（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果

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1 1,4-1 1,4- p- 1, 4-1, 4- CAS C 4 H 8 O ) 2) ) 1- / (logp ow ) mmhg 3) ) 37 mmhg25 5) 1 ppm = 3.60 mg/m 3 at 25, 6) ) 8) 9) 3 7) 7) 10) 11) OH NO NO 12) 2.6 BOD 0% mg/l 30 13) 6) n- / BCF mg/l 13) mg/l 13) 112

2 14) ,500t 113

3 1 EUSES 2.1 2,400 km

4 µg/m 3 µg/g µg/l µg/l µg/l µg/kg µg/kg /12 0/45 0/15 9/16 3/65 11/17 11/17 13/17 0/11 14/18 11/19 0/16 0/17 1/17 0/17 0/19 1/ µg/l µg/l )

5 m 3 2 L 2,000 g 50 kg µg/m µg/kg/day 0.05 µg/l µg/kg/day 0.21 µg/l µg/kg/day 0.01 µg/g µg/kg/day 0.45 µg/m µg/kg/day 0.05 µg/l µg/kg/day 88 µg/l 3.5 µg/kg/day 0.01 µg/g µg/kg/day µg/kg/day 0.45 µg/m µg/kg/day 0.4 µg/kg/day µg/l 33 µg/kg/day 0.14 µg/kg/day 0.54 µg/kg/day 116

6 2.4 µg/kg/day µg/kg/day PEC 2.5 PEC 88 µg/l 4.4 µg/l µg/l 88 µg/l 0.16 µg/l 4.4 µg/l 117

7 1 1) 3.1 LD 50 4,200 mg/kg LD 50 5,300 mg/kg LD 50 3,150 mg/kg LD 50 2,000 mg/kg LC 50 46,000 mg/m 3 (2hr) LC 50 37,000 mg/m 3 (2hr) LCLo 44,000 mg/m 3 (7hr) 2) TCLo 1,720 mg/m 3 1) Sherman ,015 mg/kg/day ,599 mg/kg NOAEL 9.6 mg/kg/day 3) F344/DuCrj mg/kg/day mg/kg/day ) LOAEL 16 mg/kg/day() Wistar mg/m / 5 / 400 mg/m 3 ALP NOAEL 400 mg/m 3 83 mg/m 3 6) mg/m mg/m 3 GOT GPT 20.5 mg/m 3 7) 118

8 Sprague-Dawley ,033 mg/kg/day ,033 mg/kg/day 8) NOAEL 517 mg/kg/day Sprague Dawley 2035 Swiss Webster % 1,1,1-300 ppm 7 / 9) 120 mg/m 3 10) Osborne-Mendel % ) GOTGPT -GPT -GPT 80g/ mg/m mg/m 3 12) mg/m 3 13) 2 Fischer 344/DuCrj mg/kg/day mg/kg/day ) 0.5 Crj:BDF mg/kg/day ,070 mg/kg/day ) B6C3F mg/kg/day mg/kg/day ) Osborne-Mendel mg/kg/day 119

9 mg/kg/day ) 19, mg/m ) IARC 2B 16) 3 NOAEL NOAEL 9.6 mg/kg/day NOAEL 400 mg/m 3 83 mg/m MOE 0.40 µg/kg/day 0.40 µg/kg/day 9.6 mg/kg/day 2, µg/kg/day µg/m µg/m 3 18, mg/m 3 1 2() 0.40 µg/kg/day 33 µg/kg/day 9.6 mg/kg/day MOEMargin of Exposure 2,

10 MOE µg/m µg/m 3 83 mg/m 3 MOE 18,

11 [µg/l] [] a b c No. 580,000 Selenastrum capricornutum NOEC BMS 3 1,000,000 Selenastrum capricornutum NOEC GRO 3 >1,000,000 Selenastrum capricornutum EC 50 BMS 3 >1,000,000 Selenastrum capricornutum EC 50 GRO 3 1,000,000 Daphnia magna NOEC REP 21 >1,000,000 Daphnia magna EC 50 IMM 2 4,700,000 Daphnia magna LC 50 MOR ,450,000 Daphnia magna EC >100,000 Oryzias latipes LC 50 MOR 4 1,870,000 Oryzias latipes NOEC GRO ,700,000 Menidia beryllina LC 50 MOR ,850,000 Pimephales promelas LC 50 MOR ,800,000 Pimephales promelas LC 50 MOR PNEC PNEC EC 50 Median Effective Concentration: LC 50 Median Lethal Concentration): NOECNo Observed Effect Concentration: BMSBiomass : GROGrowth IMMImmobilization): MORMortality): REPReproduction): 2 PNEC PNEC Selenastrum capricornutum 72 EC 50 1,000,000 µg/l Daphnia magna 48 EC 50 1,000,000 µg/l Pimephales promelas 96 LC 50 9,850,000 µg/l ,850,000µg/L PNEC 98,500 µg/l Selenastrum capricornutum

12 NOEC 580,000 µg/l Daphnia magna 21 NOEC 1,000,000 µg/l Oryzias latipes 28 NOEC 1,870,000µg/L ,000 µg/l PNEC 58,000 µg/l PNEC 10 58,000µg/L [95 ] PNEC PEC/ PEC PNEC 0.21µg/L () 88µg/L () 58, µg/L () 4.4µg/L () µg/l µg/L 0.16 µg/l PEC 88µg/L 4.4µg/L PEC PNEC

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化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]

化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質] (1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16