Technologyfor soundsleepbased on human circadianrhythm Hiroki NOGUCHI Lighting Research Center Lighting Manufacturing Business Unit Matsushita Electri

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1 Technologyfor soundsleepbased on human circadianrhythm Hiroki NOGUCHI Lighting Research Center Lighting Manufacturing Business Unit Matsushita Electric Works, Ltd. 1048, Kadoma, Osaka , Japan Toshio NAKANO Research & Development Center Home Appliances Manufacturing Business Unit Matsushita Electric Works, Ltd. 1048, Kadoma, Osaka , Japan Creatures on Earth have circadian system to live efficiently in light/dark cycle of 24-hour. After twilight, core body temperature and alertness start declining following beginning of melatonin secretion in human. These physiological functions help us sleep soundly. In the first half of this paper, core body temperature and melatonin known as indices reflecting circadian rhythmicity are explained regarding the relationship between its circadian variation and sleep. Later, some specific ways to support sound sleep by designing lighting environment and bedroom from the viewpoint of circadian physiology are introduced. (Japanese Journal of Physiological Psychology and Psychophysiology, 25(1) : 73-87, 2007.) Key words : circadian rhythm, sleep promotion, lighting, body temperature and melatonin

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3 Figure 1. Core body temperature in a regular schedule (shin line) and laying condition (solid line). (Nakano et al. 1997).

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6 Figure 2. Core body temperature in the baseline period (left) and the second-week of dawn lighting (right). a: alarm clock, b: dawn lighting.

7 Figure 3. OSA sleepiness scale Figure 4. Mean SE in rectal temperature

8 Figure 5. Experimental conditions

9 Figure 6. Variation of urinary melatonin after waking up

10 Figure 7. Variation of rectal temperature Table 1. Change of the amplitude of circadian rectal temperature rhythm

11 Figure 8. Variation of salivary melatonin concentration Figure 9. Relationship between melatonin suppression and sleep phase

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13 Figure 10. Sleep latency Figure 11. Support for sound sleep based on sleep/wake cycle

14 Berson, D. M., Dunn, F. A., & Takao, M. (2002). Phototransduction by retinal ganglion cells that set the circadian clock. Science, 295, Boivin, D., Duffy, J., Kronauer, R., & Czeisler, C. (1996). Dose-response relationships for resetting of human circadian clock by light. Nature, 379, Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001). Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. The Journal of neuroscience, 21, Breithaupt, H., Hildebrandt, G., Dohre, D., Josch, R., Sieber, U., & Werner, M. (1978). Tolerance to shift of sleep, as related to the individual's circadian phase position. Elgonomics, 21, Burgess, H. J., Savic, N., Sletten, T., Roach, G., Gilbert, S. S., & Dawson, D. (2003). The relationship between the dim light melatonin onset and sleep on a regular schedule in young healthy adults. Behavioral sleep medicine, 1, Carrier, J., Monk, T. H., Buysse, D. J., & Kupfe, D. J. (1996). Amplitude Reduction of the Circadian Temperature and Sleep Rhythms in the Elderly. Chronobiology International, 13, Czeisler, C. A., Weitzman, E., Moore-Ede, M. C., Zimmerman, J. C., & Knauer, R. S. (1980). Human sleep: its duration and organization depend on its circadian phase. Science, 210, Home, J. A., & Ostberg, 0. (1976). A self-assessment questionnaire to determine morningness-eveningness human circadian rhythms. International journal of chronobiology, 4, Inzunza, 0., Seron-Ferre, M. J., Bravo, H., & Torrealba, F. (2000). Tuberomammillary nucleus activation acticipates feeding under a restricted schedule in rats. Neuroscience letters, 293, Kanikowska, D., Hirata, Y., Hyun, K., & Tokura, H. (2001). Acute phase proteins, body temperature and urinary melatonin under the influence of bright and dim light in intensities during the daytime. Journal of physiological anthropology and applied human science, 20, Krauchi, K., Cajochen, C., & Wirz-Justice, A. (1997). A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. Journal of applied physiology, 83, Lewy, A. J., Wehr, T. A., & Goodwin, F. K. (1980). Light suppresses melatonin secretion in humans. Science, 210, Lewy, A. J. (1999). The dim light melatonin onset, melatonin assays and biological rhythm research in humans. Biological signals and receptors, 8, Lockley, S. W., Brainard, G. C., & Czeisler, C. A. (2003). High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. The Journal of clinical endocrinology and metabolism, 88, Mishima, K., Okawa, M., Hozumi, S., & Hishikawa, Y. (2001). Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiology international, 17, Mishima, Y., Hozumi, S., Shimizu, T., Hishikawa, Y., & Mishima, K. (2005). Passive body heating ameliorates sleep disturnbances in patients with vascular dementia without circadian phase-shifting. The American journal of geriatric psychiatry, 13, Monk, T. H., Buysse, D. J., Reynolds, C. F., & Kupfe, D. J. (1993). Inducting Jet Lag in Older People: Adjusting to a

15 6-hour Phase Advance in Routine. Experimental Gerontology, 28, Nakamura, K., Hashimoto, S., Honma, S., Honma, K., & Tagawa, Y. (1997). A sighted man with Non-24-hour Sleep-Wake Syndrome Shows Damped Plasma Melatonin Rhythm. Psychiatry & Clinical Neurosciences, 51, Nakano, T., Koyama, E., Imai, T., & Hagiwara, H. (1997). Circadian Rhythm Estimation by Core Body Temperature Filtered with Simultaneously Recorded Physiological Data. Methods of Information in Medicine, 36, Souetre, E., Salvati, E., Belugou, J. L., Pringuey, D., Candito, M., Krebs, B., Ardisson, J. L., & Darcourt, G. (1989). Circadian rhythms in depression and recovery: evidence for blunted amplitude as the main chronobiological abnormality. Psychiatry research, 28, Wright, H., Lack, L., & Kennaway, D. (2004). Differential effects of light wavelength in phase advancing the melatonin rhythm. Journal of Pineral Research, 36, Zeitzer, J. M., Dijk, D. J., Kronauer, R., Brown, E., & Czeisler, C. (2000). Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. The Journal of physiology, 526, Zulley, J., Weyer, R., & Aschoff, J. (1981). The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature. Pflfigers Archiv, 391, hftyosa00/ (2000)

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