ver5.1 HS 1. ALPHA LIPOIC ACID () S S COOH HS 1. α - SH COOH - ( 1) CoA -( 2)- - --P80 (--WSP8-L1-WSPC8 -LC1) - 1
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1 ORYZA OIL & FAT CHEMICAL CO., LTD. ALPHA LIPOIC ACID --P () --P80 () --WSP8 () --L1 () --PC () --PC80 () --WSPC8 () --LC1 () ver. 5.1HS
2 ver5.1 HS 1. ALPHA LIPOIC ACID () S S COOH HS 1. α - SH COOH - ( 1) CoA -( 2)- - --P80 (--WSP8-L1-WSPC8 -LC1) - 1
3 ver5.1 HS [] [] CO 2 [] [] - CoA [] [-] - CO 2 H 2 O e - [] ATP e - Q10 [] H 2 O e - ATP* *
4 ver5.1 HS 2. () - 1) () - 2) 2004 Nature Medicine- ( ) 3) - 4) 1) Saengsirisuwan V., Perez F. R., Sloniger J. A. Maier T., Henriksen E. J. Interaction of exercise training and α-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats. Am. J. Physiol. Endocrinol. Metab., 287, E (2004). 2) Burke D. G., Chilibeck P. D., Parise G., Tarnopolsky M. A., Candow D. G. Effect of α-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration. Int. J. Spot. Nutr. Exerc. Metab., 13, (2003). 3) Kim M. S., Park J. Y., Namkoong C., Jang P. G., Ryu J. W., Song H. S., Yun J. Y., Namgoong I. S., Ha J., Park I. S., Lee I. K., Viollet B., Youn J. H., Lee H. K., Lee K. U. Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat. Med., 10, (2004). 4) Dicter N., Madar Z., Tirosh O. α-lipoic acid inhibits glycogen synthesis in rat soleus muscle via its oxidative activity and the uncoupling of mitochondria. J. Nutr., 132, (2002). 3
5 ver5.1 HS (1) (in vitro) L ( 3) 3. α- (L6) (±S.E., n=6) L MTT (2) (in vivo) - 24 in vivo ( 4) 4. - (±S.E., n=6) (ddy5 ) - ( %) (MF, ) 24 4
6 ver5.1 HS (3) (in vitro) - (3T3-L1) ( ) 5) ( 5) - 3- (GPDH) 3T3-L1 GPDH - ( 6) - 5) Cho K. J., Moon H. E., Moini H., Packer L., Yoon D. Y., Chung A. S. α-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathway. J. Biol. Chem., 278, (2003). Control 1 µg/ml 3 µg/ml 10 µg/ml 5. α GPDH (n=2-3) 5
7 ver5.1 HS 3T3-L1 2 (1 µg/ml) (0.25 µm) (0.5 mm) (1 µg/ml) 1 7 3T3-L1 GPDH [ () ] (4) (in vivo) (0.1%) 7. - (n=5) (ddy5 ) - (0.1%) (MF, ) 13 (MK-770M) 10 (5 rpm) 1 1 (5) (in vitro) (HepG2) (L6) 1 -CPTACOX AMPK PPAR ( 9) 6
8 ver5.1 HS 8. CPT CoA ACOX camp AMPK PPAR - CPT - CPT - -ACOX ACOX - AMPK PPARα PPARγ β-actin - CPTACOX AMPK PPAR ( 9) 7
