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1 腎 臓 透 析 医 のための 臨 床 研 究 デザイン 塾 修 了 者 による 臨 床 研 究 業 績 この 業 績 一 覧 は 塾 修 了 後 に 発 表 された 臨 床 研 究 に 関 する 原 著 論 文 学 会 抄 録 ( 基 礎 研 究 総 説 以 外 )のみを 記 載 いたしました 自 己 報 告 に 基 づいて 作 成 した 報 告 書 ですので 全 てを 網 羅 した 業 績 集 計 ではございません 同 一 の 業 績 が 複 数 の 塾 生 により 報 告 されている 場 合 集 計 では 1 編 ( 件 )としています なお 記 載 の 順 は 塾 参 加 当 時 の 名 簿 に 依 ります 業 績 集 計 英 文 原 著 論 文 331 編... p.1 和 文 原 著 論 文 国 際 学 会 発 表 国 内 学 会 発 表 102 編...p 件...p 件...p.53 受 賞 39 件...p.84 (2013 年 8 月 現 在 ) 認 定 NPO 法 人 健 康 医 療 評 価 研 究 機 構 (ihope International)

2 英 文 原 著 論 文 長 谷 川 毅 (1 期 生 ) 20. Shoji S, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, Van der Hoom, FA, Manabe I, Honma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M. Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis and its expression correlates with the prognosis of renal cell carcinoma. Am J Pathol (in press). 19. Perl J, Zhang J, Gillespie B, Wikström B, Fort J, Hasegawa T, Fuller DS, Pisoni RL, Robinson BM, Tentori F. Reduced survival and quality of life following return to dialysis after transplant failure: the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant. 2012; 27(12): Nakai S, Iseki K, Itami N, Ogata S, Kazama JJ, Kimata N, Shigematsu T, Shinoda T, Shoji T, Suzuki K, Taniguchi M, Tsuchida K, Nakamoto H, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Masakane I, Marubayashi S, Morita O,Yamagata K, Wakai K, Wada A, Watanabe Y, Tsubakihara Y. An overview of regular dialysis treatment in Japan (as of 31 december 2010). Ther Apher Dial. 2012; 16(6): Fukagawa M, Fukuma S, Onishi Y, Yamaguchi T, Hasegawa T, Akizawa T, Kurokawa K, Fukuhara S. Prescription Patterns and Mineral Metabolism Abnormalities in the Cinacalcet Era: Results from the MBD-5D Study. Clin J Am Soc Nephrol. 2012; 7(9): Nakai S, Suzuki K, Masakane I, Wada A, Itami N, Ogata S, Kimata N, Shigematsu T, Shinoda T, Syouji T, Taniguchi M, Tsuchida K, Nakamoto H, Nishi S, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Marubayashi S, Morita O, Yamagata K, Wakai K, Watanabe Y, Iseki K, Tsubakihara Y. Overview of regular dialysis treatment in Japan (as of 31 December 2009). Ther Apher Dial. 2012;16(1): Yokoyama Y, Sasaki S, Suzukamo Y, Yamazaki S, Takegami M, Kakudate N, Hasegawa T, Haga M, Kawaguchi T, Moriya T, Hotta O, Fukuhara S, for the Dialysis Nutrition Research Group. Interpersonal psychosocial factors associated with underreported dietary energy intake in hemodialysis patients. Journal of Renal Nutrition 2012 (in press). 14. Akizawa T, Kido R, Fukagawa M, Onishi Y, Yamaguchi T, Hasegawa T, Fukuhara S, Kurokawa K. Decreases in PTH in Japanese Hemodialysis Patients with Secondary Hyperparathyroidism: Associations with Changing Practice Patterns. Clin J Am Soc Nephrol. 2011; 6(9): Fukuhara S, Akizawa T, Fukagawa M, Onishi Y, Yamaguchi T, Hasegawa T, Kurokawa K. Mineral and bone disorders outcomes study for Japanese chronic kidney disease stage 5D patients (MBD-5D): rationale and study design. Ther Apher Dial. 2011; 15(2): Hasegawa T, Bragg-Gresham JL, Pisoni RL, Robinson BM, Fukuhara S, Akiba T, Saito A, Kurokawa K, Akizawa T. Changes in Anemia Management And Hemoglobin Levels following Revision of a Bundling Policy to Incorporate Recombinant Human Erythropoietin. Kidney Int. 2011; 79(3): Nakai S, Suzuki K, Masakane I, Wada A, Itami N, Ogata S, Kimata N, Shigematsu T, Shinoda T, Syouji T, Taniguchi M, Tsuchida K, Nakamoto H, Nishi S, Nishi H, Hashimoto 1

3 S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Marubayashi S, Morita O, Yamagata K, Wakai K, Watanabe Y, Iseki K, Tsubakihara Y. Overview of regular dialysis treatment in Japan (as of 31 December 2008). Ther Apher Dial. 2010;14(6): Hasegawa T, Koiwa F, Yamazaki S, Yoshimura A. In Reply to 'Predialytic Period and Baseline Peritoneal Membrane Status-Any Connection?'. Perit Dial Int. 2010; 30(4): Nakai S, Masakane I, Shigematsu T, Hamano T, Yamagata K,Watanabe Y, Itami N, Ogata S, Kimata N, Shinoda T, Syouji T, Suzuki K, Taniguchi M, Tsuchida K, Nakamoto H, Nishi S, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Fujii N, Marubayashi S, Morita O,Wakai K, Wada A, Iseki K, Tsubakihara Y. An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2007). Ther Apher Dial. 2009; 13(6): Yokoyama Y, Suzukamo Y, Hotta O, Yamazaki S, Kawaguchi T, Hasegawa T, Chiba S, Moriya T, Abe E, Sasaki S, Haga M, Fukuhara S. Dialysis Staff Encouragement and fluid control adherence in patient on hemodialysis. Nephrol Nurs J. 2009;36(3): Yokoyama Y, Yamazaki S, Hasegawa T, Wakita T, Akiba T, Akizawa T, Asano Y, Saito A, Kurokawa K, Fukuhara S. Impact of early referral to nephrologist on mental health among hemodialysis patients: a Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephron Clin Pract ;113(3):c191-c Hasegawa T, Bragg-Gresham JL, Yamazaki S, Fukuhara S, Akizawa T, Kleophas W, Greenwood R, Pisoni RL. Greater First-Year Survival on Hemodialysis in Facilities in Which Patients Are Provided Earlier and More Frequent Pre-Nephrology Visit. Clin J Am Soc Nephrol. 2009; 4(3): Hasegawa T, Yoshimura A, Hirose M, Komukai D, Tayama H, Watanabe S, Koiwa F, Yamazaki S, Ideura T. A Strict Low Protein Diet during the Predialysis Period Suppresses Peritoneal Permeability at the Induction of Peritoneal Dialysis. Perit. Dial. Int. 2009; 29(3): Koiwa F, Hasegawa T, Tanaka R, Kakuta T. Indication and efficacy of PEIT in the management of secondary hyperparathyroidism. NDT Plus. 2008; 1(Supplement 3): iii14-iii Akizawa T, Pisoni RL, Akiba T, Saito A, Fukuhara S, Asano Y, Hasegawa T, Port FK, Kurokawa K. Japanese Hemodialysis Anemia Management Practices and Outcomes ( ): Results from the DOPPS. Nephrol Dial Transplant. 2008; 23(11): Ethier J, Mendelssohn D, Elder S, Hasegawa T, Akizawa T, Akiba T, Canaud B, Pisoni RL. Vascular Access Use and Outcomes: An International Perspective From the Dialysis and Outcomes Practice Patterns Study. Nephrol Dial Transplant. 2008; 23(10): Hasegawa T, Elder SJ, Bragg-Gresham JL, Pisoni RL, Yamazaki S, Akizawa T, Jadoul M, Hugh RC, Port FK, Fukuhara S. Consistent Aspirin Use Associated with Improved Arteriovenous Fistula Survival among Incident Hemodialysis Patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nephrol. 2008; 3(5):

