untitled
|
|
|
- きみとし かやぬま
- 4 years ago
- Views:
Transcription
1 -DLZnsodium zinc dihydrolipoylhistidinatezn2+/ -- B-16 -α PLC- Lineweaver-Burk - -
2 (1/3) 2
3 (2/3) ~~ - + R=/C R 2 2,, C
4 (3/3) ~~ 4 DPAchrome (µm) DPA only + DLA + LA α-ladla DLA DLA Time (min) xidation by Tyrosinase DLA DPA DPAquinone 5--LipoylDPA * Tsuji-aito, K.; atani, T.; kada, T.; Tehara, T. Biochem. Biophys. Res. Commun. 26, 343, 15.
5 - -DLZnsodium zinc dihydrolipoylhistidinate Zn 2+ / Zn a - --
6 -B16 75M % DLAα- 36.3%38.3% DLA DLZn α-arbutin control 1 5 -B16 - α- Inhibitory effect of melanin synthesis (%)
7 1 5 - LADLA * - -DLA α-dla - LA DLA DLZn -Cystein L α-arbutin Kojic acid * Tsuji-aito, K.; atani, T.; kada, T.; Tehara, T. Biochem. Biophys. Res. Commun. 26, 343, 15. control Inhibitory effect of tyrosinase (%)
8 -- (1/4) DLA a -
9 -- (2/4) Absorbance at 26 nm Relative Intensity (%) 1 5 Peak II Peak I Peak III Time (min) m/z Wavelength (nm) [M+] m/z The three molecular ion peaks of the expected monoconjugate product, named peak I, II (a shoulder peak of peak III), and III, were detected at m/z 541; the substances coeluted at the time characteristic of the major reaction products. Absorbance (mau) -- UV EI+-MPLC m/z 5413 IIIIII III DLA 256nm291nm 3DLA
10 -- (3/4) III PLCII Relative Intensity (%) C. a mw m/z [M+] M/M M/M -DLA m/z DLA
11 -- (4/4) 1 A. - DLZn 5 M/M B. + DLZn - - -B16 Relative Intensity (%) M/M C. + DLZn M/M PLC/M/M m/z 541. [M + ] B D. Reserpine (Internal standard) M/M Time (min)
12 - (1/2) DL DPA conjugate(s) / reserpine (rate of peak area counts) Peak II + III Peak I Incubaton time (hour) - m/z 69. [M + ] PLC/M/M - B DL DPA conjugate(s) / reserpine (rate of peak area counts) Peak II + III Peak I Peak II + III Peak I DPA concentration (µm) DLZn concentration (µm)
13 - (2/2) Absorbance at 475 nm control DLZn Incubation time (hour)
14 - (1/2) - - DLZn IC5 (µm) 1.33 K m (M) 4.7 x 1-3 V m ( A 492 /min) 1.28 x 1-1 K I (M) 3.56 x 1-7 Inhibitor type competitive DLZn. µm.5 µm 1. µm 1.5 µm 2. µm 1/v ( A 492 /min) /[] (mm -1 ) - 4.µMIC51.3µM82.9% - - Km Vmax Vmax DA492/min1.3 x 1-4Km.86mM 1.3µM- Vmax1.3 x 1-4 Km4.1 x DPA - -
15 - (2/2) E + E E + P 1 [ 2 ] P 1 P 2 Lineweaver-Burk- P' 1 [DLZn] E: tyrosinase : L -DPA P 1 : DPAquinone P 2 : DPAchrome (Abs 492 nm) P 1 : DL DPA conjugated product(s) - - -
16 DPA-quinone Tyrosinase Tyrosine Tyrosinase DPA-quinone - DLZn - + DPA-chrome R = /C DL DPA conjugate a 2 Uncharacterized series of reactions Cysteine Cysteinyl-DPA Indoles Benzothiazine 2 R Eumelanin Modulation of melanin synthesis Pheomelanin
17 -DLZnsodium zinc dihydrolipoylhistidinate
訪問看護ステーションにおける安全性及び安定的なサービス提供の確保に関する調査研究事業報告書
1... 1 2... 3 I... 3 II... 3 1.... 3 2....15 3....17 4....19 5....25 6....34 7....38 8....48 9....58 III...70 3...73 I...73 1....73 2....82 II...98 4...99 1....99 2....104 3....106 4....108 5.... 110 6....
