Contributes to The Health of Individuals Worldwide

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1 ANNUAL REPORT 2008 Annual Report 2008 Our Contribution to Financial and Social Responsibility

2 Contributes to The Health of Individuals Worldwide

3

4 Highlights

5

6 Message

7

8

9

10

11

12 U. S. 1 U.S.operations The restructuring of

13 1 Message Alan MacKenzie

14 2 Message

15 2 Strengthening strategy in Oncology Area

16 2 Millennium, The Takeda Oncology Company

17 2 Strengthening strategy in Oncology Area

18 Corporate Philosophy

19 Corporate Governance

20 Corporate Governance

21

22 Intellectual Property

23

24 E UROPE R&D in Europe

25 TCB TGRD

26 TPEU TPEU

27 Europe Operations in

28 Marketing in Europe

29 Stakeholder's Voice CSR in Europe

30 Contribution to Society through Pharmaceutical Business Based on Takeda-ism

31

32

33 R&D

34

35 R&D pipeline

36

37 R&D pipeline

38 R&D alliance Ulf Wiinberg Partner's Voice

39 P roduction system

40

41 Products

42

43 Marketing

44

45 Marketing

46 Relationship with Our Stakeholders Based on Takeda-ism

47

48 Message

49 Relationship with Society Society Relationship with

50 2 Stakeholder's Voice

51 Relationship with Society

52 3 Stakeholder's Voice

53 2 Stakeholder's Voice Relationship with Society

54 2 Stakeholder's Voice

55 2 Stakeholder's Voice Relationship with Society

56

57 Relationship with Environment Environment Relationship with

58

59 Relationship with Environment

60

61 Relationship with Environment

62

63 Relationship with Environment

64

65 Relationship with Environment Stakeholder's Voice

66

67 Relationship with Supplier Relationship with Supplier

68

69 Relationship with Employees Relationship with Relationship with Employees

70

71 Relationship with Employees

72

73 DPC D OTC %13,748 [] / / ,806 6,617 6, % (2.0)% 49.5% 50.7% 55.7% 4,634 4,266 3, % 27.0 % 33.7% 32.7% 27.7% 2,036 1,920 1, % 6.5 % 14.8% 14.7% 14.9% [] 16, % 50.5% 12, ,942 8, ,806 4, % 19.1 % 2.0% 1.9% 1.7% 13,748 13,052 12, % 7.7 % [] / / ,240 1,275 1,224 (2.7)% 4.2 % 1,487 1,507 1,599 (1.4)% (5.7)% 2,231 2,062 1, % 8.0 % 3,962 3,363 2, % 37.9 %

74 6936.9%10, %4, % 10,962 1, % % %5, % 567 TAP TAP % % / / ,994 3,825 3, % 3.3% 37.0% 37.9% 41.4% 6,234 5,617 4, % 20.9% 57.7% 55.6% 51.9% 4,219 3,765 2, % 27.5% 39.1% 37.3% 33.0% 1,825 1,680 1, % 8.1% 16.9% 16.6% 17.4% % 25.5% 1.8% 1.7% 1.5% (14.0)% 10.7% 5.3% 6.6% 6.7% % 19.2% 0.3% 0.2% 0.2% (16.0)% 10.5% 5.0% 6.4% 6.5% 10,798 10,104 8, % 13.0% 62.8% 62.0% 58.5% [] 5,000 4,000 3,000 2,000 1,000 0 [] 3,000 2,000 1, % , % % 2, % 20.1% [] (

75 1965.9%3, EPS %41897 ROE15.1% %12, %4, %12, %5, %6,806 [] 4,000 3,000 2,000 1, ,027 1,024 1, % (25.6)% [] / 2006/ ,721 12,028 10, % 11.9 % 12,102 11,441 10, % 12.3 % 5,297 5,149 4, % 4.3 % EPSROE [] 6,806 6,291 5, % 19.7 % % 5.9 % % (30.4)% % 2.2% 3.7% % % [] / 2006/ ,113 4,482 3,881 (8.2)% 15.5 % 97.2% 97.8% 96.3% 3, % 30 %

76 TPNA % 1, % %2, SN20082 EX31 5.3%618 [] / / ,748 13,052 12, % 7.7 % 8,593 8,546 8, % (2.1)% 3,579 3,078 2, % 43.7 % 1,473 1,325 1, % 13.6 % (0.1)% 23.1 % 4,231 4,585 4,028 (7.7)% 13.8 % 5,401 5,304 5, % 2.5 % 1, % % (2.0)% 33.0 % (9.4)% 23.3 % (2,765) (1,960) (1,733)