4 柴 垣 有 吾 (1 期 生 ) 26. Hanafusa N, Hamasaki Y, Kawarasaki H, Kido R, Shibagaki Y, Ishikawa A, Enomoto. Y, Fujita T, Noiri E, Nangaku M. The effect of different apheresis modalities on coagulation factor XIII level during antibody removal in ABO-blood type incompatible living related renal transplantation. Transfus Apher Sci Jul 1. doi:pii: S (13) /j.transci [Epub ahead of print] PubMed PMID: Fukagawa M, Yokoyama K, Koiwa F, Taniguchi M, Shoji T, Kazama JJ, Komaba H, Ando R, Kakuta T, Fujii H, Nakayama M, Shibagaki Y, Fukumoto S, Fujii N, Hattori M, Ashida A, Iseki K, Shigematsu T, Tsukamoto Y, Tsubakihara Y, Tomo T, Hirakata H, Akizawa T; CKD-MBD Guideline Working Group; Japanese Society for Dialysis Therapy. Clinical practice guideline for the management of chronic kidney disease-mineral and bone disorder. Ther Apher Dial Jun;17(3): doi: / PubMed PMID: Hiraki K, Yasuda T, Hotta C, Izawa KP, Morio Y, Watanabe S, Sakurada T, Shibagaki Y, Kimura K. Decreased physical function in pre-dialysis patients with chronic kidney disease. Clin Exp Nephrol Apr;17(2): doi: /s Epub 2012 Aug 22. PubMed PMID: Nishi H, Shibagaki Y, Kido R, Tamura S, Nangaku M, Sugawara Y, Fujita T. Chronic renal outcome after living donor liver transplantation. Clin Transplant Jan-Feb;27(1):90-7. doi: /ctr Epub 2012 Sep 2. PubMed PMID: Oishi D, Koitabashi K, Hiraki K, Imai N, Sakurada T, Konno Y, Shibagaki Y, Yasuda T, Kimura K. Physical activity is associated with serum albumin in peritoneal dialysis patients. Adv Perit Dial. 2012;28: PubMed PMID: Kawarazaki H, Shibagaki Y, Kido R, Nakajima I, Fuchinoue S, Ando K, Fujita T, Fukagawa M, Teraoka S, Fukumoto S. Kidney transplantation restored uncoupled bone turnover in end-stage renal disease. Clin Nephrol Jul;78(1):10-6. PubMed PMID: Sakurada T, Kojima S, Oishi D, Koitabashi K, Miyamoto M, Shirai S, Shibagaki Y, Yasuda T, Sato T, Kimura K. Prothrombin fragment (F1 + 2) in effluent is a useful marker for peritoneal permeability in peritoneal dialysis patients using neutral dialysate. Adv Perit Dial. 2011;27:2-5. PubMed PMID: Kawarazaki H, Shibagaki Y, Fukumoto S, Kido R, Ando K, Nakajima I, Fuchinoue S, Fujita T, Fukagawa M, Teraoka S. Natural history of mineral and bone disorders after living-donor kidney transplantation: a one-year prospective observational study. Ther Apher Dial Oct;15(5): doi: /j x. Epub 2011 May 25. PubMed PMID: Yazawa M, Kido R, Shibagaki Y, Yasuda T, Nakazawa R, Sasaki H, Sato Y, Chikaraishi T, Kimura K. Kidney function, albuminuria and cardiovascular risk factors in post-operative living kidney donors: a single-center, cross-sectional study. Clin Exp Nephrol Aug;15(4): doi: /s Epub 2011 Apr 19. PubMed PMID: Kawarazaki H, Shibagaki Y, Fukumoto S, Kido R, Nakajima I, Fuchinoue S, Fujita T, Fukagawa M, Teraoka S. The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor 3

5 kidney transplantation: a 1-year prospective observational study. Nephrol Dial Transplant Aug;26(8): doi: /ndt/gfq777. Epub 2011 Feb 8. PubMed PMID: Nakaya I, Namikoshi T, Tsuruta Y, Nakata T, Shibagaki Y, Onishi Y, Fukuhara S; School of Designing Clinical Study for Nephrologists and Dialysis Physicians. Management of asymptomatic hyperuricaemia in patients with chronic kidney disease by Japanese nephrologists: a questionnaire survey. Nephrology (Carlton) Jul;16(5): doi: /j x. PubMed PMID: Tsuruoka K, Yasuda T, Koitabashi K, Yazawa M, Shimazaki M, Sakurada T, Shirai S, Shibagaki Y, Kimura K, Tsujimoto F. Evaluation of renal microcirculation by contrast-enhanced ultrasound with Sonazoid as a contrast agent. Int Heart J May;51(3): PubMed PMID: Nishi H, Shibagaki Y, Hirano K, Akahane M, Kido R, Nangaku M, Kaname S, Sasahira N, Isayama H, Tada M, Tsukamoto R, Ohtomo K, Omata M, Fujita T. Laboratory and imaging features of kidney involvement in autoimmune pancreatitis: incidence, correlation, and steroid therapy response. Clin Nephrol Apr;73(4): PubMed PMID: Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy. Am J Transplant Jul;10(7): doi: /j x. Epub 2010 Mar 26. PubMed PMID: Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. Very low but stable glomerular filtration rate after living kidney donation: is the concept of "chronic kidney disease" applicable to kidney donors? Clin Exp Nephrol Aug;14(4): doi: /s y. Epub 2010 Mar 26. PubMed PMID: Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. How do living kidney donors develop end-stage renal disease? Am J Transplant Nov;9(11): doi: /j x. Epub 2009 Aug 14. PubMed PMID: Kusumi E, Kami M, Hara S, Hoshino J, Yamaguchi Y, Murashige N, Kishi Y, Shibagaki Y, Shibata T, Matsumura T, Yuji K, Masuoka K, Wake A, Miyakoshi S, Taniguchi S. Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: possible involvement of graft-versus-host disease. Int J Hematol Mar;87(2): doi: /s Epub 2008 Feb 9. PubMed PMID: Kawarazaki H, Shibagaki Y, Shimizu H, Kawarazaki W, Ito N, Ishikawa A, Fukumoto S, Fujita T. Persistent high level of fibroblast growth factor 23 as a cause of post-renal transplant hypophosphatemia.clin Exp Nephrol. 2007;11: Shibagaki Y, Matsumoto M, Kokame K, Ohba S, Miyata T, Fujimura Y, Fujita T.: Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure. Nephrol Dial Transplant ;

