CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa

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1 CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa mmhg20 2 log Pow-0.32 m/z 41, Koc g/l ppm = 4.49 mg/m 3, 20 1 mg/m 3 = 0.223ppm 3

2 ,118 t 0 t 8,118 t mg/l 30 mg/l BOD 3543 NO NH 3 TOC 86 GC 96 OH = cm 3 / sec 25 7 OH /cm ppb ppm ppm B/A B/A B/A B/A 0/21 0/ B/A

3 3 4. LC 50 mg/l EC 50 mg/l : Daphnia magna h: Lepomis macrochirus 10 Poecilia reticulata 10 Pimephales promelas h h h * OECD 5. 2, 11, 12, 13, 14, 15, 16 1 LD mg/kg mg/kg mg/kg LC ppm 4h LD 50 > 2,000 mg/kg 2,134-2,290 mg/kg LD mg/kg LD mg/kg ppm 250-3,030 mg/m ppm 710 mg/m LC ppm 1,710 mg/m ml

4 ppm ppm 2, ppm mg/l 6 / 5 / ppm 21.5 ppm 60.6 ppm 2, ppm mg/m 3 6 / 5 / ppm 111 ppm 2, 18/18 9/ ppm mg/m 3 6 / 5 / ppm NOAEL 6.92 ppm 2, 14, 18 5 * in vitro TA97TA98TA100 TA1535TA1537S9 mix +/- 12 TA98TA1535TA1537 TA1538S9 mix +/ ,000 µg/plate 14 L5178YS9 mix +/- 5µL/mL 14 DNA S9 mix +/- 2,500 µl/ml 14 in vivo SD * , mg/kg/day , 14

5 ppm mg/m 3 6 / 22 14, ppm mg/m 3 6 / 5 / , , 14, ml 2, , 22, 23 3 EPA 1999 D EU 2000 NTP 2000 IARC 2000 ACGIH , 23 4 ACGIH ppm 8.8 mg/m

6 , mg/kg 79 12, 14, 15, mg/kg OECD * 9 2 * OECD OECD 9. 1 in vitro in vivo OH

8 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine IPCS, International Chemical Safety Cards NIST Library of 54K Compounds. 5 10, ,,, AOPWIN ver1.86 Syracuse Research Corporation OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures, OECD Series on Testing and Assessment No AQUIRE US EPA, ECOTOX Database System. 11 Registry of Toxic Effects of Chemical Substances RTECS, US NIOSH Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry Ladd W. Smith, Inhalation Toxicity of adiponitrile in Rats, Toxicology and Applied Pharmacology, 65, IUCLID International Uniform Chemical Information Data Base Data Sheet, EU OECD/UNEP/WHO/ILO, Screening Information Data Set SIDS, 5 1, ,,,, O. L. Dashiell, The Effects of Fasting on the Acute Oral Toxicity of Nine Chemicals in the Rat, Journal of Applied Toxicology, 4 6, R. D. Short, 13-Week Iinhalation Toxicity Study and Fertility Assessment in Rats exposed to Atmospheres Containing Adiponitrile, Journal of Toxicology and Environmental Health, 30, EPA/OTS Doc#: , Monsanto Co., Female Fertility Study of Sprague-Dawley Rats exposed by the Inhalation Route to Adiponitrile with Attachments Final report EPA/OTS Doc#: , Monsanto Co., Male Fertility Study of Sprague-Dawley Rats exposed by Inhalation to Adiponitrile Final report with Cover Letter dated JETOC,,, ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices ,, 42,

9 9 1 2

10 10 mg/l 1, h h h h 100 LC 50 EC AQUIRE US EPA, ECOTOX Database System.

11 11 4 h 6 h/d 5 d/w 2 w 6 h/d 5 d/w 4 w 6 h/d 5 d/w 13 w 6 h/d 1,000 ppm 386 LC d d NOAEL 1 2 ACGIH

橡アジポニトリル.PDF

橡アジポニトリル.PDF 1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log