I? 3 1 3 1.1?................................. 3 1.2?............................... 3 1.3!................................... 3 2 4 2.1........................................ 4 2.2.......................................
20 15 14.6 15.3 14.9 15.7 16.0 15.7 13.4 14.5 13.7 14.2 10 10 13 16 19 22 1 70,000 60,000 50,000 40,000 30,000 20,000 10,000 0 2,500 59,862 56,384 2,000 42,662 44,211 40,639 37,323 1,500 33,408 34,472
- 2 -
- 2 - - 3 - (1) (2) (3) (1) - 4 - ~ - 5 - (2) - 6 - (1) (1) - 7 - - 8 - (i) (ii) (iii) (ii) (iii) (ii) 10 - 9 - (3) - 10 - (3) - 11 - - 12 - (1) - 13 - - 14 - (2) - 15 - - 16 - (3) - 17 - - 18 - (4) -
2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4 4 4 2 5 5 2 4 4 4 0 3 3 0 9 10 10 9 1 1
1 1979 6 24 3 4 4 4 4 3 4 4 2 3 4 4 6 0 0 6 2 4 4 4 3 0 0 3 3 3 4 3 2 4 3? 4 3 4 3 4 4 4 4 3 3 4 4 4 4 2 1 1 2 15 4 4 15 0 1 2 1980 8 4 4 4 4 4 3 4 2 4 4 2 4 6 0 0 6 4 2 4 1 2 2 1 4 4 4 2 3 3 3 4 3 4 4
1 (1) (2)
1 2 (1) (2) (3) 3-78 - 1 (1) (2) - 79 - i) ii) iii) (3) (4) (5) (6) - 80 - (7) (8) (9) (10) 2 (1) (2) (3) (4) i) - 81 - ii) (a) (b) 3 (1) (2) - 82 - - 83 - - 84 - - 85 - - 86 - (1) (2) (3) (4) (5) (6)
untitled
CH 2 H H H CH 2 n-1 H CH 2 n H Potato α-glucan phosphorylase H n soluble starch P i n-1 H P() 2 glucose-1-phosphate Pi H CBPase H glucose P i glucose-1-phospate cellobiose H cellooligosaccharide n+1 CDPase
030801調査結果速報版.PDF
15 8 1 15 7 26 1. 2. 15 7 27 15 7 28 1 2 7:13 16:56 0:13 3km 45 346 108 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 3.10 3.11 3. 3.1 26 7 10 1 20cm 2 1 2 45 1/15 3 4 5,6 3 4 3 5 6 ( ) 7,8 8 7 8 2 55 9 10 9 10
cm H.11.3 P.13 2 3-106-
H11.3 H.11.3 P.4-105- cm H.11.3 P.13 2 3-106- 2 H.11.3 P.47 H.11.3 P.27 i vl1 vl2-107- 3 h vl l1 l2 1 2 0 ii H.11.3 P.49 2 iii i 2 vl1 vl2-108- H.11.3 P.50 ii 2 H.11.3 P.52 cm -109- H.11.3 P.44 S S H.11.3
low_ JAJP.qxd
LC/MS Chad Borges, Matthew Slawson, James Taccogno, and Dennis Crouch Center for uman Toxicology University of Utah Salt Lake City, UT USA John M. ughes Agilent Technologies, Inc. Pleasanton, CA USA (oa-tof)
研修コーナー
l l l l l l l l l l l α α β l µ l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l
untitled
