=PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ml /ml AI ml

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1 : 0: + : +0 : : } = (38 )? [ ] = etc Ru

2 =PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ml /ml AI ml ] ] 4

3 & = 6 = = = = :714 ;2026 ph ( ) K/Na = / = 10 5 : 7 : / 8 : 6 9 : 10 / & / / /

4 for /K/.. +. rat/mouse with / : : for (Ru & S ) ( S 11 ) / : < < : < (+) < < : & V

5 ( = ) - / ( ) 1 (etc ) n at 3 2n ] / 4 n & 5 n ] 6 n+n 1 : 4 2 / 2 : 5 : Ru 3 : 6 :

6 / & & Ru: 2hour { } 1week [ ] 1week ( ( ) : ( )) [ ( ) ] [ ] / / etc 2 Ru, 7 9 / 8 10 : A A A

7 3 7 3 { } F B1 3 F B2 4 F B FB: GnRH h CRH ACTH h LH/FSH / ACTH 1 / 2 PIF PRL PRL / - OT LH h FSH h / / ACTH h PRL / FB hcg ecg PL PG FSH FB / h LH h FSH 1 β GnRH 2

8 [ ] 2. [ ] / 1. LHFSH FSH GnRHF SH RHLH RH F SHLH ( ) Estrogen/P rogesterone 1. FSH-RH FSH 2. FSH E 3. E LH-RH 4. LH-RH LH 5. LH FSH E P E 6. E 7. FSH-RH LH-RH 8. LH LH E P 9. P LH FSH-RH FSH 2. FSH =FSH FSH 3 - -

9 gonadotropin GnRH LHFSH / / FSH/LH LHRH/FSHRH GnRH LH GnRH FB(-)= FB(+)= GnRH 4 GnRH-analogue LH/FSH LH/FSH 5 6 LHRH etc LH etc = ? 6 GnRH LH?

10 FSH LH FSH LH 7 ( ) 8 / 9 / LH FSH / LH [LH ] GnRH & = LH LH/FSH / + LH PIH TRHE / etc / = / = 7 FSH 9 LH 8 FSH FSH

11 LH ( ) / / / etc etc = BW GTHFSH/LH Androgen sterility etc 1 : 3065 : 2223 : (E 1 ) (E 2 ) (E 3 E ) estriol LH F SH / 10 () + FSH/LH LH E/P E + 10 E+: / / /

12 LH FSH LH FSH/LH + LH +E 13 etc LH 19- P // / /// 14 // 11 : / / // / 12 P : / / :

13 FSH / FSH LH 15 GnRH ecg PMSG MW:53k FSH LH PMSG = FSH LH hcg LH / /Ru 15 GnRH GTH GnRH LH

14 local hormone or / / F 2α etc? CCMCounter Current Mechanism PGF 2α CCM PGF 2α V V A V /// PGF 2α / / ex 19 / 16 PGF 2α : & 17 PG etc GTH PGF 2α 18 : 19 etc LH /

15 / GnRH 1 etc etc 4.1 = P / = / = [ ] 1 : : 2 :

16 = [ ] SM + [ ]= SM [ ] SM - + SM = [ ] + [ ] = GnRH = SM

17 delayed implantation 3 3 4

18 5 Q Q54 6 Q Ru / 7 Q80 8 Q97

19 / 1% = / / H-Y 3. XX/XY % 1 1/80 1/200

20 XX XX/XY XY/XYY / ex. = & Bruce effect &

=PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ] ] 4

=PAS.. =.. =.... 1% 01% ] = = = = 4 (A/A 2 / /B ) 1 8 2n / n n 64 n 64 n ] ] 4 1 1 1 1.1 1.1.1 3 : 0: + : +0 : : } 40 40 40 = 3 35 35 (38 )? +0+7 30 35-0+0 38 38 +30 5 30 30 +20 16 16 1. [ ] 2. 3. 4. + = etc 1.1.2 Ru 1 2 1.2 1.2.1 =PAS.. =.. =.... 1% 01% ] 1.2.2 = = = = 4 (A/A 2

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