CHEMOTHERAPY MAY Fig. 1 Chemical structure of CS-807 and its analogues CS-807 R-4060 R-3763 R-1073 R-5002 * 14C-labelled position

Size: px
Start display at page:

Download "CHEMOTHERAPY MAY Fig. 1 Chemical structure of CS-807 and its analogues CS-807 R-4060 R-3763 R-1073 R-5002 * 14C-labelled position"

Transcription

1 CHEMOTHERAPY

2 CHEMOTHERAPY MAY Fig. 1 Chemical structure of CS-807 and its analogues CS-807 R-4060 R-3763 R-1073 R-5002 * 14C-labelled position

3 CHEMOTHERAPY Fig. 2 Plasma concentration of radioactivity and R-3763 after oral administration of CS C to rats, dogs and monkeys

4 CHEMOTHERAPY MAY Table 1-A Urinary and fecal excretion of radioactivity after oral and I.V. administration of CS C or R C to rats (13mg/kg, n=3-4) Table-1B Urinary and fecal excretion of radioactivity after oral administration of CS C to Beagle dogs (13mg/kg, n=4) Table 1-C Urinary and fecal excretion of radioactivity after oral administration of CS C to Cynoonolgia monkeys (13mg/kg, n=3) Values represent mean }S.E.

5 VOL.36 S-I CHEMOTHERAPY Table 2 Distribution of radioactivity in gastrointestinal lumen and gastrointestinal walls after oral administration of CS C to rats (13mg/kg, n=2) Table 3 Absorption of CS C from different part of rat digestive tract (Dose;lmg/8cm loop, n=4, 30min) Fig. 3 Hydrolysis of CS-807 in 9000 g supernatants from rat small intestine Concentration of CS-807=130 Đg/ml Values represent mean }S.E.

6 234 CHEMOT MAY. HERAPY 小 腸 中部>胃 の順 で あ り胃か ら も吸 収 が認 め られ る もの propylfluorophosphate)を の十 二 指腸,小 腸 上 部 か らの 吸収 が 最 も大 きい こ とが 示 著 明 に抑 制 され た され た 5. 2) 腸 管 での加 水 分 解 添 加 す る と,加 水 分解 が 門脈 血 中 の吸 収形 態 CS C(1mg/loop)を 1) ホ モ ジネ ー ト中 での 加 水分 解 ラ ッ ト小 腸 上 部 の結 紮 腸 ル ー プ内 に投 与 し,門 脈 血 中 に到 達 した放 射能 の形 消 化 管上 部 か ら吸 収 され たCS-807は,循 環 血 で はR -3763の 形 に な って い た こ とか ら,吸 収 過 程 にお い て, 態 をFig.4にTLCオ CS-807がR--3763el加 ー トラ ジオ グ ラム と して示 した の み で あ り投与 形 で あ るCS-807は 有 意 な放 射性 ス ポ ッ トと して検 出 され た の は,R-3763 水 分 解 され る こ とが 推 察 され た 有 意 に は検 出 されrt そ こで,ラ ッ ト小腸 上 部 の9000G遠 心 上 清 にお け るCS -807(130μg/ml)の 加水 分解 性 を測 定 した Fig.3に か った 本 試験 の 投 与量 は約5mg/kgに 示 した よ うに25%ホ 水 分解 されR-3763と モ ジネ ー ト中で,CS-807は この投 与 量 で はCS-807が 急速 に 加 水 分解 され,ほ ぼ定 量 的 に活 性体 で あ るR-3763が 成 した この結 果 はCS-807が 生 吸収 過 程 に お い て腸 管壁 異 性 体 で あ るR-1073と され た CS-807を1/15Mリ ン酸 緩 衝 液(pH で60分3TCで 速 や か に腸壁 内 に移 行 し,加 して 門脈 血 に吸 収 され る こ とが示 6. 組 織 内濃度 Table4に 異 な る生成 物 が 検 出 され たが,こ れ は標 品 との比 較 か らR-3763の 相 当す る域 され た で 十 分加 水 分解 され うる こ とを示 して い る この加 水分 解 でR-3763と 1988 示 した よ う に消化 管 を除 く組 織 内 濃度 は, 投 与 後 急速 に上昇 し,投 与1時 間 に ピー ク値 に達 した 同定 消化 管壁 以 外 で 最大 濃 度 を示 した の は腎 で あ り,血 蟻 7.4)中 肝,肺 が これ につ ぐ濃度 を示 した 以後 イ ン キ ュベ ー トす る と徐 々 に加 水 分解 さ 血 漿で は,半 減期1.9時 間(ピ ー ク 4時 間 まで)で 減少 し,24時 間 れ2時 間 後 に は15%のR-1073を 生 じた こ とか ら,R -1073の 生 成 は,CS-807の 化 学 的 な分 解 に よ り副 生 し ぼ 血 漿 同様 の 減 少 を示 した Fig.5に た もの と結 論 された また,Fig,3で 2時 間,6時 間 後 の ラ ッ ト全 身 オー トラ ジオ グ ラム を示 には ピー ク時 の1%程 は,腸 ホ モ ジネ ー トに非 特 異 的 エ ス テ ラー ゼ 阻 害 剤 で あ るDFP(Diiso- Fig. 4 In situ absorption 度 に まで低 下 し,他 の組 織 で もほ したが 腎 で最 も高 く,肝,肺,皮 from in portal blood は,投 与30分 膚,な らび に全 身の体

