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12 2) Dolphin, A., Jenner, P., Marsden, C,D., Pycock, C. and Tarsy, D. : Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodents, Psychopharmacologia, 41 : 133, ) Mori, M., Kobayashi, I., Shimomura, S., Uehara, T., Nemoto, T., Fukuda, H. and Kamio, N. : Effect of Sulpiride on serum growth hormone and prolactin concentrations following L-DOPA administration in man. Endocrinol. Japon., 24 : 149, ) McNeilly, A, S., Thorner, M, O., Volants, G. and Besser, G, M.: Metoclopramide and prolactin. Brit. Med. J., 13 : 729, ) Wood, L, J. : Value of gastric biopsy in the study of chronic gastritis and pernicious anemia, Brit. Med. J., II : 823, ) Borenstein, P and Bles, G. : Effects cliniques et electroencephalographiques du metoclopramide en psychiatrie. Therapie, , ) McGuigan, J, E. : The Gastrointestinal Hormones, The Textbook of Endocrinology (edited by Willias, R, H.), 5th ed., W.B. Saunders Co., Philadelphia, 1974, P.841, 20) Wesdorp, R, I, C. and Fisher, G, E. : Plasma gastrin and acid secretion in patients with peptic ulceration, Lancet, II : 857, 1974.

13 21) Trudeau, W, L. and McGuigan, J, E. : Relations between serum gastrin levels and rates of gastric hydrochloric acid secretion, New Engl. J. Med., 284 : 408, ) Trudeau, W, L. and McGuigan, J, E.: Serum gastrin levels in patients with peptic ulcer disease, Gastroenterology, 59 : 6, ) Korman, M, G., Strickland, R, G. and Hansky, G. : Serum gastrin in chronic gastritis, Brit. Med. J., 2 : 16, ) Korman, M, G., Hansky, J. and Strickland, R, G. : Progressive increase in the functional G cell mass with age in atrophic gastritis, Gut, 14 : 549, ) Connell, A. M. and George, J. D, : Effect of metoclopramide on gastric function in man, Gut, 10 : 678, 1969.

14 CLINICAL STUDIES ON CHRONIC GASTRITIS. I. EFFECT OF A FEW DRUGS ON CLINICAL EVALUATIONS AND SERUM GASTRIN LEVELS. TAIDOH ARAI The First Department of Internal Medicine, School of Medicine, Gunma University, Maebashi, Japan (Director Prof. Setsuo Kobayashi) The pathophysiology of chronic gastritis remains to be determined. Metoclopramide, sulpiride and drugs which mainly act on the central nervous system, were reported to be effective against various complaints in patients with chronic gastritis. The aim of the present study was to analyze the part of pathophysiology of chronic gastritis. In addition, the effects of these drugs on clinical evaluations were compared. Nineteen patients with chronic gastritis (aged 25 to 74 years), 21 men and 8 women, were studied. All patients were orally given a therapeutic dose of metoclopramide (30 mg/day), sulpiride (300 mg/ day) and ć-oryzanol (300 mg/day) for 4 weeks. Serum gastrin was determined by radioimmunoassay. The results obtained herein were as follows : 1. Sixty two% of the patients was found to be neurotic, suggested by the method of modification of CMI test. 2. Various kinds of complaints were observed in patients with chronic gastritis. These include nausea, fatigability, and postpradial fullness and discomfort in the upper abdomen. 3. The effective rates of metoclopramide, sulpiride and ć-oryzanol against various complaints were 66.7%, 86.7% and 75.0%, respectively. It was of interest to note that sulpiride was the most effective against psychic complaints. 4. Administration of ć-oryzanol resulted in decreased serum gastrin levels, while no change was observed in metoclopramide or sulpiride-treated groups. 5. No effect by these drugs on the rate of secretion of gastric juice was found. Key words : Chronic gastritis, Gastrin.

1) Roth, J., Glick, S. M., Yalow, R. S. and Berson, S. A.: Hypoglycemia: A potent stimulus to secretion of growth hormone. Science, 140, 987-988, 1963. 2) Ogawa, N.: Routine Ultramicro-Measurement of Human

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