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1

2

3 RR QT

4

5

6

7

8 V1 V2 V3 avr V4 avl V5 avf V6

9 V1 V2 V3 avr avl avf V4 V5 V6

10 Torsades de pointes

11 () PVC ( ) late potentials T-wave alternans QT dispersion ()

12 3 (QTDLPTWA) TWA 56 max Valt : 8.8 µv (in Z lead) max Ralt : 759 (in Z lead)

13 LP 62 f-qrs: 149 ms (<135) RMS 40 : 12 µv (>20) LAS 40 : 46 ms (<38) QTD 58 QTD = 102 ms (<5070) 50 mm/s

14 Kaplan Meier (Event-Free Curve) 100 TWA LP Event-Free (%) P=0.006 : TWA positive : TWA negative P= : LP positive : LP negative Follow-up (Months) Follow-up (Months) Kaplan Meier (Event-Free Curve) 100 QTD EF Event-Free (%) P=0.03 : QTD > 65 ms : QTD < 65 ms P=0.003 : EF < 40% : EF > 40% Follow-up (Months) Follow-up (Months)

15 TWA 93% 59% 28% 98% 64% LP 53% 85% 38% 91% 80% QTD 40% 84% 30% 92% 77% EF 60% 78% 32% 89% 75% Kaplan Meier(Event-Free Curve) TWALP 50% 100 Event-Free (%) P< : TWALP : TWALP : TWALP : TWALP Follow-up (Months)

16

17 V1 V2 V3 avr V4 avl V5 avf V6

18

19 (DCM, HCM) QT (ARVC) Brugada WPW 1:1

20

21

22

23

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25 QTD,LP,TWA

26

27 Torsades de pointes

28

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30 c Baseline Post Pilsicainide mg/kg i.v.

31

I PD-I-3 VA ICD 2006 NYHA ~ LVEF 35% a ICD SCD-HeFT ICD MADIT- ICD a CABG-Patch ICD EF b MADITø MADIT- MUSTT EPS EPS 19 EPS 5/19 VA PD-I-4 Holter LP f

I PD-I-3 VA ICD 2006 NYHA ~ LVEF 35% a ICD SCD-HeFT ICD MADIT- ICD a CABG-Patch ICD EF b MADITø MADIT- MUSTT EPS EPS 19 EPS 5/19 VA PD-I-4 Holter LP f J Arrhythmia Vol 23 (Suppl) 2007 PD-I-1 OACIS 95% 6.4 (1.5 27.8 4.3 (1.0 18.5), 0.2 (0.05 0.93), respectively MADIT LVEF 30% 192 2.0 12.4% 24 3.1% MADIT 12.1% p=.001), ICD direct PCI OACIS (Osaka Acute

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