9 ver5.1 HS CPT ACOX PPAR AMPK β-actin α-µg/ml α-µg/ml α-β-actin 10- S.E., n=6 ( 10) Triglyceride (% of control) Triglyceride (% of control) α-lipoic acid (µg/ml) α-lipoic acid (µg/ml) (HepG2) 12 - DMSO 24 (L6) DMSO 24 RNA (RNeasy micro QIAGEN ) RNA (SuperScript IIIInvitrogen ) DNA (PCR) 2. (HepG2) (L6) 96 1 () 8
10 ver5.1 HS (6) mg mg 4 - (100 mg/) 4 (p<0.01) (p<0.05) ( 2 ) - (200 mg/) BMI (p<0.05) ( 3 ) - ( mg/) (100 mg) / (kg) / 7 (%) / 7 BMI (kg/m 2 ) / 7 Ω / 7 (%) / 7 (%) / 7 (cm) / 7 (cm) / 7 / / 7 (mm) / 7 (mg/dl) p< / 7 (mg/dl) / 7 HDL- (mg/dl) / 7 (mg/dl) / 7 (mg/dl) / 7 (mg/dl) p< / 7 (g/dl) / 7 7 (1 ) 9
11 ver5.1 HS 3. - (200 mg) (kg) / 10 (%) / 10 BMI (kg/m 2 ) / 10 Ω / 10 (%) / 7 (%) / 10 (cm) / 10 (cm) / 10 / / 10 (mm) / 10 (mg/dl) / 10 (mg/dl) / 10 HDL- (mg/dl) / 10 (mg/dl) / 10 (mg/dl) / 10 (mg/dl) p< / 10 (g/dl) /
12 ver5.1 HS 11- (100 mg) 11
13 ver5.1 HS 3. (1) (in vitro) - B16 ( 12) (B16) (±S.E., n=6) B16 2 mmmem (10%100 units/ml100 µg/ml) ( /ml) µl - (55 µl) 3 PBS (300 µl) 96 (415 nm 700 nm) (in vivo) (- 0 mg/kg) (0 ) - (25 50 mg/kg) ( 14 ) - in vitro in vivo 12
14 (L ) mg/kg 1 mg/kg 25 mg/kg 50 mg/kg ver5.1 HS 13. (±SD, n=3) 1 mg/kg 25 mg/kg 50 mg/kg (4 ) (0 ) 2 (2 ) [ () ] (UVB2000 mj/cm 2 ) (0 ) 8 10 (L*) () 13
15 ver5.1 HS (2) (in vitro) - NB1RGB Control NB1RGB (±S.E., n=6) NB1RGB 96-2 MTT (in vitro) Control - (1 µg/ml) ( 16) - () [TESTSKIN () ]
16 ver5.1 HS Control - (1g/mL) ( 400 ) 4. SOD SOD DPPH 15
17 ver5.1 HS 5. - (--WSP8 WSPC8) - (WSP8 WSPC8) WSP8 WSPC8 6. α --WSP8 (- 8)- -P (- 100) - 30 mg/kg (SD 7 ) - (n=3)- -WSP8 --P 3 (AUC) --WSP8 --P 3 --WSP8 --WSP WSP ( ) 16
18 ver5.1 HS 7. (1) --P (2) ph pH ph ph 17
19 ver5.1 HS 8. α 0.2 g/100g 0.0 g/100g g/100g 0.0 g/100g 0.0 g/100g kcal/100g g/100 1 mg/100g 1) ) ( ) 100 (+++) 3) ( ) 4; 9; 4; α (1) (LD 50 ) ddy-ld mg/kg 277 mg/kg60 kg g (2) / OECD No.404 ( ) Commission Directive 2004/73/EC 3 () /- 0.5 g Draize p.i.i. (primary irritation index) 3 1 () 24 p.i.i / Safepharm Laboratories Limited /007 (3) 3 () L Draize C-I168 18
