₂₆₁255 精神医学のフロンティア 統合失調症患者における認知機能障害の推定 : 多施設共同研究 藤野陽生 1,2, 住吉チカ 3, 安田由華 4, 山森英長 4, 藤本美智子 4, 福永雅喜 5, 三浦健一郎 6, 竹林佑人 7, 岡田直大 8, 磯村周一 9, 河
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1 ₂₆₁255 精神医学のフロンティア 統合失調症患者における認知機能障害の推定 : 多施設共同研究 藤野陽生 12 住吉チカ 3 安田由華 4 山森英長 4 藤本美智子 4 福永雅喜 5 三浦健一郎 6 竹林佑人 7 岡田直大 8 磯村周一 9 河野直子 1011 豊巻敦人 12 久我弘典 1314 磯部昌憲 815 大矢一登 16 岡久祐子 17 髙木学 17 橋本直樹 12 加藤正樹 18 鬼塚俊明 9 上野雄文 914 大沼徹 7 笠井清登 8 尾崎紀夫 11 住吉太幹 19 井村修 1 橋本亮太 420 COCORO Haruo Fujino Chika Sumiyoshi Yuka Yasuda Hidenaga Yamamori Michiko Fujimoto Masaki Fukunaga Kenichiro Miura Yuto Takebayashi Naohiro Okada Shuichi Isomura Naoko Kawano Atsuhito Toyomaki Hironori Kuga Masanori Isobe Kazuto Oya Yuko Okahisa Manabu Takaki Naoki Hashimoto Masaki Kato Toshiaki Onitsuka Takefumi Ueno Tohru Ohnuma Kiyoto Kasai Norio Ozaki Tomiki Sumiyoshi Osamu Imura Ryota Hashimoto COCORO(Cognitive Genetics Collaborative Research Organization) WAIS JART 索引用語
2 はじめに SD IQ IQ 332 IQ 332 JART WAIS JART IQ Ⅰ. 研究の方法および結果 PCN 9 1
3 257 1 N 446 N F P IQ JART IQ FSIQ FSIQ full scale intelligence quotient FSIQ IQ 9 SCID NP WAIS IQ FSIQ IQ JART WAIS FSIQ IQ WAIS 30 2 IQ EIQ FSIQ 2 P P 度数(% )10 推定認知機能障害スコア 1 9 F P FSIQ IQ F P F P FSIQ EIQ Kruskal Wallis test P 0.35 WAIS
4 感度 AUC=0.88 (95% Cl:0.86~0.90) 特異度 2 ROC 9 EIQ FSIQ receiver operating characteristic ROC AUC Ⅱ. 考察 本論文の意義 苦労 工夫したことなどを含めて IQ FSIQ WAIS EIQ EIQ JART JART IQ 10 EIQ FSIQ 0.9 1
5 WAIS おわりに 今後の課題および方向性 6 JSPS JP JP16H05375 JP H H H K21720 利益相反 MSD
6 Meiji Seika MSD Meiji Seika Meiji Seika MSD CogState Meiji Seika 謝辞 文献 1 Allen D. N. Goldstein G. Warnick E. A consideration of neuropsychologically normal schizophrenia. J Int Neuropsychol Soc Azechi M. Iwase M. Ikezawa K. et al. Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks a near infrared spectroscopy. Schizophr Res Badcock J. C. Dragović M. Waters F. A. et al. Dimensions of intelligence in schizophrenia evidence from patients with preserved deteriorated and compromised intellect. J Psychiatr Res Bowie C. R. Harvey P. D. Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatr Dis Treat Chou P. H. Koike S. Nishimura Y. et al. Similar age related decline in cortical activity over frontotemporal regions in schizophrenia a multichannel near infrared spectroscopy study. Schizophr Bull COCORO web.sakura.ne.jp/ lab/method_cognitive impairment.html Fujino H. Sumiyoshi C. Sumiyoshi T. et al. Performance on the Wechsler Adult Intelligence Scale in Japanese patients with schizophrenia. Psychiatry Clin Neurosci Fujino H. Sumiyoshi C. Sumiyoshi T. et al. Predicting employment status and subjective quality of life in patients with schizophrenia. Schizophr Res Cogn Fujino H. Sumiyoshi C. Yasuda Y. et al. Estimated cognitive decline in patients with schizophrenia a multicenter study. Psychiatry Clin Neurosci Fukumoto M. Hashimoto R. Ohi K. et al. Relation between remission status and attention in patients with schizophrenia. Psychiatry Clin Neurosci Hagiya K. Sumiyoshi T. Kanie A. et al. Facial expression perception correlates with verbal working memory function in schizophrenia. Psychiatry Clin Neurosci Hashimoto R. Ikeda M. Ohi K. et al. Genome wide association