大阪大学0623

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1

2 , , ,200H ,534 86,666 2

3 3

4 WP-12

5 1, H28.3) ( 5

6 () () ()

7 7

8 N= % 53% 35% % 48.2% 65.1% 62.6% 57.7%57.8% 55.9% 42.3%42.2% 44.1% 37.4% 34.9% % 0%

9 NDB 9

10 ( ) 71,758 21,313 3,956,676, ,974 41,451 7,830,396, ,515 59,478 10,451,638, ,067 60,989 9,631,677,960 73,371 15,773 2,833,419,270 67,561 16,210 3,059,349, ,350 26,148 4,105,116, ,704 40,447 6,816,669, ,997 49,996 11,638,430, ,674 63,506 12,764,100,020 81,596 21,037 4,454,553,590 64,973 17,883 3,574,217,650 1,601, ,231 76,608,500,710 10

11 12 11

12 % 20.0% 19.0% 18.9% 19.7% 20.0% 18.0% 17.0% 16.0% 15.0% % % % 14.0% 13.0% 12.9% 13.3% 13.6% 12.0% % 14.8% 16.8% 16.8% 18.9% 12.9% 13.6% 15.0% 14.0% 13.5% 15.2% 13.7% 15.2% % 15.6% 17.9% 17.7% 19.7% 13.3% 14.5% 16.1% 14.9% 14.5% 16.4% 14.5% 16.0% % 16.1% 18.9% 18.8% 20.0% 13.6% 15.1% 16.7% 15.7% 15.1% 17.3% 14.9% 16.7% 12

13 % 8.7% 8.8% 9.8% 10.9% 5.9% 9.0% 6.2% 9.3% 7.8% 8.4% 8.2% 8.4% % 9.0% 8.9% 10.2% 10.9% 6.4% 9.4% 6.5% 8.9% 8.4% 9.3% 8.4% 8.6% % 9.1% 9.2% 10.6% 11.1% 6.7% 9.7% 6.7% 9.2% 8.7% 9.8% 8.8% 9.0% 13

14 5.0% % 4.2% 3.5% 3.8% 3.0% 2.0% % % % 1.0% 1.4% 1.2% 1.2% 0.0% % 3.4% 2.3% 2.2% 1.4% 4.2% 3.4% 3.8% 3.0% 1.6% 1.4% 3.0% 2.6% % 2.3% 2.0% 1.3% 1.4% 3.4% 3.5% 2.5% 2.1% 1.5% 1.2% 2.5% 2.1% % 2.3% 2.0% 1.4% 1.4% 3.4% 3.8% 2.1% 2.2% 1.6% 1.2% 2.4% 2.1% 14

15 12 2 Ⅰ. 787 Ⅱ. 4,445 Ⅲ. 28,587 Ⅳ.HbA1c 6 2,986 36,805 HbA1c 665,724 15

16

17

18 % 10.0% 9.7% 10.0% 10.4% 9.0% 8.0% % % % 7.0% 6.0% 6.1% 6.2% 6.5% 5.0% % 8.6% 8.1% 9.7% 9.3% 8.0% 8.6% 6.1% 8.6% 8.5% 8.4% 8.2% 8.4% 8.5% 8.7% 8.4% 10.0% 9.5% 8.6% 8.9% 6.2% 8.5% 8.8% 9.0% 8.4% 8.6% 8.9% 8.8% 8.8% 10.4% 9.8% 9.2% 9.2% 6.5% 8.7% 9.0% 9.4% 8.9% 9.0% 18

19 1 19

20 1 30, ,500 15,000 7,

21 1 550, , , , , , , ,000 21

22 1 22

23 DPP a.sglt2 0.0% 2.6% 6.1% b.dpp4 62.7% 67.9% 71.3% c.glp-1 d. e. 0.8% 0.9% 1.2% 4.8% 5.0% 5.0% 47.3% 47.3% 47.4% 2013N=28,795) 2014N=30,817) 2015N=31,735) f.α- 25.0% 23.0% 21.2% g. 46.6% 42.3% 38.6% h. 4.2% 4.6% 6.4% 0.0% 20.0% 40.0% 60.0% 80.0% 23

24 DPP % 54.9% 64.3% 56.0% 62.5% 65.1% 67.3% 62.7% 64.4% 63.6% 69.9% 56.9% 62.7% % 57.0% 69.0% 62.7% 69.3% 70.3% 72.2% 68.0% 69.0% 68.9% 73.8% 63.0% 67.9% % 60.6% 71.8% 67.3% 72.6% 72.7% 73.7% 74.1% 72.2% 71.9% 77.4% 67.1% 71.3% 24

25 % 57.9% 40.3% 56.6% 48.1% 44.1% 41.6% 41.0% 50.7% 50.5% 44.8% 47.3% 47.3% % 58.2% 39.5% 55.2% 48.3% 45.6% 42.8% 41.5% 52.0% 49.7% 43.7% 44.7% 47.3% % 57.1% 40.1% 56.9% 48.2% 45.3% 45.0% 42.0% 51.5% 48.5% 42.4% 45.9% 47.4% 25

26 1 DPP4 DPP4 26

27 12 DPP4 DPP4 27

28 1 28

29 12 29

30 J-DOME Japan medical association Diabetes database O clinical MEdicine (

31 J-DOME 40 J-DOME J-DREAMS 31

32 HbA1c HDLALT DPP-4 32

33 J-DREAMS J-DOME J-DOME

34 / / HbA1c NGSP % egfr 9 0 m L / m i n / m L / m i n / m L / m i n / m L / m i n / m L / m i n / m L / m i n / m L / m i n / m L / m i n / % n=2,396 n=1,643 n=753 n=49 34

35 9 2 35

36 36

37 37

38

39 39

40 H

41

42

43 43

44

100 BMILDL HDL HbA1c HDL HbA1c(6.1%) 19.02 18.2%45.3% 54.5 45 BMIHDL HbA1c 70 45 60 25 26 27 28 29 30 38 45 53 60 25 26 27 28 29 45 49 53 57 60 20 29 24.28 18.21 BMI HbA1c NGSP HDLLDL GOTGPT-GTP egfr 38.7

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