20 ver5.1 HS (4) OECD No Commission Directive 2004/73/EC 3 () - 70mg Kay ( 18 5) Safepharm Laboratories Limited /008 (5) OECD No Commission Directive 2004/73/EC 1 4 (CBA/Ca ) (LLNA Assay) Safepharm Laboratories Limited /009 (6) (Ames ) OECD No.471 Commission Directive 2000/32/EC (Ames ) Salminella typhimurium (TA1535TA1537TA98TA100) Escherichia coli (WP2uvrA) 10 S9-Mix g/- Safepharm Laboratories Limited /010 (7) 1 5 ppm ppm - 3 -tert- 5 ppm ppm ppm ppm ppm
21 ver5.1 HS 10. α (1) - -- () 2 - A () - B ( ) 23 - A B R 1 S S : A R 1 = R 2 = H or R 2 n COOH B : R 1 = R 2 = H or COOR 3 R 3 = H or Et (2) - () - B () 500 mg/kg - B IB05039 in press. 11.α mg mg 20
22 ver5.1 HS 12.α --P --P80 --WSP8 --L1 --PC --PC80 --WSPC () --LC P, P80, WSP8 () --PC, PC80, WSPC8 () 5 kg --L1 () --LC1 () 5 kg 14. (15) (- -L1-LC1) 5 21
23 ver5.1 HS P --P80 --WSP8 --L1 --PC --WSPC8 --LC1 INCI Thioctic acid INCIMaltosilcyclodextrin (and) Thioctic acid INCI Polyglyceryl-10 Myristate (and) Propylene Glycol Caprylate (and) Glycerin (and) Thioctic acid (and) Alcohol -10 PG ( ) 100g (g)
24 ver5.1 HS P α- (1,2-dithiolane-6-pentanoic acid) 98.0 % nm nm α % (HPLC) () 0.5 % (1 g40, 4 ) 0.1 % (1 g) (1) 6,8-Epitrithiooctanoic acid 0.1 % (HPLC) (2) 2.0 % () (3) Pb 10 ppm () (4) As 2 O 3 1 ppm () /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 100 % 23
25 ver5.1 HS P80 α- (1,2-dithiolane-6-pentanoic acid) 80.0 % nm nm α % (HPLC) 0.5 % (1 g40, 4 ) 0.1 % ( 1 g) (1) 6,8-Epitrithiooctanoic acid 0.1 % (HPLC) (2) 10 ppm () (3) 1 ppm () /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 80 % 20 % 100 % 24
26 ver5.1 HS WSP8 α- (1,2-dithiolane-6-pentanoic acid) 8.0 % nm nm α- 8.0 % (HPLC) 9.0 % (1 g40, 4 ) 0.10 % ( 1 g) (1) 10 ppm () (2) 1 ppm () /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 8 % 92 % 100 % 25
27 ver5.1 HS L1 α- (1,2-dithiolane-6-pentanoic acid) α % α % (HPLC) (1) 10 ppm () (2) 1 ppm () /g () /g ( ) (BGLB ) (0.1 ppm ) (GCMS) 10 % 2 % 50 % 23 % 15 % 100 % 26
28 ver5.1 HS PC α- (1,2-dithiolane-6-pentanoic acid) 98.0 % nm nm α % (HPLC) () 0.5 % (1 g40, 4 ) 0.1 % (1 g) (1) 6,8-Epitrithiooctanoic acid 0.1 % (HPLC) (2) 2.0 % () (3) Pb 10 ppm ( 2 ) (4) As 2 O 3 1 ppm ( 3 ) /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 100 %, 27
29 ver5.1 HS PC80 α- (1,2-dithiolane-6-pentanoic acid) 80.0 % nm nm α % (HPLC) 0.5 % (1 g40, 4 ) 0.1 % (1 g) (1) 6,8-Epitrithiooctanoic acid 0.1 % (HPLC) (2) Pb 10 ppm ( 2 ) (3) As 2 O 3 1 ppm ( 3 ) /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 80 % 20 % 100 %, 28