1 (1) (2) (3) (4) (1) (2) (3) (1) (2) (3) (1) (2) (3) (4) (5) (1) (2) (3) (1) (2) 10 11 12 2 2520159 3 (1) (2) (3) (4) (5) (6) 103 59529 600 12 42 4 42 68 53 53 C 30 30 5 56 6 (3) (1) 7 () () (()) () ()
) km 200 m ) ) ) ) ) ) ) kg kg ) 017 x y x 2 y 5x 5 y )
001 ) g 20 g 5 300 g 7 002 720 g 2 ) g 003 0.8 m 2 ) cm 2 004 12 15 1 3 1 ) 005 5 0.8 0.4 ) 6 006 5 2 3 66 ) 007 1 700 12 ) 008 0.315 ) 009 500 g ) kg 0.2 t 189 kg 17.1 kg 010 5 1 2 cm 3 cm )km 2-1 - 011
44 4 I (1) ( ) (10 15 ) ( 17 ) ( 3 1 ) (2)
(1) I 44 II 45 III 47 IV 52 44 4 I (1) ( ) 1945 8 9 (10 15 ) ( 17 ) ( 3 1 ) (2) 45 II 1 (3) 511 ( 451 1 ) ( ) 365 1 2 512 1 2 365 1 2 363 2 ( ) 3 ( ) ( 451 2 ( 314 1 ) ( 339 1 4 ) 337 2 3 ) 363 (4) 46
untitled
( ) 200133 3 3 3 3, 7 347 57 10 i ii iii -1- -2- -3- -4- 90011001700mm -5- 4.2 1991 73.5 44.4 7.4 10.5 10.5 7.4 W 3 H 2.25 H 2.25 7.4 51.8 140.6 88.8 268.8m 5,037.9m 2 2mm 16cm916cm 10.5 W 3 H 2.25 62.8
i ii i iii iv 1 3 3 10 14 17 17 18 22 23 28 29 31 36 37 39 40 43 48 59 70 75 75 77 90 95 102 107 109 110 118 125 128 130 132 134 48 43 43 51 52 61 61 64 62 124 70 58 3 10 17 29 78 82 85 102 95 109 iii
untitled
1998 6 25 ( ) 1 10 1982 10 28 37/7 1990 12 14 45/94 (WHO) 1 1989 12 8 NGO (ECE) 3 1995 10 25 ECE 1991 2 25 1992 3 17 1998 6 4 1 2 1. 2. a b c (a) (b) d 17 3. a b (a) c (b) 4. 5. 3 1. 2. 3. 4. 5. 6. 7.
67.5km 299.4km 2 2 2 16km 1/6 47km 2 1 1 (m) (km 2 ) 2,700 7.6 9,927 47.1 8,100 13.4 8,120 4.8 52 0.4 1,100 6.0 2,200 3.8 6,982 45.3 4,473 14.4 5,000 9.5 2 (km 2 ) (km) 1 299.4 67.5 2 284.5 38.8 3 267.0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 () - 1 - - 2 - - 3 - - 4 - - 5 - 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57
... 1... 2... 2... 3... 4... 16... 18... 19... 23... 26... 29... 31... 35... 36... 38... 40... 40... 41... 41... 41... 42... 42... 44... 44... 44 1 2 3 1707 10 28 (4104) 1854 12 24 ([ 1 ]11 5 ) 8.6 33.2
i ii iii iv 2,200,000 2,500,000 2,300,000 530,000 37 57 6 0 0 48 30 19 3 2,700 15,000 30 40 360,000 360,000 360,000 140,000 0 8 76 16 0 68 3 10 19 4,200 15,000 70 2,300 340,000 320,000 330,000 120,000
１
10 1113 14 1516 1719 20 21 22 2324 25 2627 i 2829 30 31 32 33 3437 38 3941 42 4344 4547 48 4950 5152 53 5455 ii 56 5758 59 6061 iii 1 2 3 4 5 6 7 8 9 10 PFI 30 20 10 PFI 11 12 13 14 15 10 11 16 (1) 17
