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1 FDG-PET (2007) PET

2 FDG PET * 2 * PET FDG PET PET/CT PET PET PET PET PET PET PET CT PET QOL PET PET PET PET 2

3 ) 9-2) 9-3) FDG-PET 9-4) 9-5) A. CT B. PET/CT 9-6) MRI 9-7) ) 12-2) 12-3) 12-4) 12-5) 12-6) 12-7) 12-8) 12-9) 12-10) 12-11)

4 PET 1994 PET PET PET FDG-PET QOL PET PET PET PET/CT PET FDG-PET PET 3-1) FDG-PET (0.54%) (0.66%) (0.97%) (1.43%) (2.31%) % ) 3-3) PET PET PET PET 4

5 PET (1) (2) (3) PET 26.2% 1 1 FDG-PET PET (1) (2) (3) (1) (2) (3) (4) (1) PET PET/CT 5

6 (2) CT (3) MRI (4) (5) (6) (7) (8) (9) (10) (1) PET (2) (1) (2) (3) BMI A. (1) (2) HDL HbA1 c BUNCRP H. (3) B. CEA AFP PSA CA125 CA19-9 NCC-ST-439 SCC C. FDG-PET FDG FDG PET PET PET/CT 4 FDG 6

7 150 mg/dl 200 mg/dl FDG 30 FDG 3.7 MBq/kg FDG 60 2D 3D FDG 2 Delayed scan SAC (Segmented Attenuation Correction) FDG-PET FDG-PET MHz FDG-PET MRI 7

8 PET/CT FDG-PET FDG-PET FDG-PET FDG-PET CT MRI MRI CT CT PET/CT CT CT 10 mm 10 mm MDCT MPR PET CT 6 CT 120 kv ma 10 mm mm CT kv ma 2 5 mm mm 8 16 MDCT PET/CT CT MDCT CT CT CT CT CT CT CT CT CT ( CT CT 8

9 PET/CT CT PET/CT PET/CT PET CT PET/CT CT CT PET PET/CT (1) PET/CT PET CT 20 (2) CT PET/CT CT CT PET CT 3 PET/CT PET/CT PET CT MR PET/CT CT PET/CT CT CT CT PET CT 9

10 PET/CT CT PET CT PET PET/CT (3) PET/CT PET SUV MIP 3 PET/CT PET/CT CT PET 2 CT PET CT PET CT SUV PET (4) PET CT (5) PET/CT PET CT CT 2 msv 12 msv PET/CT (6) PET/CT PET FDG CT delayed scan 10

11 PET PET/CT PET/CT delayed scan FDG-PET FDG-PET 1.0 T phased-array coil 5 mm SE T2 T1 (1) T2 T2 (T2 ) T1 T1 (2) T2 T2 T2 T1 FDG-PET MRS (MR spectroscopy) MRS FDG-PET 16% 12% 3 FDG-PET PET PET PET PET PET PET PET PET PET (1) (3) (4) PET 11

12 PET ID (1) PET PET/CT PET/CT CT PET (2) (3) PET PET/CT (4) PET PET/CT PET 1 PET PET PET PET 12

13 PET PET , ,919 FDG-PET 204 FDG-PET 104 FDG-PET , FDG-PET 167 FDG-PET 107 FDG-PET 60 glucose-6-phosphatase FDG-PET FDG 43, % % FDG-PET FDG FDG-PET FDG-PET 21/33 (63%) FDG-PET PET FDG-PET 87.9% 13

14 32.9% PET 80.6% 28.9% PET/CT 100% 40.4% PET/CT (p 0.01) FDG 1 PET PET 10 mm FDG-PET CT FDG-PET 5 33% % FDG-PET FDG-PET FDG 10% 9% PET H. 4 FDG-PET 26.6% 15.5% PET 3 FDG FDG FDG-PET 90.2% 22.6% PET/ CT PET II (88.6%) 14

15 PET FDG-PET PET PET (CEA) PET 10 mm 13 mm 90% PET FDG 2 PET hot spot 50% 90% N Engl J Med 2000; 343: FOBT sigmoidoscopy or colonoscopy USPSTF Ann Intern Med 2002; 137: CT CT CT FDG-PET 9 5 (56%) CT FDG-PET PET/CT PET CT FDG-PET CT PET MDCT 1 X CT FDG-PET IIA PET 65.7% IIB 100% FDG IIA CT CT 15

