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1 Davis, R.J., D Cruz, C.M., Lovell, M.A., Biegel, J.A., & Barr, F.G. Cancer Res.,,. Nakae,J.,Oki,M.,&Cao,Y. FEBS Lett.,,. Kodama, S., Koike, C., Negishi, M., & Yamamoto, Y. Mol. Cell Biol.,,. Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K., Fukamizu, A. Proc. Natl. Acad. Sci. USA,,. Kamei, Y., Mizukami, J., Miura, S., Suzuki, M., Takahashi, N., Kawada, T., Taniguchi, T., & Ezaki, O. FEBS Lett.,,. Furuyama, T., Kitayama, K., Yamashita, H., & Mori, N. Biochem. J.,,. Kamei, Y., Miura, S., Suganami, T., Akaike, F., Kanai, S., Sugita, S., Katsumata, A., Aburatani, H., Unterman, T.G., Ezaki, O., & Ogawa, Y. Endocrinology,,. Kamei, Y., Miura, S., Suzuki, M., Kai, Y., Mizukami, J., Taniguchi, T., Mochida, K., Hata, T., Matsuda, J., Aburatani, H., Nishino, I., & Ezaki, O. J. Biol. Chem.,,. Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S.H., & Goldberg, A.L. Cell,,. Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf,R.,DelPiccolo,P.,Burden,S.J.,DiLisi,R.,Sandri,C., Zhao, J., Goldberg, A.L., Schiaffino, S., & Sandri, M. Cell Metab.,,. Southgate, R.J., Neill, B., Prelovsek, O., El-Osta, A., Kamei, Y., Miura, S., Ezaki, O., McLoughlin, T.J., Zhang, W., Unterman, T.G., & Febbraio, M.A. J. Biol. Chem.,,. Kitamura, T., Kitamura, Y.I., Funahashi, Y., Shawber, C.J., Castrillon, D.H., Kollipara, R., DePinho, R.A., Kitajewski, J., & Accili, D. J. Clin. Invest.,,. Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R.X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S., Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M., Kodama, T., & Sakai, J. Proc. Natl. Acad. Sci. USA,,. Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A. Proc. Natl. Acad. Sci. USA,,. COE Skeletal muscle function and FOXO Yasutomi Kamei and Yoshihiro Ogawa Department of Molecular Medicine & Metabolism, Medical Research Institute, Tokyo Medical & Dental University, Yushima, Bunkyo-ku, Tokyo, Japan; Global COE Program, Tokyo Medical & Dental University DNA DNA DNA DNA DNA DNA DSB NHEJHR Rad DNA DNA S G G NHEJ DNA DSB NHEJ HR G G S G DNA DSB
2 DNA DSB HR NHEJ NHEJ NHEJ DSB NHEJ DNA DNL DNA ligaseiv-nej -Lif YKU HDF YKU HDF LIF NEJ DNL MRE RAD XRS micro-homology dependent NHEJ POL RAD ligase IV NHEJ classical-nhej HR DNA DSB CDK G NHEJ NHEJ Mre Mre Rad Rad SMC Xrs Nbs MRX N Dnl DNA ligase IV NHEJ DNA Lif Xrcc ligase IV Nej XLF ligase IV Ku Hdf Ku DSB Ku Hdf Ku DSB DNA-PKcs PI Pso Artemis DSB Pol Polµ DNA Polλ DNA Rad FEN- Flap NHEJ DNL Nej NHEJ
3 NHEJ Xrs FHA NHEJ Mre -Rad -Xrs MRX Mre -Rad -Nbs MRN DSB DSB xrs -SH MRX foci DSB A Xrs Mre FHA Xrs DSB Mre B HO DSB DSB DNA FHA NHEJ
4 DSB DNA MRX HR NHEJ MRN NHEJ Mre Rad sbccd structural maintenance of chromosomes SMC DSB Xrs Nbs Nijmegen breakage syndrome NBS Nbs N Xrs Nbs N Xrs Nbs N fork-head associated FHA FHA DNA Rad FHA Rad Xrs FHA FHA MRX A DNA DNA MMS DNA NHEJ DNA Xrs FHA NHEJ FHA XRS FHA FHA xrs xrs - M FHA xrs -SH DNA HO DSB B G HO DSB NHEJ LIF DSB DSB NHEJ FHA DSB Xrs FHA NHEJ NHEJ FHA Lif FHA NHEJ NHEJ Xrs NHEJ DNA DNL Lif Xrs FHA DSB DSB MRX Xrs FHA DNL DSB Xrs Lif FHA Nbs Xrcc Nbs NHEJ Lif Lif C Xrs Lif N Nej Dnl C Xrs Xrs CK Lif CK
5 Lif Xrs DSB DNA DNA Xrs FHA FHA Lif CDK NHEJ Matsuzaki et al., unpublished result Xrs NHEJ Hefferin, M.L. & Tomkinson, A.E. DNA Repair Amst,,. Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., Haber, J.E., & Foiani, M. Nature,,. Valencia, M., Bentele, M., Vaze, M.B., Herrmann, G., Kraus, E., Lee, S.E., Schar, P., & Haber, J.E. Nature,,. Frank-Vaillant, M. & Marcand, S. Genes Dev.,,. Moore, J.K. & Haber, J.E. Mol. Cell Biol.,,. Wiltzius, J.J., Hohl, M., Fleming, J.C., & Petrini, J.H. Nat. Struct. Mol. Biol.,,. Sun, Z., Hsiao, J., Fay, D.S., & Stern, D.F. Science,,. Shima, H., Suzuki, M., & Shinohara, M. Genetics,,. Matsuzaki, K., Shinohara, A., & Shinohara, M. Genetics,,. Palmbos, P.L., Daley, J.M., & Wilson, T.E. Mol. Cell Biol.,,. Regulation mechanism of non-homologous end joining through the Lif phosphorylation Miki Shinohara Department of Integrated Protein Functions, Institute for Protein Research, Osaka University, Ymada-oka, Suita, Osaka, Japan plant secondary product glycosyltransferases PSPG Arabi-