6 7. de Mattos AM, Prather J, Olyaei AJ, Shibagaki Y, Keith DS, Mori M, Norman DJ, Becker T. Cardiovascular events following renal transplantation: role of traditional and transplant-specific risk factors. Kidney Int. 2006;70: Shibagaki Y, Tai C, Nayak A, Wahba I. Abdominal compartment syndrome as a common but under-recognized cause of acute renal failure: Report of 5 cases and review of literature. Nephrol Dial Transplant. 2006; 21: Shibagaki Y, and Fujita T. Thrombotic Microangiopathy in Malignant Hypertension and HUS (hemolytic uremic syndrome) / TTP (thrombotic thrombocytopenic purpura) : Can We Differentiate One from the Other? Hypertens Res 2005; 28: Kishi Y, Murashige N, Kami M, Miyakoshi S, Shibagaki Y, Hamaki T, Takaue Y, Taniguchi, S. for the Tokyo Stem Cell Transplantation (SCT) Consortium. Optimal initial dose of oral cyclosporine in relation to its toxicities for graft-versus-host disease prophylaxis following reduced-intensity stem cell transplantation in Japanese patients. Bone Marrow Transplant. 2005; 35: Nishi H, Shibagaki Y, Hatakeyama S, Ito T, Nagata T, Tojo A, Nangaku M, Fujita T. Metastatic intracranial subdural empyema from renal cyst infection in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2005; 20: Ando K, Takahashi K, Shibata S, Matsui H, Fujita M, Shibagaki Y, Shimosawa T, Isshiki M, Fujita T. Two cases of renovascular hypertension and ischemic renal dysfunction: reliable choice of examinations and treatments. Hypertens Res.2004; 27: Shibagaki Y, Shetty A. Anemia is Common after Renal Transplantation, especially among African Americans. Nephrol Dial Transplant. 2004; 19: 濱 野 高 行 (1 期 生 ) 35. Hamano T, Nakano C, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Shimomura A, Okada N, Rakugi H, Isaka Y, Tsubakihara Y. Reply to "FGF23 adds value to risk prediction in patients with chronic kidney disease" Bone in press 34. Taniguchi M, Fukagawa M, Fujii N, Hamano T, Shoji T, Yokoyama K, Nakai S, Shigematsu T, Iseki K, Tsubakihara Y; Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy. Serum phosphate and calcium should be primarily and consistently controlled in prevalent hemodialysis patients. Ther Apher Dial Apr;17(2): Inoue K, Hamano T, Nango N, Matsui I, Tomida K, Mikami S, Fujii N, Nakano C, Obi Y, Shimomura A, Kusunoki Y, Rakugi H, Isaka Y, Tsubakihara Y. Multidetector-row computed tomography is useful to evaluate the therapeutic effects of bisphosphonates in glucocorticoid-induced osteoporosis. cvbfrhg in press 32. Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC. Combination of factor h mutation and properdin deficiency causes severe c3 glomerulonephritis. J Am Soc Nephrol Jan;24(1): Liu KD, Yang W, Anderson AH, Feldman HI, Demirjian S, Hamano T, He J, Lash J, Lustigova E, Rosas SE, Simonson MS, Tao K, Hsu CY; on behalf of the Chronic Renal Insufficiency Cohort (CRIC) study investigators. Urine neutrophil gelatinase-associated 5

7 lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int May;83(5): Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, Chavkin NW, Rahman M, Wahl P, Amaral AP, Hamano T, Master SR, Nessel L, Chai B, Xie D, Kallem RR, Chen J, Lash JP, Kusek JW, Budoff MJ, Giachelli CM, Wolf M. Fibroblast Growth Factor 23 and Arterial Calcification in the Chronic Renal Insufficiency Cohort Study. Kidney Int Jun;83(6): Nakai S, Iseki K, Itami N, Ogata S, Kazama JJ, Kimata N, Shigematsu T, Shinoda T, Shoji T, Suzuki K, Taniguchi M, Tsuchida K, Nakamoto H, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Masakane I, Marubayashi S, Morita O, Yamagata K, Wakai K, Wada A, Watanabe Y, Tsubakihara Y. An overview of regular dialysis treatment in Japan (as of 31 December 2010). Ther Apher Dial Dec;16(6): Tomida K, Hamano T, Ichimaru N, Fujii N, Matsui I, Nonomura N, Tsubakihara Y, Rakugi H, Takahara S, Isaka Y. Dialysis vintage and parathyroid hormone level, not fibroblast growth factor-23, determines chronic-phase phosphate wasting after renal transplantation. Bone Oct; 51(4): Obi Y, Ichimaru N, Hamano T, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Tsubakihara Y, Nonomura N, Rakugi H, Takahara S, Isaka Y. Orally Active Vitamin D for Potential Chemoprevention of Post-transplant Malignancy. Cancer Prev Res 2012 Oct; 5(10): Nakano C, Hamano T, Fujii N, Obi Y, Matsui I, Tomida K, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Okada N, Tsubakihara Y, Rakugi H, Isaka Y. Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis. Bone Jun; 50(6): Nakano C, Hamano T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Okada N, Tsubakihara Y, Isaka Y, Rakugi H. Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome. Clin J Am Soc Nephrol May; 7(5): Fukagawa M, Komaba H, Hamano T. Vitamin D supplementation in renal disease: Is calcitriol all that is needed? Scand J Clin Lab Invest Suppl Apr; 243: Nakai S, Iseki K, Itami N, Ogata S, Kazama JJ, Kimata N, Shigematsu T, Shinoda T, Shoji T, Suzuki K, Taniguchi M, Tsuchida K, Nakamoto H, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Masakane I, Marubayashi S, Morita O, Yamagata K, Wakai K, Wada A, Watanabe Y, Tsubakihara Y. Overview of regular dialysis treatment in Japan (as of 31 December 2009). Ther Apher Dial Feb; 16(1): Reese PP, Bloom RD, Feldman HI, Huverserian A, Thomasson A, Shults J, Hamano T, Goral S, Shaked A, Olthoff K, Rickels MR, Bleicher M, Leonard MB. Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation. Liver Int Feb; 32(2): Taniguchi M, Tanaka M, Hamano T, Nakanishi S, Fujii H, Kato H, Koiwa F, Ando R, Kimata N, Akiba T, Kono T, Yokoyama K, Shigematsu T, Kakuta T, Kazama JJ, Tominaga Y, Fukagawa M. Comparison between whole and intact parathyroid hormone assays. Ther Apher Dial Jun; 15 Suppl 1:

8 20. Hamano T, Fujii N, Matsui I, Nakano C, Inoue K, Tomida K, Mikami S, Okada N, Tsubakihara Y, Rakugi H, Isaka Y The Guideline-Practice Gap in the Management of Predialysis CKD-MBD in Japan Ther Apher Dial Jun; 15 Suppl 1: Nakai S, Suzuki K, Masakane I, Wada A, Itami N, Ogata S, Kimata N, Shigematsu T, Shinoda T, Syouji T, Taniguchi M, Tsuchida K, Nakamoto H, Nishi S, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Hamano T, Fujii N, Marubayashi S, Morita O, Yamagata K, Wakai K, Watanabe Y, Iseki K, Tsubakihara Y. Overview of Regular Dialysis Treatment in Japan (as of 31 December 2008). Ther Apher Dial Dec;14(6): Hamano T, Matsui I, Mikami S, Tomida K, Fujii N, Imai E, Rakugi H, Isaka Y. Fetuin-mineral complex reflects extraosseous calcification stress in CKD. J Am Soc Nephrol Nov;21(11): Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y. Cigarette Smoking and Progression of IgA nephropathy. Am J Kidney Dis 2010 Aug;56(2): Tanaka H, Hamano T, Fujii N, Tomida K, Matsui I, Mikami S, Nagasawa Y, Ito T, Moriyama T, Horio M, Imai E, Isaka Y, Rakugi H. The impact of diabetes mellitus on vitamin D metabolism in predialysis patients. Bone Nov; 45(5): Hamano T, Tomida K, Mikami S, Matsui I, Fujii N, Imai E, Rakugi H, Isaka Y. Usefulness of bone resorption markers in hemodialysis patients. Bone. 2009; 45(Suppl.1):S Tomida K, Hamano T, Mikami S, Fujii N, Okada N, Matsui I, Nagasawa Y, MoriyamaT, Ito T, Imai E, Isaka Y, Rakugi H. Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients. Bone. 2009; 44(4): Hamano T. Women with a history of preeclampsia should be monitored for the onset and progression of chronic kidney disease. Nat Clin Pract Nephrol. 2009; 5(1): Tanaka H, Nagasawa Y, Matsui I, Hamano T, Iwatani H, Kawada N, Horio M, Ito T, Isaka Y, Imai E. Pharmacokinetics of olmesartan medoxomil in hemodialysis patients: little effect of dialysis upon its pharmacokinetics. Clin Exp Nephrol. 2009; 13(1): Nakai S, Masakane I, Shigematsu T, Hamano T, Yamagata K, Watanabe Y, Itami N, Ogata S, Kimata N, Shinoda T, Syouji T, Suzuki K, Taniguchi M, Tsuchida K, Nakamoto H, Nishi S, Nishi H, Hashimoto S, Hasegawa T, Hanafusa N, Fujii N, Marubayashi S, Morita O, Wakai K, Wada A, Iseki K, and Tsubakihara Y. An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2007). Ther Apher Dial. 2009; 13(6): Matsui I, Hamano T, Mikami S, Fujii N, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Imai E, Rakugi H, and Isaka Y. Fully phosphorylated fetuin-a forms a mineral complex in the serum of rats with adenine-induced renal failure. Kidney Int. 2009; 75(9): Iio K, Nagasawa Y, Kimura T, Yamasaki K, Takeda Y, Hamano T, Iwatani H, Sumitsuji S, Nagai Y, Ito T, Imai E, and Hayashi T. Assessment of coronary stenosis by 16-MDCT in asymptomatic diabetic patients starting dialysis therapy. Nephron Clinical Practice. 7

