VENTANA ALK D5F3 Rabbit Monoclonal Antibody OptiView ALK D5F3

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1 VENTANA ALK D5F3 Rabbit Monoclonal Antibody OptiView ALK D5F3

2 2 OptiView ALK D5F %31% 18% 80 85NSCLC 40% 1, ALK ALK 2 ALK 3 5% ALK EML4 EML4-ALK Coild-Coil ALK ALK 3,4,5 2 6 EGFR 50% KRAS 15% ALK 5% HER2 3% 100% MET 4% unknown 22% ALK 7 ALK ALK 8 ALK ALK ALK ALK ALK ALK

3 OptiView ALK D5F3 3 ALK OptiView ALK D5F3 ALK 9-12 OptiView ALK D5F3 FISHALK 3 OptiView ALK D5F3 ALK + + = OptiView AMP D5F3 ALK D5F3 OptiView DAB OptiView ULTRA XT XT GX ALK OptiView ALK D5F34 FISH 4 OptiView ALK D5F3 OptiView ALK D5F3 ALKDAB NordiQC OptiView ALK D5F3 13

4 4 OptiView ALK D5F3 OptiView ALK D5F3 ALK ALK NMP ALK 2007 EML4-ALK ALK ALK ALK 14 OptiView ALK D5F3 ALK D5F3 - DAB H2O2 HN OH DAB HN H2O2 OH OH H2O2 OH OptiView DAB - ALK D5F3 - OptiView DAB - OptiView ALK D5F3 ALK D5F OptiView ALK D5F3 OptiView ALK D5F3 15 ALK ALK FISH 16 ALK OptiView ALK D5F3 OptiView OptiView OptiView ALK D5F3 5A4

5 OptiView ALK D5F3 5 ALK OptiView ALK D5F3 OptiView ALK D5F EZX ALK D5F3 RxDx OptiView DAB OptiView 50 XT, GX OptiView DAB Cell Conditioning Pre-Primary Peroxidase Inhibitor Antibody OptiView Univ Linker OptiView Multimer OptiView Amplification OV AMP H2O2, OV Amplifier OV AMP Multimer Counterstain Post Counterstain CC1 92min Selected 16 min 12 min 12 min Selected 8 min 8 min Hematoxylin, 4 min Bluing, 4 min ULTRA ULTRA ALK U VENTANA ALK D5F3 Antibody Primary Counterstain Post Counterstain VENTANA ALK AB 16 min EU/Other Negative Control Hematoxylin, 4 min Bluing, 4 min OptiView ALK D5F3 NordiQCALK IHC ALK DAB DAB ALK ALK

6 6 OptiView ALK D5F3 OptiView ALK D5F ALK ALK ALK CD56 x20 x20

7 OptiView ALK D5F3 7 References 1., ganjoho.jp, , zangankyo.ncc.go.jp, Soda M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature Aug 2; Shaw AT, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol Sep 10; Pao W, et al. New driver mutations in non-small-cell lung cancer. Lancet Oncol Feb;12 2 : Mitsudomi T. Advances in target therapy for lung cancer. Jpn J Clin Oncol Feb; ALK 2, 9. XALKORI Crizotinib Package Insert Thorne-Nuzzo T, et al. A Sensitive ALK Immunohistochemistry Companion Diagnostic Test Identifies Patients Eligible for Treatment with Crizotinib. J Thorac Oncol Jan 29. pii S ZYKADIA ceritinib Package Insert Jean-Charles Soria, et al. First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer ASCEND-4 a randomised, open-label, phase 3 study. Lancet March Mino-Kenudson M, Chirieac LR, Law K, Hornick JL, Lindeman N, Mark EJ, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010; Murry W. et al. An International Interpretation Study Using the ALK IHC Antibody D5F3 and a Sensitive Detection Kit Demonstrates High Concordance between ALK IHC and ALK FISH and between Evaluators. Journal of Thoracic Oncology May; Greta Ali, et al. ALK Rearrangement in a Large Series of Consecutive Non Small Cell Lung Cancers. Arch Pathol Lab Med Nov;

8 東京都港区港南 カスタマーソリューションセンター VENTANA は ロシュ社の登録商標です 1078.TD.TMS.2000.PAB01-024A

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