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13 (Quincke s edema) 12

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16 15 J Allergy Clin Immunol 115;S483-S523, 2005

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19 IgE IgE IgE 18

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23 腿 22

24 Hydrocortisone mg 5 mg/kg Methylprednisolone 40 mg 1 mg/kg μg/kg 15 mg 2030μg/kg 5 515μg 23

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26 腿 腿 25

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30 1)deShazo RD and Kemp AF:Allergic reactions to drugs and biologic agents.jama 278: (1997) 2)Adkinson NF Jr: Drug allergy in Allergy: Principles and practice. 6 th Eddition. (edited by NF Adkinson Jr. et al. ) Mosby Year Book Philadelphia, pp (2003) 3) Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October J Allergy Clin Immunol 113: (2004) 4) Soar J, Pumphrey R, Cant A, Clarke S, Corbett A, Dawson P, Ewan P, Foex B, Gabbott D, Griffiths M, Hall J, Harper N, Jewkes F, Maconochie I, Mitchell S, Nasser S, Nolan J, Rylance G, Sheikh A, Unsworth DJ, Warrell D; Working Group of the Resuscitation Council (UK). Emergency treatment of anaphylactic reactions? Guidelines for healthcare providers. Resuscitation 77, (2008) 5)2005) 6)54: (2005) 7)pp (1998) 8) The diagnosis and management of anaphylaxis: An updated practice parameter. J Allergy Clin Immunol 115: s (2005) 9) Guidelines for the management of anaphylaxis in the emergency department. J Accid Emerg Med. 15;96-98 (1998) 10) Simons FER: Anaphylaxis, killer allergy :Long-term management in the community. J Allergy Clin Immunol. 117; (2006) 11) Lane SJ, Lee TH: Anaphylaxis. In Allergy and Allergic Diseases, edited by A.B.Kay, Blackwell Science Ltd. London, pp (1997) 29

31 1 1 1 ICH MedDRA/Jver Preferred Term 30

32 31 兎

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34 ICH MedDRA/Jver.10.1 EU ICHICH MedDRA ICH MedDRA/J MedDRA SMQSMQ MedDRA PT (Preferred Term) LLT (Lowest Level Term) Anaphylactic shock Anaphylactic shock Anaphylactic shock due to tree nuts and seeds Anaphylactic shock due to peanuts Penicillin shock Anaphylactic shock due to fruits and vegetables Anaphylactic shock due to fish Anaphylactic shock due to crustaceans Anaphylactic shock due to unspecified food Anaphylactic shock due to food additives Anaphylactic shock due to milk products Drug shock Anaphylactic shock due to adverse food reaction 33

35 Anaphylactic shock due to eggs PT (Preferred Term) LLT (Lowest Level Term) Anaphylactic reaction Anaphylaxis Anaphylactic reaction Anaphylactic reaction to vaccine Exercise-induced anaphylaxis Anaphylactic reaction to chemical Acute anaphylaxis Acute anaphylactic reaction Anaphylactic reaction to food Systemic anaphylaxis Systemic anaphylactic reaction Systemic allergic reaction Anaphylactic reaction to drug PT (Preferred Term) LLT (Lowest Level Term) Anaphylactoid shock Anaphylactoid shock PT (Preferred Term) LLT (Lowest Level Term) Anaphylactoid reaction Anaphylactoid reaction Delayed anaphylactoid reaction 34

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