9 2008;109(2):c Hamano T. Is calcitriol treatment associated with improved survival in predialysis patients with chronic kidney disease? Nature Clinical Practice Nephrology Aug;4(8): Mikami S, Hamano T, Fujii N, Nagasawa Y, Isaka Y, Moriyama T, Matsuhisa M, Ito T, Imai E, Hori M., Serum Osteoprotegerin as a screening tool for Coronary Artery Calcification Score in Diabetic Pre-dialysis patients. Hypertension Research2008. Jun;31(6): Nakai S, Masakane I, Akiba T, Iseki K, Watanabe Y, Itami N, Kimata N, Shigematsu T, Shinoda T, Syoji T, Syoji T, Suzuki K, Tsuchida K, Nakamoto H, Hamano T, Marubayashi S, Morita O, Morozumi K, Yamagata K, Yamashita A, Wakai K, Wada A, Tsubakihara Y. Overview of Regular Dialysis Treatment in Japan (as of 31 December 2005). Ther Apher Dial Dec;11(6): Hamano T. Daily versus thrice-weekly hemodialysis for phosphorus control. Nature Clinical Practice Nephrology Jul;3(7): Fujii N, Hamano T, Mikami S, Nagasawa Y, Isaka Y, Moriyama T, Horio M, Imai E, Hori M, Ito T.Risedronate. an effective treatment for glucocorticoid-induced bone loss in CKD patients with or without concomitant active vitamin D (PRIUS-CKD). Nephrol Dial Transplant. 2007; 22: Hamano T, Fujii N, Ito T, Nagasawa Y, Isaka Y, Moriyama T, Horio M, Okada N, Imai E. Serum NTX is a practical marker for assessing antiresorptive therapy for glucocorticoid treated patients with chronic kidney disease. Bone. 2006; 39(5): Hamano T, Fujii N, Ito T, Imai E. Different routes bridging calcium in Japanese hemodialysis patients. Ther Apher Dial. 2005; 9(1): Hamano T, Oseto S, Fujii N, Ito T, Katayama M, Horio M, Imai E, Hori M. Impact of lowering dialysate calcium concentration on serum bone turnover markers in hemodialysis patients. Bone. 2005; 36(5): 小 松 弘 幸 (1 期 生 ) 10. Komatsu H, Fujimoto S, Kikuchi M, Sato Y, Kitamura K. Tonsillectomy delays progression of advanced IgA nephropathy to end-stage kidney disease. Ren Fail 2012; 34: Komatsu H, Fujimoto S. Tonsillectomy combined with steroid pulse therapy induces clinical remission of IgA nephropathy. Adv Otorhinolaryngol 2011; 72: Komatsu H, Fujimoto S, Hara S, Fukuda A, Fukudome K, Yamada K, Sato Y, Kitamura K. Recent therapeutic strategies improve renal outcome in patients with IgA nephropathy. Am J Nephrol 2009; 30: Nishiura R, Kita T, Yamada K, Komatsu H, Hara S, Sato Y, Fujimoto S. Radial augmentation index is related to cardiovascular risk in hemodialysis patients. Ther Apher Dial 2008; 12: Komatsu H, Fujimoto S, Hara S, Sato Y, Yamada K, Kitamura K. Effect of tonsillectomy 8

10 plus steroid pulse therapy on clinical remission of IgA nephropathy: A controlled study. Clin J Am Soc Nephrol. 2008;3(5): Yamada K, Fujimoto S, Nishiura R, Komatsu H, Tatsumoto M, Sato Y, Hara S, Hisanaga S, Ochiai H, Nakao H, Eto T. Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis. Nephron Dial Trasplant 2007; 22: Uezono S, Hara S, Sato Y, Komatsu H, Ikeda N, Shimao Y, Hayashi T, Asada Y, Fujimoto S, Eto T. Renal biopsy in elderly patients: A clinicopathological analysis. Ren Fail 2006; 28: Komatsu H, Fujimoto S, Hara S, Nakao H, Sato Y, Yamada K, Eto T. Multivariate analysis of prognostic factors and effect of treatment in patients with IgA nephropathy. Ren Fail 2005; 27: Komatsu H, Fujimoto S, Sato Y, Hara S, Morita S, Yamada K, Eto T. Point of no return (PNR) in progressive IgA nephropathy: Significance of blood pressure and proteinuria management up to PNR. J Nephrol. 2005; 18: Komatsu H, Fujimoto S, Hara S, Sato Y, Yamada K, Eto T. Relationship between serum IgA/C3 ratio and progression of IgA nephropathy. Intern Med 2004; 43: 石 川 英 二 (2 期 生 ) 3. Ito T, Ishikawa E, Matsuda Y, Tanoue A, Fujimoto M, Matsuo H, Murata T, Hiramoto T, Ito M, Nomura S. Elevated serum levels of bromine do not always indicate pseudohyperchloremia.clin Exp Nephrol. 2010; 14, Ishikawa E, Nomura S, Hamaguchi T, Obe T, Inoue-Kiyohara M, Oosugi K, Katayama K, Ito M. Ultrasonography as a predictor of overt bleeding after renal biopsy. Clin Exp Nephrol. 2009;13: Ishikawa E, Nomura S, Obe T, Katayama K, Oosugi K, Murata T, Tanoue A, Fujimoto M, Matsuo H, Ito M. How long is strict bed rest necessary after renal biopsy? Clin Exp Nephrol. 2009; 13: 金 森 弘 志 (2 期 生 ) 7. Kanamori H, Nagai K, Matsubara T, Mima A, Yanagita M, Iehara N, Takechi H, Fujimaki K, Usami K, Fukatsu A, Kita T, Matsubayashi K, Arai H. Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and non-elderly using a visual analogue scale: The importance of appetite and depressive mood. Geriatr Gerontol Int Jan;12(1): Kanamori H, Yanagita M, Nagai K, Matsubara T, Takechi H, Fujimaki K, Hara A, Usami K, Fukatsu A, Kita T, Matsubayashi K, Arai H. Psychosocial quality of life of elderly hemodialysis patients using visual analog scale: Comparison with healthy elderly in Japan. Journal of Clinical Gerontology and Geriatrics 2011; Kanamori H, Toma M, Fukatsu A. Improvement of renal function after opening occluded atherosclerotic renal arteries. J Invasive Cardiol Sep;21(9):E Mima A, Ichida K, Matsubara T, Kanamori H, Inui E, Tanaka M, Manabe Y, Iehara N, Tanaka Y, Yanagita M, Yoshioka A, Arai H, Kawamura M, Usami K, Hosoya T, Kita T, 9