7 CHEMOTHERAPY Table 4 Tissue distribution of radioactivity after oral administration CS C to rat (13mg/kg, n=4) Concentration (ki g/ml or g)a) a) Values represent the mean }S.E. as pg equivalent to R-3763; b) n=3

8 236 CHEMOT Fig. 5 Whole-body autoradiograms Fig. 6 Whole-body autoradiogram MAY. HERAPY of CS C in Wistar-Imamichi rats (13 mg/kg, p.o.) of CS C in squirrel monkey 2hr after oral administration (13 mg/kg) 1988

9 VOL.36 S-1 CHEMOTHERAPY Table 5 Urinary and fecal metabolites 24hr after oral administration of CS-807-HC to rats, dogs and monkeys (13mg/kg) Fig. 7 TLC-Bioautogram of urine, plasma and feces in rats administered with CS-807 (13 mg/kg, p.o.) Plate: Silica gel G (Merck Co.) Solvent: n-butanol: Acetic acid: H204: 1: 1 Test organism: S.aureus 209P

10 CHEMOTHERAPY MAY Table 6 Serum protein binding of R-3763 and other oral antibiotics In vitro,, 90% of serum Incubated for 30min at 37 Ž Ultrafiltration method (25ug/ml)

11 \ VOL. 36 S- 1 CHEMOTHERAPY Fig. 8 Metabolic pathways of CS-807 in rats.

12 CHEMOTHERAPY MAY. I 988 5) SHINDO, H.; K. FUKUDA, K. KAWAI & K. TANAKA: Studies on intestinal absorption of pivampicillin and species difference in the intestinal esterase activity. J. Pharm. Dyn. 1: 310 `323, ) SHINDO, H.; K. KAWAI, T. IKEDA, I. IGARASHI & S. SUGAWARA: Absorption, Distribution, Excretion and Metabolism of C,efmetazole in Cynomo4lucl, Monkeys. J. Antibiotics 35 : 742 `754, 1982 ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF CS-807, A NEW ORAL CEPHEM ANTIBIOTIC, IN EXPERIMENTAL ANIMALS TORU KOMAI, KENJI KAWAI, HIDEMI TSUBAKI, TARO TOKUI, TAKESHI KINOSHITA and MINORU TANAKA Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd., Tokyo Absorption, distribution, excretion and biotransformation of "C-labeled CS-807 was studied after oral administration to Wistar-Imamichi rats, beagle dogs and Cynomolgus monkeys, at the dose of 13mg/kg. CS-807-"C was mainly absorbed from the upper part of the small intestine and the absorption rate was approximately 70% in rats. During absorption, CS-807 was rapidly hydrolyzed to its active form, R-3763, by non-specific esterase in the intestinal epithelium, and transferred to the circulatory blood. The plasma concentration of radioactivity was the highest in dogs(23.4pg/m1), followed by rats(8.4pg/m1)and monkeys (3. 9 gem1). R-3763 was mainly excreted to the urine after being distributed to the kidney, liver, lung, skin or extracellular space in the whole body. Approximately 3% of the dose was excreted in the bile as the active acid. Bioautography showed that R-3763 was the only active substance in the plasma and urine. Serum protein binding ratio in the human was approximately 40% and was lower than those in the experimental animals.

CHEMOTHERAPY JUNE 1988 ( })-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-l-piperaziny1) 4-oxo-3-quinolinecarboxylic acid hydrochloride Fig. 1. Chemica

CHEMOTHERAPY JUNE 1988 ( })-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-l-piperaziny1) 4-oxo-3-quinolinecarboxylic acid hydrochloride Fig. 1. Chemica CHEMOTHERAPY JUNE 1988 ( })-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-l-piperaziny1) 4-oxo-3-quinolinecarboxylic acid hydrochloride Fig. 1. Chemical structure of NY-198 VOL. 36 5-2 CHEMOTHERAPY Mouse

More information

Jan THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis

Jan THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Jan. 1987 Jan. 1987 THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis

More information

Key word : halcinonide, topical anti-inflammatory steroid, metabolism, autoradio graphy, rat liver, rat skin, perfusion. Biotransformation of Halcinonide, a Systemic Topical Anti-inflammatory Corticosteroid,

More information

Fig. 1. Structure of [methyl-14c]zonisamide

Fig. 1. Structure of [methyl-14c]zonisamide Key words : Zonisamide, Metabolism, Plasma, Erythrocytes, Preputial gland, Urine, Bile, Rat, Dog, Monkey Metabolism of ["Clzonisamide in rats, dogs and monkeys Katashi MATSUMOTO, Koji YOSHIDA, Toshihiko

More information

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin CHEMOTHERAPY Fig. 2 Urinary excretion of mezlocillin Fig. 1 Blood levels of mezlocillin CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels

More information

CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09330)

CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09330) CHEMOTHERAPY APR. 1982 Fig. 1 Chemical structure of cefotetan (CTT, YM09330) VOL.30 S-1 CHEMOTHERAPY Fig. 2 Comparison of standard curves of CTT on various test organisms by cylinder plate method Column

