薬物動態解析ソフトを用いた 造影CT検査シミュレーション
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- さみ いちぞの
- 5 years ago
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1 CT
2 CT
3 CTA
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7 1.
8 A), D), E) 4 Drug metabolism and Pharmacokinetics DMPK
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13 AUC C=Ae -ket ke MRT
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18 OGAWA V(ml) = 0.168H W H (m) W (kg) V(ml) = 0.250H W
19 6
20 9% 64% 3.5% 13% 3.5% 7%
21 ? =64% CT 9% 64% 3.5% 13% 3.5% 7%
22 ) 110ml
23 1kg 110ml Wt kg Vd(ml/kg Wt kg 110 Wt 110 Wt =110 Wt 0.36V
24 V R V p V L V V V mlv C V A 7 13
25 V R V p V L V V V C V A 7 13
26 V R V p V L V V V C V A 7 13
27 V R V p V L V V V C V A 7 13
28 Cardiac output(ml/sec) =(100/6) CI H W CI,H (m),w (kg)
29 CI( (L/min)
30 CI( L/min/m 2 )
31 4.5 /min/m Age Guyton &Hall
32 V R V p V L V V V C V A Vd Wt
33 V R dc R /dt Q0C0-Q R C R +Q V C V Vp dcp/dt Q R C R -Q P C P V L dc L /dt Q P C P -Q L C L V A dc A /dt Q L C L -Q A C A V C dc C /dt Q A C A -Q C C C V dcv/dt QcCc/kp-QvCv/kp
34 V R V p V L V V V C V A Vd Wt
35 C R Injector [sec] [mg/sec] [m V R Injector [mg/sec] [ml]
36 Q R =Q P =Q L =Q A =Q C =Q V ml/sec
37 CT CT
38
39 Carnel:FC13 [mgi]
40 CT u
41 TDC ( Runge-Kutta Method) PC TDC dc A /dt Q L C L -Q A C A )/ V A C A CT
42 2.Polymath soft
43 Polymath software Home page
44 Polymath software Mordechai Shacham,Michael B. Cutlip Add in
45 http// POLYMATH 6.1-Professional Use Version CD-ROM 22,125 POLYMATH 6.1-Educational Use Version 4, Trial
46 Simulation
47 Simulation (164.7cm (64kg 2.7 L/min/m 2 CI BSA 2.7 BSA 300mgI 3.0ml/sec 60 20sec 100
48
49 Program
50 Ordinary Differential Eqations solver
51 Step :
52 Step2
53 Step3
54 Step4
55 Step5
56 Step6:
57
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59 3.Polymath soft
60 CTA
61 CTA
62 CTA
63 Windows PC Polymath professional ver.6.10 CT Toshiba Aquilion64 Work Station ZAIO STATION AMIN MEDRAD Stellant D ystat2004,
64 Test injection CTA 163 ( ) CTA 63 ( ) 33 ( ) 120kV 225mAs 0.75sec 3.0mm 0.5mm PF:0.641 HP:41
65 Test injection 3.0ml/s 15ml Test injection sec 3.0ml/s 60ml Test injection 3.0ml/s 15ml Test injection sec 3.0ml/s 60ml
66 3.0ml/s 60ml 3.0ml/s 15ml 3ml/s 15mL 3ml/s 60mL 10s Fig.1 (sec)
67 14 Test injection 3ml/s 15mL 3ml/s 60mL peak to peak time[sec] CI)
68 2x2 Chi square test P Fig.2 CTA
69 24 Fig.3
70 ( Test injection TEST200HU TEST200HU HU TEST CT HU TEST CT Test injection CT HU) Fig.4 2
![gi/sec]](/docs-images/93/113990877/images/71-0.jpg "350HU")
![[gi/kg]](/docs-images/93/113990877/images/71-1.jpg "Fig.4")
71 gi/sec] 350HU 350HU [gi/kg] Fig.4
72 2x2 Chi square test P Fig.5
73 Iodine flux per BW 0.4 I/kg 20s Fig.6 Iodine flux per BW
74 Test injection sec Test injection CT 200HU 20mgI/sec/kg 20s
75 CT MCA Fig.7 MCA CT
76 n = n = n = Fig.8
77 v
78 Simulation 10sec mgi/sec/kg Enhancement(HU) Scan duration Scan duration Scan duration injection time=10sec 164cm 66kg CI=3.5 30ml 40ml 60ml injection time=20sec injection time=15sec time(sec) Enhancement(HU) Scan duration 164cm 64kg CI=3.5 injection time=10sec 0 20 time(sec) mgi/sec/kg 25.2mgI/sec/kg 22.4mgI/sec/kg 20.0mgI/sec/kg 16.8mgI/sec/kg
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スライド タイトルなし
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スライド 1
CT May 23, 2009 MDCT ~ 350 135mL ~ Clinical Experience with Highest Iodine Dose (630mgI/kg) of 135mL Syringe (Iomeprol 350mgI/mL) in Multiphasic MDCT of Liver Backgrounds A. multiphasic study for detecting
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スライド 1
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