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1 : : : : Peter St. George - Hyslop University of Toronto : Randall Bateman Neurology at Washington University School of Medicine 21
2 240 Dementia Japan Vol. 29 No. 3 September : Reisa Sperling Harvard University, Brigham and Women s Hospital, Massachusetts General Hospital : Steven G. Younkin Department of Neuroscience, MAYO clinic Jacksonville, Florida : Todd E. Golde Director, Center for Translational Research in Neurodegenerative Disease Professor, Department of Neuroscience, College of Medicine University of Florida : Eric M. Reiman Banner Alzheimer s Institute and Banner Research, University of Arizona, Arizona State University, Translational Genomics Research Institute, and Arizona Alzheimer s Consortium : β Thierry Bussiére Biogen, Cambridge, Massachusetts 02142, USA 22
3 241 Jeffrey J. Sevigny Biogen Idec Inc, Cambridge, MA, USA : : : : : 23
4 242 Dementia Japan Vol. 29 No. 3 September : : Tau imaging with PET in Tohoku University : :
5 : NanoSomiX 4. β : : HDLS 3. Alexander : 4. Neuronal Intranuclear Inclusion disease NIID 5. Vanishing white matter disease VWMD :
6 244 Dementia Japan Vol. 29 No. 3 September NHO 4. NCSE : 1. AD : 1. PET 2. plasma biomarker :
7 : Aβ immunotherapy for Alzheimer s disease : effects on apoe and vasculopathy Clinical Neurosciences, University of Southampton Kenji Sakai : MRI Time - SLIP 3. VSRAD MRS 4. VSRAD 5. MRI :
8 246 Dementia Japan Vol. 29 No. 3 September : : 4. : : ips 1. ips ips CiRA 2. ips γ 3. ips 4. ips ips β : 1. Aβ 2. Aβ 3. Aβ KLK7 4. β 28
9 : 1. PSP CBD 2. PSP CBD 3. PSP 4. PSP CBD : 5. CBD PSP : Aβ oligomer :
10 248 Dementia Japan Vol. 29 No. 3 September : 1. Aβ 2. Osaka mutation Aβ : :
11 : : : : : : & 31
12 250 Dementia Japan Vol. 29 No. 3 September : : : : : : : RI : 1. : 2. : 32
13 : 1. : : BPSD 2. : : : : Reisa Sperling Harvard University, Brigham and Women s Hospital, Massachusetts General Hospital : : : 33
14 252 Dementia Japan Vol. 29 No. 3 September 2015 NMDA NMDA NMDA enmdar enmdar enmdar β : : : Paulo Fontoura Vice President, Global Head Clinical Development Neuroscience F. Hoffmann - La Roche Ltd : : : 1. : ChE AChE BuChE 2. : F A B : : : 1. DLB : 34
15 253 DLB AD DAT DLB DAT MIBG DAT DLB AD DAT MIBG 2. : MRI MIBG (DAT) DAT : : : BPSD 2000 McKeith BPSD AchEIs AchEIs Iwasaki BPSD evidence BPSD : : : PD ADL QOL PD PD 35
16 254 Dementia Japan Vol. 29 No. 3 September : : : AD AChE NMDA AChE nachr BPSD nachr AD AD nachr : : : MIBG : : : : : : 36
17 : : : Treatable Dementia inph inph L - P L - P inph LP Lancet Neurology SINPHONI : : : : : : AD 6 QOL AD DLB 37
18 256 Dementia Japan Vol. 29 No. 3 September : : / : Lewy 38
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400 Dementia Japan Vol. 27 No. 4 October 2013 11 9 13 45 14 15 1 : 11 9 14 15 15 15 1 : β β Jorge A Ghiso Departments of Pathology and Psychiatry, New York University School of Medicine, New York, USA
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118 Dementia Japan Vol. 31 No. 1 January 2017 表 1. DLB に対して mect を行った先行研究 Rasmussen K 2003 USA Japan Japan Japan Japan 1 2
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