30 ver5.1 HS WSPC8 α- (1,2-dithiolane-6-pentanoic acid) 8.0 % nm nm α- 8.0 % (HPLC) 9.0 % (1 g40, 4 ) 0.10 % (1 g) (1) Pb 10 ppm ( 2 ) (2) As 2 O 3 1 ppm ( 3 ) /g () /g ( ) (BGLB ) (1) 0.1 % (GC) (2) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) (1 ppm ) (GCMS) 92 % 8 % 100 %, 29
31 ver5.1 HS LC1 - (1,2-dithiolane-6-pentanoic acid) % % (HPLC) (1) 10 ppm ( 2 ) Pb (2) 1 ppm ( 3 ) As 2 O /g () /g ( ) (BGLB ) (0.1 ppm ) (GCMS) % 23 % 15 % 10 % 2 % 100 %, 30
32 TEL(0586) () FAX(0586) URL/ F TEL(03) FAX(03) * * * * Ver. 5.1 (pp.25-32)
ORYZA OIL & FAT CHEMICAL CO., LTD. α- リポ酸 ALPHA LIPOIC ACID ver. 6.0 MK
ORYZA OIL & FAT CHEMICAL CO., LTD. α- リポ酸 ALPHA LIPOIC ACID ver. 6.0 MK α- リポ酸 ALPHA LIPOIC ACID 1. はじめに 平成 16 年 3 月 31 日付薬食発第 0331009 号通知により 医薬品の範囲に関する基準 が改正され, 従来医薬品として重度の糖尿病患者の末梢疼痛緩和に用いられてきた α-リポ酸 (
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RYZA IL & FAT CHEMICAL C., LTD. SAKURA EXTRACT Ver.1.4MK Ver. 1.4MK 1) 1300 1929 1 Ver. 1.4MK Sakura 1-caffeoyl---D-glucopyranoside quercetin 3---D-glucopyranoside 1) :, 4, 11-22 (1995). 2 Ver. 1.4MK 3
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ORYZA CERAMIDE -PTPCDP8TP20CD -WSPWSP8 -LL0.8 -PCPC8PC20 -WSPCWSPC8 -LCLC0.8 Ver.13.0HS ORYZA CERAMIDE Ver.13.0HS 1. 2. 20 NMR 4 ( 1) 1 Ver.13.0HS HO CH 2 OH O O OH OH OH C CH CH H 2 NH C O R C H C H (CH
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er. 3.0SJ ver.3.0 SJ 3 2 1 ver.3.0 SJ 900 1200 () 400 2 ver.3.0 SJ OH OMe OMe O O O MeO O MeO OMe O O OMe O OMe OMe O O MeO O O H O O MeO OMe O H O OH OMe O CH 2 HO O O O O CH 3 OH HO OH OH HO OH O 1 3
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ORYZA OIL & FAT CHEMICAL CO., LTD. WHITE JELLY FUNGUS EXTRACT -P () Ver. 1.3SJ Ver. 1.3SJ 1. 3000 ph 1 Ver. 1.3SJ 1. 1 2. 3 2-1. 2-2. 2-3. 2-4. SOD 3. 7 3-1. in vitro 3-2. in vivo 3-3. in vivo 3-4. in
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ver. 4.3 HS 14 1,620-6- 1) 2) 1 24% p- 45 1) Schwab D. et al., Hepatic uptake of synthetic chlorogenic acid derivatives by the organic anion transport proteins. J. Pharmacol. Exp. Ther. 296, 91-8 (2001).