16 FDG PET PET/CT 59% 25.0% 100% 47.1% FDG-PET FDG FDG FDG CT FDG FDG-PET CT FDG 1) 2) CT FDG CT FDG-PET 25 35% PET/CT PET PET CT (fusion image) PET FDG-PET fusion image GGO 2 FDG CT FDG fusion image 30 fusion image PET/CT fusion image 1) FDG CT FDG-PET CT FDG FDG CT 16

17 2) PET/CT CT FDG PET/CT GGO CT PET/CT PET/CT CT CT CT CT 10 CT CT CT decision tree CT 5 mm pure GGO mixed GGO pure GGO CT CT 3) CT FDG FDG FDG FDG volume CT Single slice helical CT CT CT CT Multislice CT CT CT CT CT (A, B, C, D1, D2, D3, 17

18 D4, E1, E2) PET 4) CT CT I 1 2 X CT CT CT CT CT CT 18

19 19

20 PET FDG-PET 87.2% 42% PET PET/CT % I 99% II 100% FDG-PET 0.56% (0.09%) FDG 71% 6 1 PET CT 8 mm implant FDG 40 dense breast FDG-PET CT MRI FDG-PET 8 32% CT MRI FDG-PET FDG-PET (glucose-6-phosphatase) FDG-6- FDG FDG PDG-PET PET-CT 20

21 SUV SUV CT MRI ERCP FDG FDG-PET MRI 10 mm MRI MRCP % 65 (0.08%) % PET FDG-PET (PSA) MRI PET MRI PET PSA PET OSEM PET FDG- PET 44.7% 58.3% FDG-PET PSA MRI T2 PSA MRI 21

22 PSA MRI MRI 66.7% 53.3% PSA 100% 52.5% MRI CT 7% PET CT MRI CT MRI MRI CA125 CA19-9 FDG PET 4 stage I PET MRI T2 22

23 MRI T2 FDG FDG-PET MRI 1 16 mm 1 2 mm 7 16 mm 5 mm FDG-PET Staging FDG MALToma FDG-PET CT MRI CT MRI MRI FDG-PET 67 88% FDG-PET MRI MRI MRI FDG-PET 100% FDG-PET report/pet-anzen-gl.pdf A. FDG-PET PET/CT CT PET CT 1 FDG B. 3 23

24 (1) FDG (2) FDG C. (1) FDG (2) (3) FDG-PET 16 8 PET 2004 FDG-PET 18 PET FDG-PET PET/ CT MRI 2007 CT CT PET FDG-PET

25 1 FDG-PET 1) FDG-PET MRI MRI 2) FDG-PET 3) CT, MDCT MDCT 4) MMG MRI 5) AFP CT FDG-PET MRI 6) CA19-9 CT MRI 7) FDG-PET 8) 9) PSA TUR PSA MRI FDG-PET 10) MRI MRI CA125 CT CA125 11) MRI MRI CT CA125 12) FDG-PET CT MRI CT 13) MR, CT, CT FDG-PET NMP22 MRI CA125

26 1., : Transmission Scan PET. 1996; 33: Yasuda S, et al: Application of positron emission tomography imaging to cancer screening. Br J Cancer 2000; 83: , : FDG PET ; 38: Shreve PD, et al: Normal variants in FDG PET imaging. Principles and practice of positron emission tomography. Lippincott Williams & Wilkins, 2002: , : FDG-PET. 2002; 47: Nakai K, et al: Cancer screening with 18 F FDG-PET, In PET and PET/CT in Oncology, Springer, Berlin, 2003: , : FDG-PET. 2004; 31: , : FDG-PET. 2004; 49: : PET. 2004: 11: : FDG-PET 2004; 49: , : DWIBS FDG-PET. 2005; 50: , : FDG-PET (PET ). 2005; 37: : PET/CT PET/CT. 2006; 21: : PET/CT PET, CT. RadFan 2006; 4: : PET. Pharma Medica 2006; 24: Delbeke D, et al: Procedure guideline for tumor imaging with 18 F-FDG PET/CT 1.0. J Nucl Med 2006; 47: FDG-PET (2005 ). 16 ( ) PET 2005; 42 (2): : PET PET/CT. 2007; 14: , : FDG-PET. 2007; 44: Ono K, et al: The detection rates and tumor clinical/pathological stages of whole-body FDG-PET cancer screening. Ann Nucl Med 2007; 21: FDG. 22. Himeno S, et al: Evaluation of esophageal cancer by positron emission tomography. Jpn J Clin Oncol 2002; 32: Yasuda S, et al: Factors influencing physiological FDG uptake in the intestine. Tokai J Exp Clin Med 1998; 23: Kobori O, et al: Positron emission tomography of esophageal carcinoma using 11 C-choline and 18 F-fluorodeoxyglucose. Cancer 1999; 86: Fujii H, et al: Factors influencing nonpathological FDG uptake in various organs. In Positron Emission Tomography in the Millennium, Amsterdam, Elsevier, Yasuda S, et al: 18 F-FDG PET detection of colonic adenomas. J Nucl Med 2001; 42: , : FDG-PET. 2001; 28: , : PET. 2003; 61: Uno K, et al: FDG-PET in the diagnosis of colorectal cancer as a cancer screening approach. J Nucl Med 2004; 45: 32p. 30. : FDG-PET.,, , : FDG-PET GLUT

