DCHP
|
|
- らむ えいさか
- 5 years ago
- Views:
Transcription
1 2. 2
2 1. 1) 2) 2 Crj:CD(SD)IGS SPF ppm 2 F0 10 F0 10 F1 21 F F F ppm 1 F mg/kg/day F mg/kg/day F mg/kg/dya F mg/kg/day F0 F ppm 6000 ppm F ppm F ppm F1 F1 F ppm 6000 ppm F ppm F
3 NOEL NOAEL 240 ppm F mg/kg/day F mg/kg/day F mg/kg/day F mg/kg/day NOEL NOAEL 240 ppm 1200 ppm F mg/kg/day F mg/kg/day NOEL NOAEL 240 ppm 1200 ppm - 3 -
4 2. (DCHP) 99.9 (MERCK-Schuchardt Lot No. S26063) NEDO 2 5. Crj:CD(SD)IGS ( ) 1 24 F F F1 21 F F2 21 F0 F ppm NIH-07M ppm ppm ppm 600 ppm ppm 6000 ppm 6000 ppm ppm 240 ppm - 4 -
5 (NIH-07M ) m / 12 (7-19 ) (265W 426D 200H mm ) F F F F1-5 -
6 35 27 F0 13 F F0 F1 10 HTM-IVOS Ver ppm 10 HTM-IVOS Ver.10.8F ppm ppm 2000 ppm F0 F RIA FSH LH FSH LH - 6 -
7 10.8, % F1 14 * F2 12 * * F1 F2 F ppm F1 14 F F0 F1-7 -
8 1 F1 F F0 F ppm ppm F0 F1 F1 F Bartlett Kruskal-Wallis Dunnett Dunnett Kruskal-Wallis Dunnett Fisher 5 Kruskal-Wallis Dunnett - 8 -
9 Fisher / - 9 -
10 1. F : %
11 F0/F F : FSH LH FSH LH
12 F % F1/F FSH LH FSH LH
13 tk tk tk tk tk # tk #
14 Tables A4 to A7 and B6 to B9 F0 F1 F0 F1 240 ppm ppm ppm ppm ppm ppm ppm ppm ppm F0 F Tables A8 to A15, B11 to B14, and B16 to B ppm F F , , 0-21, F , 28-91, ,F1 21, , ppm F0 7 F F F
15 240 ppm F0 0 F0 F ppm F0 F Tables A16 to A18 and B20 to B ppm F F F0 F ppm F F0 14 F ppm F0 F1 240 ppm F0 F1 F ppm F ppm Tables A19 to A21 and B23 to B ppm F0 7 F1 28 F1 7 F0 35 F ppm F0 7 F ,F1 7 F0 35 F ppm F1 7 F0 F ppm F0 F1-15 -
16 Tables A22 and B ppm F0 F ppm F0 F1 F ppm F ppm F Tables A22, A24, B30, and B32 F0 F ppm F ppm F0 F Table A23 B31 F ppm 6000 ppm F1 1 F ppm 1200 ppm F Tables A25, A26, B34, and B ppm F0 F0 F1-16 -
17 F0 F1 F0 F ppm F0 F ppm F0 F0 F1 F ppm F0 F1 F1 240 ppm F1 F ppm F0 F1 F0 F Table A27, A28, B38, and B ppm F0 F ppm F ppm F1 F0 F1 F ppm F ppm F ppm F ppm F ppm F ppm F0 F1 F0 F1 240 ppm
18 6000 ppm F ppm ppm ppm ppm 3 F ppm 1 F0 F ppm F ppm F ppm F ppm F0 F ppm F0 F ppm F Table A29 B ppm F0 240 ppm F 1 FSH 6000 ppm 6000 ppm FSH LH Tables B5, and C2 F1 F ppm F1 F Tables B10, B15, C3, and C ppm F F
19 ppm F1 F ppm F1 F2, Tables B4, B26, B29, B41, C1, C5, C8, and C ppm F1 F ppm F2 240 ppm F1 F ppm F ppm F Tables B27, B28, C6, and C7 F1 F2 F1 F ppm F ppm F1 F Table2 B33, B35, C9, and C ppm F1 F1 F2 F1 F2 F1 F1 F2-19 -
20 1200 ppm 6000 ppm F1 F Tables B37 and C11 F1 240 ppm 6000 ppm 2, 240 ppm 1200 ppm 1, F2 1, 1-2,, F2 1, ppm F1 F NOELNOAEL F0 F ppm 6000 ppm F1 3,4) 7 P ) 6) F0 F ppm 2U
21 7) 2U 8) 2U F ppm ,10) 2500 mg/kg ) 11) F0 F ppm F ppm F1 12 F0 F1 11) F ppm 1200 ppm F1 F ppm 6000 ppm F ppm F2,
