DIALOG MEDLINE...1 BIOSIS PREVIEWS...7 DIOGENES: ADVERSE DRUG EVENTS DATABASE PHARMAPROJECTS...21 IMS R&D FOCUS...22 DATASTAR..

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1 DIALOG MEDLINE...1 BIOSIS PREVIEWS...7 DIOGENES: ADVERSE DRUG EVENTS DATABASE PHARMAPROJECTS...21 IMS R&D FOCUS...22 DATASTAR Loop-X F FAX FAX

2 OUG 2004/04/15 Dialog MEDLINE MEDLINE Dialog 2004 Annual Reload MeSH NLM Alert Search Save (1)MeSH (2) a. CASE REPORTS Publication Type DT= Prefix DT=CASE REPORTS b. ANIMALS ANIMALS" ANIMAL POPULATION GROUPS (GS) "ANIMAL" "ANIMALS" ANIMALS B1 Cascaded Term DC=B Tree 2004 Tree B1 Invertebrates B1 Animals B2 Vertebrates Animal Population Groups B3 Bacteria Chordata B4 Viruses Chordata, Nonvertebrate B5 Algae and Fungi Vertebrates B6 Plants Invertebrates B7 Archaea B2 Algae B3 Bacteria B4 Viruses B5 Fungi B6 Plants B7 Archaea 1

3 2004/04/15 OUG MeSH B3 D20 D27 MeSH URL URL c. Clinical Trial Cochrane Publication Type "Randomized Controlled Trial", "Controlled Clinical Trial" "Clinical Trial" 1,900 MEDLINE d. In Data Review "In Data Review" (NLM ) RT= Prefix MEDLINE NLM In Data Review MEDLINE In Process Completed "In Data Review" 2

4 OUG 2004/04/15 Original Paper e. AN=NLM AA= PubMed 3

5 2004/04/15 OUG 4

6 OUG 2004/04/15 5

7 2004/04/15 OUG 6

8 OUG 2004/04/15 BIOSIS Previews BIOSIS Previews 5, 55 (1) a. CAS CAS b ,300 c. BIOSIS BIOSIS (2) a. b. MeSH 1998 MeSH MeSH c. d. ECTI e. SLCODENCDIL SZPRDI 7

9 2004/04/15 OUG f. (NP) (IN) (MI) (CO) MI CO (3) support.dialog.com/searchaids/dialog/f5_codes/ 8

10 OUG 2004/04/15 DIOGENES: Adverse Drug Events Database FDA DIOGENES: Adverse Drug Events Database ( 181) DIOGENES: Adverse Drug Events Database FOI 2 ADR (Adverse Drug Reactions) AER ADR FDA (Adverse Event Reporting Systems) DIOGENES: Adverse Drug Events Database DIOGENES: Adverse Drug Events Database FDA FDA DIOGENES: Adverse Drug Events Database QC/QA VIRAMUNE 9

11 2004/04/15 OUG 10

12 OUG 2004/04/15 11

13 2004/04/15 OUG 12

14 OUG 2004/04/15 13

15 2004/04/15 OUG 14

16 OUG 2004/04/15 National Center for Health StatisticsNCHS Dialog Hospital Inpatient ProfilesHIP Hospital Outpatient Profiles DatabaseHOP 463 Emergency RoomERDatabase 454 2,600 ICD 15

17 2004/04/15 OUG 16

18 OUG 2004/04/15 17

19 2004/04/15 OUG Hospital Outpatient Profile 18

20 OUG 2004/04/

21 2004/04/15 OUG 20

22 OUG 2004/04/15 Pharmaprojects Pharmaprojects Bioavailabillity T1/2 Tmax Cmax AUC Vd Cl Dialog PharmacokineticsPK Pharmacokinetics: Human (5mg po)--bioavailability--18--% Human (5mg po)--t1/ hr Human (5mg po)--tmax hr Human (5mg po)--cmax ng/ml Human (5mg po)--auc nghr/ml Human (5mg po)--vd l/kg Human (5mg po)--cl l/hr/kg --(S) 21

23 2004/04/15 OUG IMS R&D Focus IMS R&D Focus RT=IMAGE 19 Substance Origin 22

OUG 2004/04/15 DATASTAR (1)Alert Alert e-mail HTML PDF Alert

NAHL 11,000 DataStarWeb Cinahl ThesaurusMapping DataStarWeb

24 OUG 2004/04/15 DATASTAR (1)Alert Alert HTML PDF Alert E-Journal Link (2)Cinahl Thesaurus Mapping Cinahl NAHL 11,000 DataStarWeb Cinahl ThesaurusMapping DataStarWeb ThesaurusMapping MEDLINEEMBASETOXFILEPsycINFO (3) DataStarWeb 23

25 2004/04/15 OUG (4)EBM Evidence-Based Medical Journals EBMJBMJ's Evidence-Based Journals British Medical Association Evidence-Based Medicine Evidence-Based Mental Health Evidence-Based Nursing (5)BIOSIS DataStar BIOSIS Previews Thesaurus Mapping Biosis Previews 24

PubMed 1. CD-ROM MEDLINE MeSH PubMed 2. Automatic Term Mapping MeSH 3. Related Article 1 1. 2. MeSH Browser MeSH PreMEDLINE MeSH -2-

PubMed 1. CD-ROM MEDLINE MeSH PubMed 2. Automatic Term Mapping MeSH 3. Related Article 1 1. 2. MeSH Browser MeSH PreMEDLINE MeSH -2- PubMed MEDLINE NLM 1879 Index Medicus 1960 MEDLARS Medical Literature Analysis and Retrieval System 1970 MEDLINE MEDlars online 1966 70 4,000 170 PubMed MEDLINE NLM National Center for Biotechnology Information