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1 Financial Section Santen Pharmaceutical Co., Ltd. Annual Report

2 4% P % 11.1%1, % %1, %1, % 3.5%1, % %1, % Santen Pharmaceutical Co., Ltd. Annual Report 215

3 % %23 27 % , , ,59 9,629 6,868 6,76 2,569 2, , ,32 136,88 125,33 1,251 1,595 6,44 2,94 2, , (6.1) (12.6) (13.1) (7.4) 1.6 % 2, 4 1,618 1,463 1,18 1,144 1, , % % 17.4% % % %21.9% % Santen Pharmaceutical Co., Ltd. Annual Report

4 16.2% % %33.% 28.% % ,42 ROA 8.9%1, %49.5% % % 14.9%1 EPS EPS EPS 1 EPS ROA 3,5 1,988 1,996 1,848 1, ROA % 3 3,42 2, , %69.6% 1 13.% ROE11.1%12.% 52 Santen Pharmaceutical Co., Ltd. Annual Report 215

5 ROE 2,5 1,25 ROE % 3 2,118 1,872 1,561 1,645 1, ROE 13% 4% ROE 12.% ,386 26,686 (1,3) (61,79) (7,847) (53,862) 28,96 (7,954) 36,914 65,923 72,397 (6,474) Santen Pharmaceutical Co., Ltd. Annual Report

6 54 Santen Pharmaceutical Co., Ltd. Annual Report % PL % 54 Santen Pharmaceutical Co., Ltd. Annual Report % PL %

7 55 Santen Pharmaceutical Co., Ltd. Annual Report % PL 55 Santen Pharmaceutical Co., Ltd. Annual Report % PL

8 : 92,696 98,398 1,486 13,394 33,71 34,535 35,484 36, ,4 42,868 44,59 46,51 18,982 2,995 2,412 2,371 18,436 2,342 21,39 2,483 7,413 7,319 7,891 7,832 11,23 13,23 13,148 12,651 4,97 2,16 3,556 3,151 4,75 4,824 4,761 4,593 12,62 13,971 13,663 12, , , , , : 6,619 2,879 14,959 15,468 (2,97) (1,33) (5,846) (2,83) (12,712) (5,9) (5,691) (11,415) ,98 15, ,99 156,547 32,676 3,395 3,485 29,849 82,735 93,893 1,82 12,754 18,24 118, , ,998 6,882 5,614 5,446 5,278 ROE% ROA% % % PER DOE% ,659 86,751 86,825 86,867 2,38 2,312 2,49 2, Santen Pharmaceutical Co., Ltd. Annual Report 215

9 ,619 11,594 11, , ,66 146,26 161,831 $1,346,68 35,947 34,71 34,437 35,385 41,51 57,353 56, ,17 5,178 46,244 45,636 52,299 52,884 41,642 48,893 46,864 15,494 29,64 3,739 26,732 24,681 29,878 35, ,369 15,824 28,61 31,74 27,791 25,592 3,361 35, ,437 5,71 9,887 9,741 1,63 9,71 1,643 11,831 98,452 1,123 18,723 21,333 17,161 16,521 24,32 199,985 2,953 1,315 1,651 3,281 3,69 5,879 66,44 552,889 4,21 3,421 2,976 2,949 3,291 2,841 6,958 57,899 18,458 14,123 13,221 17,225 16,72 16,862 17, , $ , , , , , ,849 26,11 17,768 21,483 9,943 26,686 25,386 $ 211,248 (5,619) (829) (7,676) (1,273) (4,596) (7,847) (61,79) (513,514) (11,373) (6,753) (1,57) (8,559) (21,557) (7,954) 28,96 24, ,285. 3,37.8 2, ,12 166, ,81 198,81 199, ,64 34,2 $2,531,411 28,665 26,574 24,957 25,523 27,42 27,175 29,14 242,188 11,53 118, ,668 14, , ,241 15,672 1,253, , , ,99 164, ,88 187,21 211,779 1,762, ,351 21, ,916 86,992 87,53 87,147 82,469 82,583 82,653 2,69 2,756 2,867 3,53 3,5 3,72 3,23 Santen Pharmaceutical Co., Ltd. Annual Report