77 2008 1=1001=155 TPNA TAP 1, %15,700 1, %2,800 TAP 1, % 2,000 TAP 20085~

78 200728,493 2, , , %80.0% 1BPS , ,706.0 [] / / ,438 23,577 23,720 (4.8)% (0.6)% 2,361 2,384 2,157 (1.0)% 10.6 % 3,694 4,763 4,547 (22.5)% 4.8 % 28,493 30,725 30,423 (7.3)% 1.0 % 5,267 6,114 6,467 (13.8)% (5.5)% ,225 24,611 23,484 (5.6)% 4.8 % 2006 [] 40,000 30,000 20,000 10, ,493 [] ,925 2,093 3,736 1,017 1, (2,621) (3,159) (893) (1,666) (345) 215 3, (345) 215 3,619

79 , , , % % ,497 1, ,403 3,420 46, ,9941,578 57, % ,990 [] 1 [] 18, % % 12,000 6, % % 43.8% ,000 8,

80 1 2 3 OTC 4

81 AWP Average Wholesale Price: AWP TAP : AWP1 TPNA 6 6,942 AWP 50.5% 4, %TAP TAP TAP 6 1,

82 ,374,802 1,305,167 1,212,207 1,122, , , , , , , , , , , , , ,622 3,730 3,347 3, , , , , ,908 38,510 32,616 49, ,690 28,820 28,728 31, , , , , ,243,792 2,357,713 2,371,970 1,969, , , , , , , , , ,849,279 3,072,501 3,042,294 2,545, , , , , , , , , ,194 44, ,322,533 2,461,116 2,348,429 2,001, , , , , ,717 14,993 15,069 14,

83 ,086,431 1,046,081 1,005, , , , ,816 $13,748, , , , , , , ,952 4,231, , , , , , , ,649 5,768, , , , ,148 81,446 89,019 83,368 2,187,660 2,969 2,651 2,879 2,073 1,693 1,368 1,671 26, , , , , ,625 91,755 81,610 3,554,540 62,472 35,888 44,766 27,411 37,893 29,241 34, ,080 28,083 29,962 28,430 33,605 33,364 32,651 32, , , , ,278 89,846 77,260 80,034 79,039 2,757, $ ,730,147 1,542,198 1,345,094 1,138, , , ,240 $22,437, , , , , , , ,092 2,361, , , , , , , ,628 3,693,530 2,335,660 2,059,369 1,965,216 1,747,772 1,431,662 1,314,045 1,288,960 28,492, , , , , , , ,375 4,287, , , , , , , , ,350 42,460 40,593 39,251 37,217 37,220 29,236 27,792 1,781,010 1,567,732 1,420,081 1,212, , , ,783 23,225, ,343 76,107 53,364 50,921 51,495 54,059 59,008 14,592 14,547 14,511 15,900 16,254 15,776 16,443

84 ,613,240 1,647,694 $16,132, ,453 92, , ,300 59, , ,212 20, , , ,639 2,245, ,440 8,641 84, (899) (535) (8,990) , ,440 2,472, , ,307 1,161, , ,223 1,409, ,416 51, , ,243,792 2,357,713 22,437, ,835 62, , , ,546 2,701, , ,693 2,604, ,330 63, , ,804 4,987 98, , ,688 6,456, (409,468) (382,242) (4,094,680) , ,446 2,361, , ,806 2,631, ,639 38, , ,625 22, , ,400 18,582 44, ,551 40, , , ,342 3,693, ,849,279 3,072,501 $28,492,790

85 ,561 3,561 $ 25, ,400 8, ,220 4,606 12, ,036 55, , ,209 17,177 22, ,465 76, , , , , , ,241 1,751, , , , , ,407 4,287, ,250 2,050 12, ,757 28, , ,152 4,315 41, , , , ,930 9, , , , , ,541 63, ,410 3,500,000, ,272, ,272, ,638 49, , ,523,641 2,297,438 25,236, (322,644) (193,932) (3,226,440) ,411, ,895, ,314,176 2,216,685 23,141, , ,045 1,304, (118) (398) (1,180) (163,728) 17,913 (1,637,280) (33,393) 203,560 (333,930) ,750 40, , ,322,533 2,461,116 23,225, ,849,279 3,072,501 $28,492,790

86 ,374,802 1,305,167 1,212,207 $13,748, , , ,102 2,786, , , ,296 6,730, , , ,398 9,516, , , ,809 4,231, ,063 56,244 34, , (333) (247) (365) (3,330) ,711 66,201 54, , , , ,645 17,058 12, , , , ,031 10, (5,149) 4,321 (5,486) (51,490) , , ,148 1,537, , , ,957 5,768, , , ,449 2,385, , (19,783) (15,078) (39,088) (197,830) , , ,361 2,187, , , ,596 3,580, ,622 3,730 3,347 26, , , ,249 $ 3,554, $