More information

CHEMOTHERAPY SEPT. 1992

CHEMOTHERAPY SEPT. 1992 VOL.40 S-4 CHEMOTHERAPY SEPT. 1992 Fig. 1. Plasma levels of cefclidin and ceftazidime in animals after a single intravenous administration (20mg/kg). Table 1. Pharmacokinetic parameters of cefclidn and

More information

VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega

VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega 1066 CHEMOTHERAPY MAR. 1975 Table 1 Sensitivity of standard strains VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity

More information

VOL. 36 S-3 CHEMOTHERAPY 437

VOL. 36 S-3 CHEMOTHERAPY 437 VOL. 36 S-3 CHEMOTHERAPY 437 438 CHEMOTHERAPY JULY 1988 Fig. 1 Contractile response of gastrointestinal tract to intravenous administration of saline and EM in interdigestive state in dogs (a) : Saline,

More information

CHEMOTHERAPY APR Fig. 2 The inactivation of aminoglycoside antibiotics by PC-904 Fig. 3 Serum concentration of PC-904 (1) Fig. 4 Urinary recover

CHEMOTHERAPY APR Fig. 2 The inactivation of aminoglycoside antibiotics by PC-904 Fig. 3 Serum concentration of PC-904 (1) Fig. 4 Urinary recover VOL.26 S-2 CHEMOTHERAPY Gentamicin (GM), Dibekacin (DKB), Tobramycin Fig. 1 Protein concentration and protein binding rate Table 2 Protein binding rate of PC-904 in serum of healthy adults, and patients

More information

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX Fig. 1 Chemical structure of CXM-AX NOV. 1986 Fig. 2 Sensitivity distribution of clinical isolates organisms (106 cells/ml) a Smurcus 27 strains d) P.m irabilis 15 strains b Ecol i 27 strains 111.morganii

More information

VOL. 36 S Fig. 1 Chemical structures of cefotiam hexetil and related compounds

VOL. 36 S Fig. 1 Chemical structures of cefotiam hexetil and related compounds VOL. 36 S-6 111 Fig. 1 Chemical structures of cefotiam hexetil and related compounds 112 CHEMOTHERAPY DEC. 1988 (Đg/ml) (Đg/ml) Fig. 2 Standard curves for assay of cefotiam using Proteus mirabilis ATCC21100

More information

VOL. 36 S-3 CHEMOTHERAPY 239

VOL. 36 S-3 CHEMOTHERAPY 239 238 CHEMOTHERAPY JULY 1988 Fig. 1 Chemical structure of 14C-TE-031 * : Labelled position VOL. 36 S-3 CHEMOTHERAPY 239 240 CHEMOTHERAPY JULY 1988 Table 1 Tissue levels of radioactivity in 12th and 19th

More information

988 CHEMOTHERAPY NOV. 1971

988 CHEMOTHERAPY NOV. 1971 988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical

More information

VOL. 34 S-2 CHEMOTH8RAPY 913

VOL. 34 S-2 CHEMOTH8RAPY 913 VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(

More information

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (Đg/ml or Đg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration

More information

2108 CHEMOTHERAPY SEPT Table 1 Antimicrobial spectrum Fig. 1

2108 CHEMOTHERAPY SEPT Table 1 Antimicrobial spectrum Fig. 1 2108 CHEMOTHERAPY SEPT. 1977 Table 1 Antimicrobial spectrum Fig. 1 VOL. 25 NO. 7 CHEM 014 HERAPY 2109 Table 2 Susceptibility distribution of Staphylococcus aureus to aminoglycosides (54 strains) Table

More information

CHEMOTHERAPY MAY. 1988

CHEMOTHERAPY MAY. 1988 CHEMOTHERAPY MAY. 1988 CHEMOTHERAPY Fig. 1 Chemical structure CHEMOTHERAPY MAY. 1988 VOL.36 5-1 CHEMOTHERAPY CHEMOTHERAPY MAY. 1988 VOL.36 S-1 CHEMOTHERAPY CHEMOTHERAPY MAY. 1988 VOL.36 S-1 CHEMOTHERAPY

More information

CHEMOTHERAPY SEPT. 1970

CHEMOTHERAPY SEPT. 1970 CHEMOTHERAPY SEPT. 1970 VOL. 18 NO. 5 CHEMOTHERAPY CHEMOTHERAPY SEPT. 1970 VOL. 18 NO. 5 CHEMOTHERAPY 691 692 CHEMOTHERAPY SEPT. 1970 VOL. 78 NO. CHEMOTHERAPY 5 写 真1 第1病 693 写 真4 日 In vitroの しCEZの 第22病

More information

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak

More information

Fig. 1 Chemical structure of DL-8280

Fig. 1 Chemical structure of DL-8280 Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.

