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1 Akiko Morikawa, Hiroshi Suzuki, Yuichi Sugiyama, sugiyama@amol.f.u to kyo.ac.jp Multiplicity and molecular mechanism of substrate recognition by MRP

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7 1) Cole, S.P., Bhardwaj, G., Gerlach, J.H., Mackie, J.E., Grant, C. E., Almquist, K.C., Stewart, A.J., Kurz, E.U., Duncan, A.M., Deeley, R.G. : Science, 258, (1992) 2) Borst, P., Evers, R., Kool, M., Wijnholds, J.: J. Natl. Cancer Inst.. 92, (2000) 3) Konig, J., Nies, A.T., Cui, Y., Leier, I., Keppler. D.: Biochim. Biophys. Acta, 1461, (1999) 4) Keppler, D., Kamisako, T., Leier, I., Cui, Y., Nies, A.T., Tsu jii, H., Konig, J.: Adv. Enzyme. Regul., 40, (2000) 5) Wijnholds, J., Evers, R., van Leusden, M.R., Mol, C.A., Zaman, G. J., Mayer, U., Beijnen, J. H., van der Valk, M., Krimpenfort, P., Borst, P.: Nature Med., 3, (1997) 6) Kartenbeck, J., Leuschner, U., Mayer, R., Keppler, D. : He patology, 23, (1996) 7) Paulusma, C.C., Kool, M., Bosma, P.J., Scheffer, G.L., Borg, F.T., Scheper, R.J., Tytgat, G.N.J., Borst, P., Baas, F., Oude Elferink, P.J. : Hepatology, 25, (1997) 8) Wada, M., Toh, S.. Taniguchi, K., Nakamura, T., Uchiumi, T., Kohno, K., Yoshida, I., Kimura, A., Sakisaka, S., Adachi, Y., Kuwano, M.: Hum. Mol. Genet., 7, (1998) 9) Keitel, V., Kartenbeck, J., Nies, A.T., Spring, H., Brom, M., Keppler, D. : Hepatology, 32, (2000) 10) Ito. K., Suzuki. H.. Hirohashi, T., Kume, K., Shimizu, T., Sugiyama, Y.: Am. J. Physiol., 272, G16-22 (1997) 11) Paulusma, C.C., Bosma, P.J., Zaman, G.J., Bailer, C.T., Otter, M., Scheffer, G.L., Borst, P., Oude Elferink, P.J.: Science. 271, (1996) 12) Kool. M., van der Linden. M., de Haas, M., Scheffer, G.L., de Vree, J.M., Smith, A.J., Jansen, G., Peters. G.J., Ponne, N., Scheper, R.J.. Elferink, R.P., Baas, F., Borst, P. : Proc. Natl. Acad. Sci. USA, 96, (1999) 13) Hirohashi, T., Suzuki, H., Ito, K., Ogawa, K., Kume, K., Shimizu, T., Sugiyama, Y.: Mol. Pharmacol., 53,