22 13) n- 14) 6000 ppm F ppm F2 2 NOEL NOAEL 240 ppm F mg/kg/day F mg/kg/day F mg/kg/day F mg/kg/day NOELNOAEL 240 ppm 1200 ppm F mg/kg/day F mg/kg/day NOELNOAEL 240 ppm 1200 ppm 12. 1) HSDB 2001 Hazardous Substance Data Bank, National Library of Medicine. 2) CERI 2001a 12 3) Gopinath C, Prentice, DE, Lewis DJ. (1987): The liver. Morphological lesions in the liver. Hypertrophy. In: Gopinath C, Prentice, DE, Lewis DJ, editors. Atlas of experimental toxicological pathology. Lancaster: MTP Press Limited; p.53. 4) Greaves P. Digestive system 2. (1990): Liver. Hepatocellular hypertrophy and hyperplasia. In: Greaves P, editor. Histopathology of preclinical toxicity studies. Amsterdam: Elsevier; p ) Lake BG, Foster JR, Collins MA, Stubberfield CR, Gangolli SD, Srivastava SP. (1982): Studies on the effects of orally administered dicyclohexyl phthalate in the rat. Acta Pharmacol Toxicol (Copenh) ) Gopinath C, Prentice DE, Lewis DJ. (1987): The endocrine glands. Thyroid. In: Gopinath C, Prentice DE, Lewis DJ, editors. Atlas of experimental toxicological pathology. Lancaster: MTP Press Limited; p ) Greaves P. Urinary tract. Kidney. Hyaline droplets. (1990): Greaves P, editor. Histopathology of preclinical toxicity studies. Amsterdam: Elsevier; p ),...,.. : ; p
23 9) Gopinath C, Prentice DE, Lewis DJ. The reproductive system. Male reproductive system. Testis and epididymis. In: Gopinath C, Prentice DE, Lewis DJ, editors. Atlas of experimental toxicological pathology. Lancaster: MTP Press Limited; p ),....,.. : ; p ) CERI 2001b 11 12) Chapin, R.E., Gulati,D.K., Barnes,L.H., and Teague, J.L. (1993): The Effects of Feed Reproductive Function in Sprague-Dawley Rats. Fundam. Appl. Toxicol. 20, ) Gray, L.E., et al. (2001): Effects of environmental antiandorigens on reproductive development in experimental animals. Human Reproduction Update, 7, ) Shultz, V.D., et al (2001): Altered Gene Profiles in Fetal Rat Testes after in Utero Exposure to Di(n-butyl) Phthalate. Toxicol. Sci.64,
24 2. F0 F1 F1 F2 ppm mg/kg/day /24 0/24 0/24 0/24 0/20 0/23 0/20 0/22 0/24 0/24 0/24 0/24 0/20 1/23 1) 0/20 1/22 2) 0/24 0/24 0/24 1/24 0/20 0/23 0/20 0/22 0/24 0/24 0/24 1/24 0/20 0/23 0/20 0/22 0/24 1/24 0/24 1/24 0/20 0/23 1/20 0/22 0/24 0/24 1/24 0/24 0/24 1/24 0/24 0/24 0/20 0/20 0/23 0/23 1/20 0/20 0/22 0/22 1/24 1/24 2/24 0/24 3/24 0/24 5/24 0/24 4/20 0/20 2/23 0/23 0/20 0/20 1/22 0/22 1/24 0/24 0/24 0/24 0/20 0/23 0/20 0/ ) ) ) ) (g) ) ) [MeanS.D.] ) ) ) ) ) ) ) ) (g) ) ) ) ) ) ) ) (%) ) ) ) ) ) ) ) )
25 2. -1 F0 F1 F1 F2 ppm (g) /24 23/24 22/24 23/24 19/20 23/23 20/20 19/ [MeanS.D.] (x 10 6 ) ) ) ( )(%) ) (%) (g) /24 0/24 0/24 0/24 1/20 2/23 0/20 0/ ) [MeanS.D.] 22/24 23/24 22/24 23/24 19/20 23/23 20/20 19/21 20/22 23/23 20/22 22/23 19/19 22/23 19/20 17/19 20/20 23/23 20/20 22/22 19/19 22/22 19/19 17/17 (%) (g) (mg) ()(mg) ()(mg) , (g) [MeanS.D.] () (g) ()(mg) ()(g) ()(g) (g) (g) (g) / / p0.05 p0.01
