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47 BMJ 1997; 315: Esophageal Doppler FTc > 0.35

48 Protocol

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50 (1997) Esophageal Doppler GDT

51 Anesthesiology 2002; 97: Major surgery Esophageal Doppler FTc >0.35

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57 GDT PONV LOSGDT5 vs 7

58 6% hetastarchgoal directed fluid administration

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60 Year Journal Device Goal 2007 Crit Care HandmadePPV PPV <10% 2008 Int J Surg LiDCO cft > Diseases of colon ESO D PVI < 13% 2010 A&A PVI CI > 2.5, SVV < Crit Care Flo Trac CI > EJA Flo Trac 15ml/kg vs 40 ml/kg 2010 Obase Surg SV maximization 2010 Crit Care Flo Trac SV increase < 10% 2011 A&A Mashimo Raibow ESO D PPV < 13% 4ml/kg/hr vs 12 ml/kg/hr 2011 Crit Care LiDCO SV increase < 10% 2012 BJA ESO D SV increase < 10% 2012 BJA ESO D SV increase < 10% 2013Acta Anaesth Scand LiDCO SV increase < 10% 2013 BJA ESO D SV increase < 10% 2013 J Clin Monit Comp Flo Trac SV increase < 10% 2013 BJS ESO D SV increase < 10%

61 Flo Trac LiDCO SV increase < 10%

62 Year Journal N Patients Outcome 2007 Crit Care 33 High risk surgery LOS Int J Surg 50 Emergency abdominal surgery Renal function Diseases of colon 64Laparoscopic colectomy Colloid is worse 2010 A&A 82 Major abdominal surgery PVI less fluid 2010 Crit Care 60 High risk abdominal suregry LOS +, Complication less 2010EJA 57 Peripheral Vascular Surgery No difference 2010 Obase Surg 100 Bariatic surgery 2010 Crit Care 40 Total Hip (regional) Less complication 2011 A&A 25 Major colorectal suregry PVI can predict FR 2011 Crit Care 88 High risk major surgery Restricted is better 2012BJA 150Elective colorectal suregry No difference 2012 BJA 179 Colorectal surgery No difference 2013Acta Anaesth Scand 70Abdominal aortic surgery No dofference 2013 BJA 50 Ovarina Cancer surgery HES is better 2013 J Clin Monit Comp 64High risk surgery Almost no difference 2013 BJS 85 Colorectal surgery No difference

63 Year Jorunal Device Bolus Fluid 2007 Crit Care HandmadePPV HES 2008 Int J Surg LiDCO HES 2009 Diseases of colon ESO D HES or LR 2010 A&A PVI HES 2010 Crit Care Flo Trac Colloid 2010 EJA Flo Trac HES 2010 Obase Surg 2010 Crit Care Flo Trac HES 2011 A&A Mashimo Raibow ESO D HES 2011 Crit Care LiDCO Gelatin 2012 BJA ESO D HES 2012 BJA ESO D HES 2013Acta Anaesth Scand LiDCO HES 2013 BJA ESO D HES vs crystaloid 2013 J Clin Monit Comp Flo Trac HES 2013 BJS ESO D HES

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