untitled
E-mail: khatano@fms.saitama-u.ac.jp Tel & Fax: 048-858-3535 Toxin Virus Bacterium Glycolipid Glycoprotein Vero toxin (Stx1 and Stx2) Side view Bottom view H H H H N H Grobotriaosyl Ceramide (Gb 3 : Galα1-4Galβ1-4Glcβ-Cer)
2 7 ( ) µ 
平成20年5月 協会創立50年の歩み 海の安全と環境保全を目指して 友國八郎 海上保安庁 長官 岩崎貞二 日本船主協会 会長 前川弘幸 JF全国漁業協同組合連合会 代表理事会長 服部郁弘 日本船長協会 会長 森本靖之 日本船舶機関士協会 会長 大内博文 航海訓練所 練習船船長 竹本孝弘 第二管区海上保安本部長 梅田宜弘
![Œ{Ł¶/1ŒÊ −ªfiª„¾ [ 1…y†[…W ]](/thumbs/50/26134150.jpg "Œ{Ł¶/1ŒÊ −ªfiª„¾ [ 1…y†[…W ]")
OB OG (2 ) 2 (1 ) m 800m 3000m OB OG :30 100m 2 (2 ) 4 (4 ) 6 (3 )
2004 10 1 1 1.1............ 1 1.2............ 2 1.3.......... 2 1.4.............. 2 1.5.............. 7 1.6.............. 9 2 10 2.1............ 10 2.2....... 10 2.3...... 10 2.4............ 11 2.5..............
n 2 + π2 6 x [10 n x] x = lim n 10 n n 10 k x 1.1. a 1, a 2,, a n, (a n ) n=1 {a n } n=1 1.2 ( ). {a n } n=1 Q ε > 0 N N m, n N a m
![n 2 + π2 6 x [10 n x] x = lim n 10 n n 10 k x 1.1. a 1, a 2,, a n, (a n ) n=1 {a n } n=1 1.2 ( ). {a n } n=1 Q ε > 0 N N m, n N a m](/thumbs/94/118912662.jpg "n 2 + π2 6 x [10 n x] x = lim n 10 n n 10 k x 1.1. a 1, a 2,, a n, (a n ) n=1 {a n } n=1 1.2 ( ). {a n } n=1 Q ε > 0 N N m, n N a m")
1 1 1 + 1 4 + + 1 n 2 + π2 6 x [10 n x] x = lim n 10 n n 10 k x 1.1. a 1, a 2,, a n, (a n ) n=1 {a n } n=1 1.2 ( ). {a n } n=1 Q ε > 0 N N m, n N a m a n < ε 1 1. ε = 10 1 N m, n N a m a n < ε = 10 1 N
（個別のテーマ） 薬剤に関連した医療事故
- 67 - III - 68 - - 69 - III - 70 - - 71 - III - 72 - - 73 - III - 74 - - 75 - III - 76 - - 77 - III - 78 - - 79 - III - 80 - - 81 - III - 82 - - 83 - III - 84 - - 85 - - 86 - III - 87 - III - 88 - - 89
（個別のテーマ） 放射線検査に関連した医療事故
- 131 - III - 132 - - 133 - III - 134 - - 135 - III - 136 - - 137 - III - 138 - - 139 - III - 140 - - 141 - III - 142 - - 143 - III - 144 - - 145 - III - 146 - - 147 - III - 148 - - 149 - III - 150 - -
0810_UIT250_soto
UIT UNIMETER SERIES 250 201 Accumulated UV Meter Digital UV Intensity Meter Research & Development CD Medical Biotech Sterilization Exposure Bonding Manufacturing Curing Production Electronic Components
untitled
RYZA IL & FAT CHEMICAL C., LTD. SAKURA EXTRACT Ver.1.4MK Ver. 1.4MK 1) 1300 1929 1 Ver. 1.4MK Sakura 1-caffeoyl---D-glucopyranoside quercetin 3---D-glucopyranoside 1) :, 4, 11-22 (1995). 2 Ver. 1.4MK 3