87 , , , (16,523) (32,165) (26) , , , , ,541 63,541 63,541 $ 635, ,541 63,541 63,541 $ 635, ,638 49,641 49,638 $ 496, (3) ,638 49,638 49,641 $ 496, ,297,438 2,062,226 1,834,931 $22,974, , , ,249 3,554, (129,251) (98,778) (85,561) (1,292,510) (1,495) (320) (393) ,523,641 2,297,438 2,062,226 $25,236, (193,932) (3,046) (2,908) $ (1,939,320) (128,758) (235,834) (156) (1,287,580) , (322,644) (193,932) (3,046) $ (3,226,440) ,314,176 2,216,685 2,172,362 $23,141, , , ,342 $ 1,860, (55,592) 14,201 46,502 (555,920) , , ,844 $ 1,304, (398) $ (3,980) (398) 2, (118) (398) $ (1,180) ,913 4,223 (69,130) $ 179, (181,641) 13,690 73,353 (1,816,410) (163,728) 17,913 4,223 $ (1,637,280) (33,393) 203, ,067 $ (333,930) ,871 $ 408, , (6,323) 8, ,750 40,871 $ 417, ,322,533 2,461,116 2,348,429 $23,225,330

88 , , ,957 $ 5,768, (263,795) (356,979) (161,843) (2,637,950) ,690 28,820 28, , (96) (3,413) 2,005 (960) (12,192) (8,145) (11,541) (121,920) (38,645) (17,058) (12,048) (386,450) (20,411) (18,981) ,832 (30,020) (13,156) 68, (14,510) (7,052) (5,647) (145,100) (1,033) 1,213 8,789 (10,330) ,402 (4,484) 40,742 74, (284,347) (416,099) (144,382) (2,843,470) , , ,575 2,924, (252,637) (325,813) (468,274) (2,526,370) , , ,011 3,084, (41,300) (59,900) (29,900) (413,000) ,900 29, , (32,618) (29,151) (32,093) (326,180) ,228 6, , (455) (5,210) (1,588) (4,550) ,503 39,968 13, , , (1,756) (4,724) (17,560) , (2,594) (1,798) (406) (25,940) , ,392 6,566 1,017, (787) 188 (884) (7,870) , (1,400) (2,076) (3,218) (14,000) (128,758) (213,734) (156) (1,287,580) (129,167) (98,757) (85,529) (1,291,670) (1,970) (1,563) (1,353) (19,700) (262,082) (315,942) (89,290) (2,620,820) (166,616) 11,729 71,060 (1,666,160) (34,454) 21, ,911 (344,540) ,647,694 1,626,235 1,264,324 16,476, ,613,240 1,647,694 1,626,235 $16,132,400

89 $ 1, , , (5,237) (1,794) (39) (89) (585) , , (1,389) ,772 $ $ 5, ,824 3,146 18, , (286) (501) (2,860) (311) (791) (3,110) (180) ,762 5,080 17, (6) (356) (60) ,756 4,724 $17, ,056 $ , (7,568) (3,255) (422) , , ,800 $ ,429 $

90 = TAP i ii iii

91 ,65636,5601,34313,

92 a b ,403869,957885,

93 : , , , , , , ,480 : , , , , , , , ,466 : $ $ $ $ ,120 2,156,750 4,900 2,530, , , , , : : ,344 7,113 $ 73, ,000 5,000 50, , : : ,906 $459, , ,507 25, ,932 $489, : : ,800 25,906 $ 48, ,839 12, , ,639 38,839 $296,390

94 : : , ,449 $1,810, ,138 79, , , ,378 2,282, , ,614 1,345, ,016 39, , , ,197 $ 796,170 : : , , ,378 $4,368, , , ,994 1,086,700 : : , , ,522 $1,111, ,144 77,827 72, , : : ,696 36,410 $ 456, ,712 34, , ,723 34, , , ,307 $1,161, % 2.2% : : : [:2008~ % %] ,200 $ 8,000 : [: % %] ,250 1,250 12, ,050 3,450 20, ,400 8, ,250 2,050 $12,500

95 : : $ 8, ,250 12, ,050 $20, : : ,617 $56, : ,255 3,466 13, ,116 1,791 6, ,139 1,675 6,814 : ,110 3,292 13, ,145 1,672 6, ,965 1,620 6,585 : $102,550 $34,660 $137, ,160 17,910 69, $ 51,390 $16,750 $ 68,140 : : ,541 2,468 $ 25, ,273 4,117 42, ,814 6,585 $ 68,140

