V W Q R a

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1

2 V W Q R a

3 E 2 E 4 ip ELIpot ph EiP Nutritem BLG 230 CFC RD 238 CRC 242 QA PMC 244 CEB 249 AX QA AX 250 CL 252 RD 256 MagCellect TM RD 259 Cytoelect TM 2496CBL 261 Chemotaxis Cytoelect TM CBL 264 Haptotaxis Cytoelect TM CBL 268 Cytoselect TM CBL 270 PMC 272

4

5 " 57 R 57 R 57 R 57 R 57 R 57 R 57 R 57 R 57 Q 57 R

6

7

8

9

10 5 R 5 R 5 R

11

12 5 V 5 V 5 R 5 R 5 V R 5 V R

13

14 5 5 V V R R 5 5 V V R R

15 R R 5 R 5 5 R R

16 5 V R 5 V R 5 V R 5 V R 5 5 V R

17 5 /5 0 0 R R 0 0 R R R R R

18 0 0 R 0 R 0 R 0 R a a a 0 a

19 5 Ra Ra Ra Ra Ra Ra

20 5 a a a a a

21 5 5 5

22 a a a a a R

23

24 R 5 5 R 5 R R 5 R 5 R 5 R 5 R 4 R 5 R 5 R 5 R

25 5 R 5 V R 5 V R 5 V R 5 V R 5 V R 5 V R 5 V R

26

27 5 R 5 R R R

28 "

29 5 5 R 5 R

30 V R R V R R

31 W W Q

32 W Q R 0 a 0 a

33 V R R

34 !!

35

36

37 R R

38

39 R Q R Q R

40 V V R R

41

42

43

44

45

46

47 a a

48 Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

49 Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

50 Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

51 5 a

52

53

54

55

56

57

58

59

60

61

62

63

64 ( ( ( a R

65 ( ( Ra Ra R

66 a a a a a a

67 /5 /5 5 R 5 a 5 R 5 R 5 5 R R 5 5

68 5 5 a a 5 R !!!!

69 5 5 Q R

70 44 44 R Q Q

71

72 R R R R R R

73 R 40 4 R ( 5 5 ( 5 R 5 R

74 ( 5 ( a a 5 a 5 a

75 R 5 R 5 R

76 ( 5 ( R 5 5

77 5 5 Q

78 5 1!!

79 Q

80 Ra Ra 5 a a

81 ( (

82 ( 5 5 (

83

84 (

85

86

87

88

89

90 5 a 5 a 5 a 5

91 5

92 5

93

94

95 5# " 05 5 #

96

97

98

99

100 5

101

102 Day 0 Day 20 Ra Ra 0 R 0 R 0 R 0 R 1 R

103 5 Q 5 Q a

104 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a

105 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a 5 a

106

107 4 4

108

109 17 3 "

110

111

112

113

114 R R

115

116

117

118 5 5 5

119

120

121

122 5

123 25 5 # Q Q Q Q Q

124 Q Q

125 Q 5 Q

126 W Q W Q Q Q

127

128 Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q

129

130 " " " "

131 2 Q Q

132 2 Q "

133 V V V V V V V V V V V V V

134 V V V V V V V V V V V V V V V V

135 ! #5#5

136 Q 5 5

137

138 V 5!! Q

139

140

141

142

143

144 5 5 4# R

145 4 R R R QR

146 5 Q Total Tubule Length (pixel) Compound Concentration (M ) 5 4 R R "!! R R

147 " Invasion Plate Top Middle Bottom Plate Cover Membrane Chamber Feeder Tray! "

148 " Q R

149 " R Q R Q R Q R Q R Q R Q R Q R aq R Q

150 5 a 5 a 5 R 1 R 1 a 1 R 0 a a a a a a a R a a R R R R R a a

151 " " " " R " R " R 05 R

152 " " " " " " " " "

153 " " " " " " " " " " "

154 # W W R R

155 04 R

156 ! Q R Q R Q R Q R W W W W Q Q Q Q Q Q

157 i " R Q R Q " R R

158

159 !

