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1 Streptomyces mobaraensis N N N Sm b Sm N N Sm

2 Sm Sm ' ' Sm Sm ak K k K bk k K

3 Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab S. lividansab S. lividans n f Sm Sm

4 Sm a b ba ba E. coli ba Sm Sm S. lividansabs. lividansab S. lividans ab Sm f ab f S. lividans ab S. lividansab Sm Sm S. lividansab

5 Sm Sm S. lividansab Sm Sm Sm a Sm Sm E. coli ba Sm Sm Sm Sm Sm Sm Sm

6

7 n n S. mobaraensis S. mobaraensis S. lividans E. coli S. lividans Sm Sm Streptomyces mobaraensis N NJ. Agric. Food Chem., Biochem. Mol. Biol. Int., Streptomyces mobaraensis. J. Biotechnol., Biochem. Biophys. Acta, Life Sci.,

8 Eur. J. Pharmacol., Br. J. Anaesth., Tetrahedron Lett., Biotechnol. Lett., Streptomyces mobaraensis. Biosci. Biotechnol. Biochem., Eur. J. Biochem., J. Biosci. Bioeng., Streptomyces. Proc. Natl. Acad. Sci. USA, Protein Sci.,

9 Streptomyces mobaraensis Streptomyces mobaraensis N S. mobaraensis Sm b Sm Sm S. lividansescherichia coli.s. lividanssm E. coli

Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)

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