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Teru Ogura, Tomoko Yamada-Inagawa, E-mail : ogura@gpo.kumamotou.ac.jp AAA family ATPases : ring-shaped chaperones which catalyze energy-dependent conformational changes of proteins 29) Braun, S.,
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Review Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge E-mail : m.mishima @gurdon.cam.ac.uk http://www.gurdon.cam.ac.uk/groups/mishima.html Cytokinesis :
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The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Key words Shigeyuki Kawai, Chikako Fukuda, Kousaku Murata E-mail : kawais@kais.kyoto-u.ac.jp, chikakko@kais.kyotou.ac.jp,
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核内受容体コファクターによる脂肪形成の制御 亀井康富 研究のねらい 核内受容体はステロイドや脂溶性ビタミンをリガンドとする転写因子である 核内受容体は複数のコファクターと蛋白質 蛋白質相互作用し 機能している 本研究者は さきがけ研究 21において 環境の変化に応答してコファクター蛋白質の発現量が変動し 生体外部あるいは内部の環境に適応するシステム を仮説モデルとして提言した そして 1) コファクター
Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,
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The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical
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第５８巻６号／投稿規定・目次・表２・奥付・背
Feature articles 1Why is it that allergic diseases have been increasing? Feature articles 2Space medicine and medicine for the future Review γ ε γ γ γγ α αβ et al et al et al et al et al et al Is nutritional
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1) Bittner, J. J.: Science, 84, 162 (1936) 13) Michalides, R., van Ooyen, A., Nusse, R.: Curr. Top. Microbiol. Immunol., 106, 57-74 (1983) 2 z Yamamoto, K. R.: Ann. Rev. Genn., 19, 209-252 (1985) 3) Evans,
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Establishment and progress of Sendai virus engineering 2) Schnell, M. J., Mebatsion, T., Conzelmann, K.-K.: EMBO J., 13,4195-4203(1994) 3) Kato, A. et al.: Genes Cells, 1, 569-579 (1996) 4) Nagai,
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第６１巻５・６号（１２月号）／特集１頁目（本刷）
Special Issue 1Sudden cardiac death symposium in Tokushima Special Issue 2How to do for your health? Reviews Original Epidemiologic problems of sudden death of school children in Tokushima Prefecture
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1) Araki, T.: Curr. Opin. Plant Biol., 4, 63-68 (2001) 2) Boss, P. K., Bastow, R. M., Mylne, J. S., Dean, C.: Plant Cell, 16, S18-S31(2004) 3) Simpson, G. G., Dean, C. : Science, 296, 285-289 (2002) 4)
[Department of Pediatrics, Gifu University School Clinical. Pathological and Biochemical Abnormality in peroxisomal Disorders 1) Goldfischer, S., Moore, C. L., Johnson, A. B., Spiro, A. J., Valsamis,
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[ Nippon Nageikagaku Kaishi Vol. 72, No. 11, pp. 1333 `1344, 1998 l Key words: methylotrophic yeast; gene expres sion; C1-metabolism; peroxisome Cellular Functions of the Methylotrophic Yeast: Their Molecular
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Database Center for Life Science Online Service Key words Kikuya Kato, E-mail : kkato@bs.aist-nara. ac.jp http://love2.aist-nara.ac.jp Shin Ishii, E-mail : ishii@is.aist-nara.ac.jp http://hawaii.aist-nara.
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Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,
第124回日本医学会シンポジウム
III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2
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Feature articlesdiet in a society with a growing elderly population and a low birth rate Original The problems of breastfeeding Kazuhisa Maeda, Ryuji Mitani, Satoko Endo, Yoshika Saijo, and Toshihiro
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