8 (1998) 14) Ogawa, K., Suzuki, H., Hirohashi, T., Ishikawa, T., Meier, P. J., Hirose, K., Akizawa, T., Yoshioka, M.. Sugiyama, Y.: Am. J. Physiol. Gastrointest. Liver Physiol., 278, G (2000) 15) Cole, S.P., Deeley, R.G. : Bioessavs, 20, (1998) 16) Hipfner, D.R., Deeley, R.G., Cole, S.P.: Biochim. Biophys. Acta, 1461, (1999) 17) Gao, M., Cui, H.R., Loe, D.W., Grant, C.E., Almquist, K.C., Cole, S.P., Deeley, R.G. : J. Biol. Chem., 275, (2000) 18) Hou, Y., Cui, L., Riordan. J. R., Chang, X. : J. Biol. Chem., (2000) 19) Tusnady, G.E., Bakos, E., Varadi, A., Sarkadi, B. : FEBS Lett., 402, 1-3 (1997) 20) Kast, C., Gros, P.: J. Biol. Chem., 272, (1997) 21) Suzuki, H., Sugiyama, Y. : Semin. Liver Dis., 18, (1998) 22) Masuda, M., I'Izuka, Y., Yamazaki, M., Nishigaki, R., Kato, Y., Ni'inuma, K., Suzuki, H., Sugiyama, Y.: Cancer Res., 57, (1997) 23) Kusuhara, H., Han, Y.H., Shimoda, M., Kokue, E., Suzuki, H., Sugiyama, Y.: Am. J. Phvsiol., 275, G (1998) 24) Ito, K., Suzuki, H., Hirohashi. T., Kume, K., Shimizu, T., Sugiyama, Y. : J. Biol. Chem., 273, (1998) 25) Chu, X.Y., Kato, Y., Ueda, K.. Suzuki, H., Niinuma, K., Tyson, C.A., Weizer, V., Dabbs, J.E.. Froehlich, R., Green, C.E., Sugiyama, Y.: Cancer Res., (1998) 26) Koike, K., Kawabe, T., Tanaka, T., Toh, S., Uchiumi, T., Wada, M., Akiyama, S., Ono, M., Kuwano, M': Cancer Res., 57, (1997) 27) Kawabe, T., Chen, Z.S., Wada, M., Uchiumi, T., Ono, M., Akiyama, S., Kuwano, M. : FEBS Lett., 456, (1999) 28) Loe, D.W., Deeley, R.G., Cole, S.P.: J. Pharmacol. Exp. Ther., 293, (2000) 29) Mao, Q., Deeley, R.G., Cole, S.P.: J. Biol. Chem., 275, (2000) 30) Hirohashi, T., Suzuki, H., Sugiyama, Y. : J. Biol. Chem., 274, (1999) 31) Hirohashi, T., Suzuki. H., Takikawa. H., Sugiyama. Y.: J. Biol. Chem., 275, (2000) 32) Morikawa, A., Goto, Y., Suzuki, H., Hirohashi, T., Sugiyama, Y.: Pharm. Res., 17, (2000) 33) Keel, M., de Haas, M., Scheffer. G.L., Scheper, R.J., van Eijk, M.J., Juijn, J.A., Baas, F., Borst, P.: Cancer Res., 57, (1997) 34) Schuetz, J.D., Connelly, M.C., Sun, D., Paibir, S.G., Flynn. P. M.. Srinivas, R.V., Kumar, A., Fridland, A. : Nature Med., 5, (1999) 35) McAleer, M.A., Breen, M.A., White. N.L.. Matthews. N.: J. Biol. Chem., (1999) 36) Wijnholds, J., Mol, C.A., van Deemter, L.. de Haas, M., Scheffer, G.L., Baas, F., Beijnen, J.H., Scheper, R.J., Hatse, S., De Clercq, E., Balzarini, J., Borst, P. : Proc. Natl. Acad. Sci. USA, 97, (2000) 37) Jedlitschky, G.. Burchell, B., Keppler, D. : J. Biol. Chem., (2000) 38) Keel, M., van der Linden, M., de Haas, M., Baas, F., Borst, P.: Cancer Res., 59, (1999) 39) Madon, J., Hagenbuch, B., Landmann, L., Meier, P.J., Stieger, B. : Mol. Pharmacol., 57, (2000) 40) Bergen, A.A., Plomp, A.S., Schuurman, E.J., Terry, S., Bre uning, M., Dauwerse, H., Swart, J., Keel, M., van Soest, S., Baas, F., ten Brink, J.B., de Jong, P.T.: Nature Genet., 25, (2000) 41) Le Saux, 0., Urban, Z., Tschuch, C., Csiszar, K., Bacchelli, B., Quaglino, D., Pasquali-Ronchetti, I., Pope, F.M., Richards, A., Terry, S., Bercovitch, L., de Paepe, A., Boyd, C. D. : Nature Genet., 25, (2000) 42) Ringpfeil, F., Lebwohl, M.G., Christiano, A.M., Uitto, J. Proc. Natl. Acad. Sci. USA, 97, (2000) 43) Gao, M., Loe, D.W., Grant, C.E.. Cole. S.P.C.. Deeley. R.G. : J. Biol. Chem., 271, (1996) 44) Gao, M., Yamazaki, M., Loe, D.W., Westlake, C.J., Grant, C.E., Cole, S.P., Deeley, R.G.: J. Biol. Chem., 273, (1998) 45) Bakos, E., Evers, R., Szakacs, G., Tusnady, G.E., Welker, E., Szabo, K., de Haas, M., van Deemter, L., Borst, P., Varadi, A., Sarkadi, B.: J. Biol. Chem., (1998) 46) Deeley, R. G., Cole, S. P.: Semin. Cancer Biol., 8, (1997) 47) Stride, B.D., Cole, S.P., Deeley, R.G. : J. Biol. Chem., 274, (1999) 48) Ryu, S., Kawabe, T., Nada, S., Yamaguchi, A. : J. Biol. Chem., 275, (2000) 49) Loo, T.W., Clarke, D.M.: J. Biol. Chem., 274, (1999) 50) Ito, K., Suzuki, H., Sugiyama, Y. : Proc. Am. Assoc. Cancer Res., 41, 673 (2000) ; Mol. Pharmacol., in press (2001) 51) Ito, K., Suzuki, H., Sugiyama, Y.: Hepatology., 32, 439A (2000) 52) Ito, K., Suzuki, H., Sugiyama. Y.: Hepatology., 32, 442A (2000) ; Am. J. Physiol., in press (2001) 53) Niinuma, K., Kato, Y., Suzuki, H., Tyson, C.A., Weizer, V., Dabbs, J.E., Froehlich, R., Green, C.E., Sugiyama, Y.: Am. J. Physiol., 276, G (1999) 54) Hopper, E. et al.: Cancer Lett.. 162, (2001)

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