More information

VOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence

More information

CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus

CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus VOL. 32 S-4 CHEMOTHERAPY Fig. 1 Chemical structure of sodium cefoperazone Fig. 2 Chemical structure of sodium cefoperazone CHEMOTHERAPY JUN. 1984 Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter

More information

VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT against standard strains

VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT against standard strains CHEMOTHERAPY APR. 1982 Fig. 1 Chemical structure of cefotetan (CTT, YM09330) VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT

More information

Tazobactam Piperacillin Fig. 1. Plasma concentrations of tazobactam and piperacillin in animals following a single intravenous administration of tazobactam/piperacillin (10/40 mg/kg). Data represent the

More information

CHEMOTHERAPY DEC Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus, G; Gaffk

CHEMOTHERAPY DEC Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus, G; Gaffk VOL. 30 S-3 CHEMOTHERAPY imeumoniae, Serratia marcescens, Proteus sp, CHEMOTHERAPY DEC. 1982 Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus,

More information

CHEMOTHERAPY SEPT. 1991

CHEMOTHERAPY SEPT. 1991 CHEMOTHERAPY SEPT. 1991 VOL. 39 S-3 Table 1. Background of characteristics and allocation of 9 healthy male volunteers in a single-dose study on betamipron Table 2. Background of characteristics and allocation

More information

CHEMO THER APY Table 1. Background of the volunteers in the phase I clinical trial of ME1207 Table 2. Methods for Phase I clinical trial of ME1207 All doses are expressed in terms of potency as ME1206

More information

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz VOL.33 S-5 CHEMOTHERAPY 381 Fig. 1 Chemical structure of HAPA-B Chemical name 1-N-[(2S)-3-Amino-2-hydroxypropiony1]-4-0-(6-amino- 6-deoxy-a-D-glucopyranosyl)-6-013-deoxy-4-C-methyl- 3-(methylamino)-ƒÀ-L-arabinopyranosyl]-2-deoxystreptamine

More information

CHEMOTHERAPY Fig. 1 Chemical structure of TE-031

CHEMOTHERAPY Fig. 1 Chemical structure of TE-031 CHEMOTHERAPY Fig. 1 Chemical structure of TE-031 CHEMOTHERAPY Table 1 Experimental groups for active systemic anaphylaxis in guinea pigs : Single dosage Fig. 2 Schedule for active systemic anaphylaxis

More information

CHEMOTHERAPY FEB Table 1 Background of volunteers

CHEMOTHERAPY FEB Table 1 Background of volunteers CHEMOTHERAPY FEB. 1985 Table 1 Background of volunteers Table 3 Reproducibility of saisomicln In the EIA and the RIA Fig.1 Comparison of the EIA with the RIA or bioassay of sisomicin Table 4 Blood levels

More information

VOL. 20 NO. 5 CHEMOTHERAPY Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3

VOL. 20 NO. 5 CHEMOTHERAPY Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3 VOL. 20 NO. 5 CHEMOTHERAPY 653 2-Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3376, SDM, SIZ and SMZ against Gram-positive and negative

More information

CHEMOTHERAPY APR. 1982

CHEMOTHERAPY APR. 1982 VOL.30 S-1 CHEMOTHERAPY Table 1 Dose of CTT and subjects i. v.: Intravenous bolus injection d. i. v.: Intravenous drip infusion i. m.: Intramuscular injection Fig. 1 Schedule for examination of CTT, 1.0g

More information

VOL.42 S-1

VOL.42 S-1 CHEMOTHERAPY APR. 1994 VOL.42 S-1 CHEMOTHERAPY APR. 1994 Table 1. Criteria for evaluation of clinical efficacy by the Japanese Society of Oral and Maxillo-Facial Surgeons Grades of symptoms and numerical

More information

VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human

VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human CHEMOTHERAPY Fig. 1 Chemical structure of carumonam Disodium(+)-(Z)-CCE1-(2-amino-4-thiazoly1)-2-[[(2S, -(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetidinyll -2-oxoethylidene] amino] oxy] acetate 3S)-2

More information

CHEMOTHERAPY MAY 1988

CHEMOTHERAPY MAY 1988 VOL. 36 NO. 5 Table 1. Subjects studied B. W. Body weight B. H. Body height Abbreviations Ccr Endogenous creatinine clearance PSP Phenolsulfonphthalein test for 15 min BUN Blood urea nitrogen Scr Serum

More information

CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation

CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference

More information

CHEMOTHERAPY APR. 1984

CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated

More information

56 CHEMOTHERAPY JAN Fig. 1 Effect of Mezlocillin on respiration, blood pressure and ECG in the rabbit

56 CHEMOTHERAPY JAN Fig. 1 Effect of Mezlocillin on respiration, blood pressure and ECG in the rabbit VOL.27 S-1 CHEMOTHERAPY 55 56 CHEMOTHERAPY JAN. 1979 Fig. 1 Effect of Mezlocillin on respiration, blood pressure and ECG in the rabbit VOL.27 CHEMOT S-1 Fig. 2 Effect of Mezlocillin on blood pressure (Sensitivity

More information

Fig. 1. Structures of NM394, NAD-358 and NAD-245 Fig. 2. Typical HPLC chromatograms of NM394 in human plasma by organic solvent extraction method (a): Blank plasma (b): Plasma spiked with NM394 and internal

More information

CHEMOTHERAPY

CHEMOTHERAPY CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin

More information

CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection

More information

VOL.39 S-3

VOL.39 S-3 VOL.39 S-3 CHEMOTHERAPY SEPT.1991 Table 1. Background of characteristics and allocation of 5 healthy male volunteers in a multiple-dose study on panipenem/betamipron Day 1 Fig. 1. Schedule of multiple-dose

More information

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains ) CHEMOTHERAPY OCT. 1984 Fig. I Chemical structure of CTRX VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains ) CHEMOTHERAPY Fig. 3 Cumulative

