特集・総説・報告(44行)/P045-055_報告 日本肝移植研究会

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1 45 Liver Transplantation in Japan in 2006 Part 2 Registry by the The Summary Four thousand three hundred thirty liver transplants have been performed as of December 31, 2006 in 59 institutions in Japan. There were 4,292 living-donor transplants and 38 cadaveric transplants 35 from heart-beating donor and 3from non-heart-beating donor. Although the number of living-donor transplants has increased progressively every year since inception in 1989, reaching 566 in 2005, the total decreased for the first time, to 505, in The most popular frequent indication was cholestatic disease, followed by neoplastic disease. As for the graft liver in living-donor cases, the proportion of right lobe graft has been increasing. Patient survival following transplantation from heart-beating donor 1 year, 80.0%; 3 year, 77.0%; 5 year, 73.2% was similar to that from living donor 1 year, 82.2%; 3 year, 78.2%; 5 year, 76.0%; 10 year, 72.4%; 15 year, 68.8%., registry, cadaveric liver transplantation, living-donor liver transplantation, prognosis FAX Kaplan-Meier logrank test ,

2 46 Vol. 43, No Living-donor Transplantation 4,292 Cadaveric Transplantation 38 Heart Beating Donor 35 Non-heart Beating Donor 3 Primary Transplantation 4,215 Retransplantation 110 Third Transplantation , ,292 4, , Year Total Living-donor , ,621 Cadaveric Total , ,647 Adults: 18 years Age Total Male Female Total Age Total Male ,057 Female ,235 Total 1, , ,292

3 47 Cholestatic Diseases 14 Biliary Atresia 9 Primary Biliary Cirrhosis 3 Primary Sclerosing Cholangitis 2 Hepatocellular Diseases 7 HCV 3 Cryptogenic Cirrhosis 2 HBV 1 Alcoholic 1 Vascular Diseases 0 Neoplastic Diseases 2 Hepatocellular Carcinoma 2 Acute Liver Failure 5 HBV 4 Unknown 1 Metabolic Diseases 4 Wilson Disease 2 Familial Amyloid Polyneuropathy 2 Total 32 Age of Recipient 18 y.o. 18 y.o. Total Whole Liver Lateral Segment Right Lobe Age of The Recipient Total 18 y.o. 18 y.o. Monosegment Lateral Segment 1, ,171 Posterior Segment Left Lobe Left Lobe Caudate Lobe Right Lobe 60 1,568 1,628 Whole Liver Domino Dual Graft Left Right Lobes ,671 2,621 4,292 Age of The Recipient Total 18 y.o. 18 y.o. Cholestatic Diseases 1, ,856 Biliary Atresia 1, ,242 Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Alagille Syndrome Byler s Disease Others Hepatocellular Diseases HCV HBV Alcoholic Autoimmune hepatitis Cryptogenic cirrhosis Others Vascular Diseases Budd-Chiari Syndrome Others Neoplastic Diseases Hepatocellular Carcinoma HCV HBV Alcoholic Others Hepatoblastoma Liver Metastasis Others Acute Liver Failure HBV Drug-induced Autoimmune hepatitis Viral HBV Unknown Others Metabolic Diseases Wilson Disease Familial Amyloid Polyneuropathy Citrullinemia OTC Deficiency Glycogen Storage Disease Tyrosinemia Primary hyperoxaluria Others Others Total 1,612 2,571 4,183

4 48 Vol. 43, No. 1 Age Unknown Total Male Female Unknown Total Age Total Male ,335 Female ,959 Total ,124 1, , / Caroli 8 4 HCV HBV NASH 6 cryptogenic cirrhosis solid pseudopapillary tumor 1 8 4, epithelioid hemangioendothelioma Dubin-Johnson graft split 3 reduced 2 graft split graft graft split dual graft split

5 49 Age of The Recipient Total 18 y.o. 18 y.o. Age of The Recipient Total Mother , y.o. 18 y.o. Father Identical 1,137 1,859 2,996 Son Compatible Daughter Incompatible Brother ,671 2,620 4,291 Sister Nephew Grandmother Cousin 1 Male 16 Male 15, Female Grandfather Aunt Uncle Niece Father s cousin 2 Male 1, Female dual graft 2 Grandson , ,294 Cousin s son Wife split Husband Brother-in-law Son-in-law ,291 Father-in-law Sister-in-law Nephew-in-law % Daughter-in-law %23% 19% Mother-in-law % dual graft Uncle-in-law , ,294 Grandfather-in-law split Common-law wife Common-law husband ,291 split Friend 0 1 Female Domino 1 Male 27 Male 15, Female ,671 2,623 4,294 Year Total 18 years years Total

6 50 Vol. 43, No. 1 Year Total 18 years years Total Patient Survival % Graft Survival % n n year year year year year year year year year year Cadaveric Donor Heart-beating Non-heart-beating Living Donor 4, , FAP ABO dual graft 1 ABO ABO 2 dual graft 1 ABO 2 ABO 7% 12% ABO 1 p

7 51 Primary or Retransplant Recipient Gender Recipient Age Indication Donor Age Graft Gender Combination ABO Compatibility n Cumulative Survival % 1year 3year 5 year 10 year 15 year Primary 4, Re-transplantation Re-re-transplantation Male 2, Female 2, , , Cholestatic Disease 1, Biliary Atresia 1, Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Alagille Syndrome Byler s Disease Hepatocellular Disease HCV HBV Alcoholic Autoimmune hepatitis Cryptogenic Cirrhosis Vascular Disease Budd-Chiari Syndrome Congenital Absence of Portal Vein Neoplastic Disease HCC Hepatoblastoma Liver Metastasis Acute Liver Failure HBV Drug-induced Autoimmune hepatitis Viral HBV Unknown Metabolic Disease Wilson Disease Familial Amyloid Polyneuropathy Citrullinemia OTC Deficiency Glycogen Storage Diseases Tyrosinemia Primary Hyperoxaluria , , Monosegment Lateral Segment 1, Posterior Segment Left Lobe Left Lobe Caudate Lobe Right Lobe 1, Whole Liver Male Female 1, Male Male 1, Female Male Female Female Identical 2, Compatible Incompatible

8 52 Vol. 43, No. 1 p p p p p p p p p p p p p p p

9 53 p p p p p p Alagille p Alagille p Byler p n % % % HCV % % % HBV % % % % % %

10 54 Vol. 43, No. 1 p Wilson p FAP p p OTC p OTC p % % % % % % % 5 7 graft p ABO data not shown 7 data not shown p HCV 5 p HCV n % % % % % 10

11 55 p ABO % % % % % % % % % % % % % 2 ABO p % % % % % % p p % % % % % % % % p ; 39: ; 35: ; 37: ; 38: ; 39: ; 40: ; 41:

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