10 ,26 (57,353) 88,97 (41,642) (19) (16,862) 681 (1,16) 29, (433) 3,361 (1,643) 161,831 (56,373) 15,458 (48,893) (3,979) (17,477) 723 (458) 35, (279) 35,863 (11,831) 24,32 $1,346,68 (469,17) 877,573 (46,864) (33,111) (145,437) 6,19 (3,811) 294,369 6,392 (2,324) 298,437 (98,452) 199, , ,863 2,524 65,442 4,752 27, ,446 2,6 7,26 27,11 24,32 24,32 199, ,985 27,169 27,169 32,446 32,446 27,11 $ 27, $ Santen Pharmaceutical Co., Ltd. Annual Report 215

11 59 Santen Pharmaceutical Co., Ltd. Annual Report $ 242,188 72, ,964 24,784 19,39 1,277, , ,45 1,552 22,74 548,581 1,253,822 1,253,822 21,958 45,43 12,15 23,914 7,937 3, ,57 16,593 55,993 9,962 73, ,827 61,439 67,217 (158) 1,488, ,65 1,762,33 1,762, ,175 26,61 23,334 5,215 2,65 84, ,63 22,65 19,35 5,11 2,234 76,218 29,14 84,433 34,725 2,978 2, ,528 19,461 53,986 4,587 2,356 72, , ,241 2,35 45,324 2,217 2,45 6,237 13, ,542 2,133 61, ,728 65,923 15,672 15, ,64 26,76 34,2 2,531,411 5,43 38,93 92, ,64 26,76 34,2 769,81 $2,531, ,41 1,467 2,795 1,479 11, ,966 1,278 2,395 1,7 1,787 25,351 5,459 1,444 2, ,81 19,72 4,88 8, ,157 39,186 13,766 5,846 3, ,634 28,116 2,25 19,298 6,729 1,197 8,866 56,34 7,264 7, ,727 9, ,21 187,21 7,81 7,776 (2) 15,516 2, , ,857 7,383 8,77 (18) 178,84 17, , , Santen Pharmaceutical Co., Ltd. Annual Report $ 242,188 72, ,964 24,784 19,39 1,277, , ,45 1,552 22,74 548,581 1,253,822 1,253,822 21,958 45,43 12,15 23,914 7,937 3, ,57 16,593 55,993 9,962 73, ,827 61,439 67,217 (158) 1,488, ,65 1,762,33 1,762, ,175 26,61 23,334 5,215 2,65 84, ,63 22,65 19,35 5,11 2,234 76,218 29,14 84,433 34,725 2,978 2, ,528 19,461 53,986 4,587 2,356 72, , ,241 2,35 45,324 2,217 2,45 6,237 13, ,542 2,133 61, ,728 65,923 15,672 15, ,64 26,76 34,2 2,531,411 5,43 38,93 92, ,64 26,76 34,2 769,81 $2,531, ,41 1,467 2,795 1,479 11, ,966 1,278 2,395 1,7 1,787 25,351 5,459 1,444 2, ,81 19,72 4,88 8, ,157 39,186 13,766 5,846 3, ,634 28,116 2,25 19,298 6,729 1,197 8,866 56,34 7,264 7, ,727 9, ,21 187,21 7,81 7,776 (2) 15,516 2, , ,857 7,383 8,77 (18) 178,84 17, , ,

12 6 Santen Pharmaceutical Co., Ltd. Annual Report 215 7,81 7,776 (2) ,516 2,162 2,236 2, ,959 (7) (7) (8,25) 743 (7,57) 162,727 (463) (463) (28) (28) 4,118 4,752 4, , ,857 27, ,857 27,169 4,752 (49) (49) 124 (743) (668) 9, (7) (8,25) 124 (7,816) 187, (7) (8,25) 124 (7,816) 187, , Santen Pharmaceutical Co., Ltd. Annual Report 215 7,81 7,776 (2) ,516 2,162 2,236 2, ,959 (7) (7) (8,25) 743 (7,57) 162,727 (463) (463) (28) (28) 4,118 4,752 4, , ,857 27, ,857 27,169 4,752 (49) (49) 124 (743) (668) 9, (7) (8,25) 124 (7,816) 187, (7) (8,25) 124 (7,816) 187, ,

