æ æ2 \ R esults of Open Patch Tests in Control Solutions Containing Ammonium Thioglycollate or Cysteine Group Using Cold Permanent Wave 3 \ Results of

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2 æ æ2 \ R esults of Open Patch Tests in Control Solutions Containing Ammonium Thioglycollate or Cysteine Group Using Cold Permanent Wave 3 \ Results of Patch Tests Using Cold Permanent Wave Solutions on Hairdressers with Hand Dermatitis

3 æ æ4 \ Results of Open and Closed Patch Tests Using Ammonium Thioglycollate Solutions on Control Group 5 \ Results of Patch Tests Using Ammonium Thioglycollate Solutions on Hairdressers with Hand Dermatitis

4 æ æ6 \ Results of Patch Tests Using Sodium Bromate Solutions on Hairdressers with Hand Dermatitis 7 \ Results of Patch Tests Using Hair Colorings and 1%, Paraphenylenediamine on Hairdressers with Hand Dermatitis

5 æ8 \ Results of Patch Tests Using Shampoos and Rinses on Hairdressers with Hand Dermatitis

6 æ 9 \ Results of Patch Tests Using Set Lotions and Rubber Gloves on Hairdressers with Hand Dermatitis æ10 \ Results of Open Patch Tests Using Hair Preparations and Closed Patch Tests Using ppda Nickel sulfate and Rubber Gloves on Hairdressers with Hand Dermatitis,

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8 æ11 \ Frequency of Irritant Reactions to Ammonium Thioglycollate and Sodium Bromate in Hydrophilic Ointment in Guinea Pigs æ 12 \ Frequency of Sensitization to Ammonium Thioglycollate and Sodium Bromate in Guinea Pigs

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10 10. Fisher, A. A.: Permanent hair waving, Contact Dermatitis, 2nd Ed., Lea and Febiger, Philadel- 11. Downing, J. G.: Dangers involved in dyes, phia, ,1973. cos- metics and permanent wave lotions applied to hair and scalp, Arch. Dermatol.,63: , Behrman, H. T., Combes, F. C., Weissberg, G., Mulinos, M. G. and Hurwitz, M.: The cold permanent hair-waving process, JAMA.,140: , Cronin, E.: Hairdressers, Contact Dermatitis, 2nd Ed., Churchill Livingstone, New York, , Lynde, C. W. and Mitchell, J. C.: results in 66 hairdressers , Patch test Contact Dermatitis, 8: , J.: Allergic contact dermatitis from glyceryl mo- in hairdressers, Contact Dermatitis, nothioglycolate 7: , Ishihara,M.: The composition of hair preparations and their skin hazards, Biology and Diseases of the Hair (Kobori, T. and Montagna, W. Ed.) Univ. of Tokyo Press, Tokyo, , Ishihara, M., Nogami, T., Itoh,M., Hosono, K., Kantoh, H. and Nishimura, M.: Basic studies on contact dermatitis due to hair coloring and cold permanent wave solutions, J. Jap. Cosm. Sci. Soc., 7: , low molecular weight, J. Invest. : , Norris, J. A.: Toxicity of home permanent waving and neutralizer solutions, Food Cosmet. Toxicol., 3: 93, Warshawshki, L., Mitchell, J. C. and Storrs, F. 20. Voss, J. G.: Skin sesitization by mercaptans of Dermatol.,31

11 Allergens in Hairdresser Hand Dermatitis Masatoshi Itoh, Masaru Ishihara, Kumiko Hosono and Hiromi Kantoh Department of Dermatology, Toho University School of Medicine (Director: Prof. M. Ishihara) Makoto Nishimura Department of Pharmacology, Toho University School of Medicine (Director: Prof. R. Ito) During the period, 19 hairdressers with hand and finger eczema were treated at our clinic. Open patch tests using hair colorings, cold permanent wave first and second solutions, shampoos, and hair rinses, which these patients had handeled, as well as closed patch tests using rubber hand gloves, paraphenylene diamine, and nickel sulfate were performed. The positive frequency was 56% to ppda, 28% to cold permanent wave first solution, and 9% to rubber gloves. Some of the patients with cold permanent wave first solution dermatitis exhibited positive reactions to ammonium thioglycollate solutions in open patch tests. It was concluded that open patch tests using cold permanent wave first solutions must be performed in order to determine the responsible agents in hairdresser patients exhibiting hand and finger dermatitis. It was confirmed using the guinea pig closed epicutaneous test that ammonium thioglycollate is a mild sensitizer.

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