11 Fukatsu A. Acute renal failure after exercise in a Japanese sumo wrestler with renal hypouricemia. Am J Med Sci Dec;336(6): Mima A, Arai H, Matsubara T, Abe H, nagai K, Tamura Y, Torikoshi K, Araki M, Kanamori H, Takahashi T, Tominaga T, Matsuura M, Iehara N, Fukatsu A, KitaT, Doi T. Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy. Diabetes Jun;57(6): Kanamori H, Matsubara T, Mima A, Sumi E, Nagai K, Takahashi T, Abe H, Iehara N, Fukatsu A, Okamoto H, Kita T, Doi T, Arai H. Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy. Biochem Biophys Res Commun Sep 7;360(4): Kanamori H, Ota M, Takeoka H, Osafune K, Yonezu S, Fukatsu A, Kanatsu K. IgM-immune complex glomerulonephritis associated with sarcoidosis. Clin Exp Nephrol Mar;10(1): 木 村 久 仁 子 (2 期 生 ) 1. Kimura K, Yamaguchi Y, Horii M, Kawata H, Yamamoto H, Uemura S, Saito Y. ANP is Cleared Much Faster than BNP in Patients with Congestive Heart Failure. Eur J Clin Pharmacol Jul;63(7): 篠 原 加 代 (2 期 生 ) 5. Tsuchikura S, Shoji T, Kimoto E, Shinohara K,Hatsuda S, Koyama H,Emoto M, Nishizawa Y. Brachial-ankle pulse wave velocity as an index of central arterial stiffness. J Atheroscler Thromb. 2010;17(6): Tsuchikura S, Shoji T, Kimoto E, Shinohara K,Hatsuda S, Koyama H,Emoto M, Nishizawa Y. Central versus peripheral arterial stiffness in association with coronary, cerebral and peripheral arterial disease. Atherosclerosis. 2010;211(2): Hiroki Ueno, Hidenori Koyama Shinji Tanaka, Shinya Fukumoto, Kayo Shinohara, Tetsuo Shoji, Masanori Emoto, Hideki Tahara, Ryusuke Kakiya, Tsutomu Tabata, Toshio Miyata, Yoshiki Nishizawa. Skin autofluorescence, a marker for advanced glycation end product accumulation, is associated with arterial stiffness in patients with end-stage renal disease. Metabolism 2008:57(10), Kimoto E, Shoji T, Shinohara K, et al.: Regional arterial stiffness in patients with type 2 diabetes and chronic kidney disease. J Am Soc Nephrol.2006:17(8): Shinohara K, Shoji T, Kimoto E, Yokoyama H, Fujiwara S, Hatsuda S, Maeno T, Shoji T, Fukumoto S, Emoto M, Koyama H, Nishizawa Y. Effect of atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus. J Atheroscler Thromb. 2005;12(4): 玉 垣 圭 一 (2 期 生 ) 4. Shiotsu Y, Mori Y, Nishimura M, Hatta T, Imada N, Maki N, Iida K, Iwamoto N, Matsuoka E, Tamagaki K, Kosaki A. Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan. BMC Nephrol. 2013; 14: Shimizu H, Ichikawa D, Tamagaki K, Komatsu S, Kubota T, Okamoto K, Shiozaki A, 10

12 Fujiwara H, Ota N, Otsuji E. Evaluation of postoperative nephrolithiasis and renal dysfunction in gastric cancer patients. Gastric Cancer. 2013; 16(3): Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, Hatta T, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A. Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients. Clin J Am Soc Nephrol. 2011; 6(4): Shiotsu Y, Mori Y, Hatta T, Maki N, Iida K, Matsuoka E, Kado H, Ishida R, Kishimoto N, Tamagaki K, Nishimura M, Iwamoto N, Ono T, Matsubara H, Kosaki A. Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease. Nephron Extra. 2011; 1(1): 戸 田 晋 (2 期 生 ) 2. Susumu Toda, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Isao Ito, Hideki Hiramatsu,Takenori Ozaki, Naotake Tsuboi, Waichi Sato, Shoichi Maruyama, Enyu Imai and Seiichi Matsuo. Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Nephrol Dial Transplant (2012) 27: Akiho Sawai, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Susumu Toda, Isao Ito,Ryohei Hattori, Yoshihisa Matsukawa, Momokazu Gotoh, Yoshifumi Takei, Yukio Yuzawa and Seiichi Matsuo. Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients. Nephrol Dial Transplant (2011) 26: 藤 井 直 彦 (2 期 生 ) 5. Chikako Nakano, Takayuki Hamano, Naohiko Fujii, Isao Matsui, Kodo Tomida, Satoshi Mikami, Kazunori Inoue, Yoshitsugu Obi, Noriyuki Okada, Yoshiharu Tsubakihara, Yoshitaka Isaka, and Hiromi Rakugi, Combined Use of Vitamin D Status and FGF23 for Risk Stratification of Renal Outcome, Clin J Am Soc Nephrol 7: , Fujii N, Hamano T, Mikami S, Nagasawa Y, Isaka Y, Moriyama T, Horio M, Imai E, Hori M, Ito T. Risedronate, an effective treatment for glucocorticoid-induced bone loss in CKD patients with or without concomitant active vitamin D (PRIUS-CKD). Nephrol Dial Transplant. 2007; 22: Hamano T, Fujii N, Ito T, Nagasawa Y, Isaka Y, Moriyama T, Horio M, Okada N, Imai E. Serum NTX is a practical marker for assessing antiresorptive therapy for glucocorticoid treated patients with chronic kidney disease. Bone. 2006; 39(5): Hamano T, Fujii N, Ito T, Imai E. Different routes bridging calcium in Japanese hemodialysis patients. Ther Apher Dial. 2005; 9(1): Hamano T, Oseto S, Fujii N, Ito T, Katayama M, Horio M, Imai E, Hori M. Impact of lowering dialysate calcium concentration on serum bone turnover markers in hemodialysis patients. Bone. 2005; 36(5): 古 松 慶 之 (2 期 生 ) 10. Nakajima F, Morimoto S, Yurugi T, Amari Y, Kasuno Y, Fukui M, Furumatsu Y, Kitamura T. Increment of cerebral blood flow by LDL-apheresis in dialysis patients with arteriosclerosis obliterans: a pilot study. Int J Artif Organs. 2012; 35(11): Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori 11

