41 PCI 1980 PCI III. 疫 学 的 特 徴 PCI PubMed Web or trichloroethylene and or or pneumatosis cystoides intestinalis , 8 26) 46 PCI Table
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1 2015; 57 (2): 資 料 Epidemiological characteristic of occupational pneumatosis cystoides intestinalis 1,1,1-1,1, ) PCI PCI PCI PCI Shinji Kumagai Department of Management of Occupational Safety and Health, University of Occupational and Environmental Health, Japan I. はじめに 2015; 57(2): doi: /sangyoeisei.A14002 pneumatosis cystoides intestinalis, PCI PCI PCI 1 3) α PCI J-STAGE Correspondence to: S. Kumagai, Department of Management of Occupational Safety and Health, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka , Japan ( shkumagai@ health.uoeh-u.ac.jp) II. 職 業 性 腸 管 嚢 腫 様 気 腫 症 の 発 見 PCI 4) PCI % 5) % , PCI 6) PCI PCI % 7) PCI PCI 8 PCI 50 PCI 15 PCI 2 PCI % PCI % PCI
2 41 PCI 1980 PCI III. 疫 学 的 特 徴 PCI PubMed Web or trichloroethylene and or or pneumatosis cystoides intestinalis , 8 26) 46 PCI Table S Table ppm 25 ppm 27) 1/3 2 American Conference of Governmental Industrial Hygienists ACGIH Threshold Limited Values TLV, 10 ppm 28) 1 6 PCI Florin 29) PCI 6 IV. 地 域 年 代 的 傾 向 と 労 災 認 定 状 況 Table 1 PCI PCI Table 1 PCI 1 PCI 30) ) PCI
3 Table 1. Patients with Pneumatosis cystoides intestinalis related to trichloroethylene exposure Patient Sex Year at Age at diagnosis diagnosis Symptom*1 Site* 2 Work content 1 F AF AC, Ce Degreasing 2 F BFS SC Degreasing 3 F BFS SC Degreasing 4 F BFS SC Degreasing 5 F BFS SC Degreasing 6 M BFS SC Degreasing 7 F BFS SC Degreasing 8 F BFS SC Degreasing 9 M AF TC, AC Degreasing 10 M BFS SC Degreasing 11 F AF SF, HF Degreasing 12 M Before 13 F Before 14 F Before 15 M Before 16 M Before 17 F Before 18 F Before 19 M Before 20 F Before 21 F Before 22 F Before 23 F Before 24 F Before 25 F Before 26 F Before 35 BS, Di SC Degreasing 31 BS SC Degreasing automobile parts 42 BS, Di SC Degreasing 45 BS, AP SC Degreasing copper pipes 45 AP, As SC Degreasing 38 AP SC, DC Degreasing 40 BS SC Degreasing 41 AP, Di SF, HF Degreasing 44 AP, AF SF, AC Degreasing 40 BS, Di SC Degreasing blades 31 Di, As SC Degreasing dishes 51 AF, As DC AC Degreasing stainless products 53 BS SC Degreasing aluminum pipes 25 BS, AF SC Degreasing 20 BS, AF SC Degreasing 27 M 51 AF DC, TC Degreasing 28 M Dy SC, SF Removing ink in printing Trichloroethylene expsoure Duration (y) Exposure level Other solvents Area* 3 Reference No. of I.D. of reference patient* 4 5 Nagano 4, 5, Nagano 4, 5, Nagano 4, 5, Ether Nagano 4, 5, Methanol Nagano 4, 5, ,1,1-TCE Freon Nagano 4, 5, Nagano 4, 5, U-TTC = 209 mg/l, U-TCA = 34 mg/l, U-TCEOH = 175 mg/l (end of shift), A-TCE = 36 ppm Methanol Nagano 4, 5, Nagano 4, 5, 8, A-TCE = 8 ppm, 41 ppm Nagano 4, 5, 8, Methanol Nagano 4, 5, 8 12 Ether 3 Yamanashi Tokyo Nagano Osaka Saitama Shimane Shimane Saitama Saitama Gifu Niigata Niigata Gunma Nagano Nagano Nagano 5, U-TTC = 85.9 mg/l (3rd day after exposure), A-TCE = 29 ppm Tochigi 10
4 43 Table 1. Patients with Pneumatosis cystoides intestinalis related to trichloroethylene exposure (Continued) Patient Sex Year at Age at diagnosis diagnosis Symptom*1 Site* 2 Work content Trichloroethylene expsoure Duration (y) Exposure level Other solvents Area* 3 Reference No. of I.D. of reference patient* 4 29 F BFS, AP SC, SF Degreasing 30 F Before F Before Non written 25 BFS SC Degreasing 35 AP SF, HF Degreasing AP, AF, As SC, DC Removing paint 33 M AF, As SC, AC Degreasing 34 F BS, As SC AC Degreasing 35 M AP, AF DC HF Degreasing 36 M BS, AF AP 37 M BS, Di, As, Dy SC SC TC