27 , : PET CEA. 2007; 14: , : F-18 FDG PET. 1999; 16: , : F-18 FDG PET. 1999; 44: , : FDG-PET. 2001; 17: Nomori H, et al: Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images. Lung Cancer 2004; 45: Tsukamoto E, Ochi S: PET/CT today: System and its impact on cancer diagnosis. Ann Nucl Med 2006; 20 (4): CT 2003., 6,,, 2003: CT CT. CT,,, :. CT 2004; 10: Single slice helical CT CT. 1, CT. CT, , : CT.,,,,,, 2003: : CT. 2007; 14: : FDG-PET. 2007; 29: Uno K, et al: FDG-PET evaluation of fibrocystic mastopathy in patients with breast tumor. Eur J Nucl Med 1994; 21: S , : 18 F-FDG PET. 1997; 12: Noh DY, et al: Detection of cancer in augmented breasts by positron emission tomography. Eur J Surg 1999; 165: , : FDG PET. Radioisotopes 2000; 49: Hicks RJ, et al: Pattern of uptake and excretion of 18 F-FDG in the lactating breast. J Nucl Med 2001; 42: , : F-18 FDG-PET. 2001; 46: Hurwitz R: F-18 FDG positron emission tomographic imaging in a case of ruptured breast implant: inflammation or recurrent tumor? Clin Nucl Med 2003; 28: : 5. PET.,, 2004: Iwata Y, et al: Clinical usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in the diagnosis of liver tumors. Ann Nucl Med 2000; 14: Ho CL, et al: 11 C-acetate PET imaging in hepatocellular carcinoma and other liver masses. J Nucl Med 2003; 44: Delbeke D, et al: Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma. 27

28 J Nucl Med 1999; 40: Papos M, et al: The possible role of F-18 FDG positron emission tomography in the differential diagnosis of focal pancreatic lesions. Clin Nucl Med 2002; 27: Higashi T, et al: Diagnosis of pancreatic cancer using fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) usefulness and limitations in clinical reality. Ann Nucl Med 2003; 17: Nakajo M, et al: FDG PET and PET/CT monitoring of autoimmune pancreatitis associated with extrapanceratic autoimmune disease. Clin Nucl Med 2007; 32: Seltzer MA, et al: Comparison of whole body 11 C-acetate and FDG PET in patients with prostate cancer. J Nucl Med 2000; 41: Kotzerke J, et al: 11 C-acetate positron emission tomography (PET) of prostate cancer-first clinical experience. J Nucl Med 2001; 42: Yen TC, et al: Value of dual-phase 2-fluoro-2-deoxy-D-glucose positron emission tomography in cervical cancer. J Clin Oncol 21 (19): : 15.. FDG-PET.,, 2004: Okada J, et al: The use of FDG-PET in the detection and management of malignant lymphoma: correlation of uptake with prognosis. J Nucl Med 1991; 32: Kosuda S, et al: Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer. Eur J Nucl Med 1997; 24: Ramdave S, et al: Clinical role of F-18 fluorodeoxyglucose positron emission tomography for detection and management of renal cell carcinoma. J Urol 2001; 166:

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