26 2. -2 [MeanS.D.] F0 F1 F1 F2 ppm (x10-3 ) () (x10-3 ) () (x10-3 ) (%) () () (x10-3 ) () () (g) ()(mg) ()(mg) (g) ()(g) ()(g) ()(mg) ()(mg) () (x10-3 ) () (x10-3 ) (%) () () () (x10-3 ) () (x10-3 ) / / p0.05 p
27 2. -3 F0 F1 F1 F2 ppm ) /24 0/24 0/24 24/24 0/20 0/23 0/20 8/22 26) 0/24 0/24 0/24 0/24 0/20 0/23 0/20 3/22 0/24 0/24 0/24 0/24 0/20 0/23 0/20 2/22 0/24 0/24 0/24 7/24 0/20 0/22 1/20 4/21 + 0/24 0/24 4/24 16/24 0/20 0/23 0/20 14/22 + 0/24 0/24 3/24 7/24 0/20 0/23 0/20 7/ /24 22/24 23/24 9/24 19/20 22/23 20/20 14/ /24 1/24-15/24 27) 1/20 1/23-8/22 27) /20 0/23 0/20 3/22 + 1/24 1/24 1/20 0/23 2/20 6/22 + 0/24 0/24 3/24 12/24 0/20 0/22 0/20 9/21 + 0/24 0/24 0/24 6/24 0/20 0/22 0/20 6/ (ng/ml) FSH (ng/ml) LH (ng/ml) (pg/ml) FSH (ng/ml) LH (ng/ml) ) F ppm ppm 6000 ppm 26) / - / 27) (++) / / p0.05 p0.01
28 2. -4 F0 F1 F1 F2 ppm ) / 0-21 / /1 28) (g) [MeanS.D.] AGDmm AGD/BW AGD 4 AGDmm [MeanS.D.] AGD/BW (%) F1Day 14 F2Day / / p0.05 p0.0128) / -
29 2. -5 F0 F1 F1 F2 ppm % % % ) % % % % [Mean] % % % (g) (mg) (g) (%) (x10-3 ) [MeanS.D.] (g) (g) (%) /19 30) 2/20 2/22-2/ / / 1/20 1/23 1/ / / p0.05 p ) 5 1, /
繁殖性に及ぼす影響
5. 2 1. (DEP) 1) DEP 2) 3) 4) DEP 0 600 3000 15000 ppm(0 43 210 1083 mg/kg/day 0 54 261 1336 mg/kg/day ) 24 Crj:CD(SD) IGS 2 DEP 15000 ppm F0 0-21 F1 F0 F1 DEP F1 F1 15000 ppm 15000 ppm F0 F1 F0 F0 P-450
More informationCAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
More informationCAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
More informationt 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
More information橡アジポニトリル.PDF
1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log
More information98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
More information,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
More informationCAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
More information3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
More information,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
More information橡99-24_00 アリルアルコール.PDF
1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log
More information0774 CAS No. 111-15-9 2014 3 25 0774 1 3 1 3 11 3 12 3 13 3 2 3 3 4 31 4 32 4 4 4 5 1 5 11 5 12 5 13 5 14 5 15 5 16 6 17 6 2 7 21 7 22 7 23 7 1 7 2 8 3 8 3 8 31 8 32 9 33 9 34 9 35 9 36 9 37 10 1 10
More information橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
More information化学物質の環境リスク初期評価(平成9~12年度)結果[39物質]
(1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16
More informationCHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation
CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference
More information橡H1102答申別添1.PDF
1993 10mg/ Walton 1951 WHO 1993 1992 Walton American Journal of Public Health 41 1951 10ppm 10mgN/, 50mg/ 1993 1990 1997 10 HAN TEAN HAN 61%, TEAN19%, 20% WHO FAO JECFA 0, 0.1, 1, 5, 10% 5 NOEL % 500mg/kg/day
More information040202PC用.doc
