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9 2) Shin, S. I., Fredman, V. H., Risser, P., Pol lack,r.: Proc. Natl. Acad. Sci. USA, 72, (1975) 3) Marquardt, H., Todaro, G. J.: J. Biol. Chem., 256, (1981) 4) Dicker, P., Pohjanpelto, P., Rozengurt, E.: Exp. Cell Res., 135, (1981) 5) Graves, D. T., Owen, A. J., Antoniades, H. N.: Cancer Res., 43, (1983) 6) Garrett, J. S., Coughlin, S. R., Niman, H. L., Tremble, P. M., Giels, G. M., Williams, L. T.: Proc. Natl. Acad. Sci. USA, 81, (1984) 7) Sporn, M. B., Todaro, G. J.: New Engl. J. Med., 303, (1980) 8) DeLarco, J. E., Todaro, G. J.: Proc. Natl. Acad. Sci. USA, 75, (1978) 9 zroberts, A. B., Frolik, C. A., Anzano, M. A., Sporn, M. B.: Federation Proc., 42, (1983) 10 zroberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F., Sporn, M. B.: Proc. Natl. Acad. Sci. USA, 82, (1985) 11) Tucker, R. F., Shipley, G. D., Moses, H. L., Holley, R. W.: Science, 226, (1984) 12) Anzano, M. A., Roberts, A. B., Smith,.J. M., Sporn, M. B., DeLarco, J. E.: Proc. Natl. Acad. Sci. USA, 80, (1983) 13) Marquardt, H., Hunkapiller, M. W., Hood, L. E., Twardzik, D. R., DeLarco, J. E., Stephen son,j. R., Todaro, G. J.: Proc. Natl. Acad. Sci. USA, 80, (1983) 14) Marquardt, H., Hunkapiller, M. W., Hood, L. E., Todaro, G. J.: Science, 223, (1984) 15) Massague, J.: J. Biol. Chem., 258, (1983) 16 zderynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y., Goeddel, D. V.: Cell, 38, (1984) 17) Brissenden, J. E., Derynck, R., Franke, U.: Cancer Res., 45, (1985) 18) Smith, J. M., Sporn, M. B., Roberts, A. B., Derynck, R., Winkler, M. E., Gregory, H.: B., Sporn, M. B., Goeddel, D. V.: Nature, 316, (1985) 23) Roberts, A. B., Anzano, M. A., Meyers, C. A., Wideman, J., Blacher, R., Pan, Y.-C. E., Stein, S., Lehrman, S. R., Smith, J. M., Lamb,, L. C., Sporn, M. B.: Biochemistry, 22, (1983) 24 zassoian, R. K., Komoriya, A., Meyers, C. A., Miller, D. M., Sporn, M. B.: J. Biol. Chem., 258, (1983) 25) Sporn, M. B., Roberts, A. B., Shull, J. H., Ward, J. M., Sodek, J.: Science, 219, (1983) 26) Frolik, C. A., Wakefield, L. M., Smith, J. M., Sporn, M. B.: J. Biol. Chem., 259, (1984) 27) Tucker, R. F., Branum, E. L., Shipley, G. D., Ryan, R. J., Moses, H. L.: Proc. Natl. Acad. Sci. USA, 81, (1984) 28 zmassague, J., Like, B.: J. Biol. Chem., 260, (1985) 29) Hirai, R.,. Yamaoka, K., Mitsui, H.: Cancer Res., 43, (1983) 30 zyamaoka, K., Hirai, R., Tsugita, A., Mitsui, H.: J. Cell. Physiol., 119, (1984) 31) Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devere, S. G., Robbins, K. C., Aaronson, S. A., Antoniades, H. N.: Science, 221, (1983) 32) Waterfield, M. D., Scarace, G. T., Whittle, N., Stroobant, P., Johnson, A., Wasteson, A., Westermark, B., Heldin, C.-H., Huang, J. S., Deuel, T. F.: Nature, 304, (1983) 33) DeLarco, J. E., Todaro, G. J.: J. Cell. Phisiol., 102, (1980) 34) Anzano, M. A., Roberts, A. B., DeLarco, J. E., Wakefield, L. M., Assoian, R. K., Roche, N. S., Smith, J. M., Lazrus, J. E., Sporn, M. B.: Mol. Cell. Biol., 5, (1985) 35) Bowen-Pope, D. F., Vogel, A., Ross, R.: Proc. Natl. Acad. Sci. USA, 81, (1984) 36) Huang, J. S., Huang, S. S., Deuel, T. F.: Cell, 39, (1984) 37 zlee, D. C., Rochford, R., Todaro, G. J., Villar - real,l. P.: Mol. Cell. Biol., 5, Nature, 315, (1985) (1985) 19) Ibbotson, K. J., Twardzik, D. R., D'Souza, S. 38) Nexo, E., Hollenberg, M. D., Figueora, A., M., Hargreaves, W. R., Todaro, G. J., Mundy, Pratt, R. M.: Proc. Natl. Acad. Sci. USA, G. R.: Science, 228, (1985) 77, (1980) 20) Linsley, P. S., Hargreaves, W. R., Twardzik, 39) ŽR ª ažq E ½ˆä æžq D. R., Todaro, G. J.: Proc. Natl. : ƒgƒlƒvƒrƒ ƒw [ƒtƒi [ƒ ƒ, Acad. Sci. 8, (1985) USA, 82, (1985) 40) Hirai, R., Yamaoka, K., Mitsui, H.: Proc. of 21) Twardzik, D. R., Kimball, E. S., Sherwin, S. Intenational Symp. on Growth and Differen A., Ranchalis, J. E., Todaro, G. J.: Cancer tiationof Cells in Defined Environment Res., 45, (1985) (eds. Murakami, H. et al.), (1985) 22 zderynck, R., Jarret, J. A., Chen, E. Y., Eaton, D. H., Bell, J. R., Assoian, R. K., Roberts, A. 41) Twardzik, D. R., Marquardt, H., Reynolds Jr., F. H.: Science, 216, (1982) 1124

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