13 JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H. Urinary type IV collagen in nondiabetic kidney disease. Nephron Clin Pract. 2011; 117(2):c Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H. Specialist care and improved long-term survival of dialysis patients. Nephrol Dial Transplant. 2010; 25(6): Inoue K, Nagasawa Y, Yamamoto R, Omori H, Kimura T, Tomida K, Furumatsu Y, Imai E, Isaka Yo and Rakugi H. Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug. NDT Plus. 2009; 2: Yamamoto R, Nagasawa Y, Marubashi S, Furumatsu Y, Iwatani H, Iio K, Matsui I, Dono K, Imai E, Monden M, Isaka Y. Early intervention of plasma exchange against liver failure after adult-to-adult living related liver transplantation. Blood Purification. 2009; 28: Furumatsu Y, Nagasawa Y, Hamano T, Iwatani H and Imai E. Acute renal failure with severe loin pain after anaerobic exercise (ALPE): detection of patchy renal ischaemia by contrast-enhanced colour Doppler. Nephrology Dialysis Transplantation Plus. 2008; 2: Furumatsu Y, Nagasawa Y, Hamano T, Iwatani H, Iio K, Shoji T, Ito T, Tsubakihara Y and Imai E. Integrated therapies including erythropoietin decrease the incidence of dialysis: lessons from mapping the incidence of end-stage renal disease in Japan. Nephrology Dialysis Transplantation. 2008; 23: Furumatsu Y, Nagasawa Y, Tomida K, Mikami S, Kaneko T, Okada N, Tsubakihara Y, Imai E and Shoji T. Effect of Renin-Angiotensin-Aldosterone System Triple Blockade on Non-Diabetic Renal Disease: Addition of Aldosterone Blocker, Spironolactone, to Angiotensin-Converting-Enzyme Inhibitor and Angiotensin-II Receptor Blocker Combination. Hypertension Research. 2008; 31: Furumatsu Y and Imai E. Albuminuria is associated with the incidence of some cancers in nondiabetic individuals. Nature Reviews Nephrology. 2008; 4: Shoji T, Wada A, Inoue K, Hayashi D, Tomida K, Furumatsu Y, Kaneko T, Okada N, Fukuhara Y, Imai E, Tsubakihara Y. Prospective randomized study evaluating the efficacy of the spherical adsorptive carbon AST-120 in chronic kidney disease patients with moderate decrease in renal function. Nephron Clin Pract. 2007;105(3):c Epub 2006 Dec 15. 本 間 康 一 郎 (2 期 生 ) 31. Homma K, Hayashi K, Wakino S, Tokuyama H, Kanda T, Tatematsu S, Hasegawa K, Fujishima S, Hori S, Saruta T, Itoh H. Rho Kinase Activity during Pressure-induced Constriction of Renal Microvessels. Keio J Med in press 30. Homma K, Homma Y, Shiina Y, Wakino S, Suzuki M, Fujishima S, Hayashi K, Hori S, Itoh H. Skew of plasma LDL and HDL distributions to less-dense subfractions in normotriglyceridemic CKD patients on maintenance hemodialysis treatment. Nephron Clin Pract. in press corresponding author 29. Morizane R, Monkawa T, Fujii S, Yamaguchi S, Homma K, Okano H, Itoh H. Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular 12

14 structures in vitro and differentiate into renal tubular cells. PLoS One. in press Hirowatari Y, Homma Y, Yoshizawa J, Homma K. Increase of electronegative-ldl-fraction ratio and IDL-cholesterol in chronic kidney disease patients with hemodialysis treatment. Lipids Health Dis corresponding author 27. Homma K, Homma Y, Yamaguchi S, Shiina Y, Wakino S, Hayashi K, Hori S, Itoh H. Triglyceride-rich lipoproteins in chronic kidney disease patients undergoing maintenance haemodialysis treatment. Int J Clin Pract corresponding author 26. Yamaguchi S, Yamahara K, Homma K, Suzuki S, Fujii S, Morizane R, Monkawa T, Matsuzaki Y, Kangawa K, Itoh H. The role of microrna-145 in human embryonic stem cell differentiation into vascular cells. Atherosclerosis 219: , Tokuyama H, Wakino S, Hara Y, Washida N, Fujimura K, Hosoya K, Yoshioka K, Hasegawa K, Minakuchi H, Homma K, Hayashi K, Itoh H. Role of mineralocorticoid receptor/rho/rho-kinase pathway in obesity-related renal injury. Int J Obes (Lond). 1-10, Washida N, Wakino S, Tonozuka Y, Homma K, Tokuyama H, Hara Y, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Itoh H. Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis. Nephrol Dial Transplant. 26: , Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H. Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. Sci Signal. 4: ra3, Homma Y, Michishita I, Hayashi H, Shigematsu H; Kanagawa Lipid Research Group.Effects of low-dose simvastatin on the distribution of plasma cholesterol and oxidized low-density lipoprotein in three ultra-centrifugally separated low-density lipoprotein subfractions: 12- month, open-label trial. J Atheroscler Thromb. 27: , Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, Itoh H, Yamanaka S, Nakao K. Human ES- and ips-derived vascular endothelial cells show greater functionality than adult endothelial cells due to greater expression of Sirt1. Atherosclerosis. 212: 42-47, Morita Y, Homma Y, Igarashi M, Miyano R, Yamaguchi H, Matsuda M, Tanigaki T, Shiina Y, Homma K. Decrease in glomerular filtration rate by plasma low-density lipoprotein cholesterol in subjects with normal kidney function assessed by urinalysis and plasma creatinine. Atherosclerosis. 210: , Hayashi K, Homma K, Wakino S, Tokuyama H, Sugano N, Saruta T, Itoh H. T-type ca channel blockade as a determinant of kidney protection. Keio J Med. 59: 84-95, Taura D, Sone M, Homma K, Oyamada N, Takahashi K, Tamura N, Yamanaka S, Nakao K. Induction and Isolation of Vascular Cells from Human Induced Pluripotent Stem Cells. Arterioscler Thromb Vasc Biol. 29: , Taura D, Noguchi M, Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, 13

15 Nakatsuji N, Okano H, Yamanaka S, Nakao K. Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells. FEBS Lett. 583: , Yamahara K, Sone M, Itoh H, Yamashita J, Yurugi-Kobayashi T, Ting-Hsing Chao, Homma K, Chao TH, Miyashita K, Park K, Oyamada N, Sawada N, Fukunaga Y, Tamura N, Nakao K. Augmentation of Neovascularizaiton in Hindlimb Ischemia by Combined Transplantation of Human Embryonic Stem Cells-derived Endothelial and Mural Cells. PLoS ONE 3: e1666, Yoshioka K, Wakino S, Homma K, Kanda T, Tatematsu S, Hasegawa K, Sugano N, Ito O, Omata K, Saruta T, Hayashi K. Renal Cytochrome P450 as a Determinant of Impaired Natriuresis by PPARg Ligands in Ovariectomized Obese Rats. Obesity Research 16: , Sugano N, Wakino S, Kanda T, Tatematsu S, Homma K, Yoshioka K, Hasegawa K, Hara Y, Suetsugu Y, Yoshizawa T, Utsunomiya Y, Tokudome G, Hosoya T, Saruta T, Hayashi K. T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. Kidney Int. 73: , Tatematsu S, Wakino S, Kanda T, Homma K, Yoshioka K, Hasegawa K, Sugano N, Kimoto M, Saruta T, Hayashi K. Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease. J Am Soc Nephrol. 2007;18: Hasegawa K, Wakino S, Tatematsu S, Yoshioka K, Homma K, Sugano N, Kimoto M, Hayashi K, Itoh H. Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. Circ Res. 101: e2-10, Hayashi K, Wakino S, Sugano N, Ozawa Y, Homma K, Saruta T. Ca2+ channel subtypes and pharmacology in the kidney. Circ Res. 100: , Hasegawa K, Wakino S, Tanaka T, Kimoto M, Tatematsu S, Kanda T, Yoshioka K, Homma K, Sugano N, Kuribayashi M, Saruta T, Hayashi K. Dimethylarginine Dimethylaminohydrolase 2 Increases Vascular Endothelial Growth Factor Expression Through Sp1 Transcription Factor in Endothelial Cells. Arterioscler Thromb Vasc Biol. 26: , Homma K, Hayashi K, Wakino S, Saruta T. Primary Malignant Hepatic Pheochromocytoma with Negative Adrenal Scintigraphy. Hypertens Res. 2006; 29: Hayashi K, Wakino S, Kanda T, Homma K, Sugano N, Saruta T. Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury. J Pharmacol Sci. 100: 29-33, Hasegawa K, Wakino S, Kanda T, Yoshioka K, Tatematsu S, Homma K, Takamatsu I, Sugano N, Hayashi K. Divergent action of calcium channel blockers on ATP-binding cassette protein expression. J Cardiovasc Pharmacol. 46: , Hayashi K, Wakino S, Homma K, Sugano N, Saruta T. Pathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation. J Pharmacol Sci. 99: ,