EV200R I II III 1 2 3 4 5 6 7 8 9 10 1 2 3 11 4 5 12 6 13 1 2 14 3 4 15 5 16 1 2 17 3 18 4 5 19 6 20 21 22 123 456 123 456 23 1 2 24 3 4 25 5 3 26 4 5 6 27 7 8 9 28 29 30 31 32 1 2 33 3 4 34 1 35 2 1
平成9年度水道事業年報 １概況 ２施設
() (mm) 12 3 31 12 3 31 4 5 6 7 8 9 10 11 12 1 2 3 145,085 146,117 146,352 146,409 146,605 146,685 146,807 147,014 147,002 147,277
ステンレス鋼用高性能冷間鍛造油の開発
Development of High Performance Cold Forging Oil for Stainless Steel Toshihide Ohmori, Kazuhiko Kitamura ClP ( ) Cl P-Zn ( P ) ClP-Zn High performance cold forging oil for stainless steel has been developed
Activation and Control of Electron-Transfer Reactions by Noncovalent Bond
2 + 4e- + 4 + hν 2 2 1 2 20 J. Am. Chem. oc. Angew. Chem. Int. Ed. umber of Papers 15 10 5 0 1998 1999 2000 2001 2002 2003 Year : J. Am. Chem. oc. (Trost, B. M.; tanford University, UA) 3 π 1/2 k ET =
() () () 200,000 160,000 120,000 80,000 40,000 3.3 144,688 43,867 3.1 162,624 52,254 170,934 171,246 172,183 3 2.8 2.6 57,805 61,108 65,035 3.5 3 2.5 2 1.5 1 0.5 0 0 2 7 12 17 22 10.1 12.7 17 22.3 73.4
untitled
I....1 1... 1 2... 1 3... 1 4... 2 II....3 1... 3 2... 7 (1)... 7 (2)... 8 (3)... 9 (4)...10...11...13 1... 13 (1)...13 (2)...13 (3)...14 2... 15 (1)...15 (2)...15 1)...15 2)...16 3)...16 (3)...16 (4)...17
平成26年度 化学物質分析法開発報告書
N,N- N,N-Dimethylacetamide Acethyldimethylamine CAS 127-19-5 C 4 H 9 NO 87.12 ~ 87.14 87.68413 163-165 C 1) - 18.59 C 2) 1 mg/l 25 C 3) 3.3 hpa 2 C 4) log P ow -.77 2).9429 2/4 C 1) 3.1 4) 1.31E - 8 atm-m
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 ( ) 24 25 26 27 28 29 30 ( ) ( ) ( ) 31 32 ( ) ( ) 33 34 35 36 37 38 39 40 41 42 43 44 ) i ii i ii 45 46 47 2 48 49 50 51 52 53 54 55 56 57 58
untitled
i ii (1) (1) (2) (1) (3) (1) (1) (2) (1) (3) (1) (1) (2) (1) (3) (2) (3) (1) (2) (3) (1) (1) (1) (1) (2) (1) (3) (1) (2) (1) (3) (1) (1) (1) (2) (1) (3) (1) (1) (2) (1) (3)
平成１８年度「商品先物取引に関する実態調査」報告書
... 1.... 5-1.... 6-2.... 9-3.... 10-4.... 12-5.... 13-6.... 15-7.... 16-8.... 17-9.... 20-10.... 22-11.... 24-12.... 27-13... 29-14.... 32-15... 37-16.... 39-17.... 41-18... 43-19... 45.... 49-1... 50-2...