15 48 15 8 25 15 1321 15 8 25 0825002 15 8 25 6 8 15 2 18 15 6 27 2 15 3 13 28 35 (1) 51 198 7 (2) 3 6 1 100g (1) 1 (1) 1 2 1 astaxanthin;3,3 -dihydroxy-, -carotene-4,4 -dione (2) 1 2 C40H52O4 596.86 97.0
More information橡フタル酸ブチルベンジル.PDF
1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow
More information◎⑥BBP報告書_委員会当日_20030626
4-6 6. 2-1 - 1. (BBP) ( ) 1) BBP 2) 3) 4) 3),4) 5),6) 7),8) + 7) BBP 0 100 200 400 mg/kg/day 24 Crj:CD(SD) IGS 2 F0 200 mg/kg F1 100 mg/kg F0 F1 BBP 400 mg/kg F0 F1 F0 F1 BBP F1 400 mg/kg F1 F0 BBP 200
More informationFig. 1 Mean body weight changes of male rats administered cefaclor orally on fertility study Table. 1 Serum biochemical analysis in male rats administered cefaclor orally on fertility study The values
More information14 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 20 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0
More information資料1(目消し版).ppt
1 Dr. Grandjean 2 15 45 3 4 CH 3 Hg + Hg 0 fi Hg ++ fich 3 + MeHg MeHg 5 Methylmercury-2 6 :, A. Yasutake 7 - A. Yasutake 8 :,. A. Yasutake 9 A. Yasutake 10 (%) : : : : : MeHg 0.05 250 : 2 : 1 : 0.1 :
More information,161 t 9,753 t 2,408 t LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum 6 3 Selenastrum h, Sb
1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
More informationuntitled
COLAK Mehmed 11000 305 305 180 10000 9000 8000 160 140 120 7000 100 6000 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 80 GH IGF-1 GH GH 5 4 3 2 1 0 2 3 4 5
More information() 2
1 () 2 2 4 3 6,500 4 5 2 6 A B A B A B A B - A B 7 8 A B A B A B 9 JR JR 10 11 6 5 12 17 6 13 14 B A A B A B A B 2 1 8 15 8 16 17 9 18 3 4 5 mm mm 19 2 20 3 6 7 11 12 13 14 18 4 3 2 1 21 3 12 13 14 16
More information(Ⅱ)化学物質の環境リスク初期評価(13物質)の結果
1 ( ) DBDPO CAS 1163-19-5 C 12 Br 10 O 959.2 2 1) 305 2) 3.0 1) 1- / (logp ow ) 1) 5.03 mmhg306 1) 1) 3) 4) 5) 1.010-4 6) mg/l25 3 7) OH 8) 4 9) 6 BOD 0% 14 100 mg/l 30 7) 10) BCF 5 < 42 60 mg/l 7) 50
More information橡三酸化二アンチモン.PDF
1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
More information化学物質の環境リスク初期評価(平成9~12年度)結果[39物質]
1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )
More informationMicrosoft Word - fiñfiÅ’«.doc
H N S O O H N H 3 C 3 µ µ µ µ GLP Douglas, W.W. (1980): Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. In: Goodman and Gilman s The Pharmacological Basis of Therapeutics, 6th
More information01オクタクロロスチレン.PDF
[Octachlorostyrene, CAS No. 29082-74-4] ( ) OCS C 8 C l8 379.71 0.0018 Pa (25 ) Log Pow = 6.29 ( ) 2) 0.00174 mg/l (25 ) HSDB, 2001; 2 PHYSPROP, 2000. 1 1. 1) (OCS) 9 OCS OCS 75 4 Selden et al., 1997 2
More informationCHEMOTHERAPY NOV. 1990
VOL.38 S-2 6, 8- Difluoro- 1-(2- fluoroethyl)- 1, 4- dihydro- 7-(4- methyl- 1- piperazinyl)- 4- oxo- 3- quinolinecarboxylic CHEMOTHERAPY NOV. 1990 VOL.38 S-2 Fig. 1. Body weight changes of male rats treated