More information

Fig. 2 Body weight curves rats treated orally with DL-8280 for 4 weeks

Fig. 2 Body weight curves rats treated orally with DL-8280 for 4 weeks Fig. 1 Chemical structure DL-8280 Fig. 2 Body weight curves rats treated orally with DL-8280 for 4 weeks Fig. 3 Food consumption in rats treated orally with DL-8280 for 4 weeks Fig. 4 Water consumption

More information

報告書 H22-2A-09

報告書 H22-2A-09 061-0293 1757 TEL 0133-23-1211 2.0% 0.5% in vitro QOL Quality of Life 1 MCE-400 400 mpa s Duck Algin 350M M/G 0.8 70 80 C 20% 50 C 1.0% 5 C SV-10 5 C 10 ml E TV 20H model E 1 34 R24 1 ml 5 C 30 6 12 30

More information

CHEMOTHERAPY APRIL 1992 VOL. 40 S- 1 Table 1-1. Comparative in vitro activity of meropenem against clinical isolates CNS: coagulase-negative staphylococci CHEMOTHERAPY APRIL 1992 Table 1-2. Comparative

More information

Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates

More information

Fig. 1 Chemical structure of KW-1070

Fig. 1 Chemical structure of KW-1070 Fig. 1 Chemical structure of KW-1070 Fig. 2 Sensitivity distribution of clinical isolates Fig. 4 Sensitivity distribution of clinical isolates Fig. 3 Sensitivity distribution of clinical isolates Fig.

More information

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45) Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2305(45) 2306(46) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 2307(47) 2308(48) THE JAPANESE

More information

Table 1 Antibacterial spectra of CPM and other antimicrobials against anaerobes Fig. 1 In vitro activity of CPM and other antibiotics against B. fragilis (136 strains) Fig. 2 In vitro activity of CPM and

More information

Cephaloridine Conc. 125mcg/m/+ DC 10mg/ml Cephaloridine Conc. 125mcg/ml C- adap+ E. coli Ampicillin Conc. 125mcg/ml+C 10mg/ml Cephaloridine Conc. 12.5mcg/ml D-adap+E.coil JORGENSEN : Alteration of bile

More information

Fig.1 Structural formulas of 6059-S(I) and decarboxylated product (11) Fig.2 Standard curve of 6059-S by agar well method Medium:Trypto-soy agar Diluent:0.1M Phosphate buffer,ph 7.0 Fig.3 Standard curves

More information

1272 CHEMOTHERAPY MAR. 1975

1272 CHEMOTHERAPY MAR. 1975 1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides

More information

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Key words: temafloxacin, TA-167, Bacteroides fragilis,

More information

A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc

A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal

More information

VOL.47 NO.5 Table 1. Susceptibility distribution of Ĉ- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus

VOL.47 NO.5 Table 1. Susceptibility distribution of ƒà- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus MAY 1999 VOL.47 NO.5 Table 1. Susceptibility distribution of ƒà- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus (oxacillin MIC: 4ƒÊg/ ml) FMOX: flomoxef,

More information

Fig. 1 Mean body weight of pregnant rats administered intravenously with CLM on days 7 to 17 of pregnancy (fetus group) Fig. 2 Mean body weight of female rats administered intravenously with CLM on days

More information

CHEMOTHERAPY 218 5. NFLXの 血 清お よび胆 汁中 濃度の 測定 NFLXの50mg/kgを1回 後,経 coli NIHJ JC-2を 定 した な お,血 た 度 をE. 検 定 菌 とす る 薄 層 デ ィ ス ク法 で 測 (2) NFLX治 E. 療群 coli接 種6時 50mg/kg経 間 後 の 家 兎 にNFLXを25お 液 は 耳 静 脈 よ り,胆 村

More information

VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin

VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin 1380 CHEMOTHERAPY MAR. 1975 Table 2 Susceptibility of isolated Pseudomonas aeruginosa to various antibiotics

More information

日本化学療法学会雑誌第51巻第2号

日本化学療法学会雑誌第51巻第2号 piperacillin piperacillin PIPC. g Cmax CL PIPC CL CLR CLNR CL PIPC g g Cmax PIPC Key words: piperacillin Piperacillin PIPC PIPC g g PIPC Cmax g g ml g g ml g g ml T T T PIPC g g T Ccr ml min AUCCmax PIPC

More information

Fig.1 Chemical structure of BAY o 9867

Fig.1 Chemical structure of BAY o 9867 Fig.1 Chemical structure of BAY o 9867 CHEMOTHERAPY 43 Table 3 Antibacterial spectrum of gram negative bacteria Medium:Heart infusion agar (Nissui) Method:Agar dilution (Streak) CHEMOTHERAPY DEC 1985

More information

106(18) 原 使 用 した 測 定 部 位 は 期 門 穴相 当部 位 の 表 皮 上 及 び 真 皮 下 と し, 表 皮上 で は 艾 柱 の 直 下 に 熱 電 対 先 端 を露 出 し固 定 した 真 皮 下 で は施 灸部 より10mm 下 方 を切 開 剥 離 し, 施 灸 部 直

