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3 1. Prader, A., Labhart, A. and Willi, H.: Ein Syndrom von Adipositas, Kleinwuchs, Kryptor- kysmus und Oligophrenie nach Myotonieartigem Zustand in Neugeboren, Schweiz. Med. Wocheschr., 86: , of hypotonia-hypogonadism-obesity 2. Zellweger, H. and Schneider, H. J.: Syndrome (HHHO) or

4 Prader-Willi syndrome, Am. J. Dis. Child., 115: , Hall, B. D. and Smith, D. W.: Prader-Willi Syndrome: A resume of 32 cases including an instance of affected first cousins, one of whom is of normal stature and intelligence, J. Pediatr., 81: , Bray, G. A., Dahms, W. T., Swerdloff, R. S., Fiser, R. H., Atkinson, R. L. and Carrel, R. E. : The Prader-Willi syndrome: A study of 40 patients and a review of the literature, Medicine., 62: 59-80, Garty, B., Shuper, A., Mimouni, M., Varsano, I. and Kauli, R.: Primary gonadal failure and precocious adrenarche in a boy with Prader- Labhart-Willi syndrome, Eur. J. Pediatr., 139 : , Hamilton, C. R., Scully, R. E. and Klimann, B.: Hypogonadotropinism in Prader-Willi syndrome, Am. J. Med., 52: , Tolis G., Lewis, W., Verdy, M., Friesen, H. G., Solomon, S., Pagalis, G., Pavlatos, F., Fessas, P. H. and Rochefort, J. G.: Anterior pituitary function in the Prader-Labhart-Willi syndrome, J. Clin. Endoclinol. Metab., 39: , McGuffin, W. L. and Rogal, A. D.: Response to LH-RH and clomiphene citrate in two women with the Prader-Willi syndrome, J. Clin. Endoclinol. Metab., 41: , Cassidy, S. B.: Prader-Willi syndrome, Curr. Probl. Pediatr., 14: 1-55, Laurence, B. M., Brito, A. and Wilkinson, J.: Prader-Willi syndrome after age 15 years, Arch. Dis. Child., 56: , Rochester, D. F. and Enson, Y.: Current concepts in the pathogenesis of the obesity-hypoventiration syndrome: Mechanical and circuratory factors, Am. J. Med., 57: , Holm, V. A. and Nugent, J. K.: Growth in the Prader-Willi syndrome, Birth Defects., 18 (3B) :93-100, Crnic, K. A., Sulzbacher, S., Snow, J. and Holm, V. A: Preventing mental retardation associated with gross obesity in the Prader-Willi syndrome, Pediatrics., 66: , Holm, V. A. and Lauren, E. L.: Prader-Willi syndrome and scoliosis, Dev. Med. Child. Neurol., 23: , Gurd, A. R. and Thompson, T. R.: Scoliosis in Prader-Willi syndrome, J. Pediatr. Orthop., 1: , Hawkey, C. J. and Smithies, A.: The Prader- Willi syndrome with a 15/15 translocation: Case report and review of the literature, J. Med. Genet., 13: , Ledbetter, D. H, Riccardi, V. M., Airhart, S. D., Strobel, R. J., Keenan, B. S. and Crawford, J. D.: Deletions of chromosome 15 as a cause of the Prader-Willi syndrome, N. Engl. J. Med., 304: , 1981.

5 A Case of Prader-Willi syndrome with Pseudoacanthosis Nigricans Tetsuichi Ichida, Takehiko Tanigaki and Kunihiko Yoshikawa Department of Dermatology, University of Osaka School of Medicine , Fukushima, Fukushima-ku, Osaka 553, Japan Key words: Prader-Willi syndrome-obesity-pseudoacanthosis nigricans We report the case of a 16 year-old male patient with Prader-Willi syndrome, with obesity, short stature, disappearance of the teeth, almond-shaped palpebral fissure and so on. Such patients, therefore, may visit at dermatological clinic with the chief compliant of pseudoacanthosis nigricans.

Table 2 Cases of Nail Deformity Associated with upward Distortion of Distal Soft Tissue No. Age Sex Affected RegionsDuration Results M Both grea

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