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1 Journal of Oral Health and Biosciences 臨 床 指 導 講 演 キーワード:Obstructive sleep apnea syndrome, Oral appliance, Bite-jumping appliance Oral Appliance for Treatment of Obstructive Sleep Apnea Syndrome Keisuke NISHIGAWA Abstract:Obstructive sleep apnea, OSA is a syndrome in which nasal and oral airflow ceases in spite of continued diaphragmatic efforts. This syndrome occurs during sleep and is brought about by a collapse or other obstruction in the upper airway. Because OSA prevents air from entering the lungs, it produces a rapid decrease in circulating blood oxygen levels. If the blood oxygen saturation level drops, the cardiovascular system reacts quickly in an effort to increase blood flow. As a result, OSA patients are frequently hypertensive and often exhibit dangerous cardiac arrhythmias. Other complications include the development of severe daytime sleepiness, loud snoring and disturbed nighttime sleep. Oral appliance, OA is a popular non-surgical method for treatment of sleep apnea. The OA, used in our clinic, consisted of separate lower and upper full coverage acrylic appliances, which were connected with two rod and tube devices. This device advanced the mandible and allow for opening, protrusive and some side-to-side movement, but no retrusive movement. The OA was worn during sleep and supposedly increases airway caliber and decrease airway resistance. This report introduces the clinical know-how of OA treatment for OSA patients. は じ め に CPAP - Bite-jumping appliance 口 腔 内 装 置 による 治 療 AHI Apnea Hypoapnea Index AHI CPAP General Dentistry, Tokushima University Hospital

2 Journal of Oral Health and Biosciences AHI CPAP, AHI 2. 印 象 採 得 及 び 咬 合 採 得 時 mm mm, 口 腔 内 装 置 の 作 製 手 順 1. 初 診 時 3. 口 腔 内 装 置 装 着 時 Herbst Bite-jumping appliance Ormco Corp. CA, USA Bite-jumping appliance

3 Bite-jumping appliance 4. 経 過 観 察 時

4 Journal of Oral Health and Biosciences mm 歯 科 外 来 患 者 の 経 過 調 査 1. 調 査 対 象 No.. 2. 調 査 結 果 CPAP CPAP mm n=

5 n= cd 多 数 歯 欠 損 症 例 への 対 応 例 CPAP AHI

6 Journal of Oral Health and Biosciences bc お わ り に 謝 辞

7 文 献 Guilleminault C, Tilkian A, Dement WC: The sleep apnea syndromes. Annu Rev Med, - ( ) Clark GT, Nakano M: Dental appliances for the treatment of obstructive sleep apnea. J Am Dent Assoc, - ( ) Glenn T. Clark UCLA Ferguson KA, Cartwright R, Rogers R, Schmidt- Nowara W: Oral appliances for snoring and obstructive sleep apnea: a review. Sleep, - ( ) Rose EC, Schnegelsberg C, Staats R, Jonas IE: Occlusal side effects caused by a mandibular advancement appliance in patients with obstructive sleep apnea. Angle Orthod, - ( ) Robert RR: Oral appliance therapy for the management of sleep disordered Breathing: An Overview. Sleep Breath, - ( ) de Almeida FR, Lowe AA, Tsuiki S, Otsuka R, Wong M, Fastlicht S, Ryan F: Long-term compliance and side effects of oral appliances used for the treatment of snoring and obstructive sleep apnea syndrome. J Clin Sleep Med, - ( ) Hoffstein V: Review of oral appliances for treatment of sleep-disordered breathing. Sleep Breath, - ( ) Clark GT: Mandibular advancement devices and sleep disordered breathing. Sleep Med Rev, - ( ) L'Estrange PR, Battagel JM, Harkness B, Spratley MH, Nolan PJ, Jorgensen GI: A method of studying adaptive changes of the oropharynx to variation in mandibular position in patients with obstructive sleep apnoea. J Oral Rehabil, - ( ) MAS, < professionals/dental_professionals_impression.html>; Andra Gauge, < Nishigawa K, Bando E: A method to make an interocclusal record for mandibular advancement devices. J Prosthet Dent, - ( ) -

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