106(18) 原 使 用 した 測 定 部 位 は 期 門 穴相 当部 位 の 表 皮 上 及 び 真 皮 下 と し, 表 皮上 で は 艾 柱 の 直 下 に 熱 電 対 先 端 を露 出 し固 定 した 真 皮 下 で は施 灸部 より10mm 下 方 を切 開 剥 離 し, 施 灸 部 直 106(18) 原 使 用 した 測 定 部 位 は 期 門 穴相 当部 位 の 表 皮 上 及 び 真 皮 下 と し, 表 皮上 で は 艾 柱 の 直 下 に 熱 電 対 先 端 を露 出 し固 定 した 真 皮 下 で は施 灸部 より10mm 下 方 を切 開 剥 離 し, 施 灸 部 直 下 に 熱 電 対 先端 が 届 くよ うに挿 入 した 熱 電 対 の 出 力 は 温 度 モ ジュ

More information

PowerPoint プレゼンテーション

PowerPoint プレゼンテーション Institute of Accelerator Analysis Ltd. HPLC Drug Concentration (ng/ml) 7 6 5 4 3 2 1 B D F Drug Concentration (ng/ml) 450 400 350 300 250 200 150 100 50 CREAM (MD) T007 (MD) CREAM (TD) 0 0 2

More information

Table 1 Patients with various renal function * Ccr, Creatinine clearance ml/min per 1. 48 m2 ** C.V.D., Cerebral vascular disease ; C.R F., Chronic renal failure ; H.D., Hemoclialysis ; D., Dialyzer ;

More information

Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection

Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection Table 1. Bacterial cell counts in feces of mice infected with Esclwrichia coli O 157: H7 NK2 before and during oral dosing with fosfomycin

More information

3-2 -

3-2 - 1 2-1 - 3-2 - 4 3-3 - Specific Absorption Rate 5 1 2 1 1-4 - - 5 - - 6 - - 7 - - 8 - - 9 - - 10 - - 11 - - 12 - 5-13 - / / / / / / / / / / - 14 - - 15 - - 16 - - 17 - - 18 - 2 2-19 - 3-20 - - 21 - 1 1

More information

VOL.27S-1 CHEMOTHERAPY 109 Klebsiella, Proteus, Pseudomonas Streptococcus Fig. 1 Concentration in blood and in CSF after intravenous drip infusion of

VOL.27S-1 CHEMOTHERAPY 109 Klebsiella, Proteus, Pseudomonas Streptococcus Fig. 1 Concentration in blood and in CSF after intravenous drip infusion of VOL.27S-1 CHEMOTHERAPY 109 Klebsiella, Proteus, Pseudomonas Streptococcus Fig. 1 Concentration in blood and in CSF after intravenous drip infusion of 4.9 g Mezlocillin Streptococcus pneumonzae pneumoniae

More information

untitled

untitled ORYZA OIL & FAT CHEMICAL CO., LTD. WHITE JELLY FUNGUS EXTRACT -P () Ver. 1.3SJ Ver. 1.3SJ 1. 3000 ph 1 Ver. 1.3SJ 1. 1 2. 3 2-1. 2-2. 2-3. 2-4. SOD 3. 7 3-1. in vitro 3-2. in vivo 3-3. in vivo 3-4. in

More information

Table 1 Components of corn dietary fibers

Table 1 Components of corn dietary fibers Effects of Purified Corn Dietary Fiber on Blood Glucose, and Serum and Liver Lipids in Normal Rats and Mice Sachie Ikegami *1, Saeko Ohsawa *1, Shouko Machida *2 and Akiko Hada *2 The National Institute

More information

CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table

More information

CHEMOTHERAPY APR. 1994

CHEMOTHERAPY APR. 1994 CHEMOTHERAPY APR. 1994 VOL.42 NO.4 NFLXの った 各 試 料 の放 射 能 の 測 定 は,液 体 シ ン チ レー シ ョ ン ア ナ ラ イ ザ ー(Tri-Carb2000CA型,パ ッ カ ー ド) グ ル タ ー ル ア ル デ ヒ ドで 固 定 し た後 分 離 し た イ ヌ の に よ り行 っ た 組 織 標 本 をFig回3に II.結 1.網

More information

Fig. 1 Chemical structure of 14C-bromfenac sodium *: 14C-labeled position

Fig. 1 Chemical structure of 14C-bromfenac sodium *: 14C-labeled position Ocular Tissue Distribution in Rabbit after Instillation of Bromfenac Sodium Ophthalmic Solution Mitsuyoshi ISAKA, Katsuhiro INADA, Shuichiro TSUTSUMI*, Megumi FusHIMi*, Atsuhiro INABA*, Yoshio KARASAWA*

More information

日本消化器外科学会雑誌第31巻第7号

日本消化器外科学会雑誌第31巻第7号 Key words: obstructive jaundice, biliary drainage, bile refeeding, hepatectomy Fig. 1 Animal models a: experiment I b: experiment 2 silicon tube Fig. 2 Experimantal design Sham Ope J - l r bile duct Zweeks

More information

Vol.15, No.1 43 表5 cis-3-hexenal生 そ の 結 果,沈 成 酵 素 の ラ メ ラ膜 へ の局 在 澱 画 分Iに る こ と が 判 っ た.沈 澱 画 分Iは,電 か ら 明 ら か な よ う に,葉 で,そ 全 活 性 の 約90%が 局 在 して い 子 顕 微 鏡 写 真(図13) 緑 体 の 外 膜 の み が きれ い に とん の 中 の 顆 粒