More information橡96-01.PDF
1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
More informationhttp://www.who.int/ipcs/publications/ehc/en/index.html EHC 1 2 3 4 / EHC http://www.nihs.go.jp/dcbi/publist/ehchsg/ 1-8) WHO/IPCS CICAD (Concise Inter
3 [ ] Priority IARC JMPR 2004 10 Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) http://www.cerij.or.jp/ceri_jp/koukai/sheet/sheet_indx4.htm http://www.safe.nite.go.jp/data/sougou/pk_list.html?table_name=hyoka&rank=sh
More informationフタル酸ジペンチル
147 148 Wistar- Hannover BrlHan: WIST@Jcl (GALAS) 30 100 12 6 0 20 0 20 0 2 10 50 250 µg/kg/day 1 ml/kg/day 1 1 g/kg/day ml/kg/day 8 2 1 1 1 AGD 4 21 2 2 SD 2 2 13 149 g/kg/day mg/kg/day 10 50 250 1,000
More information14 4 12 10 8 6 3 2 4 2 1 0 0 100200300400500600 100200300400500600700 0 0 100200300400500600 100200300400500600700 (ppm) (ppm) 7 4 6 5 4 3 3 2 2 1 1 0 0 100200300400500600 100200300400500600700 0 0 100200300400500600
More informationuntitled
b 0 1PPm 10PPm 100PPm 1000PPm 10000PPm 0.0001% 0.001% 0.01% 0.1% 1% 10% 1PPm 10PPm 100PPm 1000PPm 10000PPm 0.0001% 0.001% 0.01% 0.1% 1% 10% 1PPm 10PPm 100PPm 1000PPm 10000PPm 0.0001% 0.001% 0.01%
More information2.7.6 MJR a MRI CT b 2 Beecham r-afs mg/ mg/ Gn-RH 742
MJR-35 34 1 1 a MRICT b 2Beecham r-afs 3 4 20 4 mg/ 20 40 5 6 2 1 2 3 44 mg/ 5 6 7 8 4 Gn-RH 742 9 10 11 12 1 20 60 1 1MJR-351 mg/ 0.25 2 Lot. No. 2MJR-352 mg/ 1 1 Lot. No. 3MJR-354 mg/ 1 2 Lot. No. 2
More information_ _ _ _ _ _ _ _ _ _ _ _ _ _ _
1000101_ 1000102_ 1000103_ 1000301_ 1000302_ 1000303_ 1000401_ 1000402_ 1000403_ 1000701_ 1000702_ 1000703_ 1000801_ 1000802_ 1000803_ 1000901_ 1000902_ 1000903_ 1001001_ 1001002_ 1001003_ 1001101_ 1001102_
More information化学物質の環境リスク初期評価(平成9~12年度)結果[39物質]
(1) 1,2- DMP CAS 131-11-3 C 10 H 10 O 4 194.2 2 1) 5.5 2,3) 283.7 2,3) 1.192 (20 ) 4) 133 Pa (1 mmhg) (20 ) 5) 1ppm=7.94 mg/m 3 at 25, n- / 1.56 ( ) 6) 4) ( )3.2 (30 ph 7)11.6 (30 ph 9)25 (18 ph 9) 5)
More information会津若松市民の運動行動における変化ステージの評価
2 Bandura1977 2000 Bandura 50 36 3 4 MarcusSimkin1993 2002 6 6 6 6 1995 2000.81 1998 1995 2000.91 2000 5 .65 1986.83 Marcus et al1992 2002 Pros.81 Cons.80 Pros Cons Pros Cons 6 7 8 9 10 11 12 13 5 Tukey
More informationTable 1. Acute toxicity of Folin on mice. (Litchfield-Wilcoxon method) Numbers in parenthesis indicate 95% fiducial limits. Fig. 1. Analgesic effect of Folin on mice (1% acetic aid-induced writhing). Each
More informationCHEMOTHERAPY APR. 1984
VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated
More information農薬生殖毒性総合評価体系確立調査研究 添付資料I
2 1. 2 8L784 2. OECD 2 3. 1998 OECD Guidelines for Testing of Chemicals, Revised Draft Guideline 416 (Draft document), Two-Generation Reproduction Toxicity Study (1998) US EPA Health Effects Test Guidelines,
