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3 1 A ( BPA (p.5 9 ( PC ( EX BPA PC CD DVD OA EX BPA 1977 EU OECD BPA 1997 BPA 1998 ( SPEED 98 1 BPA ABPS ( A 1997 BPA 5 BPA ( A 5 A Bisphenol A Global Industry Group ( PC/BPA Global Group BPA 3 BPA BPA BPA NITE A BPA ( NEDO

4 BPA BPA ( p.8 BPA BPA 2001 ( BPA ( MSDS: Material Safety Data Sheet 3 ( ( PC BPA ( p-t- 2.5 ppm ( BPA ( p-t- 500 ppm 1 BPA BPA BPA - 2 -

5 s PC/BPA Global Group BPA BPA HP BPA EX 78 HP PC BPA 5 PC HP HP ABPS BPA 250ppm BPA 5 BPA BPA 5 ISO14000s PC BPA NEDO BPA SPEED BPA ExTEND ( (PC OECD HPV 4 Our Stolen Future ( SIDS ( 7 WHO/IPCS BPA OECD Global assessment of Endocrine Disrupters ( the state-of-the-science of endocrine disruptors Testing & Assessment Task force A - 3 -

6 ( BPA NITE A BPA 1 1 BPA , , , , , , ,213 42,600 68,800 72,000 80, , , ,829-11,700 12,300 14,900 5,000 3,600-2,391 15, , , , , , , ,274 39,400 38,800 37,200 34,600 44,700 4,700 6, , , , , , , , , , , , , , , ,200 1,200 1, ,820 2,850 84,400 79,400 84,800 81,300 65,900 68,359 65,315 8,900 9,300 12,000 12,800 11,800 21,088 23,171 1,300 2,700 3,800 3,400 4,500 4,757 5,698 4,500 4,900 5,200 5,700 4,700 7,060 7, ,900 2,600 2,800 2, ,699 1,722 1,200 1,100 1, ,000 1,800 2,100 1,900 2,200 3,121 2, ,900 2,000 3,100 3,000 4,008 7,564 ( A 5-4 -

7 PC EX PC , , , , , , , , , , , , , , , ,491 28,444 37,723 65,350 56,168 69,530 63,534 63,707 61, , , , , , , , , , , , , , , , ,748 OA 59,470 68,264 79,772 83,472 92, , , ,392 24,398 28,006 27,920 26,559 45,310 31,535 37,351 39,567 6,099 7,001 7,977 5,601 6,796 6,307 6,591 6,982 35,072 40,258 47,863 32,251 38,513 27,331 19,774 25,602 27,447 31,506 35,897 41,736 43,044 44,149 48,337 51,205 3 EX ,270 47,340 49,400 50,050 48,310 47,750 49,260 13,130 10,780 10,980 10,050 9,480 8,780 7,900 12,840 10,920 11,900 12,970 12,900 13,060 12,640 29,300 25,640 26,520 27,030 25,930 25,910 28,720 60,670 55,750 59,900 65,360 47,730 52,800 51,520 32,920 30,860 33,050 37,370 28,560 30,260 28,820 12,830 10,410 11,760 12,780 6,940 8,700 8,930 14,920 14,480 15,090 15,210 12,230 13,840 13,770 43,010 37,600 38,810 38,920 36,940 35,460 34, , , , , , , ,930 27,860 28,260 39,100 42,780 26,980 25,900 25, , , , , , , ,740 ( BPA EX EX 1 BPA BPA 1998 BPA 2 PC 3 EX 2001 EX - 5 -

8 2 2.1 PRTR (Pollutant Release and Transfer Register : ISO

9 3 NEDO NITE BPA (NOEC; No Observed Effect Concentration (MOE ; Margin of Exposure NOEC 3 OECD 10 MOE ,100 BPA

10 2 5 3 BPA 5 BPA 3 NOAEL No Observed Adverse Effect Level NOAEL BMDL Bench Mark Dose Lower confidence limit NOAEL g/kg/day ( / 2 NOAEL BMDL 2 95 MOE MOE BPA - 8 -

11 BPA 4 BPA BPA BPA BPA BPA BPA 1 BPA 4.1 BPA BPA 2002 PRTR BPA 5 BPA 363 kg BPA PRTR BPA 1 BPA 392 kg BPA BPA PC EX PVC - 9 -

12 4 BPA A ( , 2000 BPA ( ( 1999 BPA ( BPA 2001 ( A (1 (BPA A 5 A ( A 5 BPA A ( Bisphenol A Global Industry Group ( PC/BPA Global Group BPA 3 BPA ( 10 ( PC/BPA Global Group ( ( ( (

13 1996 ( 8 ( ( BPA ( A 5 BPA A 5 ( BPA BPA BPA ( (2 (BPA BPA ( PC PC 1978 ( PC BPA PC/BPA Global Group ( JIS ISO PC P ( ( PC A ( 1999 PC A 500 ppm 250 ppm PC ( BPA (

14 PC 2000 BPA PRTR ( PC PC A ( PC ( BPA ( PC BPA PC CD BPA PC BPA PC BPA PC BPA ( EX EX EX ( EX ( A ( ( 10 EX BPA ( 1998 ( BPA 2000 BPA (

15 2000 EX 3 BPA 3 BPA ( BPA EX BPA EX BPA EX BPA (1ppm BPA BPA EX EX BPA ( ( 2002 NITE BPA % ( 2004 BPA 5 ( 5 BPA 2000 ( 2004 BPA (

16 BPA 2000 BPA 2004 BPA 2001 DIDP (Diisododecyl phthalate DUP (Diundecyl phthalate BPA BPA BPA BPA 6 BPA % BPA ( 2002 NITE 2000 BPA ( ( BPA NITE BPA 2000 BPA ( 2003 BPA

17 4.2 3 BPA 12 4 ( 6 (1 (2 (3 BOD (Biochemical Oxygen Demand (4 6 BPA ( ( ( ( A 2 B C ( 1/ % 99.7% 74.0% BPA A BPA A BPA BPA A A 4 BPA BPA 1996 BPA BPA BPA A BPA BPA BPA BOD BPA ( A

18 ( BPA 2002 A BOD BOD BPA 7 BPA BOD 7 BPA BOD BPA ( g/l BOD (mg/l * * nd , 0.054, ( a,b, 2005; 2000, * (, 2004 A BPA BOD A SS (Suspended Solid ( 1 BPA BPA BOD BPA

19 (2 BPA 8 BPA COD (Chemical Oxygen Demand 8 BPA COD BPA ( g/l COD (mg/l , , , , , , nd nd nd (, 2001;, 2005;, nd 0.02 g/l g/l g/l COD SS COD SS SS COD BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA BPA

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23 BPA g/kg/day PC EX BPA BPA PC EX BPA BPA BPA BPA PRTR BPA

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