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- もりより あさま
- 7 years ago
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Transcription
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4 * 1EE +8EE neants. D. +lee + 8 EEI meants. D ( ) AUCo in (ne' hrlml) /r'
5 200ne,/ lne
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8 Precedex' i v.6.l iral +*lrr
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11 -osg :!99:5!g'g - >50m8 >0mg-'50mg >50ms
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16 ttz(hr) trtzlllr) /wrfttr-tv >omg-50mg iel Phase >Omg-50m9
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25 7, e 7, /-I, [Aripiprazole(JAU. INN)) (2,3- dichlorophenyl) -l-piperazinylj butoxyl -3,4- dihydro-2 ( I Il) -quinolinone
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33 a Otsuko
34 I'tr7v<,,nffirfr,o.1o/o
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42 li<-lvil1 llt Orzs
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45 100mg 50mg 100mg 18 (39.1) 10 (6b.e)
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48 4> V z mg
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53 CnENCIIA syrrnge FoR s.c. rnjecron
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56 Cmax " (ue/ml-) ACR20 (%) b
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61 lnjection 1000mg
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63 AUC!g.hrlmL)
64 OrenuMo'
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69 5mg/kg 25 (mglml) 7 5mg/kg l0mgn{g l5mg/kg
70
71 i.+l* F'lt /\Jf- IV F'
72 /\+I* f* *
73
74 @oz'ttu->
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77 0.5 ms m 607
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82 l+s.s) o/19 xx i50.5) o1g** 128.3) o/18 ** i30.e) 66t ) '.1s.4) 43132s03.2)
83 AUC0-r2h (ns'h/ml,) Tmax (h) AUCO - (ns'h/ml) r max \n/ Cmax(nglml-)
84 Cmax Cmax nslml)
85 1.5 mg
86 D**=Dtox125/C$ D**: Dru x 7.5 / C' )**=Dro x 7.5/C-"er
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(1) / 130 g 25 g 520% 170 g 30 g 560% 70 mg 600 mg 11.6% 0 10.5 mg 0% (1) (2) / 50100 g 25 g 200400% 50100 g 30 g 167333% 5001000 mg 600 mg 83167% 1020 mg 10.5 mg 95190% (2) / (1) 45.6 g 30 g 152% (2)
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