16 5. Kanda T, Wakino S, Homma K, Yoshioka K, Tatematsu S, Hasegawa K, Takamatsu I, Sugano N, Hayashi K, Saruta T. Rho-kinase as a molecular target for insulin resistance and hypertension. FASEB J. 20: , Wakino S, Hayashi K, Tatematsu S, Hasegawa K, Takamatsu I, Kanda T, Homma K, Yoshioka K, Sugano N, Saruta T. Pioglitazone lowers systemic asymmetric dimethylarginine by inducing dimethylarginine dimethylaminohydrolase in rats. Hypertens Res. 28: , Hayashi K, Wakino S, Ozawa Y, Homma K, Kanda T, Okubo K, Takamatsu I, Tatematsu S, Kumagai H, Saruta T. Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney. Keio J Med. 54: , Kanda T, Hayashi K, Wakino S, Homma K, Yoshioka K, Hasegawa K, Sugano N, Tatematsu S, Takamatsu I, Mitsuhashi T, Saruta T. Role of Rho-kinase and p27 in angiotensin II-induced vascular injury. Hypertension. 45: , Ichihara A, Hayashi M, Kaneshiro Y, Takemitsu T, Homma K, Kanno Y, Yoshizawa M, Furukawa T, Takenaka T, Saruta T. Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients. Am J Kidney Dis. 2005; 45: 西 裕 志 (3 期 生 ) 7. Nishi H, Shibagaki Y, Kido R, Tamura S, Nangaku M, Sugawara Y, Fujita T: Chronic renal outcome after living donor liver transplantation. Clin Transplant. 2013; 27: Mimura I, Nishi H, Nishi T, Mise N, Sugimoto T. Malnutrition and inflammation determine prognosis of patients with CRS type 4. Blood Purif. 2011; 31: Mimura I, Nishi H, Mise N, Mori M, Sugimoto T. Left ventricular geometry and cardiovascular mortality based on haemodialysis patient autopsy analyses. Nephrology (Carlton). 2010; 15: Nishi H, Shibagaki Y, Hirano K, Akahane M, Kido R, Nangaku M, Kaname S, Sasahira N, Isayama H, Tada M, Tsukamoto R, Ohtomo K, Omata M, Fujita T. Laboratory and imaging features of kidney involvement in autoimmune pancreatitis: incidence, correlation, and steroid therapy response. Clin Nephrol. 2010; 73: Nishi H, Tojo A, Onozato ML, Jimbo R, Nangaku M, Uozaki H, Hirano K, Isayama H, Omata M, Kaname S, Fujita T. Anti-carbonic anhydrase II antibody in autoimmune pancreatitis and tubulointerstitial nephritis. Nephrol Dial Transplant. 2007; 22: Nangaku M, Nishi H, Fujita T. Pathogenesis and prognosis of thrombotic microangiopathy. Clin Exp Nephrol. 2007; 11: Nishi H, Tomida C, Gotoh M, Yamagata K, Akiyama H, Shimokama T. Chronic renal failure with severe mesangiolysis in a hematopoietic stem cell transplant recipient. Ren Fail. 2006; 28: 吾 郷 里 華 (3 期 生 ) 1. Rika Ago, Ayumu Nakashima, Takayuki Naito, Shigehiro Doi, Mariko Ochiai, Naoki Hamaguchi, Yukio Yokoyama, Junko Tanaka, Noriaki Yorioka, Takao Masaki, and 15

17 Nobuoki Kohno. Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients. clinical and experimental Nephrology (2012)(16)( ) 濵 田 康 弘 (3 期 生 ) 2. Hamada Y, Shinohara Y, Yano M, Yamamoto M, Yoshio M, Satake K, Toda A, Hirai M, Usami M: Effect of the menstrual cycle on serum diamine oxidase levels in healthy women. Clin Biochem. 2013;46(1-2): Usami M, Miyoshi M, Kanbara Y, Aoyama M, Sakaki H, Shuno K, Hirata K, Takahashi M, Ueno K, Hamada Y, Tabata S, Asahara T, Nomoto K: Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. Clin Nutr. 2013; 32(3): 藤 﨑 毅 一 郎 (3 期 生 ) 1. Fujisaki K, Kanai H, Hirakata H, Nakamura S, Koga Y, Hattori F, Iida M. Midodrine hydrochloride and L-threo-3,4-dihydroxy-phenylserine preserve cerebral blood flow in hemodialysis patients with orthostatic hypotension. Ther Apher Dial. 2007; 11: 三 上 聡 司 (3 期 生 ) 1. Mikami S, Hamano T, Fujii N, Nagasawa Y, Isaka Y, Moriyama T, Matsuhisa M, Ito T, Imai E, Hori M.Serum osteoprotegerin as a screening tool for coronary artery calcification score in diabetic pre-dialysis patients. Hypertens Res Jun;31(6): 安 田 宜 成 (3 期 生 ) 24. Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S. Lower serum albumin level is associated with higher fractional excretion of creatinine. Clin Exp Nephrol. in press 23. Hara Y, Noda A, Miyata S, Otake H, Yasuda Y, Okuda M, Koike Y, Nakata S, Nakashima T. Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing. Am J Otolaryngol. in press 22. Noda A, Miyata S, Yasuda Y. Therapeutic strategies for sleep apnea in hypertension and heart failure. Pulm Med. 2013; 2013: Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S; Collaborators Developing the Japanese Equation for Estimated GFR. GFR estimation using standardized serum cystatin C in Japan. Am J Kidney Dis Feb;61(2): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S. Performance of GFR equations in Japanese subjects. Clin Exp Nephrol Jun;17(3): Okumura N, Hayashi M, Imai E, Ishii H, Yoshikawa D, Yasuda Y, Goto M, Matsuo S, Oiso Y, Murohara T. Effects of carperitide on contrast-induced acute kidney injury with a minimum volume of contrast in chronic kidney disease patients. Nephron Extra Jan;2(1): Imai E, Yasuda Y, Matsuo S. A decade after the KDOQI CKD guidelines: a perspective from Japan. Am J Kidney Dis Nov; 60(5): Tatematsu M, Yasuda Y, Morita Y, Sakamoto I, Kurata K, Naruse T, Yamamoto R, Tsuboi N, Sato W, Imai E, Matsuo S, Maruyama S. Complete Remission within Two Years 16

18 Predicts a Good Prognosis after Methylprednisolone Pulse Therapy in Patients with IgA Nephropathy. Clin Exp Nephrol Dec;16(6): Okada R, Yasuda Y, Tsushita K, Wakai K, Hamajima N, Matsuo S. Glomerular hyperfiltration in prediabetes and prehypertension. Nephrol Dial Transplant May;27(5): Horio M, Yasuda Y, Kaimori J, Ichimaru N, Isaka Y, Takahara S, Nishi S, Uchida K, Takeda A, Hattori R, Kitada H, Tsuruya K, Imai E, Takahashi K, Watanabe T, Matsuo S. Performance of the Japanese GFR equation in potential kidney donors. Clin Exp Nephrol Jun;16(3): Ando Y, Kawada K, Inada M, Morita S, Mitsuma A, Yasuda Y, Hiramatsu M, Fujimoto Y, Fujita K. Pharmacokinetic study of S-1 in patients in whom inulin clearance was measured. Oncology. 2012; 83(1): Nakazaki C, Noda A, Yasuda Y, Nakata S, Koike Y, Yasuma F, Murohara T, Nakashima T. Continuous positive airway pressure intolerance associated with elevated nasal resistance is possible mechanism of complex sleep apnea syndrome. Sleep Breath Sep;16(3): Dai SS, Yasuda Y, Zhang CL, Horio M, Zuo L, Wang HY. Evaluation of GFR measurement method as an explanation for differences among GFR estimation equations. Am J Kidney Dis Sep; 58(3): Shimokata T, Ando Y, Yasuda Y, Hamada A, Kawada K, Saito H, Matsuo S, Kondo M, Imaizumi K, Hasegawa Y. Prospective evaluation of pharmacokinetically guided dosing of carboplatin in Japanese patients with cancer. Cancer Sci Dec;101(12): Horio M, Yasuda Y, Takahara S, Imai E, Watanabe T, Matsuo S. Comparison of a simple and a standard method for inulin renal clearance. Clin Exp Nephrol Oct;14(5): Miyagi M, Ishii H, Murakami R, Isobe S, Hayashi M, Amano T, Arai K, Yoshikawa D, Ohashi T, Uetani T, Yasuda Y, Matsuo S, Matsubara T, Murohara T. Impact of renal function on coronary plaque composition. Nephrol Dial Transplant Jan; 25(1): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S. Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates. Am J Kidney Dis Jul; 56(1): Mastuo S, Yasuda Y, Imai E, Horio M. Current status of estimated GFR (egfr) equations for Asians and an approach to create a common egfr equation. Nephrology. 2010; 15(Suppl.2): Sukegawa M, Noda A, Yasuda Y, Nakata S, Sugiura T, Miyata S, Honda K, Hasegawa Y, Nakashima T, Koike Y. Impact of microarousal associated with increased negative esophageal pressure in sleep-disordered breathing. Sleep Breath Nov;13(4): Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A. Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney 17

