第43回生化学若い研究者の会夏の学校資料

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1 43 pdf WS1. Bio MBL

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4 (metabolome) 13 ``E-CELL: Software environment for whole cell simulation'' Tomita, M., Hashimoto, K., Takahashi, K., Shimizu, T., Matsuzaki, Y., Miyoshi, F., Saito, K., Tanida, S., Yugi, K., Venter, J.C., Hutchison, C.; Bioinformatics, Volume 15, Number 1, (1999) Whole cell simulation: A grand challenge of the 21 st century Tomita, M.: Trends in Biotechnology, 19:6, (2001) Towards Computer Aided Design (CAD) of Useful Microorganisms Tomita, M.: Bioinformatics 17: (2002) Computational challenges in cell simulation Takahashi, K., Yugi, K., Hashimoto, K., Yamada, Y., Pickett, C., and Tomita, M.: IEEE Intelligent Systems, Sept/Oct (2002) E-CELL2: Multi-platform E-CELL Simulation System Takahashi, K., Ishikawa, N., Sadamoto, Y., Sasamoto, H., Ohta, S., Shiozawa, A., Miyoshi. F., Naito, Y., Nakayama, Y., Tomita M.: Bioinformatics, in press. [1]

5 [2] [3] [4] (Theory of Biological Robustness) 1. Kitano, H., Computational systems biology. Nature, (6912): p Yi, T.M., et al., Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc Natl Acad Sci U S A, (9): p Morohashi, M., et al., Robustness as a measure of plausibility in models of biochemical networks. J Theor Biol, (1): p Kitano, H., Systems biology: a brief overview. Science, (5560): p

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9 1) T. Funatsu, et al.: Nature. 374, 555 (1995). 2) R.D.Vale, et al.: Nature. 380, 451 (1996). 3) H. Taguchi, et al. : Nat Biotechnol. 19, 861 (2001). 4) A. Ishijima, et al.: Cell 92, 161 (1998). 5) Lu HP, et al. : Science 282, 1877 (1998) WS5. NPO " " 3 " NIH NIH NIH

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13 Adipose formation by cofactor proteins of nuclear receptors Steroids and related fat soluble hormones regulate complex programs of gene expression via nuclear receptor family of transcription factors. Recent studies have led to the identification of cofactor protein molecules that appear to play important roles in mediating transcription by members of the nuclear receptor family. The present research will investigate the biological roles of cofactor proteins, focusing on adipose (fat) tissue, an important organ for maintaining the energy balance in the human body. The results are expected to provide further insights into the molecular basis and possibility for new treatments of obesity and obesity-linked diseases, such as diabetes mellitus and hypertension.

14 1. Kamei Y, et al A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle. FEBS Letters (2003) 536, Takahashi N, et al Overexpression and ribozyme-mediated targeting of transcriptional coactivators, CBP and p300, revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor-gamma. Journal of Biological Chemistry (2002) 277, Kawada T, et al Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. BioFactors, (2000) 13, Torchia J, et al The transcriptional co-activator p/cip binds CBP and mediates nuclear-receptor function. Nature, (1997) 387, Kamei Y, et al A CBP Integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 85, Horlein AH, et al Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature, (1995) 377,

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第124回日本医学会シンポジウム

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