160 R R

161 5 5 0 R Q R Q Q R R Q Q R R Q R

162 W

163 W!! " " " " " " " "

164 R R R R R

165 Resazurin Non-fluorescent! R LDH Resorufin trongly red fluorescent! R R 5 R

166

167 R R R R R R R

168 R R R R R R R R R R R R R R R R R R R R R R R R R R R

169 R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R R

170 R R R R R R R R R R R R R R R R R R R R

171 R R R R R R R R R R R R R R R R R R R R

172 R R R

173 5 R

174 4 4! 4 R R

175 16 R R R R

176 a a 4 4 5

177 W

178 a R a W W

179 4

180 OD 570nm Log [5-FU] (M) R

181 R 5 QR Q Q R R!! R R!! 5 or 5 R R a a

182 !!!!! R R

183 5 5 R 5 5 R

184 ! R R R!!!! R

185 4 5 Q R # R R

186 QR QR QR Q Q Q QR QR Q Q

187

188

189

190

191 R R R

192 R 5 R 5 R

193 R 5 R 5 R

194

195 R R R R # R # # # Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q # Q Q # # Q Q Q Q # Q

196 # # # # # # # # # # # Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q # # # Q Q Q Q Q Q # Q # # Q Q Q Q

197 # # # #

198 Q Q Q Q # # Q Q ( ( Q Q " "

199 0 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 0 R 0 R 0 R 0 a 0 R 0 0 R 0 R 0 R 0 R 0 R 0 R 0 0 R

200 0 R 0 R 0 R 0 R 0 R 0 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 a 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 a 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 0 R 0 R 0 R 0 R 0 0 R 0 R 0 a 0 R 0 R

201 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R / R 0 R 0 a 0 a 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 1 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 a 0 R 0 R 0 R 0 R 0 R 0 R 0 R 0 R R 0 R

202 R 5 5 R 5 R 5 R 5 R 2 R R 2 2 Q 2 Q

203 1 R 1 R 1 R 1 R 1 R 1 Q 0 R 1 2 R 2 1 Q 2 Q 2 Q 2 0 R 0 R 2 Q 2 Q 2 2 R 1 1 Q 2 Q 5 Q 2 Q 5 5

204 1 R 1 R Q 2 Q 1 2 R 1 Q R 5 R Q 2 Q 2 Q 2 2 Q 0 R 1 R Q

205 5 Q 5 R Q 2 Q 2 1 R 1 R 1 Q R 1 R 1 R 5 1 R 1 1 R 1 1 R 1 R 1 R 1 R 1 5 R

206 1 1 2 R 2 Q 2 Q 1 2 Q R 1 R 1 4 1

207 R R 5 R 5 R Q Q Q 7 Q

208 V 5 Q 4 V

209 A

210 R

211 A /// ///// A A A AAA AA 4 R

212 R

213 5 5

214 5 5

215 5 5 5

216 " 5 R

217 5 R 5 R 5 R 5 R 5 R 5 R 5 R 5 R 5 R 5 R 5 R 5 R

218 2 Q 2 Q 2 Q 5 Q 2 R 2 Q 2 Q 2 Q 2 Q 2 Q 2 Q Q 2 Q 5 Q 5 Q 2 Q 2 Q 5 3 Q 5 2 Q

219 5 5 5 R 5 5 R R R Q R 5 R

220 5 Q Q

221 1(! # # Q Q Q Q Q 1( 1(

222 5 5(

223

224 % " #

225 Q Q Q Q Q Q

226 Q Q Q Q Q Q Q Q Q Q Q Q Q Q

227 ( (

228 ## EO LTF

229

230

231

232 !!!! a a a a

233 !!!!!!!!!!!!!!!!!!!!!

234 !!!!!!!!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!!

235

236

237

238

239

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243 =

244

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247 5 5 5 = 55

248 # #

249 #5 # #

250 #5 5#

251 #5 # #

252 5 5 (,, 5

253 5 5,,, 5 5 5

254

255 5

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257

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259 5# " 05 5 #

260 555 55

261 5555 5

262 555 " 2, 5 55

263 5 5 5$

264 555 2,

265 $ 5

266

267 5

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269 # #

270

271 4 5

272 ! !!

273 !!

274 " !

275 " " "

276 !! !!

277 " " " !!

278 " " " " 5 4 4

279 4 4 4! !!

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282 15 05 (05

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