study of cognitive decline in schizophrenia. Am J Psychiatry Hashimoto R. Ikeda M. Yamashita F. et al. Common variants at 1p36 are associated with superior frontal gyrus volume. Transl Psychiatry 4 e John J. P. Arunachalam V. Ratnam B. et al. Expanding the schizophrenia phenotype a composite evaluation of neurodevelopmental markers. Compr Psychiatry Kremen W. S. Seidman L. J. Faraone S. V. et al. IQ decline in cross sectional studies of schizophrenia methodology and interpretation. Psychiatry Res Kremen W. S. Vinogradov S. Poole J. H. et al.
7 Powered by TCPDF ( 261 Cognitive decline in schizophrenia from childhood to midlife a 33 year longitudinal birth cohort study. Schizophr Res Leeson V. C. Sharma P. Harrison M. et al. IQ trajectory cognitive reserve and clinical outcome following a first episode of psychosis a 3 year longitudinal study. Schizophr Bull Marumo K. Takizawa R. Kinou M. et al. Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task and their association with thought disorder in patients with schizophrenia. Neuroimage Japanese Adult Reading Test JART Matsuoka K. Uno M. Kasai K. et al. Estimation of premorbid IQ in individuals with Alzheimer s disease using Japanese ideographic script Kanji compound words Japanese version of National Adult Reading Test. Psychiatry Clin Neurosci Meier M. H. Caspi A. Reichenberg A. et al. Neuropsychological decline in schizophrenia from the premorbid to the postonset period evidence from a population representative longitudinal study. Am J Psychiatry Miura K. Hashimoto R. Fujimoto M. et al. An integrated eye movement score as a neurophysiological marker of schizophrenia. Schizophr Res Mohamed S. Paulsen J. S. O Leary D. et al. Generalized cognitive deficits in schizophrenia a study of first episode patients. Arch Gen Psychiatry WAIS WAIS Wechsler Adult Intelligence Scale 3rd ed Nishimura Y. Takizawa R. Koike S. et al. Association of decreased prefrontal hemodynamic response during a verbal fluency task with EGR3 gene polymorphism in patients with schizophrenia and in healthy individuals. Neuroimage Ohi K. Hashimoto R. Ikeda M. et al. Glutamate networks implicate cognitive impairments in schizophrenia genome wide association studies of 52 cognitive phenotypes. Schizophr Bull Ohi K. Hashimoto R. Yasuda Y. et al. The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry Palmer B. W. Dawes S. E. Heaton R. K. What do we know about neuropsychological aspects of schizophrenia? Neuropsychol Rev Sheitman B. B. Murray M. G. Snyder J. A. et al. IQ scores of treatment resistant schizophrenia patients before and after the onset of the illness. Schizophr Res Sumiyoshi C. Fujino H. Sumiyoshi T. et al. Usefulness of the Wechsler Intelligence Scale short form for assessing functional outcomes in patients with schizophrenia. Psychiatry Res Watanabe Y. Tanaka H. Tsukabe A. et al. Neuromelanin magnetic resonance imaging reveals increased dopaminergic neuron activity in the substantia nigra of patients with schizophrenia. PLoS One 9 e Weickert T. W. Goldberg T. E. Gold J. M. et al. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry
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