Degreasing Removing stain in dyeing 7 Fukushima 11, 12 1 ND Fukushima 12 2 ND Fukushima U-TTC = 47.6 mg/l, U-TCA = 44.7 mg/l (5th day after exposure) 5 U-TTC = 11.1 mg/g Cre (8th day after exposure), A-TCE = ppm (GM = 32 ppm, measure) 12 U-TTC = 177 mg/l, U-TCA = 32 mg/l, U-TCEOH = 145 mg/l (at end of shift), A-TCE = 30 ppm 25 U-TTC = 266 mg/l, U-TCA = 13 mg/l, U-TCEOH = 253 mg/l (at end of shift), A-TCE = 27 ppm (measure) 42 U-TTC = 295 mg/l, U-TCA = 59 mg/l, U-TCEOH = 236 mg/l (For 16 hr after exposure), A-TCE = 57 ppm (estimate from U-TTC) 22 U-TTC = 38.1 mg/l, U-TCA = 32.0 mg/l (3rd day after exposure) Methanol Methnol 1,1,1-TCE Nagano 13 Okayama 14 Nagano 8 1 Nagano 8 2 Methanol Nagano 8, 15 3 Kyoto 16, M Before 61 AF AC Non written 30 Aich M FOB SC Making 20 Chiba 19 printing plate 40 M FOB SC, DC Plating ND Tokyo M Di DC, SF Printing ND Tokyo M Before AP, AF BS, Di 43 M BS, AF TC Ce Degreasing precision parts SC Printing ND Osaka U-TTC = 13.6 mg/l, U-TCA = 7.7 mg/l Saitama F FOB, AD SC HF Painting 20 U-TTC = 8.2 mg/l (in hospital) Tokyo F AF, Dy SC, AC Glass worker 10 < Kanagawa M Di, As, SC, DC Machinist 17 Tokyo 26 Dy * 1 Symptom: AD, abdominal discomfort; AF, abdominal fullness; AP, abdominal pain; As, astriction; BS, bloody stool; BFS, bloody and frothy stool; Di, diarrhea; Dy, dyschezia; FOB, fecal occult blood. * 2 Site: AC, ascending colon; Ce, cecum; DC, descending colon; HF, hepatic colon; SC, sigmoid colon; SF, splenic flexure; TC, transverse colon. * 3 Area: Location of hospital. * 4 I.D. of patient: I.D. of patient in reference. Exposure level: U-TTC, urinary total trichloro-compounds; U-TCA, urinary trichloroacetic acide; U-TCEOH, urinary trichloroethanol; A-TCE, airborne trichloroethylene. Other solvents: 1,1,1- TCE, 1,1,1-trichloroethane. 19 PCI
5 文 献 1) INTESTINE 2012; 16: ) ; 66: ) ; 26: ) 12 Trichloroethylene ; 80: ) Yamaguchi K, Shirai T, Shimakura K, et al. Pneumatosis cystoides intestinalis and trichloroethylene exposure. Am J Gastroenterol 1985; 80: ) Sato A, Yamaguchi K, Nakajima T. A new health problem due to trichloroethylene: pneumatosis cystoides intestinalis. Arch Environ Health 1987; 42: ) trichloroethylene 1988; 85: ) : 1990; 32: ) Trichoroethylene ; 32: ) ; 82: ) ; 82: ) 1986; 83: ) ; 29: ) Ogata M, Kihara T, Kamoi T, Taguchi T, Oda J, Kenmotsu K. A report of a worker suffering from pneumatosis cystoides intestinalis following trichloroethylene exposure. Ind Health 1988; 26: ) Owa S, Akamatsu T, Matsuda Y, et al. A case of pneumatosis cystoides intestinalis associated with trichloroethylene developing typical features during the follow-up of undetermined sigmoid lesions. Dig Endosc 1991; 3: ) ; 13: ) 1996: 16: ) Ina K, Morise K, Chin K, et al. Successful hyperbaric oxygen therapy of pneumatosis cystoides intestinals: a report of two cases. Dig Endosc 1993; 5: ) ; 70: ) Trichloroethylen Pneumatosis Cystoides Coli ; 47: ) Trichloroethylen Pneumatosis Cystoides Coli ; 6: ) Hosomi N, Yoshioka H, Kuroda C, et al. Pneumatosis cystoides intestinalis: CT findings. Abdom Imaging 1994; 19: ) Trichloroethylene ; 32: ) ; 60: ) ; 17: ) ; 8: ) Florin THJ. Alkyl halides, super hydrogen production and the pathogenesis of pneumatosis cystoides coli. Gut 1997; 41: ) ; 56: ) American Conference of Governmental Industrial Hygienists TLVs and BEIs. Cincinnati (OH): ACGIH, ) [Online] [cited 2014 Sep 26]; Available from: URL: shingi/2r ssx-att/2r szr.pdf 31) [Online] [cited 2014 Dec 18]; Available from: URL: roudoukijun/rousai/syokugyoubyou/kokuji1.html
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