23 15961615 1659 1657 14 1701 1711 1715 11 15 22 15 35 18 22 35 23 17 17 106 1.25 21 27 12 17 420,845 23 32 58.7 32 17 11.4 71.3 17.3 32 13.3 66.4 20.3 17 10,657 k 23 20 12 17 23 17 490,708 420,845 23
i
14 i ii iii iv v vi 14 13 86 13 12 28 14 16 14 15 31 (1) 13 12 28 20 (2) (3) 2 (4) (5) 14 14 50 48 3 11 11 22 14 15 10 14 20 21 20 (1) 14 (2) 14 4 (3) (4) (5) 12 12 (6) 14 15 5 6 7 8 9 10 7
HPLC 1M KH 2 PO 4 ph ml Anthranilic acid: AnA 600 ml ml AnA 1.0 ml / min Anthranilic acid= PRESSURE 140 kgf / cm 2
15 10-1-3. 1. HPLC 1M KH 2 PO 4 ph 3.0 50 ml Anthranilic acid: AnA 600 ml 1-1. 350 ml AnA 1.0 ml / min Anthranilic acid=137.14 PRESSURE140 kgf / cm 2 TOSOH TSK-GEL ODS- 80 Ts 1) mg / ml AnA in (φ4.6 250
1 23G 2 1 2 3 4 5 6 7 3 a a b c a 4 1 18G 18G 6 6 3 30 34 2 23G 48 23G 1 25 45 5 20 145mm 20 26 0.6 1.000 0.7 1.000mm a b c a 20 b c 24 28 a c d 3 60 70 / a RC 5 15 b 1 3 c 0.5 1 4 6 5 a 5 1 b a b a d
!!! 10 1 110 88 7 9 91 79 81 82 87 6 5 90 83 75 77 12 80 8 11 89 84 76 78 85 86 4 2 32 64 10 44 13 17 94 34 33 107 96 14 105 16 97 99 100 106 103 98 63 at 29, 66 at 58 12 16 17 25 56
FdData社会地理
[ [ 1(3 ) [ 2(3 ) A C [ [ [ 3(2 ) (1) X Y Z (2) X Y Z 3,000m [ 4(3 ) [ [ [ 5(2 ) ( ) 1 [ [ 6( ) (1) A (2) (1) B [ 7(3 ) (1) A (2) A (3) A 2 [ 8(2 ) [ 9(3 ) 2 [ 10(2 ) A H [ [ 11( ) A H 3 3 [ 12(2 ) [ (
消防力適正配置調査報告
8 5 5 20 11 22 4 25 1.1 1 1.2 1 1.3 2 2.1 6 2.2 6 2.3 8 2.4 8 2.5 9 3.1 10 3.2 10 3.3 13 4.1 15 4.2 17 4.3 19 4.4 21 4.5 23 (1) - 1 - (2) (1) ()1 ( ) 8 1 1 143 116 (2) 1-2 - 26 24 19 24 6 21 24 4 19 24
Microsoft Word - 01Ł\”ƒ.doc
226821,416* 13,226 22 62,640 46,289 13,226 28.6 * 8,030 4,788 408 13,226 2,249 2,868 55 5,173 2,153 716 93 2,962 3,628 1,204 260 5,092 173 10 361 25.5% 40 220 112 50.9% 4,922 804 16.3% 3040 141 54 38.3%
第18回海岸シンポジウム報告書
2011.6.25 2011.6.26 L1 2011.6.27 L2 2011.7.6 2011.12.7 2011.10-12 2011.9-10 2012.3.9 23 2012.4, 2013.8.30 2012.6.13 2013.9 2011.7-2011.12-2012.4 2011.12.27 2013.9 1m30 1 2 3 4 5 6 m 5.0m 2.0m -5.0m 1.0m
1 2 http://www.japan-shop.jp/ 3 4 http://www.japan-shop.jp/ 5 6 http://www.japan-shop.jp/ 7 2,930mm 2,700 mm 2,950mm 2,930mm 2,950mm 2,700mm 2,930mm 2,950mm 2,700mm 8 http://www.japan-shop.jp/ 9 10 http://www.japan-shop.jp/
1 911 34/ 22 1012 2/ 20 69 3/ 22 69 1/ 22 69 3/ 22 69 1/ 22 68 3/ 22 68 1/ 3 8 D 0.0900.129mm 0.1300.179mm 0.1800.199mm 0.1000.139mm 0.1400.409mm 0.4101.199mm 0.0900.139mm 0.1400.269mm 0.2700.289mm