More information取扱説明書 [F-12C]
F-12C 11.7 1 2 3 4 5 6 7 8 9 10 11 12 13 14 a bc b c d d a 15 a b cd e a b c d e 16 17 18 de a b 19 c d 20 a b a b c a d e k l m e b c d f g h i j p q r c d e f g h i j n o s 21 k l m n o p q r s a X
More informationN,N’-(ジスルファンー1,2-ジイルジー2,1-フェニレン)
4-(3-phenylpropyl) pyridine [CAS No. 2057-49-0] 1-Phenyl-3-(4-Pyridyl) Propane Molecular formula: C14H15N Molecular weight: 197.28 N ABSTRACT The acute oral median lethal dose (LD 50 ) of 4-(3-phenylpropyl)
More informationナノ材料の有害性評価
CRM CRM 181 TG424 TG42419971995TG407 PBPK PBPK DNA DNA PBPK C C art vein Ramsey & Andersen (1984) ( Qalv Cinh Qt Cvein ) ( Qt Qalv PN ) = + + { ( )} Qi Ci = i Pi ( C ) art Ci dai dt = Qi Qt Pi ( C ) art
More information20mg CTD 2.4 2.4 2.4... 5 2.4.1... 5 2.4.2... 7 2.4.3... 10 2.4.4... 13 2.4.5... 18 2.4.6... 20 3 2.4 2.4 2.4.1 JNS002 ( HSPC) N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2- distearoyl-sn-glycero-3-phosphoethanolamine
More informationVOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega
1066 CHEMOTHERAPY MAR. 1975 Table 1 Sensitivity of standard strains VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity
More information02スチレンダイマー、トリマー.PDF
[Styrene dimer, CAS No. 25247-68-1; Styrene trimer, 28213-80-1] -1,2 C 16 H 16 C 24 H 24 208.2 312.3 4 7 2-1,2 CH 2 CH 2 2,4- -1-2,4,6- -1-1,2-1,3,5-760 21,430 g/g 9,590 g/g 2 3 HSDB, 2001 ; 2, 1998; 3
More information(1) (2) (1) (2) (1) Seg (2) Seg (3) Seg (4) Seg (1) (2) (3) ( ) (1) (PCA)...12
(1)...109 (2)...110 (1) 28...111 (2) 28...113 (1) Seg...115 (2) Seg...117 (3) Seg...119 (4) Seg...120 (1)...122 (2)...122 (3) ( )...126 (1) (PCA)...127 (2) Draize...128 (1) Ames...129 2 in vitro...132
More information1 I ( )
1 I. 3 1. 4 2. 6 3. 7 4. 8 4.1 8 4.2 ( ) 9 4.3 13 4.4 16 4.5 17 5. 19 5.1 20 5.2 25 5.3 33 6. 37 6.1 37 6.2 41 6.3 44 7. 46 7.1 46 7.2 47 II. 48 A 50 1 50 2 51 3 56 4 59 60 B 61 1 61 2 62 3 65 4 67 68
More informationMicrosoft Word - 表紙資料2-4
(1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)
More informationNIHSS score p NIHSS score p149 4 p g ml 0.8 g ml D 1 D NIH NIHSS 14 D 0.8 g ml
NIHSS score14 1 400 1 p149 1 25 20 NIHSS score14 15 10 5 2 p149 4 p151 0 0.8 g ml 0.8 g ml D 1 D NIH NIHSS 14 D 0.8 g ml 1 2 148 149 3 2 3 A B C 4 D 2 A B C A C 1 Ogata T et al J Neurol Sci 272 83 86 2008
More informationVOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence
More informationuntitled
1% 1 mg 1 mg 2 CTD 6 Section 2.6.1 Introduction 2.6.1 H 1 descarboethoxyloratadinesch 34117 7.9 SCH 34117 2.6.1-1 O OC 2 H 5 Cl N N JAN Loratadine (JANINN) ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]
More information67.5km 299.4km 2 2 2 16km 1/6 47km 2 1 1 (m) (km 2 ) 2,700 7.6 9,927 47.1 8,100 13.4 8,120 4.8 52 0.4 1,100 6.0 2,200 3.8 6,982 45.3 4,473 14.4 5,000 9.5 2 (km 2 ) (km) 1 299.4 67.5 2 284.5 38.8 3 267.0