More information

1章A_責了.indd

1章A_責了.indd Ⅰ 章 赤 血 球 系 骨 髄 増 殖 性 疾 患 A 鉄 欠 乏 性 貧 血 Q 1 病 態, 診 断, 治 療 指 針 は? l 血 鉄 図 1 鉄 の 体 内 動 態 2 A. 鉄 欠 乏 性 貧 血 表 1 鉄 摂 取 量 の 年 次 推 移 ( 一 人 一 日 あたり) 年 鉄 摂 取 量 (mg) 1975 1980 10.8 10.4 1985 10.8 1990 11.1 1995

More information

Microsoft PowerPoint - 検討チーム甲状腺測定work20140930b2-sent

Microsoft PowerPoint - 検討チーム甲状腺測定work20140930b2-sent 第 8 回 事 前 対 策 等 検 討 チーム 会 合 追 加 配 布 資 料 2 小 児 甲 状 腺 被 ばく 線 量 について ( 独 ) 放 射 線 医 学 総 合 研 究 所 REMAT 医 療 室 立 崎 英 夫 1 原 子 力 災 害 対 策 本 部 原 子 力 安 全 委 員 会 による 小 児 甲 状 腺 簡 易 測 定 2 3 4 小 児 甲 状 腺 簡 易 測 定 結 果 ( 福

More information

主 要 な が ん 治 療 に つ い て 入 院 に か か る 医 療 費 の 支 払 い か ら 計 算 し た も の で す 例 え ば 胃 が ん に つ い て は 平 均 入 院 費 は 総 額 約 1 1 0 万 円 で 自 己 負 担 額 は 約 3 3 万 円 程 度 必 要

主 要 な が ん 治 療 に つ い て 入 院 に か か る 医 療 費 の 支 払 い か ら 計 算 し た も の で す 例 え ば 胃 が ん に つ い て は 平 均 入 院 費 は 総 額 約 1 1 0 万 円 で 自 己 負 担 額 は 約 3 3 万 円 程 度 必 要 市 民 の 健 康 ~ が ん の 予 防 と 体 操 で 健 康 づ く り ~ 1 挨 拶 こ ん に ち は 長 久 手 市 役 所 健 康 推 進 課 の 伊 藤 と 申 し ま す 本 日 は よ ろ し く お 願 い し ま す 座 っ た ま ま で 説 明 さ せ て い た だ き ま す 今 回 の タ イ ト ル は 市 民 の 健 康 が ん の 予 防 と 体 操 で 健

More information

Table 1 Sensitivity distribution of clinical isolates 1. Escherichia coli Inoculum size: 106cells/ml 2. Klebsiella pneumoniae 3. Enterobacter cloacae 4. Serratia marcescens Inoculum size: 106cells/nil

More information

Fig. 1 Effect of T-1220 on blood pressure and respiration of the rabbit Fig. 2 Effects of T-1220 and P-32 on blood pressure of the rabbit

Fig. 1 Effect of T-1220 on blood pressure and respiration of the rabbit Fig. 2 Effects of T-1220 and P-32 on blood pressure of the rabbit VOL. 25 NO. 5 CHEMOTHERAPY 769 Fig. 1 Effect of T-1220 on blood pressure and respiration of the rabbit Fig. 2 Effects of T-1220 and P-32 on blood pressure of the rabbit Fig. 3 Effect of T-1220 on blood

More information

Table 1. Clinical Background of Studied Cases.

Table 1. Clinical Background of Studied Cases. Table 1. Clinical Background of Studied Cases. Table 2. Dexamethasone and Gonadotropins Administration to the Menstrual Disorded Cases Fig. 1. Determination Method for Winary 17-ketosteroids Fractions

More information

高濃度硫化水素削減のための汚泥脱気装置の開発

高濃度硫化水素削減のための汚泥脱気装置の開発 5-(1)-2 高 濃 度 硫 化 水 素 削 減 のための 汚 泥 脱 気 装 置 の 開 発 計 画 調 整 部 技 術 開 発 課 廣 繁 直 治 山 下 博 史 ( 現 経 理 部 業 務 管 理 課 ) 1. 目 的 東 京 都 区 部 で は 汚 泥 処 理 の 効 率 化 を 図 る た め に 集 約 処 理 を 進 め て い る 汚 泥 の 集 約 処 理 の 進 展 と と も

More information

VOL. 28 S-2 CHEMOTHERAPY

VOL. 28 S-2 CHEMOTHERAPY CHEMOTHERAPY JULY 1980 Enterobacter cloacae, Escherichia coli Klebsiella pneumeinae Fig. 1 Chemical structural formula of cefadroxil VOL. 28 S-2 CHEMOTHERAPY CHEMOTHERAPY JULY 19 80 Table 1 Effect of cefadroxil

More information

Table 1. Acute toxicity of Folin on mice. (Litchfield-Wilcoxon method) Numbers in parenthesis indicate 95% fiducial limits. Fig. 1. Analgesic effect of Folin on mice (1% acetic aid-induced writhing). Each

More information

Table1MIC of BAY o 9867 against standard strains

Table1MIC of BAY o 9867 against standard strains Table1MIC of BAY o 9867 against standard strains Fig.2Cumulative and Distribution Curves of MIC (S.aureus 54 strains) 106cfu/ml Fig.3Correlogram of MIC (S.aureus 54 strains) CHEMOTHERAPY 451 Fig.4Cumulative

More information

STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U

STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical U STUDIES ON THE RELATION BETWEEN LATE DUMPING SYNDROME AND GLUCAGON RESPONCES TO GLUCOSE Taisuke MATSUI The First Department of Surgery, Nara Medical University, Kashihara (Director: Prof. H. Nakano) This