19 Dis Jun; 53(6): Horio M, Imai E, Yasuda Y, Hishida A, Matsuo S. Japanese Equation for Estimating GFR.Simple sampling strategy for measuring inulin renal clearance. Clin Exp Nephrol Feb; 13(1): Imai E, Horio M, Iseki K, Yamagata K, Watanabe T, Hara S, Ura N, Kiyohara Y, Hirakata H, Moriyama T, Ando Y, Nitta K, Inaguma D, Narita I, Iso H, Wakai K, Yasuda Y, Tsukamoto Y, Ito S, Makino H, Hishida A, Matsuo S. Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clin Exp Nephrol. 2007; 11: Imai E, Horio M, Nitta K, Yamagata K, Iseki K, Hara S, Ura N, Kiyohara Y, Hirakata H, Watanabe T, Moriyama T, Ando Y, Inaguma D, Narita I, Iso H, Wakai K, Yasuda Y, Tsukamoto Y, Ito S, Makino H, Hishida A, Matsuo S. Estimation of Glomerular Filtration Rate by the MDRD Equation Modified for Japanese Patients with Chronic Kidney Disease. Clin Exp Nehrol. 2007; 11: Sugiura T, Noda A, Nakata S, Yasuda Y, Soga T, Miyata S, Nakai S, Koike Y. Influence of nasal resistance on initial acceptance of continuous positive airway pressure in treatment for obstructive sleep apnea syndrome. Respiration. 2007; 74: 若 杉 三 奈 子 (3 期 生 ) 8. Wakasugi M, Kazama JJ, Taniguchi M, Wada A, Iseki K, Tsubakihara Y, Narita I. Increased Risk of Hip Fracture among Japanese Hemodialysis Patients. J Bone Miner Metab 2013 Jan 6. [Epub ahead of print] 7. Wakasugi M, Kazama JJ, Yamamoto S, Kawamura K, Narita I. Cause-specific excess mortality among dialysis patients: A comparison with the general population in Japan. Ther Apher Dial 2012 DEC 11. DOI: /j x [Epub ahead of print] 6. Wakasugi M, Kazama JJ, Kawamura K, Yamamoto S, Narita I. A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: a population-based cohort study. Hypertens Res Nov 22. doi: /hr [Epub ahead of print] 5. Wakasugi M, Kazama JJ, Narita I.Use of Japanese society for dialysis therapy dialysis tables to compare the local and national incidence of dialysis. Ther Apher Dial. 2012; 16: Wakasugi M, Narita I, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Kurahashi I, Ohashi Y, Watanabe T. Weight gain after 20 years of age is associated with prevalence of chronic kidney disease. Clin Exp Nephrol. 2012; 16(2): Wakasugi M, Kawamura K, Yamamoto S, Kazama JJ, Narita I. High mortality rate of infectious diseases among dialysis patients: A comparison with the general population in Japan. Ther Apher Dial. 2012; 16(3): Wakasugi M, Kazama JJ, Narita I. Differences in the Local and National Prevalences of CKD Based on Annual Health Check Program Data. Clin Exp Nephrol. 2012; 16(5):

20 1. Otaki Y, Kouda R, Fujimura T, Nakatsue T, Wakasugi M, Murakami S, Kuroda T, Narita I, Nakano M, Gejyo F. Acute renal failure as a complication of acquired hemophilia due to autoantibody to factor VIII. Clin Exp Nephrol Oct ; 14. [Epub ahead of print] 木 戸 亮 (4 期 生 ) 10. Nishi H, Shibagaki Y, Kido R, Tamura S, Nangaku M, Sugawara Y, Fujita T. Chronic renal outcome after living donor liver transplantation. Clin Transplant [Epub ahead of print]. ( 査 読 あり;IF 1.667) 9. Kawarazaki H, Shibagaki Y, Kido R, Nakajima I, Fuchinoue S, Ando K, Fujita T, Fukagawa M, Teraoka S, Fukumoto S. Kidney transplantation restored uncoupled bone turnover in end-stage renal disease. Clin Nephrol. 2012; 78(1): ( 査 読 あり;IF 1.058) 8. Kawarazaki H, Shibagaki Y, Fukumoto S, Kido R, Ando K, Nakajima I, Fuchinoue S, Fujita T, Fukagawa M, Teraoka S. Natural history of mineral and bone disorders after living-donor kidney transplantation: a one-year prospective observational study. Ther Apher Dial. 2011; 15: ( 査 読 あり;IF 1.391) 7. Akizawa T, Kido R, Fukagawa M, Onishi Y, Yamaguchi T, Hasegawa T, Fukuhara S, Kurokawa K. Decreases in PTH in Japanese hemodialysis patients with secondary hyperparathyroidism: associations with changing practice patterns. Clin J Am Soc Nephrol. 2011; 6(9): ( 査 読 あり;IF 5.227) 6. Yazawa M, Kido R, Shibagaki Y, Yasuda T, Nakazawa R, Sasaki H, Sato Y, Chikaraishi T, Kimura K. Kidney function, albuminuria and cardiovascular risk factors in post-operative living kidney donors: a single-center, cross-sectional study. Clin Exp Nephrol. 2011; 15: ( 査 読 あり;IF 1.37) 5. Kawarazaki H, Shibagaki Y, Fukumoto S, Kido R, Nakajima I, Fuchinoue S, Fujita T, Fukagawa M, Teraoka S. The relative role of fibroblast growth factor 23 and parathyroid hormone in predicting future hypophosphatemia and hypercalcemia after living donor kidney transplantation: a 1-year prospective observational study. Nephrol Dial Transplant. 2011; 26: ( 査 読 あり;IF 3.396) 4. Nishi H, Shibagaki Y, Hirano K, Akahane M, Kido R, Nangaku M, Kaname S, Sasahira N, Isayama H, Tada M, Tsukamoto R, Ohtomo K, Omata M, Fujita T. Laboratory and imaging features of kidney involvement in autoimmune pancreatitis: incidence, correlation, and steroid therapy response. Clin Nephrol. 2010; 73: ( 査 読 あり;IF 1.058) 3. Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. Persistent glomerular hematuria in living kidney donors confers a risk of progressive kidney disease in donors after heminephrectomy. Am J Transplant. 2010; 10: ( 査 読 あり;IF 6.394) 2. Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. Very low but stable glomerular filtration rate after living kidney donation: is the concept of "chronic kidney disease" applicable to kidney donors? Clin Exp Nephrol. 2010; 14: ( 査 読 あり;IF 1.37) 1. Kido R, Shibagaki Y, Iwadoh K, Nakajima I, Fuchinoue S, Fujita T, Teraoka S. How do living kidney donors develop end-stage renal disease? Am J Transplant. 2009; 9: ( 査 読 あり;IF 6.394) 19

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