More informationアミヴィッド静注 CTD 第 2 部 2.1 第 2 部から第 5 部の目次 富士フイルム RI ファーマ株式会社
CTD 第 2 部 富士フイルム RI ファーマ株式会社 ( 空白ページ ) 2 第 2 部 ( モジュール 2): CTD の概要 ( サマリー ) ---------------------------------------------- 第 2 巻 2.2 緒言 2.3 品質に関する概括資料緒言 2.3.S 原薬 (AV-105, ) 2.3.S 原薬 ( フロルベタピル ( 18 F),
More informationFig. 2 Body weight curves rats treated orally with DL-8280 for 4 weeks
Fig. 1 Chemical structure DL-8280 Fig. 2 Body weight curves rats treated orally with DL-8280 for 4 weeks Fig. 3 Food consumption in rats treated orally with DL-8280 for 4 weeks Fig. 4 Water consumption
More informationCHEMOTHERAPY
CHEMOTHERAPY Fig.1 Effect of 6059-S on body weight changes in male rats Table 1 Effect of 6059-S on body weight changes in female rats :Mean }S.E. Table 2 Reproductive findings of rats treated with 6059
More informationVOL.40 S-1
238 CHEMOTHERAPY APRIL 1992 Russell A.W. EFreeman S.J. ESiddall R.A. ICI Pharmaceuticals Safety of Medicines Department** **Alderley Park, Macclesfield Cheshire, SK10 4TG, England VOL.40 S-1 240 CHEMOTHERAPY
More informationPREFACE The tests were contracted and supported by the Ministry of Labour of Japan. The tests were conducted by Japan Bioassay Laboratory (JBL) and th
Summary of Feeding Carcinogenicity Study of 1-Chloro-2,4-Dinitrobenzene in BDF 1 Mice August 1992 Japan Bioassay Laboratory Japan Industrial Safety and Health Association PREFACE The tests were contracted
More informationCHEMOTHERAPY MAY Fig. 1 Chemical structure of CS-807 and its analogues CS-807 R-4060 R-3763 R-1073 R-5002 * 14C-labelled position
CHEMOTHERAPY CHEMOTHERAPY MAY. 1988 Fig. 1 Chemical structure of CS-807 and its analogues CS-807 R-4060 R-3763 R-1073 R-5002 * 14C-labelled position CHEMOTHERAPY Fig. 2 Plasma concentration of radioactivity
More informationFig. 1 Mean body weight of pregnant rats administered intravenously with CLM on days 7 to 17 of pregnancy (fetus group) Fig. 2 Mean body weight of female rats administered intravenously with CLM on days
More informationO157 6/23 7/4 6 25 1000 117,050 6 14:00~15:30 1 2 22 22 14:30~15:30 8 12 1 5 20 6 20 10 11 30 9 10 6 1 30 6 6 0 30 6 19 0 3 27 6 20 0 50 1 2 6 4 61 1 6 5 1 2 1 2 6 19 6 4 15 6 1 6 30 6 24 30 59
More information2 TBARS
1 - AsA) ) ( ODS AsA TOC ODS ODS ODS PQ 2 TBARS 3 1) 2) 4 5 ODS PQ 250mg/ PQ 125mg/ PQ 125mg/ PQ PQ 125mg/ Mg ODS Mg 25g Mg Na Ca ATP Mg ODS Mg PQ 6 Mg ODS Mg PQ Mg Mg 7 Table 1 Composition of basal diet
More informationLetter566.pdf
http://nibs.lin.gr.jp/ 2 2 29 1000 1990 27.4 30.0 2009 13.5 49.6 1995 475 87 2009 292 332 1995 54 22 2009 70 101 57 1 2011 3 3 13 2008 3 2009 5 11 6 4.5 2 cm 3 1 1 2 3 S 100 4 Vimentin Melan A 5 3 HE Canine
More information( ) ver.2015_01 2