参考資料５ 農薬評価書 メタアルデヒド（食品安全委員会資料）
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A B 1.A B A B 2.A B A B 3.A
1 1. 2.WHO 3. 4. 5. 2 2.0mg/kg / 1. 2. 3. 4. 5. 3 1. 90 2. 3. 4. 5. 4 1. 2. 3. 4. 5. 1 21 5 1. 2. 2050 61 3. 1 4. 5. 6 1. ----------- 2. ---- 3. ------ 4. -------- 5. --------- 7 A B 1.A B------------------A
CAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
15K00827 研究成果報告書
(TG) TG sterol regulatory element- binding protein (SREBP)-1c (Diabetes 53:560-569, 2004) SREBP-1c (1) SREBP-1c SREBP-1c liver X receptor (LXR)LXR O-Glc NAc (O-linked -N-acetyl glucosamine) (J Biol Chem
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第124回日本医学会シンポジウム
III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2
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1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
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ver.2.0 JT. Cistanche Tubulosa (Schenk) R. Wight 1 16 2 2 6m 4 100 10 100 51 183 3 1 ver.2.0 JT GAP GMP 25% 9% 1. 2. GAP 2 ver.2.0 JT echinacosideacteoside 3 15 C 5 1) 2) 3) 4 4. 100 3. 1) 2005. 2) Haihui
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(1)...109 (2)...110 (1) 28...111 (2) 28...113 (1) Seg...115 (2) Seg...117 (3) Seg...119 (4) Seg...120 (1)...122 (2)...122 (3) ( )...126 (1) (PCA)...127 (2) Draize...128 (1) Ames...129 2 in vitro...132
研修コーナー
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10 12 A 12 C 12 13 13 13 13 16 16 18 18 18 23 23 23 23 23 A 24 25 25 26 28 28 30 32 38 38 41 42 43 10 43 11 45 48 48 120g 51 52 12 3 12 3 350g 120g 1 7 10 260g 90g 90g 30g 9 11 2 gg1 g 1 120g 10 1 12 6
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2001 4 26 2003 5 22 2004 7 12 2004 7 15 54 2004 7 21 14 2004 9 16 62 IUPAC4--2--N,N --5-p --1-2 17.07 mg/kg / 100 0.17 mg/kg /ADI cyazofamidiso IUPAC 4--2--N,N- -5-p --1-4-chloro-2-cyano-N,N -dimethyl-5-p
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1 2 1 2002 8 1 2003 11 1 152 2003 11 2 21 53 2003 12 24 4 54 2004 3 22 55 2004 4 9 56 2004 4 15 41 2004 4 15 2004 5 12 2004 5 19 2004 5 20 5 2004 12 16 58 2 2005 1 25 2005 8 23 5962 2005 8 26 2005 9 1
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2005 1 872646 IF 1998 9 1g 3mg(0.3%) Deprodone Propionate 2003227 200374 1997415( ) 1998316( ) F A X 2003 7 1992 3 17 1997 10 9 1992 5 22 1997 12 19 IF 2005 4 IF 1. MR 63 2 IF 10 3 IF 2. IF IF IF 3. IF
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
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3-107- - 108 - 3.1 3.1.1 3.1.2 3.1.2.1 5 LD50 LC50 ATE 3.1.1 1 2 3 4 5 (mg kg ) 5 50 300 2000 5000 a (mg kg ) 50 200 1000 2000 a (ppm) 100 500 2500 5000 a b mg 0.5 2.0 10 20 a b c d 0.05 0.5 1.0 5 (mg
橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
日本医科大学医学会雑誌第8巻第1号
Xenopus laevis in situ μ μ Xenopus laevis Xenopus laevis Xenopus laevis UGT1A1 UGT1A1 IL28B KRAS UGT1A1 UGT1A128 UGT UGT1A1 UGT1A128 UGT1A1 286 UGT1A1 UGT1A1 28 6 UGT UGT UGT1A128 UGT IL28B UGT1A1
グリセオール注インタビューフォーム
2006 8 3 873999 871319 IF 1998 9 FAX 1 200mL 300mL 500mL 20g 30g 50g 10g 15g 25g 1.8g 2.7g 4.5g 0.9W/V 200mL500mL 1979 3 13 2004 7 9 1979 5 15 2006 8 300mL 1979 3 13 2004 7 9 1982 11 1 IF 1 MR 63 IF 10
t 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
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8 01 01 4 4 1 5 16 18 6 006 H 18 4 011 H 6 4 1 5 1 5 007 H 19 5 009 1 5 006 007 009 011 9 10 4 000 H 1 4 5 004 H 16 4 004 009 H 1 5 4 4 5 1 4 006 011 1 1 4m 5m 10m 007 1 7 009 009 1 5 10 1 000kg 10a 006
98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
1 1 2 2 3 3 4 5 5 6 6 7 7 8 8 9 9 10 10. 11 1 12 1 13 2 13 3 8 13 4 14 5 14 6 14 7 15 8 15 1 17 2 22 3 24 4 24 1 33 2 42 1 49 2 50 3 50 4 56 1 60 2 88 3 93 1 95 2 96 1 98 2 100 1 100 2 104 3 105 4 105
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