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1 drug development Toshimi Michigami, michigami@mch.pref.osaka.jp Keiichi Ozono, keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D

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10 1) McCollum, E. V. et al.: J. Biol. C' em., 53, (1922) 2) MacLaughlin, J. A. et al.: Science, 216, (1982) 3) Nykjaer, A. et al.: Cell, 96, (1999) 4) Onate, S. A. et al.: Science, 270, (1995) 5) Rachez, C. et al. : Nature, 398, (1999) 6) Kitagawa, H. et al.: Cell, 113,1-13 (2003) 7) ADHR Consortium : Nature Genet., 26, (2000) 8) Shimada, T. et al.: Proc. Natl. Acad. Sci. USA, 98, (2001) 9) Saito, H. et al.: J. Biol. Chem., 278, (2003) 10) Shimada, T. et al. : J. Clin. Invest., 113, (2004) 11) Abe, E. et al. : Proc. Natl. Acad. Sci. USA, 78, (1981) 12) Liu, M. et al. : Genes Dev., 10, (1996) 13) DeLuca, H. F., Cantorna, M. T.: FASEB J., 15, (2001) 14) Nykjaer, A. et al. : Proc. Natl. Acad. Sci. USA, 98, (2001) 15) Christensen, E. I. et al.: Proc. Natl. Acad. Sci. USA, 100, (2003) 16) Tekeyama, K. et al. : Science, 277, (1997) 17) Shinki, T. et al.: Proc. Natl. Acad. Sci. USA, 94, (1997) 18) Ohyama, Y. et al. : J. Biol. Chem., 271, (1996) 19) Yamagata, M. et al. : Endocrinology, 142, (2001) 20) Crofts, L. A. et al. : Proc. Natl. Acad. Sci. USA, 95, (1998)

11 21) Gill, R. K. et al.: Mol. Endocrinol., 12, (1998) 22) Hong, H. et al.: Proc. Natl. Acad. Sci. USA, 93, (1996) 23) Anzick, S. L. et al. : Science, 277, (1997) 24) Spencer, T. E. et al. : Nature, 389, (1997) 25) Chen, H. W. et al. : Cell, 90, (1997) 26) Goldman, P. S. et al. : Recent Prog. Horm. Res., 52, (1997) 27) Bannister, A. J., Kouzarides, T. : Nature, 384, (1996) 28) Polly, P. et al. : FASEB J., 14, (2000) 29) Rachez, C., Freedman, L. P. : Curr. Opin. Cell Biol., 13, (2000) 30) Yoshinaga, S. K. et al. : Science, 258, (1992) 31) Fujiki, R. et al.: EMBO J., 24, (2005) 32) Lemon, B. et al.: Nature, 414, (2001) 33) Yanagisawa, J. et al. : Science, 283, (1999) 34) Palmer, H. G. et al. : J. Cell Biol., 154, (2001) 35) Shah, S. et al. : Mol. Cell, 21, (2006) 36) Liu, P. T. et al. : Science, 311, (2006) 37) Freedman, N. D., Yamamoto, K. R. : Mol. Biol. Cell, 15, (2004) 38) Michigami, T. et al.: J. Biol. Chem., 274, (1999) 39) Adam, S. A. et al. : J. Cell Biol., 111, (1990) 40) Miyauchi, Y. et al. : J. Biol. Chem., 280, (2005) 41) Jakel, S. et al. : EMBO J., 21, (2002) 45) Shimada, T. et al.: J. Bone Miner. Res., 19, (2004) 46) Shimada, T. et al.: Biochem. Biophys. Res. Commun., 314, (2004) 47) Saito, H. et al.: J. Biol. Chem., 280, (2005) 48) Kuro-o, M. et al.: Nature, 390,45-51 (1997) 49) Yoshida, T. et al.: Endocrinology, 143, (2002) 50) Shimada, T. et al.: J. Clin. Invest., 113, (2004) 51) Kurosu, H. et al.: J. Biol. Chem., 281, (2006) 52) Kamao, M. et al.: J. Biol. Chem., 278, (2003) 53) Ahmed, I.: Curr. Opin. Investig. Drugs, 5, (2004) 54) Miura, D. et al.: J. Biol. Chem., 274, (1999) 55) Ozono, K. et al.: J. Biol. Chem., 274, (1999) 56) Ma, Y. et al.: J. Clin. Invest., 116, (2006) 57) Perry, H. M. 3rd. et al. : J. Clin. Endocrinol. Metab., 81, (1996) 58) Dawson-Hughes, B. et al. : N. Engl. J. Med., 337, (1997) 59) Kitanaka, S. et al.: N. Engl. J. Med., 338, (1998) 60) Hughes, M. R. et al.: Science, 242, (1988) 61) Norman, A. W. et al.: Science, 209, (1980) 62) Hypponen, E. et al. : Lancet, 359, 1248 (2001) 43) Berndt, T. et al.: J. Clin. Invest., 112, (2003) 44) Rowe, P. S. et al. : Bone, 34, (2004)

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