1 1.1 1.2 1.3 2 ( ) 2.1 2.2 2.3 2.4 3 4 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 5 5.1 5.2 5.3 5.4 6 6.1 6.2 6.3 7 7.1 7.2 7.3 8 ver.2015_01 2 1 1.1 1.2 1.3 ver.2015_01 3 2 2.1 2.2 2.3 ver.2015_01 4 2.4 ver.2015_01
More information01
2 0 0 7 0 3 2 2 i n d e x 0 7. 0 2. 0 3. 0 4. 0 8. 0 9. 1 0. 1 1. 0 5. 1 2. 1 3. 1 4. 1 5. 1 6. 1 7. 1 8. 1 9. 2 0. 2 1. 2 3. 2 4. 2 5. 2 6. O k h o t s k H a m a n a s u B e e f 0 2 http://clione-beef.n43.jp
More information2
C o r n e l i u s The Science of E m o t i o n I z a r d The Psychology of Emotions Rusalova et al. Schwartz et al E M G 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 The science of emotion The psychology
More informationI
I II 1 2 3 4 5 6 7 8 9 10 11 Rp.1) 50mg 3 3 14 Rp.2) 2.5mg 2 14 Rp.1) 2.5mg 3 2 2:1 14 Rp.) 15g 1 3 28 Rp.2) 50 600mg 1 2 28 12 Rp.1) CR 20mg 1 1 1 14 Rp.2) R 200 1 2 14 Rp.3) 3 1 3 14 Rp.1) 2.5mg 0.4
More informationCHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX
Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii
More informationVOL. 36 S-3 CHEMOTHERAPY 239
238 CHEMOTHERAPY JULY 1988 Fig. 1 Chemical structure of 14C-TE-031 * : Labelled position VOL. 36 S-3 CHEMOTHERAPY 239 240 CHEMOTHERAPY JULY 1988 Table 1 Tissue levels of radioactivity in 12th and 19th
More informationCTD 2 2.6 5.3mg 0.4mg 0.6mg 0.8mg 1.0mg 1.2mg 1.4mg 1.6mg 1.8mg 2.0mg 12mg 2.6 Page 3 2.6.6...5 2.6.6.1...6 2.6.6.2...9 2.6.6.3...9 2.6.6.4... 11 2.6.6.5... 11 2.6.6.6... 11 2.6.6.7... 11 2.6.6.8... 11
More information1
1 5% 4% 11% 8% 13% 12% 10% 6% 17% 6% 8% 4% 6% 6% 2% 17% 17% 12% 14% 16% 6% 37% 11% 17% 35% 2 (N=6,239) 0 200 400 600 800 1,000 1,200 1,400 1,600 1,800 1,585 1,126 950 494 345 296 242 263 191 150 131 116
More information初期リスク評価報告書作成指針(案)
BCF: Bioconcentration Factor EC 50 : Median Effect Concentration 1 50 EEC: Estimated Environmental Concentration EHI: Estimated Human Intake EUSES: Europian Union System for the Evaluation of Substances
More information_06.indd
30, 35-39, 2010 0.15% 1 C 40 20 1 cm 5 mm WBC 9,400, RBC 259 10 4, Hb 8.5 g/dl, Ht 25.5%, Plt 29 10 4, BUN 116 mg/dl, Cr 7.9 mg/dl, 125 mg/dl, HbA1c 4.3%, ft3 1.97 pg/ml, ft4 1.05 ng/dl, TSH 1.09 μiu/ml,
More information油圧1.indd
4 2 ff f f f f f f f f f f f f ff ff ff r f ff ff ff ff ff ff R R 6 7 φφ φφ φφ φ φ φφ φφφφφφφφ φφφφ φφφφ φφ! φ f f f f f f f f f f 9 f φ φ φ φ φ φ φ φ φφ φφ φ φ φ φ SD f f f KK MM S SL VD W Y KK MM S SL
More information地域再生計画
22 6,491ha 80 5,244ha 85.7 5,540ha 50km1 10,793 H17.5.1 15 35 51.7 1,943 1 50 9.5 351 12 2.4 130 2 16 13 5 14 1,545 1,019 35 1 20 10 3 15 3 3 H17.5.1 282 99 130 15 3 15 3 11 2 20 H16.12. 3 50km JR 9 4
More information取扱説明書 [F-02F]
F-02F 4. 2 3 4 5 6 7 8 9 0 2 3 4 5 6 7 8 a b c d a b c d a b cd 9 e a b c d e 20 2 22 ab a b 23 a b 24 c d e 25 26 o a b c p q r s t u v w d h i j k l e f g d m n a b c d e f g h i j k l m n x 27 o
More information