11 16 ( ) S S , S S S1-P1 Dual-targeting Photoimmunotherapy 58 S1-P2 diffuse

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1 11 16 ( ) ( ) ( ) ( ) ( ) ( ) ( )

2 11 16 ( ) S S , S S S1-P1 Dual-targeting Photoimmunotherapy 58 S1-P2 diffuse-type 58 1,2 1,2 1,2 1,

3 11 16 ( ) LS-1 QOL SP-1 96 SP-2 96 SP-3 97 SP ,2 1,2 1,2 1,2 1, SP-5 GSK SL-1 46 The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 15

4 11 16 ( ) S2-1 ips 62 S , S2-3 LINE-1 64 S S2-P1 S2-P2 66 myomir family microrna TS

5 11 16 ( ) S2-O1 LINC00162 RNA HNRNPH ,2 Liang Zong 1, S2-O2 Epstein-Barr 67 S2-O3 mir-143 HER S2-O4 68 1, S2-O5 oncogenic small nucleolar RNA oncsnor Ajay Goel Baylor Research Institute S2-O6 DNA JPLT O1-1 EVs 106 1,2 1,2,3 1,2 1,2 1,2 1, TR The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 17

6 O , O1-3 MDSC ( ) 2 O O1-5 RNA O , S3-O1 75 S3-O2 S3-O3 TP ,2, TI

7 POLE S3-O4 ( ) S3-O5 BRAF600E CDX Eric Fearon S3-O Ann-Marie Patch 2 Katia Nones Barbara Leggett 2 Nicola Waddell 2 1 Vicki Whitehall QIMR Berghofer Medical Research Institute, Brisbane, Australia O O2-2 hypermutator O2-3 CIMP SWI/SNF 110 1, O O O ,2 1,2 1,2 1,2 1,2 1, The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 19

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9 P1-1 EP1 ONO , ,5 1,6 1,5 1, RI P , ,4 1,5 1,2 1, RI 4 5 P1-3 / J-FAPP Study IV P P DUONG THANH TU P TI 2 3 P , ( ) The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 21

10 11 16 ( ) BRAF 133 P1-9 ARID1A MSI status/pd-l P P1-11 ARID1A P1-12 microrna-449a P ,3 1,3, AMED-CREST 4 P3-2 HMGB1 142 P3-3 PD-L1 HLA class 143 P

11 144 P3-5 P3-6 CD P3-7 FAP 145 1,2 1 1,2 1,2 1, , P3-8 NF-kappaB 145 1, P3-9 TP53 mutation CPM P3-10 T ( ) P5-1 B C ER P5-2 gemcitabine MAST4 AKT P The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 23

12 11 16 ( ) strain 151 P5-5 Conophylline P P5-7 IL , ,2 1 1, P7-1 TP73 SMAD , P7-2 chloride intracellular channel 3 CLIC P7-3 Fibroblast Growth Factor Receptor ,2 1,2 1,2 1,2 1,2 1,2 1,2 1, P ,2 1,2 1,2 1,2 1,2 1,2 1,2 1, P7-5 circmto ,2 1 1,2 1,2 1, P7-6 AFP mirna

13 161 P P P7-9 ARID1A P7-10 Osteoclast-like giant cell hamartomatous inverted polyp P7-11 Homeobox C P7-12 podoplanin ( ) The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 25

14 11 17 ( ) S S , , S S S3-P S3-P2 74 1,

15 11 17 ( ) microrna microbiota 49 Stathmin , , 2, 3 2 2, SL-2 47 NIH S AMED-CREST S , S The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 27

16 S S4-P1 GSK RS ( ) 1 RS RS-3 BRAF V600E 101 RS-4 LED 101 RS , , RS-6 PCR RS RS-8 Luciferase assay 103 1) 1,2) 3) 1) 1) 1) 1) 1) 4) 1)

17 11 17 ( ) S1-O1 FBXW7 59 Navchaa Gombodorj 1 Takehiko Yokobori 1 Kengo Kuriyama 1 Yuji Kumakura 1 Tomonori Yoshida 1 Makato Sakai 1 Makato Sohda 1 Tatsuya Miyazaki 1 Hiroyuki Kuwano 1 Ken Shirabe 1,2 1 2 S1-O S1-O3 MEK 60 1, S1-O4 StageII/III ,2 1 2 S1-O5 5MP1 MYC 61 S1-O6 PD-L O4-1 / 115 The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 29

18 O4-2 Pten Vanderbilt University 4 O O ,2 1,2 2,6 2,3 Kaidiliavi Sulidan 2, O4-5 Tenascin-C ( ) 2 O4-6 HE O3-1 HPV DNA 112 1, ,

19 11 17 ( ) ,4 1, O3-3 CCL2/CCR ,2 1,2 1, O , O3-5 Barrett 114 O3-6 Cellbed O3-2 FGF O5-1 PD , , O5-2 FOLFIRI+ramucirumab 118 O5-3 Celecoxib Cyclooxygenase The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 31

20 O5-4 O6-2 HBV HBx c-myc Early Molecular Response O5-5 Liquid biopsy O URI ( ) 2 1 1, O O6-4 Tenascin-C Annexin-A2 122 O O ,2,3,

21 11 17 ( ) O7-1 Nrf2 124 O O O7-4 2,206 nestin single nucleotide polymorphisms O Subhajyoti De 7 Lauren M Rosati 8 Joseph M Herman 8 CA Iacobuzio-Donahue MD 9 The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 33

22 11 17 ( ) P2-13 X , P2-14 Transgelin P2-15 Semaphorin3C 137 1,2 1 1, P2-16 Protocadherin B ,2 1 1, P2-17 Pterostilbene , P ,2 1,2 1,2 1, P2-19 Pterostilbene MAM 139 1, P P2-21 A

23 P P2-23 cell-free DNA P4-1 IGF - a nested case-control study 147 1, , P ,2 1,2 1, P P ,2 1,2 1,2 1, P ,2 1,2 1,3 1, ( ) P P6-9 TFR , , The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 35

24 11 17 ( ) P6-10 Rho ARHGEF2 155 P P6-12 SASP P6-13 PHGDH 156 P6-14 WHO 157 P P P P8-15 DNA -H2AX ,

25 TLS 165 P8-16 P , P8-18 PD-L2 166 P8-19 CD44v , P , P8-21 Recycling endosome RAB11A HER , P8-22 PDX P FU ( ) The 29th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis 37

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