13 61 Santen Pharmaceutical Co., Ltd. Annual Report ,264 7, ,727 24,32 24, ,118 7,863 7, ,77 (18) (8,259) 34 (7,919) 178,84 (33) (33) (37) (37) 11, , , ,21 24,32 32, ,21 24,32 32,446 5, (32) (32) 186 (34) (186) 17,497 2 (8,259) 186 (7,877) 211, (8,259) 186 (7,877) 211, , Santen Pharmaceutical Co., Ltd. Annual Report ,264 7, ,727 24,32 24, ,118 7,863 7, ,77 (18) (8,259) 34 (7,919) 178,84 (33) (33) (37) (37) 11, , , ,21 24,32 32, ,21 24,32 32,446 5, (32) (32) 186 (34) (186) 17,497 2 (8,259) 186 (7,877) 211, (8,259) 186 (7,877) 211, ,

14 $6,449 $66,227 $(78) $1,354, , ,985 $ $34,264 2,524 65,442 2,524 65, (8) (68,732) $61, $67,217 (8) $(158) 2,833 (65,899) $1,488,227 (2,524) (2,524) $ (39) (39) $99, $39,548 2,6 2,6 $3,322 $ 77,134 7,26 7,26 $1,557, ,985 7,26 27,11 $1,557, ,985 7,26 27, $41,68 (267) 1,545 1,278 $4,6 (267) 1,545 (2,833) (1,555) $145,65 1,713 (8) (68,732) 1,545 (65,554) $1,762,33 1,713 (8) (68,732) 1,545 (65,554) $1,762,33 62 Santen Pharmaceutical Co., Ltd. Annual Report 215

15 63 Santen Pharmaceutical Co., Ltd. Annual Report $199,985 57,899 2,413 (4,46) 98,452 (64,88) (4,332) 1,48 6,336 21, ,925 (73) 1,53 (945) 34,53 (24,734) 5,455 (528,155) (492) (513,514) 673 4,562 (682) (117,23) 211, , (759) 1,643 (8,128) 1,411 5, ,883 33,413 24,32 6, (529) 11,831 (7,71) (521) 1, ,554 38,926 (111) 92 (4,825) 2,933 (3,461) 2 (2,418) (59) (7,847) (84) 184 (114) 4,149 (2,972) 656 (63,468) (6) (61,79) (7,34) 26, (82) (14,87) 25, ,254 (291,254) 332,862 (24,712) (68,769) 1,67 24,988 (61,278) 62,451 7,48 $548,581 (29) (8,247) 322 (7,954) 1,885 6,237 1,275 72,397 35, (35,) 4, (2,97) (8,264) ,96 (7,363) 72, , Santen Pharmaceutical Co., Ltd. Annual Report $199,985 57,899 2,413 (4,46) 98,452 (64,88) (4,332) 1,48 6,336 21, ,925 (73) 1,53 (945) 34,53 (24,734) 5,455 (528,155) (492) (513,514) 673 4,562 (682) (117,23) 211, , (759) 1,643 (8,128) 1,411 5, ,883 33,413 24,32 6, (529) 11,831 (7,71) (521) 1, ,554 38,926 (111) 92 (4,825) 2,933 (3,461) 2 (2,418) (59) (7,847) (84) 184 (114) 4,149 (2,972) 656 (63,468) (6) (61,79) (7,34) 26, (82) (14,87) 25, ,254 (291,254) 332,862 (24,712) (68,769) 1,67 24,988 (61,278) 62,451 7,48 $548,581 (29) (8,247) 322 (7,954) 1,885 6,237 1,275 72,397 35, (35,) 4, (2,97) (8,264) ,96 (7,363) 72, ,923

16 64 Santen Pharmaceutical Co., Ltd. Annual Report 215

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