96 : : ,722 2,646 $ 27, ,722 2,646 27, : : ,031 1,568 $ 20, ,505 5,400 65, ,536 6,968 $ 85, ,411 13, ,03110, : : , ,554 $ 2,404, (262,230) (293,966) (2,622,300) (5,953) 25,681 (59,530) ,913 13, , (16,828) 2,892 (168,280) (34,365) (23,750) (343,650) ,537 26,642 $ 175,370 : : (7,423) $ (74,230) ,313 13, (6,110) $ (61,100) 5,08050,8004

97 : : ,879 5,124 $ 48, ,913 5,290 49, (5,870) (5,776) (58,700) (5,587) (2,541) (55,870) (2,981) (683) (29,810) (4,646) 1,414 (46,460) (1,031) (10,310) , (5,118) 1,414 $(51,180) %2.0% 2.0%2.3% %2.5% 1.5%2.5% ,22022,2001, % 10% 25% ,807708, ,7882,757,880193, ,645

98 , , , % 40.9% 40.9% (3.5) (3.3) (3.3) (0.1) (0.1) (0.1) (3.9) (1.2) (1.6) (0.2) % 45.7% 38.9% : : ,357 10,324 $ 103, ,972 54, , ,639 10,024 66, ,108 6,828 91, ,401 25, , ,878 12,835 88, ,039 18, , ,816 9,697 58, ,552 16, , ,530 3, , ,859 14, , ,956 34, , , ,816 2,551, (19,579) (3,443) (195,790) , ,373 2,355, (14,055) (9,713) (140,550) (31,333) (26,999) (313,330) (84,889) (120,561) (848,890) (11,904) (13,352) (119,040) (7,975) (10,631) (79,750) (150,156) (181,256) (1,501,560) ,372 33,117 $ 853, TAP 57,080

99 : ,272,061 1,202, , , ,374,802 1,305, : , , ,688 10, , , : $12,720,610 $4,113, ,027, , $13,748,020 $4,231, : , , , , ,846,091 1,980, ,849,279 3,072, : ,423 21, ,396 6, ,690 28,820

100 20083 : ,949 32, ,959 5, ,908 38,510 : $ 7,839,060 $244,230 $299, ,192,820 63,960 89, ,460,910 8, $28,492,790 $316,900 $389,080 1,847,62318,476,230 1,982, : , , , , , , ,260 10, ,374,802 1,305,167 : , , ,701 89, ,049 32, ,812 2, (276,502) (195,972) , ,500

101 20083 : , , , , , , ,153 15, ,747,041 1,905, ,849,279 3,072,501 : $ 8,593,290 $ 5,400,630 $ 7,783, ,579,050 1,257,010 1,971, ,473, ,490 1,115, ,600 18, , (2,765,020) 17,470, $13,748,020 $ 4,231,230 $28,492, ,7882,757, ,301 1,892,93818,929,380 2,055,908 : : , , ,922 $4,633, , , ,223 2,036, ,205 24,979 20, , , , ,124 $6,942, % 32.7% 27.7% % 49.3% 44.3%

102 : : ,263 $22, AWPAverage Wholesale Price: AWPTAP :AWP1 TPNAAWP TAP TAP 61, TAH 50%TAPTAP TAP TPNATGRD TAP TAPTAH100%TAP dexlansoprazoletak-390mr ilaprazoleiy-81149febuxostattmx TAPTPNATAPTGRD 3 TAP Pharmaceutical Products Inc. Takeda Pharmaceuticals North America,Inc. Takeda Global Research & Development Center Inc North Field Drive Lake Forest, IL 60045,U.S.A. One Takeda Parkway Deerfield, IL 60015, U.S.A. One Takeda Parkway Deerfield, IL 60015, U.S.A. Alan MacKenzie Mark Booth Dave Recker

103 2. 4 TAH100%Mahogany Acquisition Corp. 5 TAH100% 1 2 Millennium Pharmaceuticals, Inc. Deborah Dunsire 1, ,850, NASDAQ UBS Investment Bank 5 0% 100% ,10057, ,699100, , ,

104 KPMG AZSA & Co Takeda Pharmaceutical Company Limited Annual Report 2008 Independent Auditors Report 102

105

106

107

108 , ,272, UFJ , % 48, % 41, % 19, % 17, % , % 13, % 12, % 12, % 10, % TOPIX 9,000 TOPIX 3,000 7,500 2,500 6,000 2,000 4,500 1,500 3,000 1,000 1, TOPIXTOPIX

109 Tel: Fax: Tel: Fax:

110

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