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1 A A SCU B 10 2 SCU A 18 A B SCU HMGCoA

2 14 1 Spreading Depression (SD) Cyclooxygenase-2 (COX-2) HMGCoA 14 1 COX

3 - 30 -

4 1) Arakawa S, Minematsu K, Hirano T, Tanaka Y, Hasegawa Y, Hayashida K, Yamaguchi T: Topographic distribution of misery perfusion in relation to internal and superficial borderzones. AJNR Am J Neuroradiol 24: , 2) Chambers B, Stork J, Kimura K, Abbott A, Levi C, Donnan G: Symptomatic carotid artery stenosis: Heterogeneity of destabilizing mechanisms? Stroke 34: e41, 3) Excutive Steering Committee on behalf of the SPORTIF Investegators. (Minematsu K): Stroke prevention with the oral direct thrombin inhibitor ximelagatra compared with warfarin in patients with non-valvular atrial fibrillation(sportif ): ranbomised controlled trial. Lancet 362, , 4) Hasegawa Y, Tagaya M, Fujimoto S, Hayashida K, Yamaguchi T, Minematsu K: Extracorporeal double filtrationn plasmapheresis in acute atherothrombotic brain infarction caused by major artery occlusive lesion. J Clin Apheresis 18, , 5) Kimura K, Minematsu K, Wada K, Yonemura K, Nakajima M: Clinical characteristics in transient ischemic attack patients with atrial fibrillation. Internal Medicine 42: , 6) Matsumoto N, Kimura K, Yokota C, Yonemura K, Wada K, Uchino M, Minematsu K: Early neurological deterioration represents recurrent attack in acute small non-lacunar stroke. J Neurogical Sci , 7) Saito K, Kimura K, Minematsu K, Shiraishi A, Nakajima M:Transient global amnesia associated with an acute infarction in the retrosplenium of the corpus callosum. Journal of the Neurological Sciences 210: 95-97, 8) Okamoto A, Sakata T, Mannami T, Baba S, Katayama Y, Matsuo H, Yasaka M, Minematsu K, Tomoike H, Miyata T. Population-based distribution of plasminogen activity and estimated prevalence and relevance to thrombotic diseases of plasminogen deficiency in the Japanese : the Suita Study. Journal of Thrombosis and Haemostasis, 1: , 9) Otani R, Kazui S, Tomimoto H, Minematsu K, Naritomi H: Clinical and radiographic features of lobar cerebral hemorrhage: Hypertensive versus non-hypertensive cases. Intern Med 42; , 10) Sawada K, Naiki M, Yago H, Matsushita K, Ohtsuki T, Kitagawa K, Matsumoto M,

5 Hori M: Hypertension associated with reduced plasm thrombomodulin levels and a hypercoagulable state in rats. Clin. Exper. Hypertension. 25: 73-84, 11) The Edaravne Acute Brain Infarction Study Group: Effect of a Novel Free Radical Scavenger,Edaravone(MCI-186),onAcut Brain Infarction Randomized,Placebo-Controlled, Double-Blind Study at Multicenters. Cerebrovas Dis. 15; , 12) Yasaka M, Sakata T, Minematsu K, Naritomi H: Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication. Thrombosis Research 108: 25-30, 13) Yasaka M, Minematsu K, Naritomi H, Sakata T, Yamaguchi T: Predisposing factors for enlargement of intracerebral hemorrhage in patients treated with warfarin. Thromb Haemost 89: , 14) Yasaka M, Oomura M, Ikeno K, Naritomi H, Minematsu K: Effect of prothrombin complex concentrate on INR and blood coagulation system in emergency patients treated with warfarin overdose. Ann Hematol 82: , 15) Yokota C, Kuge Y, Inoue H, Tagaya M, Kito G, Susumu T, Tamaki N, Minematsu K: Post-ischemic cyclooxygenase-2 expression is regulated by the extent of CBF reduction in non-human primates. Neurosci Lett. 341: 37-40, 16) Yokota C, Inoue H, Kuge Y, Abumiya T, Tagaya M, Hasegawa Y, Ejima N, Tamaki N, Minematsu K: Cyclooxygenase-2 expression associated with spreading depression in a primate model. J Cereb Blood Flow Metab 23: , 17) Yonemura K, Kimura K, Yasaka M, Minematsu K: Disappearrance of an 0scillating intraluminal thrombus in the carotid artery demonstrated by ultrasonography. Internal Medicine 42: , 1) Minematsu K: Evacuation of intracerebral hematoma is likely to be beneficial. Stroke. 34; , 1) : NIHSS ; 25, ,

6 2) ) Stroke Scale 25, , 4)?. 43, 10-18, 1) Stroke unit stroke care unit ) )?. 35 I ) ). Heart View ) :. Medicina 40, , 7). BRAIN MEDICAL ) 15: ) ) ) Ca. Hypertension Focus

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