More information

Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung Carcinoma with Cancerous Pleurisy at Autopsy

Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung Carcinoma with Cancerous Pleurisy at Autopsy Clinicopathological Studies on Cancerous Pleurisy, with Emphasis on Extra-Pulmonary Malignancy Table 1. Numbers of Cancerous Pleurisy Cases According to Primary Site Table 2. Histological Type of Lung

More information

Table 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background

More information

Key words:fatty acid,plant oil,staphylococcus aureus,skin care, atopic dermatitis

Key words:fatty acid,plant oil,staphylococcus aureus,skin care, atopic dermatitis Key words:fatty acid,plant oil,staphylococcus aureus,skin care, atopic dermatitis growth was monitored at 660 nm with a biophotorecorder. Table 1.Relative inhibitory effects of fatty acids,plant oils,

More information

VOL. 19 NO. 5 CHEMOTHERAPY

VOL. 19 NO. 5 CHEMOTHERAPY VOL. 19 NO. 5 CHEMOTHERAPY CHEMOTHERAPY 424 Table 2 NAの AUG. 1971 マ ウス 胎 仔 に わ よ ば す影 響 a e) Table * * 異 常 の種 類 はTable 3お よびPhoto.1,4,5,6お よ び7に 示 す とお りで,そ の 発 現頻 度 は対 照 群 と比 較 して 有意 差 が なか つ た 化 骨 進

More information

Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): Issue Date URL

Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): Issue Date URL Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): 278-291 Issue Date 1965-04 URL http://hdl.handle.net/2433/112732 Right Type Departmental Bulletin Paper

More information

TABLE 1. CHANGES IN HEMODYNAMIC PARAMETERS DURING EXERCISE Figure 1. Hemodynamic changes in right atrial pressure (RAP) bee, and after. Figure 2. Hemo

TABLE 1. CHANGES IN HEMODYNAMIC PARAMETERS DURING EXERCISE Figure 1. Hemodynamic changes in right atrial pressure (RAP) bee, and after. Figure 2. Hemo Yozu Ryohei, Inoue T, Shimomitsu T, Morilnoto T, Sugita Y, Watanabe T, Ishikawa M, Stacy G, Jacobs G, Harasaki H, Nose Y. EXERCISE RESPONSE IN CHRONIC NONPULSATILE (NPBVB) AND PULSATILE TAH ANIMALS. Treadmill

More information

Table 1. Antibacterial activity of cefdinir, cefixime, cefteram, cefuroxime, cefaclor and amoxicillin against standard strains Inoculum size: 108 cells/ml CFDN: cefdinir, CFIX: cefixime, CFTM: cefteram,

More information

Keywords : ME1206, renal excretion, tubular secretion, transport system for anions, stop-flow analysis method, <I>p</I>-aminohippuric acid Renal excre

Keywords : ME1206, renal excretion, tubular secretion, transport system for anions, stop-flow analysis method, <I>p</I>-aminohippuric acid Renal excre Keywords : ME1206, renal excretion, tubular secretion, transport system for anions, stop-flow analysis method, p-aminohippuric acid Renal excretion mechanism of ME1206, an active form of a novel

More information

45 癌抑制遺伝子PTEN 酵 素活 性 を阻害 す る活性 中心 後述 付 近 で の ミス セ ン 者 に は 乳 癌 甲状 腺 癌 卵 巣 癌 が 発 生 しや す い こ とが ス 変 異 が 多 く 子 宮 内 膜 腫 で 頻 繁 に観 察 さ れ る よ うな 知 ら れ て い る Cowden病 ナ ン セ ン ス フ レ ー ム シ フ ト変 異 は あ ま り検 出 さ れ な

More information

Nippon Suisan Gakkaishi 55 (10), (1989) ) Effects of ph and Sodium Chloride on the Water Holding Capacity of Surimi and its Gel Yoshiaki Aka

Nippon Suisan Gakkaishi 55 (10), (1989) ) Effects of ph and Sodium Chloride on the Water Holding Capacity of Surimi and its Gel Yoshiaki Aka Nippon Suisan Gakkaishi 55 (10), 1827-1832 (1989) ) Effects of ph and Sodium Chloride on the Water Holding Capacity of Surimi and its Gel Yoshiaki Akahane*2, and Yutaka Shimizu*3 Water in Alaska pollack

More information

"G um exp." in the table means before the gum chewing experiment, and "Cont exp." in the table means Table 1. Rest values of heart rate (HR), coefficient of variation in RR (CVRR), wave height of plethysmogram

More information

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical School While the problem of late pregnant hypertension

More information

Ann. Rept. Plant Prot. North Japan Species Caught by Synthetic Sex Pheromone Trap of the Oriental Fruit Moth, Graphorita molesta (Busck)(Lepidoptera;

Ann. Rept. Plant Prot. North Japan Species Caught by Synthetic Sex Pheromone Trap of the Oriental Fruit Moth, Graphorita molesta (Busck)(Lepidoptera; Ann. Rept. Plant Prot. North Japan Species Caught by Synthetic Sex Pheromone Trap of the Oriental Fruit Moth, Graphorita molesta (Busck)(Lepidoptera; Tortricidae), and Their Seasonal Attractant Prevalence

More information