-Ming Song Sulfolobus tokodaii strain 7 P450 () DNA origami ( CREST icems) ( ) ( ) n- - - ( ) ( ) AR ( )

5 ( ) mrna5 ( GCOE ) ( ) DNA-RNA ( FIBER FIRST) Pramanik Smritimoy Saxena Sarika Bhatacharyya Jhimli -RNA ( FIBER FIRST) ( ) RNA ( ) non-coding RNA (7SK) HIV ( ) ( FIRST FIBER) RNA hairpin ( FIRST FIBER) Synchronized translation mrna ( FIRST FIBER) ( ) RNA RNAi ( ) Z DNA 5- ( ) DNA 19 F NMR ( ) 8-17DNAzyme ( ) DNAzyme Catalytic loop RNA ( ) DNA ( FIBER FIRST) ( ) DNA ( )

6 5 ( ) ( ) ( ) 1,3- ( ) ( ) Mun delanji C. Vestergaard NMR ( ) ( ) -1,2- ( ) ( ) GM3 V.harveyi ( ) ( ) ( Qbic ) - ( ) Sarah K.Coleman Kari Keinanen PEG ( ) Ralstonia eutropha (R)- ( ) ( ) ATP ( ) ( ) ( ) Sathuluri Ramachandra Rao ( ) Photoactive Yellow Protein (PYP) ( )

7 ( ) ( ) 8-OHdG 8-OHG () SET7/9 bisubstrate ( ) ( ) Siwu Eric R. O. Lee Isaac E. T. ( ) DNA ( ALCA) -S- ( ) Zhang Jie Mannervik Bengt Morgenstern Ralf ( ) ( ) ( ) LSPR ( ) ( ) Ar,O-BODIPY ( ) ( ) CD (VIII)- CD ( ) 4 -thiodna ( )

8 ( ) 19 ( ) ( ) ( ) 3-(3-Phenoxybenzyl)amino- -carboline: a novel antitumor drug targeting -tubulin ( ) (2) ( ) (1) ( ) BODIPY ( ) 13 C NMR ( ) P(V) ( ) ( ) ph ( ) DNA ( ) ( ) () / - ( )

9 ( ) DNA ( ) ( ( )) ( ) () () ( FIRST ) () ( ) ( ) ( ) ( ) ( ) ( FIRST) ( FIRST) 1,3-diol one-pot ( ) ( ) ( ) NMR ( ) ( ) c 3 2 EQCM ( )

10 EQCM c ( ) c 3 ( ) () PARK Hyejin () DNA ( ) ( ) ( ) ( ) ( /SPring-8 ) ( ) GH 10 ( ) ( ) ( ) / ( ) ( ) ( ) N- ( ) 19 F-NMR/MRI ( ) ( ) ( ) ( )

11 Met c Fe-Met ( ) () ( ) LDT schiff base ( ) Haloarcula japonica ( ) ( ) (Antigenase) Amidase, DNase ( JST CREST) ( ) SAM ( ) Turn-on 19 F MRI ( JST CREST) DNA- ( ) ( WPI-AIMR) ( ) GFP ( ) ( GCOE) ( ) Matile Stefan ( ) () ( ) Vibrio cholerae HutZ ( )

12 ( ) 5-2 ( ) c ( ) Wang Zhonghua ( ) ( ) C- ( ) DNA DNA ( ) FITC ( ) DNA ( ) DNA 19 F-NMR ( ) DNA 4 DNA DNA Cdc13 4 DNA ( ) DNA 4 DNA DNA Pot1 4 DNA ( ) ( ) ( ) ( ) ( ) RISC ( ) suppressor-trna ( SSC) BNA PCSK9 () 2,2,7- ( ) 5'-H- ( )

13 ( ) LC-MS ( ) ( ) 1,2-Di(14,14,14,13,13,12,12,11,11-nonafluorotetradecanoil)-glycero-3-phosphorylcholine ( ) ( ) () Rhodococcus ( ) 3-Galloxypropane-1,2-diyl dioleate () 3-Feruloxypropane-1,2-diyl dioleate () ( ) Sathuluri Ramachandra Rao ( ) N- -6- ( ) ( JST CREST) () Sathuluri Ramachandra Rao ( ) ( ) A ( ) ( ) Dectin-1-1,3- /C70 ( ) 暐

14 DNA ( ) ( ) NAFIE Laurence A. DUKOR Rina K. ( ) Synthesis of cholesteroyl-gelatin for the cellular uptake of protein and immune-reactions ( ) Kadengodlu Pallavi Liu Mingzhe ( ( )) ( ) - (QCM-A) ( ) Rhodol - ( ) (RIKEN) ( ) ( ) ( ) ( ) ( ) ( )

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巻頭言 夢見て行い 考えて祈る サントリー生命科学財団島本啓子 夢見て行い 考えて祈る 科学の先達のメッセージ集の中で 私が心惹かれた故山村雄一先生 ( 元阪大総長 ) の言葉である 山村先生の造語らしいが 既に多くの方が引用されているので ご存知の方もいるだろう 大切なのはこの順序 こうしたい こ

巻頭言 夢見て行い 考えて祈る サントリー生命科学財団島本啓子 夢見て行い 考えて祈る 科学の先達のメッセージ集の中で 私が心惹かれた故山村雄一先生 ( 元阪大総長 ) の言葉である 山村先生の造語らしいが 既に多くの方が引用されているので ご存知の方もいるだろう 大切なのはこの順序 こうしたい こ Division of Biofunctional Chemistry The Chemical Society of Japan Vol. 26, No.2 (2011. 9. 9) 目 次 巻頭言 夢見て行い 考えて祈る 島本啓子 1 研究紹介 新規機能性蛋白質の探索と創製 若杉桂輔 3 人工核酸アプタマー : 薬物キャリアへの応用 桒原正靖 7 分子ロボットの調製と機能測定 :BIOMOD 参戦中

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